Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 16, 2014, Pages 3764-3771

  Dragovich, Peter S ^a   Fauber, Benjamin P ^a   Boggs, Jason ^a   Chen, Jinhua ^b   Corson, Laura B ^a   Ding, Charles Z ^b   Eigenbrot, Charles ^a   Ge, Hongxiu ^b   Giannetti, Anthony M ^a   Hunsaker, Thomas ^a   Labadie, Sharada ^a   Li, Chiho ^b   Liu, Yichin ^a   Liu, Yingchun ^b   Ma, Shuguang ^a   Malek, Shiva ^a   Peterson, David ^a   Pitts, Keith E ^a   Purkey, Hans E ^a   Robarge, Kirk ^a   Salphati, Laurent ^a   Sideris, Steve ^a   Ultsch, Mark ^a   Vanderporten, Erica ^a   Wang, Jing ^b   Wei, Binqing ^a   Xu, Qing ^b   Yen, Ivana ^a   Yue, Qin ^a   Zhang, Huihui ^b   Zhang, Xuying ^b   Zhou, Aihe ^a   more..

^a GENENTECH INC   (United States)

^b WUXI APPTEC   (China)

Author keywords

Glycolysis; Lactate dehydrogenase; Tumor metabolism; X ray crystal structure

Indexed keywords

2 CYCLOHEXENONE; 3 HYDROXY 2 MERCAPTOCYCLOHEX 2 ENONE; ACETONE; ANTINEOPLASTIC AGENT; BENZALDEHYDE; CARBOXYLIC ACID; LACTATE DEHYDROGENASE; N BROMOSUCCINIMIDE; OXIDOREDUCTASE INHIBITOR; PHENYL GROUP; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG; CYCLOHEXANONE DERIVATIVE; ENZYME INHIBITOR; THIOL DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CRYSTAL STRUCTURE; DRUG BIOAVAILABILITY; DRUG SCREENING; ENZYME INHIBITION; GLYCOLYSIS; HIGH THROUGHPUT SCREENING; HUMAN; HYDROGEN BOND; IC50; LIPOPHILICITY; MICROSOME; NONHUMAN; PHARMACOPHORE; PHENOTYPE; PLASMA PROTEIN BINDING; RAT; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; TAUTOMER; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; ORAL DRUG ADMINISTRATION;

RATTUS;

ADMINISTRATION, ORAL; ANIMALS; CYCLOHEXANONES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; L-LACTATE DEHYDROGENASE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

EID: 84905914054     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.06.076     Document Type: Article

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