-
1
-
-
1042302005
-
The STATs of cancer - New molecular targets come of age
-
Yu H, Jove R,. The STATs of cancer-new molecular targets come of age. Nat Rev Cancer 2004; 4: 97-105.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 97-105
-
-
Yu, H.1
Jove, R.2
-
2
-
-
21344435775
-
Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer
-
Haura EB, Turkson J, Jove R,. Mechanisms of disease: insights into the emerging role of signal transducers and activators of transcription in cancer. Nat Clin Pract Oncol 2005; 2: 315-24.
-
(2005)
Nat Clin Pract Oncol
, vol.2
, pp. 315-324
-
-
Haura, E.B.1
Turkson, J.2
Jove, R.3
-
4
-
-
0030840464
-
STATs and gene regulation
-
Darnell JE, Jr., STATs and gene regulation. Science 1997; 277: 1630-5.
-
(1997)
Science
, vol.277
, pp. 1630-1635
-
-
Darnell, Jr.J.E.1
-
5
-
-
33845865825
-
Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
-
Yu H, Kortylewski M, Pardoll D,. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 2007; 7: 41-51.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 41-51
-
-
Yu, H.1
Kortylewski, M.2
Pardoll, D.3
-
6
-
-
70350500225
-
STATs in cancer inflammation and immunity: A leading role for STAT3
-
Yu H, Pardoll D, Jove R,. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009; 9: 798-809.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 798-809
-
-
Yu, H.1
Pardoll, D.2
Jove, R.3
-
7
-
-
77950346282
-
Immunity, inflammation, and cancer
-
Grivennikov SI, Greten FR, Karin M,. Immunity, inflammation, and cancer. Cell 2010; 140: 883-99.
-
(2010)
Cell
, vol.140
, pp. 883-899
-
-
Grivennikov, S.I.1
Greten, F.R.2
Karin, M.3
-
8
-
-
84860630975
-
Targeting the interleukin-6/Jak/stat pathway in human malignancies
-
Sansone P, Bromberg J,. Targeting the interleukin-6/Jak/stat pathway in human malignancies. J Clin Oncol 2012; 30: 1005-14.
-
(2012)
J Clin Oncol
, vol.30
, pp. 1005-1014
-
-
Sansone, P.1
Bromberg, J.2
-
9
-
-
77958509184
-
A gene expression signature for chemoradiosensitivity of colorectal cancer cells
-
Spitzner M, Emons G, Kramer F, et al. A gene expression signature for chemoradiosensitivity of colorectal cancer cells. Int J Radiat Oncol Biol Phys 2010; 78: 1184-92.
-
(2010)
Int J Radiat Oncol Biol Phys
, vol.78
, pp. 1184-1192
-
-
Spitzner, M.1
Emons, G.2
Kramer, F.3
-
12
-
-
78650720162
-
A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets
-
Grade M, Hummon AB, Camps J, et al. A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets. Int J Cancer 2011; 128: 1069-79.
-
(2011)
Int J Cancer
, vol.128
, pp. 1069-1079
-
-
Grade, M.1
Hummon, A.B.2
Camps, J.3
-
13
-
-
33750982120
-
Stattic: A small-molecule inhibitor of STAT3 activation and dimerization
-
Schust J, Sperl B, Hollis A, et al. Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem Biol 2006; 13: 1235-42.
-
(2006)
Chem Biol
, vol.13
, pp. 1235-1242
-
-
Schust, J.1
Sperl, B.2
Hollis, A.3
-
14
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
-
Livak KJ, Schmittgen TD,. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402-8.
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
15
-
-
81855217368
-
Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy
-
Kendziorra E, Ahlborn K, Spitzner M, et al. Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy. Carcinogenesis 2011; 32: 1824-31.
-
(2011)
Carcinogenesis
, vol.32
, pp. 1824-1831
-
-
Kendziorra, E.1
Ahlborn, K.2
Spitzner, M.3
-
16
-
-
79955485953
-
STAT3 inhibition is a therapeutic strategy for ABC-like diffuse large B-cell lymphoma
-
Scuto A, Kujawski M, Kowolik C, et al. STAT3 inhibition is a therapeutic strategy for ABC-like diffuse large B-cell lymphoma. Cancer Res 2011; 71: 3182-8.
-
(2011)
Cancer Res
, vol.71
, pp. 3182-3188
-
-
Scuto, A.1
Kujawski, M.2
Kowolik, C.3
-
17
-
-
26244463218
-
Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: Inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells
-
Lin Q, Lai R, Chirieac LR, et al. Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. Am J Pathol 2005; 167: 969-80.
