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Volumn 8, Issue 3, 2014, Pages 565-580

Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis

Author keywords

Breast cancer; E cadherin; EMT; Honokiol; Stat3; Zeb1

Indexed keywords

HONOKIOL; STAT3 PROTEIN; TRANSCRIPTION FACTOR ZEB1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UVOMORULIN; ANTINEOPLASTIC AGENT; BIPHENYL DERIVATIVE; CADHERIN; HOMEODOMAIN PROTEIN; LIGNAN; TRANSCRIPTION FACTOR; ZEB1 PROTEIN, HUMAN;

EID: 84899486834     PISSN: 15747891     EISSN: 18780261     Source Type: Journal    
DOI: 10.1016/j.molonc.2014.01.004     Document Type: Article
Times cited : (90)

References (79)
  • 1
    • 33749321904 scopus 로고    scopus 로고
    • Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway
    • Ahn K.S., Sethi G., Shishodia S., Sung B., Arbiser J.L., Aggarwal B.B. Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway. Mol. Cancer Res. MCR 2006, 4:621-633.
    • (2006) Mol. Cancer Res. MCR , vol.4 , pp. 621-633
    • Ahn, K.S.1    Sethi, G.2    Shishodia, S.3    Sung, B.4    Arbiser, J.L.5    Aggarwal, B.B.6
  • 2
    • 79959648566 scopus 로고    scopus 로고
    • Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells
    • Arora S., Bhardwaj A., Srivastava S.K., Singh S., McClellan S., Wang B., Singh A.P. Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells. PLoS One 2011, 6:e21573.
    • (2011) PLoS One , vol.6
    • Arora, S.1    Bhardwaj, A.2    Srivastava, S.K.3    Singh, S.4    McClellan, S.5    Wang, B.6    Singh, A.P.7
  • 5
    • 77149179813 scopus 로고    scopus 로고
    • Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications
    • Bar-Sela G., Epelbaum R., Schaffer M. Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications. Curr. Med. Chem. 2010, 17:190-197.
    • (2010) Curr. Med. Chem. , vol.17 , pp. 190-197
    • Bar-Sela, G.1    Epelbaum, R.2    Schaffer, M.3
  • 6
    • 0037572319 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids
    • Bates R.C., Mercurio A.M. Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids. Mol. Biol. Cell 2003, 14:1790-1800.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 1790-1800
    • Bates, R.C.1    Mercurio, A.M.2
  • 7
    • 22144452194 scopus 로고    scopus 로고
    • The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells
    • Battle T.E., Arbiser J., Frank D.A. The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells. Blood 2005, 106:690-697.
    • (2005) Blood , vol.106 , pp. 690-697
    • Battle, T.E.1    Arbiser, J.2    Frank, D.A.3
  • 8
    • 37549068967 scopus 로고    scopus 로고
    • Green tea polyphenols reverse cooperation between c-Rel and CK2 that induces the aryl hydrocarbon receptor, slug, and an invasive phenotype
    • Belguise K., Guo S., Yang S., Rogers A.E., Seldin D.C., Sherr D.H., Sonenshein G.E. Green tea polyphenols reverse cooperation between c-Rel and CK2 that induces the aryl hydrocarbon receptor, slug, and an invasive phenotype. Cancer Res. 2007, 67:11742-11750.
    • (2007) Cancer Res. , vol.67 , pp. 11742-11750
    • Belguise, K.1    Guo, S.2    Yang, S.3    Rogers, A.E.4    Seldin, D.C.5    Sherr, D.H.6    Sonenshein, G.E.7
  • 13
    • 0036554816 scopus 로고    scopus 로고
    • Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
    • Buettner R., Mora L.B., Jove R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res. 2002, 8:945-954.
