Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 20, 2013, Pages 5533-5539

  Fauber, Benjamin P ^a   Dragovich, Peter S ^a   Chen, Jinhua ^b   Corson, Laura B ^a   Ding, Charles Z ^b   Eigenbrot, Charles ^a   Giannetti, Anthony M ^a   Hunsaker, Thomas ^a   Labadie, Sharada ^a   Liu, Yichin ^a   Liu, Yingchun ^b   Malek, Shiva ^a   Peterson, David ^a   Pitts, Keith ^a   Sideris, Steve ^a   Ultsch, Mark ^a   Vanderporten, Erica ^a   Wang, Jing ^b   Wei, Binqing ^a   Yen, Ivana ^a   Yue, Qin ^a   more..

^a GENENTECH INC   (United States)

^b WUXI APPTEC   (China)

Author keywords

Lactate dehydrogenase; Pyrazine; Tumor metabolism; X ray crystal structure

Indexed keywords

LACTATE DEHYDROGENASE; OXIDOREDUCTASE INHIBITOR; PYRAZINE DERIVATIVE;

ARTICLE; COMPETITIVE INHIBITION; CRYSTAL STRUCTURE; DRUG IDENTIFICATION; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION;

LACTATE DEHYDROGENASE; PYRAZINE; TUMOR METABOLISM; X-RAY CRYSTAL STRUCTURE;

ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HALF-LIFE; HUMANS; L-LACTATE DEHYDROGENASE; MALE; MICROSOMES, LIVER; PROTEIN STRUCTURE, TERTIARY; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84884290578     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.08.060     Document Type: Article

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