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Volumn 6, Issue 4, 2014, Pages 1986-2011

STAT3: A novel molecular mediator of resistance to chemoradiotherapy

Author keywords

Cancer; Chemoradiotherapy; Chemoradiotherapy resistance; Chemoradiotherapy sensitization; Molecular target; Radiotherapy; STAT3

Indexed keywords

3,3' DIINDOLYLMETHANE; 5 CHLORO N2 [1 (5 FLUORO 2 PYRIMIDINYL)ETHYL] N4 (5 METHYL 1H PYRAZOL 3 YL) 2,4 PYRIMIDINEDIAMINE; BARICITINIB; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CEPHARANTHINE; CUCURBITACIN; FEDRATINIB; FLUOROURACIL; GLYCOPROTEIN GP 130; INTERLEUKIN 6; JANUS KINASE; JANUS KINASE INHIBITOR; LESTAURTINIB; LINIFANIB; MOMELOTINIB; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; NEUTRALIZING ANTIBODY; PACRITINIB; PANITUMUMAB; PROTEIN TYROSINE PHOSPHATASE SHP 2; RESVERATROL; RUXOLITINIB; SORAFENIB; STAT3 PROTEIN; TOFACITINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; XL 019;

EID: 84907617782     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers6041986     Document Type: Review
Times cited : (88)

References (160)
  • 1
    • 84863106037 scopus 로고    scopus 로고
    • Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: Initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial
    • Rodel, C.; Liersch T.; Becker H.; Fietkau R.; Hohenberger W.; Hothorn T.; Graeven U.; Arnold D.; Lang-Welzenbach M.; Raab H.R. et al. Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: Initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial. Lancet Oncol. 2012, 13, 679–687.
    • (2012) Lancet Oncol , vol.13 , pp. 679-687
    • Rodel, C.1    Liersch, T.2    Becker, H.3    Fietkau, R.4    Hohenberger, W.5    Hothorn, T.6    Graeven, U.7    Arnold, D.8    Lang-Welzenbach, M.9    Raab, H.R.10
  • 2
    • 84899461444 scopus 로고    scopus 로고
    • Progress and controversies: Radiation therapy for invasive breast cancer
    • Jagsi, R. Progress and controversies: Radiation therapy for invasive breast cancer. CA Cancer J. Clin. 2013, 64, 135–152.
    • (2013) CA Cancer J. Clin , vol.64 , pp. 135-152
    • Jagsi, R.1
  • 3
    • 84883013481 scopus 로고    scopus 로고
    • Management of non-small-cell lung cancer: Recent developments
    • Reck, M.; Heigener D.F.; Mok T.; Soria J.C.; Rabe K.F. Management of non-small-cell lung cancer: Recent developments. Lancet 2013, 382, 709–719.
    • (2013) Lancet , vol.382 , pp. 709-719
    • Reck, M.1    Heigener, D.F.2    Mok, T.3    Soria, J.C.4    Rabe, K.F.5
  • 5
    • 33846708225 scopus 로고    scopus 로고
    • The concurrent chemoradiation paradigm—General principles
    • Seiwert, T.Y.; Salama J.K.; Vokes E.E. The concurrent chemoradiation paradigm—General principles. Nat. Clin. Pract. Oncol. 2007, 4, 86-100.
    • (2007) Nat. Clin. Pract. Oncol , vol.4 , pp. 86-100
    • Seiwert, T.Y.1    Salama, J.K.2    Vokes, E.E.3
  • 7
    • 79953054421 scopus 로고    scopus 로고
    • Strategies to improve radiotherapy with targeted drugs
    • Begg, A.C.; Stewart F.A.; Vens C. Strategies to improve radiotherapy with targeted drugs. Nat. Rev. Cancer 2011, 11, 239-253.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 239-253
    • Begg, A.C.1    Stewart, F.A.2    Vens, C.3
  • 8
    • 0027493650 scopus 로고
    • A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma
    • Shuai, K.; Stark G.R.; Kerr I.M.; Darnell J.E. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science 1993, 261, 1744-1746.
    • (1993) Science , vol.261 , pp. 1744-1746
    • Shuai, K.1    Stark, G.R.2    Kerr, I.M.3    Darnell, J.E.4
  • 9
  • 10
    • 84872065897 scopus 로고    scopus 로고
    • JAKs and STATs in immunity, immunodeficiency, and cancer
    • O'Shea, J.J.; Holland S.M.; Staudt L.M. JAKs and STATs in immunity, immunodeficiency, and cancer. N Engl. J. Med. 2013, 368, 161-170.
    • (2013) N Engl. J. Med , vol.368 , pp. 161-170
    • O'shea, J.J.1    Holland, S.M.2    Staudt, L.M.3
  • 11
    • 84877095601 scopus 로고    scopus 로고
    • Molecular pathways: Jak/STAT pathway: Mutations, inhibitors, and resistance
    • Quintas-Cardama, A.; Verstovsek S. Molecular pathways: Jak/STAT pathway: Mutations, inhibitors, and resistance. Clin. Cancer Res. 2013, 19, 1933-1940.
    • (2013) Clin. Cancer Res , vol.19 , pp. 1933-1940
    • Quintas-Cardama, A.1    Verstovsek, S.2
  • 12
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-gamma: An overview of signals, mechanisms and functions
    • Schroder, K.; Hertzog P.J.; Ravasi T.; Hume D.A. Interferon-gamma: An overview of signals, mechanisms and functions. J. Leukoc. Biol. 2004, 75, 163-189.
    • (2004) J. Leukoc. Biol , vol.75 , pp. 163-189
    • Schroder, K.1    Hertzog, P.J.2    Ravasi, T.3    Hume, D.A.4
  • 13
    • 0037204953 scopus 로고    scopus 로고
    • A road map for those who don’t know JAK-STAT
    • Aaronson, D.S.; Horvath CM. A road map for those who don’t know JAK-STAT. Science 2002, 296, 1653-1655.
    • (2002) Science , vol.296 , pp. 1653-1655
    • Aaronson, D.S.1    Horvath, C.M.2
  • 14
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • Darnell, J.E. STATs and gene regulation. Science 1997, 277, 1630-1635.
    • (1997) Science , vol.277 , pp. 1630-1635
    • Darnell, J.E.1
  • 15
    • 0035315880 scopus 로고    scopus 로고
    • Role of Jak kinases and STATs in cytokine signal transduction
    • Leonard, W.J. Role of Jak kinases and STATs in cytokine signal transduction. Int. J. Hematol. 2001, 73, 271-277.
    • (2001) Int. J. Hematol , vol.73 , pp. 271-277
    • Leonard, W.J.1
  • 18
    • 0034841006 scopus 로고    scopus 로고
    • Negative regulation of cytokine signaling
    • Greenhalgh, C.J.; Hilton D.J. Negative regulation of cytokine signaling. J. Leukoc. Biol. 2001, 70, 348-356.
    • (2001) J. Leukoc. Biol , vol.70 , pp. 348-356
    • Greenhalgh, C.J.1    Hilton, D.J.2
  • 19
    • 0034801684 scopus 로고    scopus 로고
    • SOCS proteins: Negative regulators of cytokine signaling
    • Krebs, D.L.; Hilton D.J. SOCS proteins: Negative regulators of cytokine signaling. Stem Cells 2001, 19, 378-387.
    • (2001) Stem Cells , vol.19 , pp. 378-387
    • Krebs, D.L.1    Hilton, D.J.2
  • 20
    • 77956398497 scopus 로고    scopus 로고
    • Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation
    • Kim, D.J.; Tremblay M.L.; Digiovanni J. Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation. PLoS One 2010, 5, e10290.
    • (2010) PLoS One , vol.5
    • Kim, D.J.1    Tremblay, M.L.2    Digiovanni, J.3
  • 21
    • 32644459132 scopus 로고    scopus 로고
    • Regulation of cytokine signaling pathways by PIAS proteins
    • Shuai, K. Regulation of cytokine signaling pathways by PIAS proteins. Cell Res. 2006, 16, 196-202.