    • (2002) Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res. , vol.8 , pp. 945-954
    • Buettner, R.1    Mora, L.B.2    Jove, R.3
  • 16
    • 84856623196 scopus 로고    scopus 로고
    • Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer's disease
    • Choi D.Y., Lee Y.J., Hong J.T., Lee H.J. Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer's disease. Brain Res. Bull. 2012, 87:144-153.
    • (2012) Brain Res. Bull. , vol.87 , pp. 144-153
    • Choi, D.Y.1    Lee, Y.J.2    Hong, J.T.3    Lee, H.J.4
  • 17
    • 33750442231 scopus 로고    scopus 로고
    • A novel anticancer effect of garlic derivatives: inhibition of cancer cell invasion through restoration of E-cadherin expression
    • Chu Q., Ling M.T., Feng H., Cheung H.W., Tsao S.W., Wang X., Wong Y.C. A novel anticancer effect of garlic derivatives: inhibition of cancer cell invasion through restoration of E-cadherin expression. Carcinogenesis 2006, 27:2180-2189.
    • (2006) Carcinogenesis , vol.27 , pp. 2180-2189
    • Chu, Q.1    Ling, M.T.2    Feng, H.3    Cheung, H.W.4    Tsao, S.W.5    Wang, X.6    Wong, Y.C.7
  • 18
    • 33846828787 scopus 로고    scopus 로고
    • NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2
    • Chua H.L., Bhat-Nakshatri P., Clare S.E., Morimiya A., Badve S., Nakshatri H. NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2. Oncogene 2007, 26:711-724.
    • (2007) Oncogene , vol.26 , pp. 711-724
    • Chua, H.L.1    Bhat-Nakshatri, P.2    Clare, S.E.3    Morimiya, A.4    Badve, S.5    Nakshatri, H.6
  • 19
    • 59649086123 scopus 로고    scopus 로고
    • Epidermal growth factor-induced ovarian carcinoma cell migration is associated with JAK2/STAT3 signals and changes in the abundance and localization of alpha6beta1 integrin
    • Colomiere M., Findlay J., Ackland L., Ahmed N. Epidermal growth factor-induced ovarian carcinoma cell migration is associated with JAK2/STAT3 signals and changes in the abundance and localization of alpha6beta1 integrin. Int. J. Biochem. Cell Biol. 2009, 41:1034-1045.
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 1034-1045
    • Colomiere, M.1    Findlay, J.2    Ackland, L.3    Ahmed, N.4
  • 20
    • 77954861745 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer
    • Creighton C.J., Chang J.C., Rosen J.M. Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer. J.Mammary Gland Biol. Neoplasia 2010, 15:253-260.
    • (2010) J.Mammary Gland Biol. Neoplasia , vol.15 , pp. 253-260
    • Creighton, C.J.1    Chang, J.C.2    Rosen, J.M.3
  • 22
    • 84856015098 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition, cancer stem cells and treatment resistance
    • Dave B., Mittal V., Tan N.M., Chang J.C. Epithelial-mesenchymal transition, cancer stem cells and treatment resistance. Breast Cancer Res. 2012, 14:202.
    • (2012) Breast Cancer Res. , vol.14 , pp. 202
    • Dave, B.1    Mittal, V.2    Tan, N.M.3    Chang, J.C.4
  • 23
    • 64749084915 scopus 로고    scopus 로고
    • Honokiol, a multifunctional antiangiogenic and antitumor agent
    • Fried L.E., Arbiser J.L. Honokiol, a multifunctional antiangiogenic and antitumor agent. Antioxid. Redox Signal. 2009, 11:1139-1148.
    • (2009) Antioxid. Redox Signal. , vol.11 , pp. 1139-1148
    • Fried, L.E.1    Arbiser, J.L.2
  • 24
    • 0015841393 scopus 로고
    • Studies on the components of Magnolia obovata Thunb. 3. Occurrence of magnolol and honokiol in M. obovata and other allied plants
    • Fujita M., Itokawa H., Sashida Y. Yakugaku Zasshi 1973, 93:429-434.
