Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 24, 2011, Pages 7331-7336

  Granchi, Carlotta ^a   Roy, Sarabindu ^a   Mottinelli, Marco ^a   Nardini, Elisa ^a   Campinoti, Fabio ^a   Tuccinardi, Tiziano ^a   Lanza, Mario ^a   Betti, Laura ^a   Giannaccini, Gino ^a   Lucacchini, Antonio ^a   Martinelli, Adriano ^a   MacChia, Marco ^a   Minutolo, Filippo ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Docking; Enzyme inhibitors; Glycolysis; Lactate dehydrogenase; N Hydroxyindoles

Indexed keywords

LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE 5; N HYDROXYINDOLE 2 CARBOXYLATE SULFONAMIDE; OXIDOREDUCTASE INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; HUMAN;

BINDING SITES; CARBOXYLIC ACIDS; COMPUTER SIMULATION; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INDOLES; ISOENZYMES; KINETICS; L-LACTATE DEHYDROGENASE; PROTEIN STRUCTURE, TERTIARY; SULFONAMIDES;

EID: 81255190786     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.031     Document Type: Article

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