Inhibition of STAT3 and ErbB2 Suppresses Tumor Growth, Enhances Radiosensitivity, and Induces Mitochondria-Dependent Apoptosis in Glioma Cells

International Journal of Radiation Oncology Biology Physics

Volumn 77, Issue 4, 2010, Pages 1223-1231

  Gao, Ling ^a   Cong, Yue ^a   Li, Fengsheng ^a   Dong, Bo ^a   Zhang, Junquan ^a   Rao, Yalan ^a   Mao, Bingzhi ^a   Chen, Xiaohua ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

Apoptosis; ErbB2; Radiation; Signal transducers and activators of transcription; siRNA

Indexed keywords

ACTIVATED SIGNAL; ANTI-TUMOR ACTIVITIES; APOPTOSIS; APOPTOTIC PATHWAYS; ASTROCYTOMA; CASPASES; CELL APOPTOSIS; CELL LINES; CELL VIABILITY; CLONOGENIC ASSAYS; COMBINATION TREATMENTS; COMBINED TREATMENT; GLIOMA CELLS; IMMUNOBLOTTING; IN-VIVO; MITOCHONDRIAL DAMAGE; RADIATION-INDUCED; RADIO-SENSITIZATION; SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTIONS; TARGET GENE EXPRESSION; TARGET PROTEINS; TUMOR GROWTH;

BROMINE COMPOUNDS; CELL CULTURE; DAMAGE DETECTION; IRRADIATION; NUCLEIC ACIDS; PROTEINS; RNA; TRANSCRIPTION; TRANSDUCERS; TUMORS;

CELL DEATH;

CASPASE 3; CASPASE 7; EPIDERMAL GROWTH FACTOR RECEPTOR 2; SMALL INTERFERING RNA; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER RADIOTHERAPY; CELL SURVIVAL; CELL VIABILITY; CLONOGENIC ASSAY; CONTROLLED STUDY; DOWN REGULATION; GLIOMA; GLIOMA CELL; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY; RAT; RNA INTERFERENCE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; ASTROCYTES; CASPASES; CELL LINE; CELL SURVIVAL; DOWN-REGULATION; ENZYME ACTIVATION; GLIOMA; MICE; MICE, NUDE; MITOCHONDRIA; NEOPLASM PROTEINS; RADIATION TOLERANCE; RATS; RATS, WISTAR; RECEPTOR, ERBB-2; RNA, SMALL INTERFERING; STAT3 TRANSCRIPTION FACTOR; TRANSFECTION;

EID: 77953577606     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.12.036     Document Type: Article

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