    • (1973) Yakugaku Zasshi , vol.93 , pp. 429-434
    • Fujita, M.1    Itokawa, H.2    Sashida, Y.3
  • 25
    • 0013689209 scopus 로고    scopus 로고
    • Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth invitro
    • Grandis J.R., Drenning S.D., Chakraborty A., Zhou M.Y., Zeng Q., Pitt A.S., Tweardy D.J. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth invitro. J.Clin. Invest 1998, 102:1385-1392.
    • (1998) J.Clin. Invest , vol.102 , pp. 1385-1392
    • Grandis, J.R.1    Drenning, S.D.2    Chakraborty, A.3    Zhou, M.Y.4    Zeng, Q.5    Pitt, A.S.6    Tweardy, D.J.7
  • 26
    • 3242693775 scopus 로고    scopus 로고
    • Antiadhesive antibodies targeting E-cadherin sensitize multicellular tumor spheroids to chemotherapy invitro
    • Green S.K., Francia G., Isidoro C., Kerbel R.S. Antiadhesive antibodies targeting E-cadherin sensitize multicellular tumor spheroids to chemotherapy invitro. Mol. Cancer Ther. 2004, 3:149-159.
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 149-159
    • Green, S.K.1    Francia, G.2    Isidoro, C.3    Kerbel, R.S.4
  • 27
    • 21344435775 scopus 로고    scopus 로고
    • Mechanisms of disease: insights into the emerging role of signal transducers and activators of transcription in cancer
    • Haura E.B., Turkson J., Jove R. Mechanisms of disease: insights into the emerging role of signal transducers and activators of transcription in cancer. Nat. Clin. Pract. Oncol. 2005, 2:315-324.
    • (2005) Nat. Clin. Pract. Oncol. , vol.2 , pp. 315-324
    • Haura, E.B.1    Turkson, J.2    Jove, R.3
  • 29
    • 0028018410 scopus 로고
    • Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells
    • Hirano T., Gotoh M., Oka K. Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells. Life Sci. 1994, 55:1061-1069.
    • (1994) Life Sci. , vol.55 , pp. 1061-1069
    • Hirano, T.1    Gotoh, M.2    Oka, K.3
  • 31
    • 84857063740 scopus 로고    scopus 로고
    • CD44(+)/CD24(-/low) cancer stem/progenitor cells are more abundant in triple-negative invasive breast carcinoma phenotype and are associated with poor outcome
    • Idowu M.O., Kmieciak M., Dumur C., Burton R.S., Grimes M.M., Powers C.N., Manjili M.H. CD44(+)/CD24(-/low) cancer stem/progenitor cells are more abundant in triple-negative invasive breast carcinoma phenotype and are associated with poor outcome. Hum. Pathol. 2012, 43:364-373.
    • (2012) Hum. Pathol. , vol.43 , pp. 364-373
    • Idowu, M.O.1    Kmieciak, M.2    Dumur, C.3    Burton, R.S.4    Grimes, M.M.5    Powers, C.N.6    Manjili, M.H.7
  • 33
    • 79952300263 scopus 로고    scopus 로고
    • Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3
    • Kim S.H., Nagalingam A., Saxena N.K., Singh S.V., Sharma D. Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3. Carcinogenesis 2011, 32:359-367.
    • (2011) Carcinogenesis , vol.32 , pp. 359-367
    • Kim, S.H.1    Nagalingam, A.2    Saxena, N.K.3    Singh, S.V.4    Sharma, D.5
  • 34
    • 21044435937 scopus 로고    scopus 로고
    • Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-kappaB activation signaling
    • Lee J., Jung E., Park J., Jung K., Lee S., Hong S., Park E., Kim J., Park S., Park D. Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-kappaB activation signaling. Planta Med. 2005, 71:338-343.
