An update on therapeutic opportunities offered by cancer glycolytic metabolism

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 21, 2014, Pages 4915-4925

  Granchi, Carlotta ^a   Fancelli, Daniele ^b   Minutolo, Filippo ^a  

^a UNIVERSITY OF PISA   (Italy)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

Author keywords

Antitumor agents; Cancer metabolism; Glycolysis; Hypoxia; Warburg effect

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 3 BROMO PYRUVATE; 6 PHOSPHOFRUCTOKINASE; ANTINEOPLASTIC AGENT; CAFFEINE (1,3,7 TRIMETHYLXANTHINE); DEOXYGLUCOSE; ENOLASE; ENZYME INHIBITOR; GLUCOSAMINE DERIVATIVE; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 3; GLUCOSE TRANSPORTER 4; HEXOKINASE; LACTATE DEHYDROGENASE; METHYLXANTHINE PENTOXIFYLLINE [1 (5-OXOHEXIL) 3,7 DIMETHYLXANTHINE]; MONOCARBOXYLATE TRANSPORTER; OXIDOREDUCTASE INHIBITOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOGLYCERATE MUTASE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN INHIBITOR; PYRUVATE KINASE; RESVERATROL; STF 31; THEOPHYLLINE (1,3 DIMETHYLXANTHINE); TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL; CANCER GLYCOLYSIS; CANCER SURVIVAL; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CRYSTAL STRUCTURE; DNA DAMAGE; DNA REPAIR; GLUCOSE TRANSPORT; GLYCOLYSIS; GROWTH INHIBITION; HUMAN; METASTASIS POTENTIAL; NONHUMAN; UPREGULATION; ANIMAL; DRUG EFFECTS; METABOLISM; NEOPLASMS;

ANIMALS; ANTINEOPLASTIC AGENTS; GLYCOLYSIS; HUMANS; NEOPLASMS;

EID: 84908006686     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.09.041     Document Type: Review

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