-
(2005)
Am J Pathol
, vol.167
, pp. 969-980
-
-
Lin, Q.1
Lai, R.2
Chirieac, L.R.3
-
18
-
-
23444452377
-
Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; Correlation with clinicopathological factors
-
Kusaba T, Nakayama T, Yamazumi K, et al. Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors. J Clin Pathol 2005; 58: 833-8.
-
(2005)
J Clin Pathol
, vol.58
, pp. 833-838
-
-
Kusaba, T.1
Nakayama, T.2
Yamazumi, K.3
-
19
-
-
22044437986
-
Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth
-
Corvinus FM, Orth C, Moriggl R, et al. Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth. Neoplasia 2005; 7: 545-55.
-
(2005)
Neoplasia
, vol.7
, pp. 545-555
-
-
Corvinus, F.M.1
Orth, C.2
Moriggl, R.3
-
20
-
-
79952715805
-
STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers
-
Morikawa T, Baba Y, Yamauchi M, et al. STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers. Clin Cancer Res 2011; 17: 1452-62.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1452-1462
-
-
Morikawa, T.1
Baba, Y.2
Yamauchi, M.3
-
21
-
-
77957842594
-
Prognostic value of phosphorylated STAT3 in advanced rectal cancer: A study from 104 French patients included in the EORTC 22921 trial
-
Monnien F, Zaki H, Borg C, et al. Prognostic value of phosphorylated STAT3 in advanced rectal cancer: a study from 104 French patients included in the EORTC 22921 trial. J Clin Pathol 2010; 63: 873-8.
-
(2010)
J Clin Pathol
, vol.63
, pp. 873-878
-
-
Monnien, F.1
Zaki, H.2
Borg, C.3
-
22
-
-
38449098731
-
The role of signal transducers and activators of transcription in colon cancer
-
Klampfer L,. The role of signal transducers and activators of transcription in colon cancer. Front Biosci 2008; 13: 2888-99.
-
(2008)
Front Biosci
, vol.13
, pp. 2888-2899
-
-
Klampfer, L.1
-
23
-
-
84869758362
-
Interleukin-6 - A key regulator of colorectal cancer development
-
Waldner MJ, Foersch S, Neurath MF,. Interleukin-6-a key regulator of colorectal cancer development. Int J Biol Sci 2012; 8: 1248-53.
-
(2012)
Int J Biol Sci
, vol.8
, pp. 1248-1253
-
-
Waldner, M.J.1
Foersch, S.2
Neurath, M.F.3
-
24
-
-
44949130806
-
Signaling molecules: The pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancer
-
Atreya R, Neurath MF,. Signaling molecules: the pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancer. Curr Drug Targets 2008; 9: 369-74.
-
(2008)
Curr Drug Targets
, vol.9
, pp. 369-374
-
-
Atreya, R.1
Neurath, M.F.2
-
25
-
-
68449085757
-
Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease
-
Rose-John S, Mitsuyama K, Matsumoto S, et al. Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease. Curr Pharm Des 2009; 15: 2095-103.
-
(2009)
Curr Pharm des
, vol.15
, pp. 2095-2103
-
-
Rose-John, S.1
Mitsuyama, K.2
Matsumoto, S.3
-
26
-
-
33846455463
-
Gene expression profiling reveals a massive, aneuploidy-dependent transcriptional deregulation and distinct differences between lymph node-negative and lymph node-positive colon carcinomas
-
Grade M, Hormann P, Becker S, et al. Gene expression profiling reveals a massive, aneuploidy-dependent transcriptional deregulation and distinct differences between lymph node-negative and lymph node-positive colon carcinomas. Cancer Res 2007; 67: 41-56.
-
(2007)
Cancer Res
, vol.67
, pp. 41-56
-
-
Grade, M.1
Hormann, P.2
Becker, S.3
-
27
-
-
70349317146
-
Integrative genomics reveals mechanisms of copy number alterations responsible for transcriptional deregulation in colorectal cancer
-
Camps J, Nguyen QT, Padilla-Nash HM, et al. Integrative genomics reveals mechanisms of copy number alterations responsible for transcriptional deregulation in colorectal cancer. Genes Chromosomes Cancer 2009; 48: 1002-17.
-
(2009)
Genes Chromosomes Cancer
, vol.48
, pp. 1002-1017
-
-
Camps, J.1
Nguyen, Q.T.2
Padilla-Nash, H.M.3
-
28
-
-
84875477576
-
Genetic amplication of the NOTCH modulator LNX2 upregulates the WNT/beta-catenin pathway in colorectal cancer
-
Camps J, Pitt JJ, Emons G, et al. Genetic amplication of the NOTCH modulator LNX2 upregulates the WNT/beta-catenin pathway in colorectal cancer. Cancer Res 2013; 73: 2003-13.