    • (2005) Planta Med. , vol.71 , pp. 338-343
    • Lee, J.1    Jung, E.2    Park, J.3    Jung, K.4    Lee, S.5    Hong, S.6    Park, E.7    Kim, J.8    Park, S.9    Park, D.10
  • 35
    • 23844434046 scopus 로고    scopus 로고
    • Differential inhibitory effects of honokiol and magnolol on excitatory amino acid-evoked cation signals and NMDA-induced seizures
    • Lin Y.R., Chen H.H., Ko C.H., Chan M.H. Differential inhibitory effects of honokiol and magnolol on excitatory amino acid-evoked cation signals and NMDA-induced seizures. Neuropharmacology 2005, 49:542-550.
    • (2005) Neuropharmacology , vol.49 , pp. 542-550
    • Lin, Y.R.1    Chen, H.H.2    Ko, C.H.3    Chan, M.H.4
  • 36
    • 0028289204 scopus 로고
    • Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation
    • Lo Y.C., Teng C.M., Chen C.F., Chen C.C., Hong C.Y. Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation. Biochem. Pharmacol. 1994, 47:549-553.
    • (1994) Biochem. Pharmacol. , vol.47 , pp. 549-553
    • Lo, Y.C.1    Teng, C.M.2    Chen, C.F.3    Chen, C.C.4    Hong, C.Y.5
  • 40
    • 51449085561 scopus 로고    scopus 로고
    • Generation of breast cancer stem cells through epithelial-mesenchymal transition
    • Morel A.P., Lievre M., Thomas C., Hinkal G., Ansieau S., Puisieux A. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One 2008, 3:e2888.
    • (2008) PLoS One , vol.3
    • Morel, A.P.1    Lievre, M.2    Thomas, C.3    Hinkal, G.4    Ansieau, S.5    Puisieux, A.6
  • 41
    • 84857128956 scopus 로고    scopus 로고
    • Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis
    • Nagalingam A., Arbiser J.L., Bonner M.Y., Saxena N.K., Sharma D. Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis. Breast Cancer Res. 2012, 14:R35.
    • (2012) Breast Cancer Res. , vol.14
    • Nagalingam, A.1    Arbiser, J.L.2    Bonner, M.Y.3    Saxena, N.K.4    Sharma, D.5
  • 42
    • 0034764041 scopus 로고    scopus 로고
    • Inhibitory effect of magnolol and honokiol from Magnolia obovata on human fibrosarcoma HT-1080. Invasiveness invitro
    • Nagase H., Ikeda K., Sakai Y. Inhibitory effect of magnolol and honokiol from Magnolia obovata on human fibrosarcoma HT-1080. Invasiveness invitro. Planta Med. 2001, 67:705-708.
    • (2001) Planta Med. , vol.67 , pp. 705-708
    • Nagase, H.1    Ikeda, K.2    Sakai, Y.3
  • 43
    • 67349090320 scopus 로고    scopus 로고
    • Anti-inflammatory effect of 4-O-methylhonokiol, compound isolated from Magnolia officinalis through inhibition of NF-kappaB [corrected]
    • Oh J.H., Kang L.L., Ban J.O., Kim Y.H., Kim K.H., Han S.B., Hong J.T. Anti-inflammatory effect of 4-O-methylhonokiol, compound isolated from Magnolia officinalis through inhibition of NF-kappaB [corrected]. Chem.-Biol. Interact. 2009, 180:506-514.
    • (2009) Chem.-Biol. Interact. , vol.180 , pp. 506-514
    • Oh, J.H.1    Kang, L.L.2    Ban, J.O.3    Kim, Y.H.4    Kim, K.H.5    Han, S.B.6    Hong, J.T.7
  • 44
    • 70349784071 scopus 로고    scopus 로고
    • Expression analysis of E-cadherin, Slug and GSK3beta in invasive ductal carcinoma of breast
    • Prasad C.P., Rath G., Mathur S., Bhatnagar D., Parshad R., Ralhan R. Expression analysis of E-cadherin, Slug and GSK3beta in invasive ductal carcinoma of breast. BMC Cancer 2009, 9:325.