    • (2006) Cell Res , vol.16 , pp. 196-202
    • Shuai, K.1
  • 22
    • 0026508808 scopus 로고
    • Compilation of vertebrate-encoded transcription factors
    • Faisst, S.; Meyer S. Compilation of vertebrate-encoded transcription factors. Nucleic Acids Res. 1992, 20, 3-26.
    • (1992) Nucleic Acids Res , vol.20 , pp. 3-26
    • Faisst, S.1    Meyer, S.2
  • 23
    • 0036256644 scopus 로고    scopus 로고
    • What does Stat3 do
    • Levy, D.E.; Lee C.K. What does Stat3 do? J. Clin. Invest. 2002, 109, 1143-1148.
    • (2002) J. Clin. Invest , vol.109 , pp. 1143-1148
    • Levy, D.E.1    Lee, C.K.2
  • 25
    • 33750827521 scopus 로고    scopus 로고
    • Cutting edge: Inherent and acquired resistance to radiation-induced apoptosis in B cells: A pivotal role for STAT3
    • Otero, D.C.; Poli V.; David M.; Rickert R.C. Cutting edge: Inherent and acquired resistance to radiation-induced apoptosis in B cells: A pivotal role for STAT3. J. Immunol. 2006, 177, 6593-6597.
    • (2006) J. Immunol , vol.177 , pp. 6593-6597
    • Otero, D.C.1    Poli, V.2    David, M.3    Rickert, R.C.4
  • 26
    • 84888149384 scopus 로고    scopus 로고
    • Genomic and computational approaches to dissect the mechanisms of STAT3’s universal and cell type-specific functions
    • Hutchins, A.P.; Diez D.; Miranda-Saavedra D. Genomic and computational approaches to dissect the mechanisms of STAT3’s universal and cell type-specific functions. JAKSTAT 2013, 2, e25097.
    • (2013) JAKSTAT , vol.2
    • Hutchins, A.P.1    Diez, D.2    Miranda-Saavedra, D.3
  • 27
    • 84896491618 scopus 로고    scopus 로고
    • The IL-6 feed-forward loop: A driver of tumorigenesis
    • Chang, Q.; Daly L.; Bromberg J. The IL-6 feed-forward loop: A driver of tumorigenesis. Semin. Immunol. 2014, 26, 48–53.
    • (2014) Semin. Immunol , vol.26 , pp. 48-53
    • Chang, Q.1    Daly, L.2    Bromberg, J.3
  • 29
    • 0036251154 scopus 로고    scopus 로고
    • Stat proteins and oncogenesis
    • Bromberg, J. Stat proteins and oncogenesis. J. Clin. Invest. 2002, 109, 1139–1142.
    • (2002) J. Clin. Invest , vol.109 , pp. 1139-1142
    • Bromberg, J.1
  • 30
    • 84880169057 scopus 로고    scopus 로고
    • Radiation resistance of cancer stem cells as an obstacle in cancer therapy
    • Chumsri, S.; Shah P. Radiation resistance of cancer stem cells as an obstacle in cancer therapy. Mol. Cell. Pharmacol. 2013, 5, 39–49.
    • (2013) Mol. Cell. Pharmacol , vol.5 , pp. 39-49
    • Chumsri, S.1    Shah, P.2
  • 31
    • 84880697448 scopus 로고    scopus 로고
    • The role of IL-6 in the radiation response of prostate cancer
    • Wu, C.T.; Chen M.F.; Chen W.C.; Hsieh C.C. The role of IL-6 in the radiation response of prostate cancer. Radiat. Oncol. 2013, 8, 159.
    • (2013) Radiat. Oncol , vol.8 , pp. 159
    • Wu, C.T.1    Chen, M.F.2    Chen, W.C.3    Hsieh, C.C.4
  • 32
    • 78049308479 scopus 로고    scopus 로고
    • Silencing STAT3 with short hairpin RNA enhances radiosensitivity of human laryngeal squamous cell carcinoma xenografts in vivo
    • Li, X.; Wang H.; Lu X.; Di B. Silencing STAT3 with short hairpin RNA enhances radiosensitivity of human laryngeal squamous cell carcinoma xenografts in vivo. Exp. Ther. Med. 2010, 1, 947–953.
    • (2010) Exp. Ther. Med , vol.1 , pp. 947-953
    • Li, X.1    Wang, H.2    Lu, X.3    Di, B.4
  • 33
    • 84883327318 scopus 로고    scopus 로고
    • Radioresistance and cancer stem cells: Survival of the fittest
    • Sun, L.; Cabarcas S.M.; Farrar W.L. Radioresistance and cancer stem cells: Survival of the fittest. J. Carcinog. Mutagen. 2011, S1, 1–12.
    • (2011) J. Carcinog. Mutagen , vol.S1 , pp. 1-12
    • Sun, L.1    Cabarcas, S.M.2    Farrar, W.L.3
  • 34
    • 84896278080 scopus 로고    scopus 로고
    • Disruption of STAT3 by niclosamide reverses radioresistance of human lung cancer
    • You, S.; Li R.; Park D.; Xie M.; Sica G.L.; Cao Y.; Xiao Z.Q.; Deng X. Disruption of STAT3 by niclosamide reverses radioresistance of human lung cancer. Mol. Cancer Ther. 2014, 13, 606–616.
    • (2014) Mol. Cancer Ther , vol.13 , pp. 606-616
    • You, S.1    Li, R.2    Park, D.3    Xie, M.4    Sica, G.L.5    Cao, Y.6    Xiao, Z.Q.7    Deng, X.8
  • 36
    • 0034722896 scopus 로고    scopus 로고
    • STAT proteins: Novel molecular targets for cancer drug discovery
    • Turkson, J.; Jove R. STAT proteins: Novel molecular targets for cancer drug discovery. Oncogene 2000, 19, 6613–6626.
    • (2000) Oncogene , vol.19 , pp. 6613-6626
    • Turkson, J.1    Jove, R.2
  • 37
    • 84866490114 scopus 로고    scopus 로고
    • STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancers (review)
    • Wang, X.; Crowe P.J.; Goldstein D.; Yang J.L. STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancers (review). Int. J. Oncol. 2012, 41, 1181–1191.
    • (2012) Int. J. Oncol , vol.41 , pp. 1181-1191
    • Wang, X.1    Crowe, P.J.2    Goldstein, D.3    Yang, J.L.4
  • 38
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Wen, P.Y.; Kesari S. Malignant gliomas in adults. N. Engl. J. Med. 2008, 359, 492–507.
    • (2008) N. Engl. J. Med , vol.359 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 40
    • 84886302501 scopus 로고    scopus 로고
    • Advances and challenges in the treatment of glioblastoma: A clinician’s perspective
    • Mrugala, M.M. Advances and challenges in the treatment of glioblastoma: A clinician’s perspective. Discov. Med. 2013, 15, 221–230.
    • (2013) Discov. Med , vol.15 , pp. 221-230
    • Mrugala, M.M.1
  • 42
    • 78449312044 scopus 로고    scopus 로고
    • STAT3 tyrosine phosphorylation influences survival in glioblastoma
    • Birner, P.; Toumangelova-Uzeir K.; Natchev S.; Guentchev M. STAT3 tyrosine phosphorylation influences survival in glioblastoma. J. Neurooncol. 2010, 100, 339–343.
    • (2010) J. Neurooncol , vol.100 , pp. 339-343
    • Birner, P.1    Toumangelova-Uzeir, K.2    Natchev, S.3    Guentchev, M.4
  • 43
    • 51049123447 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3: A molecular hub for signaling pathways in gliomas
    • Brantley, E.C.; Benveniste E.N. Signal transducer and activator of transcription-3: A molecular hub for signaling pathways in gliomas. Mol. Cancer Res. 2008, 6, 675–684.