-
(2013)
Cancer Res
, vol.73
, pp. 2003-2013
-
-
Camps, J.1
Pitt, J.J.2
Emons, G.3
-
29
-
-
84863922124
-
Comprehensive molecular characterization of human colon and rectal cancer
-
Network CGA,. Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012; 487: 330-7.
-
(2012)
Nature
, vol.487
, pp. 330-337
-
-
Network, C.G.A.1
-
30
-
-
34247281958
-
Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction
-
Tsareva SA, Moriggl R, Corvinus FM, et al. Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction. Neoplasia 2007; 9: 279-91.
-
(2007)
Neoplasia
, vol.9
, pp. 279-291
-
-
Tsareva, S.A.1
Moriggl, R.2
Corvinus, F.M.3
-
31
-
-
79953880824
-
STAT3 controls matrix metalloproteinase-1 expression in colon carcinoma cells by both direct and AP-1-mediated interaction with the MMP-1 promoter
-
Zugowski C, Lieder F, Muller A, et al. STAT3 controls matrix metalloproteinase-1 expression in colon carcinoma cells by both direct and AP-1-mediated interaction with the MMP-1 promoter. Biol Chem 2011; 392: 449-59.
-
(2011)
Biol Chem
, vol.392
, pp. 449-459
-
-
Zugowski, C.1
Lieder, F.2
Muller, A.3
-
32
-
-
0035910753
-
CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation
-
Suzuki A, Hanada T, Mitsuyama K, et al. CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med 2001; 193: 471-81.
-
(2001)
J Exp Med
, vol.193
, pp. 471-481
-
-
Suzuki, A.1
Hanada, T.2
Mitsuyama, K.3
-
33
-
-
58649101347
-
Gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis
-
Bollrath J, Phesse TJ, von Burstin VA, et al. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell 2009; 15: 91-102.
-
(2009)
Cancer Cell
, vol.15
, pp. 91-102
-
-
Bollrath, J.1
Phesse, T.J.2
Von Burstin, V.A.3
-
34
-
-
58649108302
-
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
-
Grivennikov S, Karin E, Terzic J, et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 2009; 15: 103-13.
-
(2009)
Cancer Cell
, vol.15
, pp. 103-113
-
-
Grivennikov, S.1
Karin, E.2
Terzic, J.3
-
35
-
-
79960276970
-
Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030
-
Lin L, Liu Y, Li H, et al. Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030. Br J Cancer 2011; 105: 212-20.
-
(2011)
Br J Cancer
, vol.105
, pp. 212-220
-
-
Lin, L.1
Liu, Y.2
Li, H.3
-
36
-
-
82655189564
-
STAT3 is necessary for proliferation and survival in colon cancer-initiating cells
-
Lin L, Liu A, Peng Z, et al. STAT3 is necessary for proliferation and survival in colon cancer-initiating cells. Cancer Res 2011; 71: 7226-37.
-
(2011)
Cancer Res
, vol.71
, pp. 7226-7237
-
-
Lin, L.1
Liu, A.2
Peng, Z.3
-
37
-
-
84863989908
-
The molecular basis of chemoradiosensitivity in rectal cancer: Implications for personalized therapies
-
Grade M, Wolff HA, Gaedcke J, et al. The molecular basis of chemoradiosensitivity in rectal cancer: implications for personalized therapies. Langenbecks Arch Surg 2012; 397: 543-55.
-
(2012)
Langenbecks Arch Surg
, vol.397
, pp. 543-555
-
-
Grade, M.1
Wolff, H.A.2
Gaedcke, J.3
-
38
-
-
33845228341
-
Inhibition of signal transducer and activator of transcription 3 activity results in down-regulation of Survivin following irradiation
-
Kim KW, Mutter RW, Cao C, et al. Inhibition of signal transducer and activator of transcription 3 activity results in down-regulation of Survivin following irradiation. Mol Cancer Ther 2006; 5: 2659-65.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2659-2665
-
-
Kim, K.W.1
Mutter, R.W.2
Cao, C.3
-
39
-
-
69949140389
-
Inhibition of STAT-3 results in radiosensitization of human squamous cell carcinoma
-
Bonner JA, Trummell HQ, Willey CD, et al. Inhibition of STAT-3 results in radiosensitization of human squamous cell carcinoma. Radiother Oncol 2009; 92: 339-44.
-
(2009)
Radiother Oncol
, vol.92
, pp. 339-344
-
-
Bonner, J.A.1
Trummell, H.Q.2
Willey, C.D.3
-
40
-
-
77953577606
-
Inhibition of STAT3 and ErbB2 suppresses tumor growth, enhances radiosensitivity, and induces mitochondria-dependent apoptosis in glioma cells
-
Gao L, Li F, Dong B, et al. Inhibition of STAT3 and ErbB2 suppresses tumor growth, enhances radiosensitivity, and induces mitochondria-dependent apoptosis in glioma cells. Int J Radiat Oncol Biol Phys 2010; 77: 1223-31.