    • (2009) BMC Cancer , vol.9 , pp. 325
    • Prasad, C.P.1    Rath, G.2    Mathur, S.3    Bhatnagar, D.4    Parshad, R.5    Ralhan, R.6
  • 45
    • 44349139461 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and the stem cell phenotype
    • Radisky D.C., LaBarge M.A. Epithelial-mesenchymal transition and the stem cell phenotype. Cell Stem Cell 2008, 2:511-512.
    • (2008) Cell Stem Cell , vol.2 , pp. 511-512
    • Radisky, D.C.1    LaBarge, M.A.2
  • 48
    • 78049478003 scopus 로고    scopus 로고
    • Adiponectin modulates C-jun N-terminal kinase and mammalian target of rapamycin and inhibits hepatocellular carcinoma
    • 1773, 1761-1765
    • Saxena N.K., Fu P.P., Nagalingam A., Wang J., Handy J., Cohen C., Tighiouart M., Sharma D., Anania F.A. Adiponectin modulates C-jun N-terminal kinase and mammalian target of rapamycin and inhibits hepatocellular carcinoma. Gastroenterology 2010, 139:1762-1773. 1773, 1761-1765.
    • (2010) Gastroenterology , vol.139 , pp. 1762-1773
    • Saxena, N.K.1    Fu, P.P.2    Nagalingam, A.3    Wang, J.4    Handy, J.5    Cohen, C.6    Tighiouart, M.7    Sharma, D.8    Anania, F.A.9
  • 49
    • 34047250349 scopus 로고    scopus 로고
    • Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells
    • Saxena N.K., Sharma D., Ding X., Lin S., Marra F., Merlin D., Anania F.A. Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells. Cancer Res. 2007, 67:2497-2507.
    • (2007) Cancer Res. , vol.67 , pp. 2497-2507
    • Saxena, N.K.1    Sharma, D.2    Ding, X.3    Lin, S.4    Marra, F.5    Merlin, D.6    Anania, F.A.7
  • 50
    • 34250315764 scopus 로고    scopus 로고
    • Leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3
    • Saxena N.K., Vertino P.M., Anania F.A., Sharma D. Leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. J.Biol. Chem. 2007, 282:13316-13325.
    • (2007) J.Biol. Chem. , vol.282 , pp. 13316-13325
    • Saxena, N.K.1    Vertino, P.M.2    Anania, F.A.3    Sharma, D.4
  • 51
    • 68549106083 scopus 로고    scopus 로고
    • E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer
    • Schmalhofer O., Brabletz S., Brabletz T. E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer. Cancer Metastasis Rev. 2009, 28:151-166.
    • (2009) Cancer Metastasis Rev. , vol.28 , pp. 151-166
    • Schmalhofer, O.1    Brabletz, S.2    Brabletz, T.3
  • 52
    • 79960075594 scopus 로고    scopus 로고
    • Benzyl isothiocyanate inhibits epithelial-mesenchymal transition in cultured and xenografted human breast cancer cells
    • Sehrawat A., Singh S.V. Benzyl isothiocyanate inhibits epithelial-mesenchymal transition in cultured and xenografted human breast cancer cells. Cancer Prev. Res. (Phila) 2011, 4:1107-1117.
    • (2011) Cancer Prev. Res. (Phila) , vol.4 , pp. 1107-1117
    • Sehrawat, A.1    Singh, S.V.2
  • 53
    • 33745685866 scopus 로고    scopus 로고
    • Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes
    • Sharma D., Saxena N.K., Davidson N.E., Vertino P.M. Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes. Cancer Res. 2006, 66:6370-6378.