    • (2008) Mol. Cancer Res , vol.6 , pp. 675-684
    • Brantley, E.C.1    Benveniste, E.N.2
  • 45
    • 77953577606 scopus 로고    scopus 로고
    • Inhibition of STAT3 and ErbB2 suppresses tumor growth, enhances radiosensitivity, and induces mitochondria-dependent apoptosis in glioma cells
    • Gao, L.; Li F.; Dong B.; Zhang J.; Rao Y.; Cong Y.; Mao B.; Chen X. Inhibition of STAT3 and ErbB2 suppresses tumor growth, enhances radiosensitivity, and induces mitochondria-dependent apoptosis in glioma cells. Int. J. Radiat. Oncol. Biol. Phys. 2010, 77, 1223–1231.
    • (2010) Int. J. Radiat. Oncol. Biol. Phys , vol.77 , pp. 1223-1231
    • Gao, L.1    Li, F.2    Dong, B.3    Zhang, J.4    Rao, Y.5    Cong, Y.6    Mao, B.7    Chen, X.8
  • 46
    • 84155184247 scopus 로고    scopus 로고
    • Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis
    • Yang, Y.P.; Chang Y.L.; Huang P.I.; Chiou G.Y.; Tseng L.M.; Chiou S.H.; Chen M.H.; Chen M.T.; Shih Y.H.; Chang C.H. et al. Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis. J. Cell Physiol. 2012, 227, 976–993.
    • (2012) J. Cell Physiol , vol.227 , pp. 976-993
    • Yang, Y.P.1    Chang, Y.L.2    Huang, P.I.3    Chiou, G.Y.4    Tseng, L.M.5    Chiou, S.H.6    Chen, M.H.7    Chen, M.T.8    Shih, Y.H.9    Chang, C.H.10
  • 49
    • 58249093973 scopus 로고    scopus 로고
    • Radiation therapy for early-stage breast cancer after breast-conserving surgery
    • Buchholz, T.A. Radiation therapy for early-stage breast cancer after breast-conserving surgery. N. Engl. J. Med. 2009, 360, 63–70.
    • (2009) N. Engl. J. Med , vol.360 , pp. 63-70
    • Buchholz, T.A.1
  • 50
    • 84877341973 scopus 로고    scopus 로고
    • Review of breast conservation therapy: Then and now
    • Hoover, S.; Bloom E.; Patel S. Review of breast conservation therapy: Then and now. ISRN Oncol. 2011, 2011, 617593.
    • (2011) ISRN Oncol , vol.2011 , pp. 617593
    • Hoover, S.1    Bloom, E.2    Patel, S.3
  • 51
    • 0028923658 scopus 로고
    • Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts
    • Watson, C.J.; Miller W.R. Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts. Br. J. Cancer 1995, 71, 840–844.
    • (1995) Br. J. Cancer , vol.71 , pp. 840-844
    • Watson, C.J.1    Miller, W.R.2
  • 54
    • 0034219458 scopus 로고    scopus 로고
    • Elevated phosphorylation of AKT and Stat3 in prostate, breast, and cervical cancer cells
    • Page, C.; Huang M.; Jin X.; Cho K.; Lilja J.; Reynolds R.K.; Lin J. Elevated phosphorylation of AKT and Stat3 in prostate, breast, and cervical cancer cells. Int. J. Oncol. 2000, 17, 23–28.
    • (2000) Int. J. Oncol , vol.17 , pp. 23-28
    • Page, C.1    Huang, M.2    Jin, X.3    Cho, K.4    Lilja, J.5    Reynolds, R.K.6    Lin, J.7
  • 55
    • 85047698100 scopus 로고    scopus 로고
    • Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells
    • Burke, W.M.; Jin X.; Lin H.J.; Huang M.; Liu R.; Reynolds R.K.; Lin J. Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells. Oncogene 2001, 20, 7925–7934.
    • (2001) Oncogene , vol.20 , pp. 7925-7934
    • Burke, W.M.1    Jin, X.2    Lin, H.J.3    Huang, M.4    Liu, R.5    Reynolds, R.K.6    Lin, J.7
  • 56
    • 33845228341 scopus 로고    scopus 로고
    • Inhibition of signal transducer and activator of transcription 3 activity results in down-regulation of survivin following irradiation
    • Kim, K.W.; Mutter R.W.; Cao C.; Albert J.M.; Shinohara E.T.; Sekhar K.R.; Lu, B. Inhibition of signal transducer and activator of transcription 3 activity results in down-regulation of survivin following irradiation. Mol. Cancer Ther. 2006, 5, 2659–2665.
    • (2006) Mol. Cancer Ther , vol.5 , pp. 2659-2665
    • Kim, K.W.1    Mutter, R.W.2    Cao, C.3    Albert, J.M.4    Shinohara, E.T.5    Sekhar, K.R.6    Lu, B.7
  • 57
    • 84872775079 scopus 로고    scopus 로고
    • The radio-sensitizing effect of xanthohumol is mediated by STAT3 and EGFR suppression in doxorubicin-resistant MCF-7 human breast cancer cells
    • Kang, Y.; Park M.A.; Heo S.W.; Park S.Y.; Kang K.W.; Park P.H.; Kim J.A. The radio-sensitizing effect of xanthohumol is mediated by STAT3 and EGFR suppression in doxorubicin-resistant MCF-7 human breast cancer cells. Biochim. Biophys. Acta 2013, 1830, 2638–2648.
    • (2013) Biochim. Biophys. Acta , vol.1830 , pp. 2638-2648
    • Kang, Y.1    Park, M.A.2    Heo, S.W.3    Park, S.Y.4    Kang, K.W.5    Park, P.H.6    Kim, J.A.7
  • 60
    • 84862122981 scopus 로고    scopus 로고
    • Rectal cancer: State of the art in 2012
    • Rodel, C.; Hofheinz R.; Liersch T. Rectal cancer: State of the art in 2012. Curr. Opin. Oncol.2012, 24, 441–447.
    • (2012) Curr. Opin. Oncol , vol.24 , pp. 441-447
    • Rodel, C.1    Hofheinz, R.2    Liersch, T.3
  • 66
    • 84864643049 scopus 로고    scopus 로고
    • The role of DNA methyltransferase 3b in esophageal squamous cell carcinoma
    • Chen, M.F.; Lu M.S.; Lin P.Y.; Chen P.T.; Chen W.C.; Lee K.D. The role of DNA methyltransferase 3b in esophageal squamous cell carcinoma. Cancer 2012, 118, 4074–4089.
    • (2012) Cancer , vol.118 , pp. 4074-4089
    • Chen, M.F.1    Lu, M.S.2    Lin, P.Y.3    Chen, P.T.4    Chen, W.C.5    Lee, K.D.6
  • 67
    • 84875821295 scopus 로고    scopus 로고
    • IL-6 expression predicts treatment response and outcome in squamous cell carcinoma of the esophagus
    • Chen, M.F.; Chen P.T.; Lu M.S.; Lin P.Y.; Chen W.C.; Lee K.D. IL-6 expression predicts treatment response and outcome in squamous cell carcinoma of the esophagus. Mol. Cancer 2013, 12, 26.
    • (2013) Mol. Cancer , vol.12 , pp. 26
    • Chen, M.F.1    Chen, P.T.2    Lu, M.S.3    Lin, P.Y.4    Chen, W.C.5    Lee, K.D.6
  • 68
    • 77949898163 scopus 로고    scopus 로고
    • Time trends and local variation in primary treatment of localized prostate cancer
    • Cooperberg, M.R.; Broering J.M.; Carroll P.R. Time trends and local variation in primary treatment of localized prostate cancer. J. Clin. Oncol. 2010, 28, 1117–1123.
    • (2010) J. Clin. Oncol , vol.28 , pp. 1117-1123
    • Cooperberg, M.R.1    Broering, J.M.2    Carroll, P.R.3
  • 69
    • 81255184643 scopus 로고    scopus 로고
    • Management of low (favourable)-risk prostate cancer
    • Carter, H.B. Management of low (favourable)-risk prostate cancer. BJU Int. 2011, 108, 1684–1695.
