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Volumn 11, Issue 38, 2013, Pages 6588-6596

Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds

(8) Granchi, Carlotta a Calvaresi, Emilia C b Tuccinardi, Tiziano a Paterni, Ilaria a Macchia, Marco a Martinelli, Adriano a Hergenrother, Paul J b Minutolo, Filippo a

a UNIVERSITY OF PISA (Italy)

b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-PROLIFERATIVE ACTIVITIES; CANCER CELLS; CELL-BASED ASSAYS; CELLULAR UPTAKE; METHYL ESTERS; OPTIMAL PROPERTIES; TRIFLUOROMETHYL;

CARBOXYLATION; CELLS;

SCAFFOLDS (BIOLOGY);

ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; INDOLE DERIVATIVE; ISOENZYME; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE 5; LACTIC ACID; MALONIC ACID DERIVATIVE; METHYL 1 HYDROXY 6 PHENYL 4 (TRIFLUOROMETHYL) 1H INDOLE 2 CARBOXYLATE; METHYL 1-HYDROXY-6-PHENYL-4-(TRIFLUOROMETHYL)-1H-INDOLE-2-CARBOXYLATE;

ARTICLE; BIOSYNTHESIS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; HELA CELL; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HELA CELLS; HUMANS; INDOLES; ISOENZYMES; L-LACTATE DEHYDROGENASE; LACTIC ACID; MALONATES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84884174877 PISSN: 14770520 EISSN: None Source Type: Journal
DOI: 10.1039/c3ob40870a Document Type: Article

Times cited : (51)

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