    • (2006) Cancer Res. , vol.66 , pp. 6370-6378
    • Sharma, D.1    Saxena, N.K.2    Davidson, N.E.3    Vertino, P.M.4
  • 55
    • 43849110615 scopus 로고    scopus 로고
    • Inhibition of NADPH oxidase-related oxidative stress-triggered signaling by honokiol suppresses high glucose-induced human endothelial cell apoptosis
    • Sheu M.L., Chiang C.K., Tsai K.S., Ho F.M., Weng T.I., Wu H.Y., Liu S.H. Inhibition of NADPH oxidase-related oxidative stress-triggered signaling by honokiol suppresses high glucose-induced human endothelial cell apoptosis. Free Radic. Biol. Med. 2008, 44:2043-2050.
    • (2008) Free Radic. Biol. Med. , vol.44 , pp. 2043-2050
    • Sheu, M.L.1    Chiang, C.K.2    Tsai, K.S.3    Ho, F.M.4    Weng, T.I.5    Wu, H.Y.6    Liu, S.H.7
  • 58
    • 84875989510 scopus 로고    scopus 로고
    • Honokiol inhibits non-small cell lung cancer cell migration by targeting PGE(2)-mediated activation of beta-catenin signaling
    • Singh T., Katiyar S.K. Honokiol inhibits non-small cell lung cancer cell migration by targeting PGE(2)-mediated activation of beta-catenin signaling. PLoS One 2013, 8:e60749.
    • (2013) PLoS One , vol.8
    • Singh, T.1    Katiyar, S.K.2
  • 59
    • 84872029247 scopus 로고    scopus 로고
    • Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death invitro and invivo
    • Singh T., Prasad R., Katiyar S.K. Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death invitro and invivo. Epigenetics 2013, 8:54-65.
    • (2013) Epigenetics , vol.8 , pp. 54-65
    • Singh, T.1    Prasad, R.2    Katiyar, S.K.3
  • 60
    • 0034676267 scopus 로고    scopus 로고
    • Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling
    • Sinibaldi D., Wharton W., Turkson J., Bowman T., Pledger W.J., Jove R. Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling. Oncogene 2000, 19:5419-5427.
    • (2000) Oncogene , vol.19 , pp. 5419-5427
    • Sinibaldi, D.1    Wharton, W.2    Turkson, J.3    Bowman, T.4    Pledger, W.J.5    Jove, R.6
  • 61
    • 16344380754 scopus 로고    scopus 로고
    • A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells
    • Song H., Wang R., Wang S., Lin J. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:4700-4705.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 4700-4705
    • Song, H.1    Wang, R.2    Wang, S.3    Lin, J.4
  • 62
    • 68049137624 scopus 로고    scopus 로고
    • LKB1 is required for adiponectin-mediated modulation of AMPK-S6K axis and inhibition of migration and invasion of breast cancer cells
    • Taliaferro-Smith L., Nagalingam A., Zhong D., Zhou W., Saxena N.K., Sharma D. LKB1 is required for adiponectin-mediated modulation of AMPK-S6K axis and inhibition of migration and invasion of breast cancer cells. Oncogene 2009, 28:2621-2633.
    • (2009) Oncogene , vol.28 , pp. 2621-2633
    • Taliaferro-Smith, L.1    Nagalingam, A.2    Zhong, D.3    Zhou, W.4    Saxena, N.K.5    Sharma, D.6
  • 63
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery J.P., Acloque H., Huang R.Y., Nieto M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 65
    • 26944444312 scopus 로고    scopus 로고
    • Honokiol inhibits TNF-alpha-stimulated NF-kappaB activation and NF-kappaB-regulated gene expression through suppression of IKK activation
    • Tse A.K., Wan C.K., Shen X.L., Yang M., Fong W.F. Honokiol inhibits TNF-alpha-stimulated NF-kappaB activation and NF-kappaB-regulated gene expression through suppression of IKK activation. Biochem. Pharmacol. 2005, 70:1443-1457.