    • (2011) BJU Int , vol.108 , pp. 1684-1695
    • Carter, H.B.1
  • 70
    • 0038205813 scopus 로고    scopus 로고
    • Cancer-specific mortality after surgery or radiation for patients with clinically localized prostate cancer managed during the prostate-specific antigen era
    • D’Amico, A.V.; Moul J.; Carroll P.R.; Sun L.; Lubeck D.; Chen M.H. Cancer-specific mortality after surgery or radiation for patients with clinically localized prostate cancer managed during the prostate-specific antigen era. J. Clin. Oncol. 2003, 21, 2163–2172.
    • (2003) J. Clin. Oncol , vol.21 , pp. 2163-2172
    • D’amico, A.V.1    Moul, J.2    Carroll, P.R.3    Sun, L.4    Lubeck, D.5    Chen, M.H.6
  • 71
    • 0037112367 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 in human prostate tumors and cell lines: Direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells
    • Mora, L. B.; Buettner R.; Seigne J.; Diaz J.; Ahmad N.; Garcia R.; Bowman T.; Falcone R.; Fairclough R.; Cantor A. et al. Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. Cancer Res. 2002, 62, 6659–6666.
    • (2002) Cancer Res , vol.62 , pp. 6659-6666
    • Mora, L.B.1    Buettner, R.2    Seigne, J.3    Diaz, J.4    Ahmad, N.5    Garcia, R.6    Bowman, T.7    Falcone, R.8    Fairclough, R.9    Cantor, A.10
  • 72
    • 84879101827 scopus 로고    scopus 로고
    • Bladder preservation in the treatment of muscle-invasive bladder cancer (MIBC): A review of the literature and a practical approach to therapy
    • Smith, Z.L.; Christodouleas J.P.; Keefe S.M.; Malkowicz S.B.; Guzzo T.J. Bladder preservation in the treatment of muscle-invasive bladder cancer (MIBC): A review of the literature and a practical approach to therapy. BJU Int. 2013, 112, 13–25.
    • (2013) BJU Int , vol.112 , pp. 13-25
    • Smith, Z.L.1    Christodouleas, J.P.2    Keefe, S.M.3    Malkowicz, S.B.4    Guzzo, T.J.5
  • 74
    • 84875867239 scopus 로고    scopus 로고
    • Inhibition of STAT signalling in bladder cancer by diindolylmethane: Relevance to cell adhesion, migration and proliferation
    • Sun, Y.; Cheng M.K.; Griffiths T.R.; Mellon J.K.; Kai B.; Kriajevska M.; Manson M.M. Inhibition of STAT signalling in bladder cancer by diindolylmethane: Relevance to cell adhesion, migration and proliferation. Curr. Cancer Drug Targets 2013, 13, 57–68.
    • (2013) Curr. Cancer Drug Targets , vol.13 , pp. 57-68
    • Sun, Y.1    Cheng, M.K.2    Griffiths, T.R.3    Mellon, J.K.4    Kai, B.5    Kriajevska, M.6    Manson, M.M.7
  • 75
    • 55949095929 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 activation is associated with bladder cancer cell growth and survival
    • Chen, C.L.; Cen L.; Kohout J.; Hutzen B.; Chan C.; Hsieh F.C.; Loy A.; Huang V.; Cheng G.; Lin J. Signal transducer and activator of transcription 3 activation is associated with bladder cancer cell growth and survival. Mol. Cancer 2008, 7, 78.
    • (2008) Mol. Cancer , vol.7 , pp. 78
    • Chen, C.L.1    Cen, L.2    Kohout, J.3    Hutzen, B.4    Chan, C.5    Hsieh, F.C.6    Loy, A.7    Huang, V.8    Cheng, G.9    Lin, J.10
  • 76
    • 62949222822 scopus 로고    scopus 로고
    • Management of early and locally advanced cervical cancer
    • Barbera, L.; Thomas G. Management of early and locally advanced cervical cancer. Semin. Oncol. 2009, 36, 155–169.
    • (2009) Semin. Oncol , vol.36 , pp. 155-169
    • Barbera, L.1    Thomas, G.2
  • 77
    • 79955582400 scopus 로고    scopus 로고
    • Phase III, open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix
    • Duenas-Gonzalez, A.; Zarba J.J.; Patel F.; Alcedo J.C.; Beslija S.; Casanova L.; Pattaranutaporn P.; Hameed S.; Blair J.M.; Barraclough H. et al. Phase III, open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix. J. Clin. Oncol. 2011, 29, 1678–1685.
    • (2011) J. Clin. Oncol , vol.29 , pp. 1678-1685
    • Duenas-Gonzalez, A.1    Zarba, J.J.2    Patel, F.3    Alcedo, J.C.4    Beslija, S.5    Casanova, L.6    Pattaranutaporn, P.7    Hameed, S.8    Blair, J.M.9    Barraclough, H.10
  • 78
    • 77958500379 scopus 로고    scopus 로고
    • Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: Implications in high-risk human papillomavirus infection
    • Shukla, S.; Shishodia G.; Mahata S.; Hedau S.; Pandey A.; Bhambhani S.; Batra S.; Basir S.F.; Das B.C.; Bharti A.C. Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: Implications in high-risk human papillomavirus infection. Mol. Cancer 2010, 9, 282.
    • (2010) Mol. Cancer , vol.9 , pp. 282
    • Shukla, S.1    Shishodia, G.2    Mahata, S.3    Hedau, S.4    Pandey, A.5    Bhambhani, S.6    Batra, S.7    Basir, S.F.8    Das, B.C.9    Bharti, A.C.10
  • 79
    • 84862911190 scopus 로고    scopus 로고
    • Constitutive STAT5 activation correlates with better survival in cervical cancer patients treated with radiation therapy
    • Chen, H.H.; Chou C.Y.; Wu Y.H.; Hsueh W.T.; Hsu C.H.; Guo H.R.; Lee W.Y.; Su W.C. Constitutive STAT5 activation correlates with better survival in cervical cancer patients treated with radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 2012, 82, 658–666.
    • (2012) Int. J. Radiat. Oncol. Biol. Phys , vol.82 , pp. 658-666
    • Chen, H.H.1    Chou, C.Y.2    Wu, Y.H.3    Hsueh, W.T.4    Hsu, C.H.5    Guo, H.R.6    Lee, W.Y.7    Su, W.C.8
  • 80
    • 84879962650 scopus 로고    scopus 로고
    • Inhibition of signal transducer and activator of transcription 3 and cyclooxygenase-2 is involved in radiosensitization of cepharanthine in HeLa cells
    • Fang, Z.H.; Li Y.J.; Chen Z.; Wang J.J.; Zhu L.H. Inhibition of signal transducer and activator of transcription 3 and cyclooxygenase-2 is involved in radiosensitization of cepharanthine in HeLa cells. Int. J. Gynecol. Cancer 2013, 23, 608–614.
    • (2013) Int. J. Gynecol. Cancer , vol.23 , pp. 608-614
    • Fang, Z.H.1    Li, Y.J.2    Chen, Z.3    Wang, J.J.4    Zhu, L.H.5
  • 83
    • 16244371725 scopus 로고    scopus 로고
    • Chemoradiation after surgery for high-risk head and neck cancer patients: How strong is the evidence?
    • Bernier, J.; Cooper J.S. Chemoradiation after surgery for high-risk head and neck cancer patients: how strong is the evidence? Oncologist 2005, 10, 215–224.
    • (2005) Oncologist , vol.10 , pp. 215-224
    • Bernier, J.1    Cooper, J.S.2
  • 84
    • 0034658499 scopus 로고    scopus 로고
    • STAT signaling in head and neck cancer
    • Song, J.I.; Grandis J.R. STAT signaling in head and neck cancer. Oncogene 2000, 19, 2489–2495.
    • (2000) Oncogene , vol.19 , pp. 2489-2495
    • Song, J.I.1    Grandis, J.R.2
  • 85
    • 84867950688 scopus 로고    scopus 로고
    • Current role of EGF receptor monoclonal antibodies and tyrosine kinase inhibitors in the management of head and neck squamous cell carcinoma
    • Markovic, A.; Chung C.H. Current role of EGF receptor monoclonal antibodies and tyrosine kinase inhibitors in the management of head and neck squamous cell carcinoma. Expert. Rev. Anticancer Ther. 2012, 12, 1149–1159.
