Inactivation of H+-vacuolar ATPase by the energy blocker 3-bromopyruvate, a new antitumour agent

Life Sciences

Volumn 79, Issue 21, 2006, Pages 2049-2055

  Dell'Antone, P ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

3 bromopyruvate; Acidic compartments; Antitumour drugs; Ehrlich ascites tumour cells; H+ vacuolar ATPase; Lysosomes

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALKYLATING AGENT; ANTINEOPLASTIC AGENT; BROMOPYRUVIC ACID; DITHIOTHREITOL; HYDROGEN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; THIOL GROUP; UNCLASSIFIED DRUG;

ACIDITY; ALKYLATION; ANIMAL CELL; ARTICLE; CANCER CELL; CELL DEATH; CELL DISRUPTION; CELL ISOLATION; CELL PH; CELL TYPE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; EHRLICH ASCITES TUMOR CELL; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME INACTIVATION; LIVER CELL CARCINOMA; LYSOSOME; MALE; MOLECULAR STABILITY; MOUSE; NONHUMAN; PROTEIN DEPLETION; RAT; THYMOCYTE;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, EHRLICH TUMOR; ENERGY METABOLISM; ENZYME INHIBITORS; HYDROGEN-ION CONCENTRATION; LIVER; LYSOSOMES; MICE; PYRUVATES; RATS; THYMUS GLAND; TUMOR CELLS, CULTURED; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 33749641680     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2006.06.043     Document Type: Article

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