1-(sulfonyl)-5-(arylsulfonyl)indoline as activators of the tumor cell specific M2 isoform of pyruvate kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 20, 2012, Pages 6460-6468

  Yacovan, Avihai ^a   Ozeri, Rachel ^a   Kehat, Tzofit ^a   Mirilashvili, Sima ^a   Sherman, Daniel ^a   Aizikovich, Alex ^a   Shitrit, Alina ^a   Ben Zeev, Efrat ^a   Schutz, Nili ^a   Bohana Kashtan, Osnat ^a   Konson, Alexander ^a   Behar, Vered ^a   Becker, Oren M ^a  

^a Dynamix Pharmaceuticals   (Israel)

Author keywords

Anti cancer strategies; Cellular metabolism; PKM2; Pyruvate kinase; Small molecule activators

Indexed keywords

ENZYME ACTIVATOR; PYRUVATE KINASE; PYRUVATE KINASE M2 ACTIVATOR; UNCLASSIFIED DRUG;

ARTICLE; CELL METABOLISM; DRUG ACTIVITY; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME KINETICS; HUMAN; HUMAN CELL; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION;

CACO-2 CELLS; CARRIER PROTEINS; ENZYME ACTIVATION; HUMANS; INDOLES; MEMBRANE PROTEINS; MOLECULAR DOCKING SIMULATION; NEOPLASM PROTEINS; NEOPLASMS; PROTEIN ISOFORMS; PROTEIN MULTIMERIZATION; PYRUVATE KINASE; SULFINIC ACIDS; THYROID HORMONES;

EID: 84866731884     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.054     Document Type: Article

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