    • (2012) Expert. Rev. Anticancer Ther , vol.12 , pp. 1149-1159
    • Markovic, A.1    Chung, C.H.2
  • 86
    • 77953019852 scopus 로고    scopus 로고
    • Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: Implications for future therapeutic approaches
    • Lai, S.Y.; Johnson F.M. Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: Implications for future therapeutic approaches. Drug Resist. Updat. 2010, 13, 67–78.
    • (2010) Drug Resist. Updat , vol.13 , pp. 67-78
    • Lai, S.Y.1    Johnson, F.M.2
  • 87
    • 0041620205 scopus 로고    scopus 로고
    • Constitutive activation of STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and correlates with better prognosis
    • Hsiao, J.R.; Jin Y.T.; Tsai S.T.; Shiau A.L.; Wu C.L.; Su W.C. Constitutive activation of STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and correlates with better prognosis. Br. J. Cancer 2003, 89, 344–349.
    • (2003) Br. J. Cancer , vol.89 , pp. 344-349
    • Hsiao, J.R.1    Jin, Y.T.2    Tsai, S.T.3    Shiau, A.L.4    Wu, C.L.5    Su, W.C.6
  • 89
    • 0037096876 scopus 로고    scopus 로고
    • Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma
    • Masuda, M.; Suzui M.; Yasumatu R.; Nakashima T.; Kuratomi Y.; Azuma K.; Tomita K.; Komiyama S.; Weinstein I.B. Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. Cancer Res. 2002, 62, 3351–3355.
    • (2002) Cancer Res , vol.62 , pp. 3351-3355
    • Masuda, M.1    Suzui, M.2    Yasumatu, R.3    Nakashima, T.4    Kuratomi, Y.5    Azuma, K.6    Tomita, K.7    Komiyama, S.8    Weinstein, I.B.9
  • 90
    • 77449099620 scopus 로고    scopus 로고
    • Significance of interleukin-6 signaling in the resistance of pharyngeal cancer to irradiation and the epidermal growth factor receptor inhibitor
    • Chen, C.C.; Chen W.C.; Lu C.H.; Wang W.H.; Lin P.Y.; Lee K.D.; Chen, M.F. Significance of interleukin-6 signaling in the resistance of pharyngeal cancer to irradiation and the epidermal growth factor receptor inhibitor. Int. J. Radiat. Oncol. Biol. Phys. 2010, 76, 1214–1224.
    • (2010) Int. J. Radiat. Oncol. Biol. Phys , vol.76 , pp. 1214-1224
    • Chen, C.C.1    Chen, W.C.2    Lu, C.H.3    Wang, W.H.4    Lin, P.Y.5    Lee, K.D.6    Chen, M.F.7
  • 91
    • 78649648154 scopus 로고    scopus 로고
    • Cucurbitacin I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma—Derived CD44(+)ALDH1(+) cells
    • Chen, Y.W.; Chen K.H.; Huang P.I.; Chen Y.C.; Chiou G.Y.; Lo W.L.; Tseng L.M.; Hsu H.S.; Chang K.W.; Chiou S.H. Cucurbitacin I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma—Derived CD44(+)ALDH1(+) cells. Mol. Cancer Ther. 2010, 9, 2879–2892.
    • (2010) Mol. Cancer Ther , vol.9 , pp. 2879-2892
    • Chen, Y.W.1    Chen, K.H.2    Huang, P.I.3    Chen, Y.C.4    Chiou, G.Y.5    Lo, W.L.6    Tseng, L.M.7    Hsu, H.S.8    Chang, K.W.9    Chiou, S.H.10
  • 93
    • 76649098901 scopus 로고    scopus 로고
    • STAT3 blockade with shRNA enhances radiosensitivity in Hep-2 human laryngeal squamous carcinoma cells
    • Li, X.; Wang H.; Lu X.; Di B. STAT3 blockade with shRNA enhances radiosensitivity in Hep-2 human laryngeal squamous carcinoma cells. Oncol. Rep. 2010, 23, 345–353.
    • (2010) Oncol. Rep , vol.23 , pp. 345-353
    • Li, X.1    Wang, H.2    Lu, X.3    Di, B.4
  • 94
    • 79960347232 scopus 로고    scopus 로고
    • Inhibition of STAT-3 results in greater cetuximab sensitivity in head and neck squamous cell carcinoma
    • Bonner, J.A.; Yang E.S.; Trummell H.Q.; Nowsheen S.; Willey C.D.; Raisch, K.P. Inhibition of STAT-3 results in greater cetuximab sensitivity in head and neck squamous cell carcinoma. Radiother. Oncol. 2011, 99, 339–343.
    • (2011) Radiother. Oncol , vol.99 , pp. 339-343
    • Bonner, J.A.1    Yang, E.S.2    Trummell, H.Q.3    Nowsheen, S.4    Willey, C.D.5    Raisch, K.P.6
  • 95
    • 84869500586 scopus 로고    scopus 로고
    • Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma
    • Adachi, M.; Cui C.; Dodge C.T.; Bhayani M.K.; Lai S.Y. Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma. Oral. Oncol. 2012, 48, 1220–1226.
    • (2012) Oral. Oncol , vol.48 , pp. 1220-1226
    • Adachi, M.1    Cui, C.2    Dodge, C.T.3    Bhayani, M.K.4    Lai, S.Y.5
  • 96
    • 84873857266 scopus 로고    scopus 로고
    • Stat3 inhibitor Stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma
    • Pan, Y.; Zhou F.; Zhang R.; Claret F.X. Stat3 inhibitor Stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma. PLoS One 2013, 8, e54565.
    • (2013) PLoS One , vol.8
    • Pan, Y.1    Zhou, F.2    Zhang, R.3    Claret, F.X.4
  • 97
    • 77958011209 scopus 로고    scopus 로고
    • Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs
    • Goel, A.; Aggarwal B.B. Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutr. Cancer 2010, 62, 919–930.
    • (2010) Nutr. Cancer , vol.62 , pp. 919-930
    • Goel, A.1    Aggarwal, B.B.2
  • 99
    • 34548710844 scopus 로고    scopus 로고
    • Expression of activated and latent signal transducer and activator of transcription 3 in 303 non-small cell lung carcinomas and 44 malignant mesotheliomas: Possible role for chemotherapeutic intervention
    • Achcar Rde, O.; Cagle P.T.; Jagirdar J. Expression of activated and latent signal transducer and activator of transcription 3 in 303 non-small cell lung carcinomas and 44 malignant mesotheliomas: Possible role for chemotherapeutic intervention. Arch. Pathol. Lab. Med. 2007, 131, 1350–1360.
    • (2007) Arch. Pathol. Lab. Med , vol.131 , pp. 1350-1360
    • Achcar Rde, O.1    Cagle, P.T.2    Jagirdar, J.3
  • 102
    • 79960051228 scopus 로고    scopus 로고
    • CK2 inhibitors enhance the radiosensitivity of human non-small cell lung cancer cells through inhibition of stat3 activation
    • Lin, Y.C.; Hung M.S.; Lin C.K.; Li J.M.; Lee K.D.; Li Y.C.; Chen M.F.; Chen J.K.; Yang C.T. CK2 inhibitors enhance the radiosensitivity of human non-small cell lung cancer cells through inhibition of stat3 activation. Cancer Biother. Radiopharm. 2011, 26, 381–388.
    • (2011) Cancer Biother. Radiopharm , vol.26 , pp. 381-388
    • Lin, Y.C.1    Hung, M.S.2    Lin, C.K.3    Li, J.M.4    Lee, K.D.5    Li, Y.C.6    Chen, M.F.7    Chen, J.K.8    Yang, C.T.9
  • 103
    • 81155131866 scopus 로고    scopus 로고
    • Overexpression of STAT3 potentiates growth, survival, and radioresistance of non-small-cell lung cancer (NSCLC) cells
    • Yin, Z.J.; Jin F.G.; Liu T.G.; Fu E.Q.; Xie Y.H.; Sun, R.L. Overexpression of STAT3 potentiates growth, survival, and radioresistance of non-small-cell lung cancer (NSCLC) cells. J. Surg. Res. 2011, 171, 675–683.