    • (2005) Biochem. Pharmacol. , vol.70 , pp. 1443-1457
    • Tse, A.K.1    Wan, C.K.2    Shen, X.L.3    Yang, M.4    Fong, W.F.5
  • 66
    • 5444237088 scopus 로고    scopus 로고
    • STAT proteins as novel targets for cancer drug discovery
    • Turkson J. STAT proteins as novel targets for cancer drug discovery. Expert Opin. Ther. Targets 2004, 8:409-422.
    • (2004) Expert Opin. Ther. Targets , vol.8 , pp. 409-422
    • Turkson, J.1
  • 67
    • 0034722896 scopus 로고    scopus 로고
    • STAT proteins: novel molecular targets for cancer drug discovery
    • Turkson J., Jove R. STAT proteins: novel molecular targets for cancer drug discovery. Oncogene 2000, 19:6613-6626.
    • (2000) Oncogene , vol.19 , pp. 6613-6626
    • Turkson, J.1    Jove, R.2
  • 68
    • 4344633662 scopus 로고    scopus 로고
    • Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO
    • Wang T., Chen F., Chen Z., Wu Y.F., Xu X.L., Zheng S., Hu X. Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO. World J. Gastroenterol. WJG 2004, 10:2205-2208.
    • (2004) World J. Gastroenterol. WJG , vol.10 , pp. 2205-2208
    • Wang, T.1    Chen, F.2    Chen, Z.3    Wu, Y.F.4    Xu, X.L.5    Zheng, S.6    Hu, X.7
  • 69
    • 79955708703 scopus 로고    scopus 로고
    • Honokiol crosses BBB and BCSFB, and inhibits brain tumor growth in rat 9L intracerebral gliosarcoma model and human U251 xenograft glioma model
    • Wang X., Duan X., Yang G., Zhang X., Deng L., Zheng H., Deng C., Wen J., Wang N., Peng C., Zhao X., Wei Y., Chen L. Honokiol crosses BBB and BCSFB, and inhibits brain tumor growth in rat 9L intracerebral gliosarcoma model and human U251 xenograft glioma model. PLoS One 2011, 6:e18490.
    • (2011) PLoS One , vol.6
    • Wang, X.1    Duan, X.2    Yang, G.3    Zhang, X.4    Deng, L.5    Zheng, H.6    Deng, C.7    Wen, J.8    Wang, N.9    Peng, C.10    Zhao, X.11    Wei, Y.12    Chen, L.13
  • 70
    • 17844384822 scopus 로고    scopus 로고
    • Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis
    • Willis B.C., Liebler J.M., Luby-Phelps K., Nicholson A.G., Crandall E.D., du Bois R.M., Borok Z. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. Am. J. Pathol. 2005, 166:1321-1332.
    • (2005) Am. J. Pathol. , vol.166 , pp. 1321-1332
    • Willis, B.C.1    Liebler, J.M.2    Luby-Phelps, K.3    Nicholson, A.G.4    Crandall, E.D.5    du Bois, R.M.6    Borok, Z.7
  • 71
    • 13944250650 scopus 로고    scopus 로고
    • Invivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy
    • Xi S., Gooding W.E., Grandis J.R. Invivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy. Oncogene 2005, 24:970-979.
    • (2005) Oncogene , vol.24 , pp. 970-979
    • Xi, S.1    Gooding, W.E.2    Grandis, J.R.3
  • 72
    • 84863115473 scopus 로고    scopus 로고
    • Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition
    • Xiong H., Hong J., Du W., Lin Y.W., Ren L.L., Wang Y.C., Su W.Y., Wang J.L., Cui Y., Wang Z.H., Fang J.Y. Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition. J.Biol. Chem. 2012, 287:5819-5832.
    • (2012) J.Biol. Chem. , vol.287 , pp. 5819-5832
    • Xiong, H.1    Hong, J.2    Du, W.3    Lin, Y.W.4    Ren, L.L.5    Wang, Y.C.6    Su, W.Y.7    Wang, J.L.8    Cui, Y.9    Wang, Z.H.10    Fang, J.Y.11
  • 73
    • 39749181656 scopus 로고    scopus 로고
    • Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents
    • Xu Q., Yi L.T., Pan Y., Wang X., Li Y.C., Li J.M., Wang C.P., Kong L.D. Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents. Prog. Neuropsychopharmacol. Biol. Psychiatry 2008, 32:715-725.
