Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 11, 2013, Pages 3186-3194

  Dragovich, Peter S ^a   Fauber, Benjamin P ^a   Corson, Laura B ^a   Ding, Charles Z ^b   Eigenbrot, Charles ^a   Ge, Hongxiu ^b   Giannetti, Anthony M ^a   Hunsaker, Thomas ^a   Labadie, Sharada ^a   Liu, Yichin ^a   Malek, Shiva ^a   Pan, Borlan ^a   Peterson, David ^a   Pitts, Keith ^a   Purkey, Hans E ^a   Sideris, Steve ^a   Ultsch, Mark ^a   Vanderporten, Erica ^a   Wei, Binqing ^a   Xu, Qing ^b   Yen, Ivana ^a   Yue, Qin ^a   Zhang, Huihui ^b   Zhang, Xuying ^b   more..

^a GENENTECH INC   (United States)

^b WUXI APPTEC   (China)

Author keywords

Glycolysis; Lactate dehydrogenase; Tumor metabolism; X ray crystal structure

Indexed keywords

LACTATE DEHYDROGENASE; PYRIMIDINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ARTICLE; CRYSTAL STRUCTURE; DRUG IDENTIFICATION; DRUG SCREENING; HIGH THROUGHPUT SCREENING; HUMAN; IC 50; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; L-LACTATE DEHYDROGENASE; MAGNETIC RESONANCE SPECTROSCOPY; NAD; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE;

EID: 84877579335     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.04.001     Document Type: Article

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