    • (2011) J. Surg. Res , vol.171 , pp. 675-683
    • Yin, Z.J.1    Jin, F.G.2    Liu, T.G.3    Fu, E.Q.4    Xie, Y.H.5    Sun, R.L.6
  • 104
    • 79959622792 scopus 로고    scopus 로고
    • Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133-positive cells
    • Hsu, H.S.; Huang P.I.; Chang Y.L.; Tzao C.; Chen Y.W.; Shih H.C.; Hung S.C.; Chen Y.C.; Tseng L.M.; Chiou S.H. Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133-positive cells. Cancer 2011, 117, 2970–2985.
    • (2011) Cancer , vol.117 , pp. 2970-2985
    • Hsu, H.S.1    Huang, P.I.2    Chang, Y.L.3    Tzao, C.4    Chen, Y.W.5    Shih, H.C.6    Hung, S.C.7    Chen, Y.C.8    Tseng, L.M.9    Chiou, S.H.10
  • 105
    • 0035472223 scopus 로고    scopus 로고
    • UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer
    • De Gruijl, F.R.; van Kranen H.J.; Mullenders L.H. UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer. J. Photochem. Photobiol. B 2001, 63, 19–27.
    • (2001) J. Photochem. Photobiol. B , vol.63 , pp. 19-27
    • De Gruijl, F.R.1    Van Kranen, H.J.2    Mullenders, L.H.3
  • 106
    • 0033198793 scopus 로고    scopus 로고
    • Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis
    • Sano, S.; Itami S.; Takeda K.; Tarutani M.; Yamaguchi Y.; Miura H.; Yoshikawa K.; Akira S.; Takeda J. Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J. 1999, 18, 4657–4668.
    • (1999) EMBO J , vol.18 , pp. 4657-4668
    • Sano, S.1    Itami, S.2    Takeda, K.3    Tarutani, M.4    Yamaguchi, Y.5    Miura, H.6    Yoshikawa, K.7    Akira, S.8    Takeda, J.9
  • 107
    • 34547897027 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis
    • Kim, D.J.; Chan K.S.; Sano S.; Digiovanni J. Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis. Mol. Carcinog. 2007, 46, 725–731.
    • (2007) Mol. Carcinog , vol.46 , pp. 725-731
    • Kim, D.J.1    Chan, K.S.2    Sano, S.3    Digiovanni, J.4
  • 108
    • 39149102509 scopus 로고    scopus 로고
    • Impact of Stat3 activation upon skin biology: A dichotomy of its role between homeostasis and diseases
    • Sano, S.; Chan K.S.; DiGiovanni J. Impact of Stat3 activation upon skin biology: A dichotomy of its role between homeostasis and diseases. J. Dermatol. Sci. 2008, 50, 1–14.
    • (2008) J. Dermatol. Sci , vol.50 , pp. 1-14
    • Sano, S.1    Chan, K.S.2    Digiovanni, J.3
  • 109
    • 21344456741 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation
    • Sano, S.; Chan K.S.; Kira M.; Kataoka K.; Takagi S.; Tarutani M.; Itami S.; Kiguchi K.; Yokoi M.; Sugasawa K. et al. Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation. Cancer Res. 2005, 65, 5720–5729.
    • (2005) Cancer Res , vol.65 , pp. 5720-5729
    • Sano, S.1    Chan, K.S.2    Kira, M.3    Kataoka, K.4    Takagi, S.5    Tarutani, M.6    Itami, S.7    Kiguchi, K.8    Yokoi, M.9    Sugasawa, K.10
  • 110
    • 84883594298 scopus 로고    scopus 로고
    • Managing malignant melanoma
    • Dzwierzynski, W.W. Managing malignant melanoma. Plast. Reconstr. Surg. 2013, 132, 446e–460e.
    • (2013) Plast. Reconstr. Surg , vol.132 , pp. 446e-460e
    • Dzwierzynski, W.W.1
  • 111
    • 44149095198 scopus 로고    scopus 로고
    • Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival
    • Johnson, G.E.; Ivanov V.N.; Hei T.K. Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival. Apoptosis 2008, 13, 790–802.
    • (2008) Apoptosis , vol.13 , pp. 790-802
    • Johnson, G.E.1    Ivanov, V.N.2    Hei, T.K.3
  • 112
    • 69949140389 scopus 로고    scopus 로고
    • Inhibition of STAT-3 results in radiosensitization of human squamous cell carcinoma
    • Bonner, J.A.; Trummell H.Q.; Willey C.D.; Plants B.A.; Raisch K.P. Inhibition of STAT-3 results in radiosensitization of human squamous cell carcinoma. Radiother. Oncol. 2009, 92, 339–344.
    • (2009) Radiother. Oncol , vol.92 , pp. 339-344
    • Bonner, J.A.1    Trummell, H.Q.2    Willey, C.D.3    Plants, B.A.4    Raisch, K.P.5
  • 113
    • 0030946515 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3 (STAT3) is constitutively activated in normal, self-renewing B-1 cells but only inducibly expressed in conventional B lymphocytes
    • Karras, J.G.; Wang Z.; Huo L.; Howard R.G.; Frank D.A.; Rothstein T.L. Signal transducer and activator of transcription-3 (STAT3) is constitutively activated in normal, self-renewing B-1 cells but only inducibly expressed in conventional B lymphocytes. J. Exp. Med. 1997, 185, 1035–1042.
    • (1997) J. Exp. Med , vol.185 , pp. 1035-1042
    • Karras, J.G.1    Wang, Z.2    Huo, L.3    Howard, R.G.4    Frank, D.A.5    Rothstein, T.L.6
  • 114
    • 0036121511 scopus 로고    scopus 로고
    • The important role of operations in the management of anaplastic thyroid carcinoma
    • Sugino, K.; Ito K.; Mimura T.; Nagahama M.; Fukunari N.; Kubo A.; Iwasaki H. The important role of operations in the management of anaplastic thyroid carcinoma. Surgery 2002, 131, 245–248.
    • (2002) Surgery , vol.131 , pp. 245-248
    • Sugino, K.1    Ito, K.2    Mimura, T.3    Nagahama, M.4    Fukunari, N.5    Kubo, A.6    Iwasaki, H.7
  • 116
    • 84859994573 scopus 로고    scopus 로고
    • Targeting signal transducer and activator of transcription 3 pathway by cucurbitacin I diminishes self-renewing and radiochemoresistant abilities in thyroid cancer-derived CD133+ cells
    • Tseng, L.M.; Huang P.I.; Chen Y.R.; Chen Y.C.; Chou Y.C.; Chen Y.W.; Chang Y.L.; Hsu H.S.; Lan Y.T.; Chen K.H. et al. Targeting signal transducer and activator of transcription 3 pathway by cucurbitacin I diminishes self-renewing and radiochemoresistant abilities in thyroid cancer-derived CD133+ cells. J. Pharmacol. Exp. Ther. 2012, 341, 410–423.
    • (2012) J. Pharmacol. Exp. Ther , vol.341 , pp. 410-423
    • Tseng, L.M.1    Huang, P.I.2    Chen, Y.R.3    Chen, Y.C.4    Chou, Y.C.5    Chen, Y.W.6    Chang, Y.L.7    Hsu, H.S.8    Lan, Y.T.9    Chen, K.H.10
  • 118
    • 42949120754 scopus 로고    scopus 로고
    • Identification of novel direct Stat3 target genes for control of growth and differentiation
    • Snyder, M.; Huang X.Y.; Zhang, J.J. Identification of novel direct Stat3 target genes for control of growth and differentiation. J. Biol. Chem. 2008, 283, 3791–3798.