-
(2010)
Int J Radiat Oncol Biol Phys
, vol.77
, pp. 1223-1231
-
-
Gao, L.1
Li, F.2
Dong, B.3
-
41
-
-
78649648154
-
Cucurbitacin i suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma - Derived CD44(+)ALDH1(+) cells
-
Chen YW, Chen KH, Huang PI, et al. Cucurbitacin I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma-derived CD44(+)ALDH1(+) cells. Mol Cancer Ther 2010; 9: 2879-92.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 2879-2892
-
-
Chen, Y.W.1
Chen, K.H.2
Huang, P.I.3
-
42
-
-
84155184247
-
Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis
-
Yang YP, Chang YL, Huang PI, et al. Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis. J Cell Physiol 2012; 227: 976-93.
-
(2012)
J Cell Physiol
, vol.227
, pp. 976-993
-
-
Yang, Y.P.1
Chang, Y.L.2
Huang, P.I.3
-
43
-
-
84858590826
-
Accessories to the crime: Functions of cells recruited to the tumor microenvironment
-
Hanahan D, Coussens LM,. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 2012; 21: 309-22.
-
(2012)
Cancer Cell
, vol.21
, pp. 309-322
-
-
Hanahan, D.1
Coussens, L.M.2
-
44
-
-
84861116448
-
Tumor microenvironment complexity: Emerging roles in cancer therapy
-
Swartz MA, Iida N, Roberts EW, et al. Tumor microenvironment complexity: emerging roles in cancer therapy. Cancer Res 2012; 72: 2473-80.
-
(2012)
Cancer Res
, vol.72
, pp. 2473-2480
-
-
Swartz, M.A.1
Iida, N.2
Roberts, E.W.3
-
45
-
-
80051733032
-
Inhibiting signal transducer and activator of transcription 3: Rationality and rationale design of inhibitors
-
Mankan AK, Greten FR,. Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors. Expert Opin Investig Drugs 2011; 20: 1263-75.
-
(2011)
Expert Opin Investig Drugs
, vol.20
, pp. 1263-1275
-
-
Mankan, A.K.1
Greten, F.R.2
-
46
-
-
11144357779
-
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
-
Wang T, Niu G, Kortylewski M, et al. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat Med 2004; 10: 48-54.
-
(2004)
Nat Med
, vol.10
, pp. 48-54
-
-
Wang, T.1
Niu, G.2
Kortylewski, M.3
-
47
-
-
28644445445
-
Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
-
Kortylewski M, Kujawski M, Wang T, et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 2005; 11: 1314-21.
-
(2005)
Nat Med
, vol.11
, pp. 1314-1321
-
-
Kortylewski, M.1
Kujawski, M.2
Wang, T.3
-
48
-
-
77957327205
-
Targeting Stat3 in the myeloid compartment drastically improves the in vivo antitumor functions of adoptively transferred T cells
-
Herrmann A, Kortylewski M, Kujawski M, et al. Targeting Stat3 in the myeloid compartment drastically improves the in vivo antitumor functions of adoptively transferred T cells. Cancer Res 2010; 70: 7455-64.
-
(2010)
Cancer Res
, vol.70
, pp. 7455-7464
-
-
Herrmann, A.1
Kortylewski, M.2
Kujawski, M.3
-
49
-
-
78149415475
-
Prognostic significance of response to preoperative radiotherapy, lymph node metastasis, and CEA level in patients undergoing total mesorectal excision of rectal cancer
-
Ishihara S, Watanabe T, Kiyomatsu T, et al. Prognostic significance of response to preoperative radiotherapy, lymph node metastasis, and CEA level in patients undergoing total mesorectal excision of rectal cancer. Int J Colorectal Dis 2010; 25: 1417-25.
-
(2010)
Int J Colorectal Dis
, vol.25
, pp. 1417-1425
-
-
Ishihara, S.1
Watanabe, T.2
Kiyomatsu, T.3
-
50
-
-
72249098733
-
Lymph node status after neoadjuvant radiotherapy for rectal cancer is a biologic predictor of outcome
-
Chang GJ, Rodriguez-Bigas MA, Eng C, et al. Lymph node status after neoadjuvant radiotherapy for rectal cancer is a biologic predictor of outcome. Cancer 2009; 115: 5432-40.
-
(2009)
Cancer
, vol.115
, pp. 5432-5440
-
-
Chang, G.J.1
Rodriguez-Bigas, M.A.2
Eng, C.3
|