    • (2008) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.32 , pp. 715-725
    • Xu, Q.1    Yi, L.T.2    Pan, Y.3    Wang, X.4    Li, Y.C.5    Li, J.M.6    Wang, C.P.7    Kong, L.D.8
  • 74
    • 0036569921 scopus 로고    scopus 로고
    • Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells
    • Yang S.E., Hsieh M.T., Tsai T.H., Hsu S.L. Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells. Biochem. Pharmacol. 2002, 63:1641-1651.
    • (2002) Biochem. Pharmacol. , vol.63 , pp. 1641-1651
    • Yang, S.E.1    Hsieh, M.T.2    Tsai, T.H.3    Hsu, S.L.4
  • 75
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer - new molecular targets come of age
    • Yu H., Jove R. The STATs of cancer - new molecular targets come of age. Nat. Rev. Cancer 2004, 4:97-105.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 76
    • 64849111865 scopus 로고    scopus 로고
    • Targeting STAT3 in cancer: how successful are we?
    • Yue P., Turkson J. Targeting STAT3 in cancer: how successful are we?. Expert Opin. Investig. Drugs 2009, 18:45-56.
    • (2009) Expert Opin. Investig. Drugs , vol.18 , pp. 45-56
    • Yue, P.1    Turkson, J.2
  • 77
    • 51349125301 scopus 로고    scopus 로고
    • A novel anti-cancer effect of genistein: reversal of epithelial mesenchymal transition in prostate cancer cells
    • Zhang L.L., Li L., Wu D.P., Fan J.H., Li X., Wu K.J., Wang X.Y., He D.L. A novel anti-cancer effect of genistein: reversal of epithelial mesenchymal transition in prostate cancer cells. Acta Pharmacol. Sin 2008, 29:1060-1068.
    • (2008) Acta Pharmacol. Sin , vol.29 , pp. 1060-1068
    • Zhang, L.L.1    Li, L.2    Wu, D.P.3    Fan, J.H.4    Li, X.5    Wu, K.J.6    Wang, X.Y.7    He, D.L.8
  • 78
    • 52149095811 scopus 로고    scopus 로고
    • Knockdown of Snail, a novel zinc finger transcription factor, via RNA interference increases A549 cell sensitivity to cisplatin via JNK/mitochondrial pathway
    • Zhuo W., Wang Y., Zhuo X., Zhang Y., Ao X., Chen Z. Knockdown of Snail, a novel zinc finger transcription factor, via RNA interference increases A549 cell sensitivity to cisplatin via JNK/mitochondrial pathway. Lung Cancer 2008, 62:8-14.
    • (2008) Lung Cancer , vol.62 , pp. 8-14
    • Zhuo, W.1    Wang, Y.2    Zhuo, X.3    Zhang, Y.4    Ao, X.5    Chen, Z.6
  • 79
    • 41149143022 scopus 로고    scopus 로고
    • Short interfering RNA directed against TWIST, a novel zinc finger transcription factor, increases A549 cell sensitivity to cisplatin via MAPK/mitochondrial pathway
    • Zhuo W.L., Wang Y., Zhuo X.L., Zhang Y.S., Chen Z.T. Short interfering RNA directed against TWIST, a novel zinc finger transcription factor, increases A549 cell sensitivity to cisplatin via MAPK/mitochondrial pathway. Biochem. Biophys. Res. Commun. 2008, 369:1098-1102.
    • (2008) Biochem. Biophys. Res. Commun. , vol.369 , pp. 1098-1102
    • Zhuo, W.L.1    Wang, Y.2    Zhuo, X.L.3    Zhang, Y.S.4    Chen, Z.T.5


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