    • (2008) J. Biol. Chem , vol.283 , pp. 3791-3798
    • Snyder, M.1    Huang, X.Y.2    Zhang, J.J.3
  • 121
    • 69249107379 scopus 로고    scopus 로고
    • Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog
    • Bourillot, P.Y.; Aksoy I.; Schreiber V.; Wianny F.; Schulz H.; Hummel O.; Hubner N.; Savatier P. Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog. Stem Cells 2009, 27, 1760–1771.
    • (2009) Stem Cells , vol.27 , pp. 1760-1771
    • Bourillot, P.Y.1    Aksoy, I.2    Schreiber, V.3    Wianny, F.4    Schulz, H.5    Hummel, O.6    Hubner, N.7    Savatier, P.8
  • 125
    • 79956285590 scopus 로고    scopus 로고
    • Dynamics of the STAT3 transcription factor: Nuclear import dependent on Ran and importin-beta1
    • Cimica, V.; Chen H.C.; Iyer J.K.; Reich N.C. Dynamics of the STAT3 transcription factor: Nuclear import dependent on Ran and importin-beta1. PLoS One 2011, 6, e20188.
    • (2011) PLoS One , vol.6
    • Cimica, V.1    Chen, H.C.2    Iyer, J.K.3    Reich, N.C.4
  • 126
    • 33646365075 scopus 로고    scopus 로고
    • Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements
    • Ma, J.; Cao X. Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements. Cell Signal. 2006, 18, 1117–1126.
    • (2006) Cell Signal , vol.18 , pp. 1117-1126
    • Ma, J.1    Cao, X.2
  • 127
    • 0037327154 scopus 로고    scopus 로고
    • Regulation of Stat3 nuclear export
    • Bhattacharya, S.; Schindler C. Regulation of Stat3 nuclear export. J. Clin. Invest. 2003, 111, 553–559.
    • (2003) J. Clin. Invest , vol.111 , pp. 553-559
    • Bhattacharya, S.1    Schindler, C.2
  • 129
    • 84886496878 scopus 로고    scopus 로고
    • Role of STAT3 in cancer metastasis and translational advances
    • Kamran, M.Z.; Patil P.; Gude, R.P. Role of STAT3 in cancer metastasis and translational advances. Biomed. Res. Int. 2013, 2013, 421821.
    • (2013) Biomed. Res. Int , vol.2013 , pp. 421821
    • Kamran, M.Z.1    Patil, P.2    Gude, R.P.3
  • 131
    • 0942268712 scopus 로고    scopus 로고
    • Stat3 enhances vimentin gene expression by binding to the antisilencer element and interacting with the repressor protein, ZBP-89
    • Wu, Y.; Diab I.; Zhang X.; Izmailova E.S.; Zehner Z.E. Stat3 enhances vimentin gene expression by binding to the antisilencer element and interacting with the repressor protein, ZBP-89. Oncogene 2004, 23, 168–178.
    • (2004) Oncogene , vol.23 , pp. 168-178
    • Wu, Y.1    Diab, I.2    Zhang, X.3    Izmailova, E.S.4    Zehner, Z.E.5
  • 132
    • 58149218143 scopus 로고    scopus 로고
    • Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas
    • Colomiere, M.; Ward A.C.; Riley C.; Trenerry M.K.; Cameron-Smith D.; Findlay J.; Ackland L.; Ahmed, N. Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas. Br. J. Cancer 2009, 100, 134–144.
    • (2009) Br. J. Cancer , vol.100 , pp. 134-144
    • Colomiere, M.1    Ward, A.C.2    Riley, C.3    Trenerry, M.K.4    Cameron-Smith, D.5    Findlay, J.6    Ackland, L.7    Ahmed, N.8
  • 133
    • 84899486834 scopus 로고    scopus 로고
    • Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis
    • Avtanski, D.B.; Nagalingam A.; Bonner M.Y.; Arbiser J.L.; Saxena N.K.; Sharma, D. Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis. Mol. Oncol. 2014, 8, 565–580.
    • (2014) Mol. Oncol , vol.8 , pp. 565-580
    • Avtanski, D.B.1    Nagalingam, A.2    Bonner, M.Y.3    Arbiser, J.L.4    Saxena, N.K.5    Sharma, D.6
  • 134
    • 84891591821 scopus 로고
    • Oxidative stress impairs multiple regulatory events to drive persistent cytokine-stimulated STAT3 phosphorylation
    • Ng, I.H.; Yeap Y.Y.; Ong L.S.; Jans D.A.; Bogoyevitch M.A. Oxidative stress impairs multiple regulatory events to drive persistent cytokine-stimulated STAT3 phosphorylation. Biochim. Biophys. Acta 2014, 1843, 483–494.
    • (1843) Biochim. Biophys. Acta , vol.2014 , pp. 483-494
    • Ng, I.H.1    Yeap, Y.Y.2    Ong, L.S.3    Jans, D.A.4    Bogoyevitch, M.A.5
  • 135
    • 84896708939 scopus 로고    scopus 로고
    • Nongenomic functions of STAT3
    • Decker, T., Müller, M., Eds.; Springer Vienna: Vienna, Austria
    • Gough, D.J.; Sehgal P.; Levy D.E. Nongenomic functions of STAT3. In Jak-Stat Signaling: From Basics to Disease; Decker, T., Müller, M., Eds.; Springer Vienna: Vienna, Austria, 2012; pp. 91–98.
    • (2012) Jak-Stat Signaling: From Basics to Disease , pp. 91-98
    • Gough, D.J.1    Sehgal, P.2    Levy, D.E.3
  • 136
    • 84893395842 scopus 로고    scopus 로고
    • Dancing rhinos in stilettos: The amazing saga of the genomic and nongenomic actions of STAT3 in the heart
    • Zouein, F.A.; Kurdi M.; Booz G.W. Dancing rhinos in stilettos: The amazing saga of the genomic and nongenomic actions of STAT3 in the heart. JAKSTAT 2013, 2, e24352.
    • (2013) JAKSTAT , vol.2
    • Zouein, F.A.1    Kurdi, M.2    Booz, G.W.3
  • 138
    • 84896490633 scopus 로고    scopus 로고
    • Toward a new STATe: The role of STATs in mitochondrial function
    • Meier, J.A.; Larner A.C. Toward a new STATe: The role of STATs in mitochondrial function. Semin. Immunol. 2014, 26, 20–28.
    • (2014) Semin. Immunol , vol.26 , pp. 20-28
    • Meier, J.A.1    Larner, A.C.2
  • 139
    • 84870375907 scopus 로고    scopus 로고
    • Reduction of STAT3 expression induces mitochondrial dysfunction and autophagy in cardiac HL-1 cells
    • Elschami, M.; Scherr M.; Philippens B.; Gerardy-Schahn, R. Reduction of STAT3 expression induces mitochondrial dysfunction and autophagy in cardiac HL-1 cells. Eur. J. Cell Biol. 2013, 92, 21–29.
    • (2013) Eur. J. Cell Biol , vol.92 , pp. 21-29
    • Elschami, M.1    Scherr, M.2    Philippens, B.3    Gerardy-Schahn, R.4
  • 140
    • 78649251953 scopus 로고    scopus 로고
    • STAT3 transcriptional factor activated by reactive oxygen species induces IL6 in starvation-induced autophagy of cancer cells
    • Yoon, S.; Woo S.U.; Kang J.H.; Kim K.; Kwon M.H.; Park S.; Shin H.J.; Gwak H.S.; Chwae Y.J. STAT3 transcriptional factor activated by reactive oxygen species induces IL6 in starvation-induced autophagy of cancer cells. Autophagy 2010, 6, 1125–1138.
    • (2010) Autophagy , vol.6 , pp. 1125-1138
    • Yoon, S.1    Woo, S.U.2    Kang, J.H.3    Kim, K.4    Kwon, M.H.5    Park, S.6    Shin, H.J.7    Gwak, H.S.8    Chwae, Y.J.9
  • 143
    • 0036782706 scopus 로고    scopus 로고
    • Transcription factors as targets for cancer therapy
    • Darnell, J.E. Transcription factors as targets for cancer therapy. Nat. Rev. Cancer 2002, 2, 740–749.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 740-749
    • Darnell, J.E.1
  • 144
    • 64849111865 scopus 로고    scopus 로고
    • Targeting STAT3 in cancer: How successful are we?
    • Yue, P.; Turkson J. Targeting STAT3 in cancer: How successful are we? Expert Opin. Investig. Drugs 2009, 18, 45–56.
    • (2009) Expert Opin. Investig. Drugs , vol.18 , pp. 45-56
    • Yue, P.1    Turkson, J.2
  • 145
    • 80051733032 scopus 로고    scopus 로고
    • Inhibiting signal transducer and activator of transcription 3: Rationality and rationale design of inhibitors
    • Mankan, A.K.; Greten F.R. Inhibiting signal transducer and activator of transcription 3: Rationality and rationale design of inhibitors. Expert Opin. Investig. Drugs 2011, 20, 1263–1275.
    • (2011) Expert Opin. Investig. Drugs , vol.20 , pp. 1263-1275
    • Mankan, A.K.1    Greten, F.R.2
  • 146
    • 80555149872 scopus 로고    scopus 로고
    • A chemical biology approach to developing STAT inhibitors: Molecular strategies for accelerating clinical translation
    • Nelson, E.A.; Sharma S.V.; Settleman J.; Frank D.A. A chemical biology approach to developing STAT inhibitors: Molecular strategies for accelerating clinical translation. Oncotarget 2011, 2, 518–524.
    • (2011) Oncotarget , vol.2 , pp. 518-524
    • Nelson, E.A.1    Sharma, S.V.2    Settleman, J.3    Frank, D.A.4
  • 147
    • 84864917825 scopus 로고    scopus 로고
    • Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein
    • Debnath, B.; Xu S.; Neamati, N. Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein. J. Med. Chem. 2012, 55, 6645–6668.
    • (2012) J. Med. Chem , vol.55 , pp. 6645-6668
    • Debnath, B.1    Xu, S.2    Neamati, N.3
  • 148
    • 84858259071 scopus 로고    scopus 로고
    • Targeting JAK2 in the therapy of myeloproliferative neoplasms
    • Reddy, M.M.; Deshpande A.; Sattler M. Targeting JAK2 in the therapy of myeloproliferative neoplasms. Expert Opin. Ther. Targets 2012, 16, 313–324.
    • (2012) Expert Opin. Ther. Targets , vol.16 , pp. 313-324
    • Reddy, M.M.1    Deshpande, A.2    Sattler, M.3
  • 149
    • 84859721377 scopus 로고    scopus 로고
    • JAK2 inhibition for the treatment of hematologic and solid malignancies
    • Harry, B.L.; Eckhardt S.G.; Jimeno A. JAK2 inhibition for the treatment of hematologic and solid malignancies. Expert Opin. Investig. Drugs 2012, 21, 637–655.
    • (2012) Expert Opin. Investig. Drugs , vol.21 , pp. 637-655
    • Harry, B.L.1    Eckhardt, S.G.2    Jimeno, A.3
  • 150
    • 84860630975 scopus 로고    scopus 로고
    • Targeting the interleukin-6/Jak/stat pathway in human malignancies
    • Sansone, P.; Bromberg J. Targeting the interleukin-6/Jak/stat pathway in human malignancies. J. Clin. Oncol. 2012, 30, 1005–1014.
    • (2012) J. Clin. Oncol , vol.30 , pp. 1005-1014
    • Sansone, P.1    Bromberg, J.2
  • 151
    • 84891830024 scopus 로고    scopus 로고
    • A phase II trial of saracatinib, an inhibitor of src kinases, in previously-treated advanced non-small-cell lung cancer: The princess margaret hospital phase II consortium
    • Laurie, S.A.; Goss G.D.; Shepherd F.A.; Reaume M.N.; Nicholas G.; Philip L.; Wang L.; Schwock J.; Hirsh V.; Oza A. et al. A phase II trial of saracatinib, an inhibitor of src kinases, in previously-treated advanced non-small-cell lung cancer: The princess margaret hospital phase II consortium. Clin. Lung Cancer 2014, 15, 52–57.
    • (2014) Clin. Lung Cancer , vol.15 , pp. 52-57
    • Laurie, S.A.1    Goss, G.D.2    Shepherd, F.A.3    Reaume, M.N.4    Nicholas, G.5    Philip, L.6    Wang, L.7    Schwock, J.8    Hirsh, V.9    Oza, A.10
  • 152
    • 26444468152 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells
    • Johnson, F.M.; Saigal B.; Talpaz M.; Donato N.J. Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells. Clin. Cancer Res. 2005, 11, 6924–6932.
    • (2005) Clin. Cancer Res , vol.11 , pp. 6924-6932
    • Johnson, F.M.1    Saigal, B.2    Talpaz, M.3    Donato, N.J.4
  • 153
    • 84865422083 scopus 로고    scopus 로고
    • Interleukin-6 signaling pathway in targeted therapy for cancer
    • Guo, Y.; Xu F.; Lu T.; Duan Z.; Zhang Z. Interleukin-6 signaling pathway in targeted therapy for cancer. Cancer Treat Rev. 2012, 38, 904–910.
    • (2012) Cancer Treat Rev , vol.38 , pp. 904-910
    • Guo, Y.1    Xu, F.2    Lu, T.3    Duan, Z.4    Zhang, Z.5
  • 154
    • 84907626985 scopus 로고    scopus 로고
    • NCT01066663, a phase I/II study of pyrimethamine, a STAT3 inhibitor, for the treatment of relapsed chronic lymphocytic Leukemia/small Lymphocytic Lymphoma
    • accessed on 9 February
    • NCT01066663, a phase I/II study of pyrimethamine, a STAT3 inhibitor, for the treatment of relapsed chronic lymphocytic Leukemia/small Lymphocytic Lymphoma. Available online: http://clinicaltrials.gov (accessed on 9 February 2010).
    • (2010)
  • 155
    • 84907626984 scopus 로고    scopus 로고
    • NCT00529113, a randomized phase I/II study with gemcitabine and RTA 402 or gemcitabine and placebo for patients with unresectable pancreatic cancer
    • accessed on 12 September
    • NCT00529113, a randomized phase I/II study with gemcitabine and RTA 402 or gemcitabine and placebo for patients with unresectable pancreatic cancer. Available online: http://clinicaltrials.gov (accessed on 12 September 2007).
    • (2007)
  • 157
    • 84898990827 scopus 로고    scopus 로고
    • Molecular pathways: Molecular basis for sensitivity and resistance to JAK kinase inhibitors
    • Meyer, S.C.; Levine R.L. Molecular pathways: Molecular basis for sensitivity and resistance to JAK kinase inhibitors. Clin. Cancer Res. 2014, 20, 2051–2059.
    • (2014) Clin. Cancer Res , vol.20 , pp. 2051-2059
    • Meyer, S.C.1    Levine, R.L.2
  • 158
    • 84892482473 scopus 로고    scopus 로고
    • Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection
    • Guo, X.; Qiu J.; Tu T.; Yang X.; Deng L.; Anders R.A.; Zhou L.; Fu Y.X. Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection. Immunity 2014, 40, 25–39.
    • (2014) Immunity , vol.40 , pp. 25-39
    • Guo, X.1    Qiu, J.2    Tu, T.3    Yang, X.4    Deng, L.5    Anders, R.A.6    Zhou, L.7    Fu, Y.X.8
  • 160
    • 25444454543 scopus 로고    scopus 로고
    • New and old functions of STAT3: A pivotal target for individualized treatment of cancer
    • Inghirami, G.; Chiarle R.; Simmons W.J.; Piva R.; Schlessinger K.; Levy D.E. New and old functions of STAT3: A pivotal target for individualized treatment of cancer. Cell Cycle 2005, 4, 1131–1133.
    • (2005) Cell Cycle , vol.4 , pp. 1131-1133
    • Inghirami, G.1    Chiarle, R.2    Simmons, W.J.3    Piva, R.4    Schlessinger, K.5    Levy, D.E.6


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