Signal transducer and activator of transcription 3 activation is associated with bladder cancer cell growth and survival

Molecular Cancer

Volumn 7, Issue , 2008, Pages

  Chen, Chun Liang ^a,b   Cen, Ling ^b   Kohout, Jennifer ^b   Hutzen, Brian ^b   Chan, Christina ^b   Hsieh, Fu Chuan ^a,b   Loy, Abbey ^c   Huang, Victor ^a,b   Cheng, Gong ^a,b   Lin, Jiayuh ^a,b  

^a NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN D1; PHOSPHOTRANSFERASE; PROTEIN BCL 2; PROTEIN BCL XL; STAT3 PROTEIN; SURVIVIN; CASPASE; POLYCYCLIC HYDROCARBON; STA 21; STA-21; STAT3 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ADULT; AGED; APOPTOSIS; ARTICLE; BLADDER CANCER; BLADDER CARCINOGENESIS; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CANCER TISSUE; CELL CYCLE REGULATION; CELL GROWTH; CELL NUCLEUS; CELL SURVIVAL; CONTROLLED STUDY; DIMERIZATION; DOWN REGULATION; FEMALE; GENE ACTIVATION; GENE CONTROL; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; BLADDER TUMOR; DRUG ANTAGONISM; METABOLISM; MIDDLE AGED; PATHOLOGY; TUMOR CELL LINE;

ADENOVIRIDAE;

ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; HUMANS; MALE; MIDDLE AGED; POLYCYCLIC COMPOUNDS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; URINARY BLADDER NEOPLASMS;

EID: 55949095929     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-7-78     Document Type: Article

References (50)

1. Bowman T Garcia R Turkson J Jove R STATs in Oncogenesis Oncogene 2000, 19:2474-2488. 10851046
2. Garcia R Yu C Hudnall A Catlett R Nelson K Smithgall T Fujita D Ethier S Jove R Constitutive Activation of STAT 3 in Fibroblasts Transformed by Diverse Oncoproteins and in Breast Carcinoma Cells Cell Growth Differ 1997, 8:1267-1275. 9419415
3. Chen CL Hsieh FC Lin J Systemic evaluation of total Stat3 and Stat3 tyrosine phosphorylation in normal human tissues Exp Mol Pathol 2006, 80:295-305. 16427042
4. Kamimura D Ishihara K Hirano T IL-6 signal transduction and its physiological roles: The signal orchestration model Rev Physiol Biochem Pharmacol 2003, 149:1-38. 12687404
5. Valentino L Pierre J JAK/STAT signal transduction: Regulators and implication in hematological malignancies Biochem Pharmacol 2006, 71:713-721. 16426581
6. Bromberg J Wrzeszczynska M Devgan G Zhao Y Pestell R Albanese C Darnell JJ Stat3 as an oncogene Cell 1999, 98:295-303. 10458605
7. Buettner R Mora L Jove R Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention Clin Cancer Res 2002, 8:945-954. 11948098
8. Song H Wang R Wang S Lin J A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells Proc Natl Acad Sci USA 2005, 102:4700-4705. 555708 15781862
9. Jing N Tweardy DJ Targeting Stat3 in cancer therapy Anticancer Drugs 2005, 16:601-607. 15930886
10. Knowles MA Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese? Carcinogenesis 2006, 27:361-373. 16352616
11. Sanchez-Carbayo M Socci ND Lozano J Saint F Cordon-Cardo C Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays J Clin Oncol 2006, 24:778-789. 16432078
12. Zieger K Dyrskjot L Wiuf C Jensen JL Andersen CL Jensen KM Orntoft TF Role of activating fibroblast growth factor receptor 3 mutations in the development of bladder tumors Clin Cancer Res 2005, 11:7709-7719. 16278391
13. Salz W Eisenberg D Plescia J Garlick DS Weiss RM Wu XR Sun TT Altieri DC A survivin gene signature predicts aggressive tumor behavior Cancer Res 2005, 65:3531-3534. 15867343
14. Schultz IJ Kiemeney LA Witjes JA Schalken JA Willems JL Swinkels DW de Kok JB Survivin mRNA expression is elevated in malignant urothelial cell carcinomas and predicts time to recurrence Anticancer Res 2003, 23:3327-3331. 12926071
15. Schaaf A Sagi S Langbein S Trojan L Alken P Michel MS Cytotoxicity of cisplatin in bladder cancer is significantly enhanced by application of bcl-2 antisense oligonucleotides Urol Oncol 2004, 22:188-192. 15271313
16. Xia G Kumar SR Stein JP Singh J Krasnoperov V Zhu S Hassanieh L Smith DL Buscarini M Broek D Quinn DI Weaver FA Gill PS EphB4 receptor tyrosine kinase is expressed in bladder cancer and provides signals for cell survival Oncogene 2006, 25:769-780. 16205642
17. Korkolopoulou P Lazaris A Konstantinidou AE Kavantzas N Patsouris E Christodoulou P Thomas-Tsagli E Davaris P Differential expression of bcl-2 family proteins in bladder carcinomas. Relationship with apoptotic rate and survival Eur Urol 2002, 41:274-283. 12180228
18. Swana HS Grossman D Anthony JN Weiss RM Altieri DC Tumor content of the antiapoptosis molecule survivin and recurrence of bladder cancer N Engl J Med 1999, 341:452-453. 10438269
19. Itoh M Murata T Suzuki T Shindoh M Nakajima K Imai K Yoshida K Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells Oncogene 2006, 25:1195-1204. 16205632
20. Chen C-L Loy A Cen L Chan C Hsieh F-C Cheng G Wu B Qualman SJ Kunisada K Yamauchi-Takihara K Lin J Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells BMC Cancer 2007, 7:111. 1964761 17598902
21. Zhong Z Wen Z Darnell J Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6 Science 1994, 264:95-98. 8140422
22. Darnell JJ Kerr I Stark G Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins Science 1994, 264:1415-1421. 8197455
23. Kunisada K Tone E Fujio Y Matsui H Yamauchi-Takihara K Kishimoto T Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes Circulation 1998, 98:346-352. 9711940
24. Funamoto M Fujio Y Kunisada K Negoro S Tone E Osugi T Hirota H Izumi M Yoshizaki K Walsh K Kishimoto T Yamauchi-Takihara K Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes J Biol Chem 2000, 275:10561-10566. 10744750
25. Hirano T Ishihara K Hibi M Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors Oncogene 2000, 19:2548-2556. 10851053
26. Levy DE Darnell JE Jr Stats: Transcriptional control and biological impact Nat Rev Mol Cell Biol 2002, 3:651-662. 12209125
27. Takeda K Noguchi K Shi W Tanaka T Matsumoto M Yoshida N Kishimoto T Akira S Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality Proc Natl Acad Sci USA 1997, 94:3801-3804. 20521 9108058
28. Amin HM McDonnell TJ Ma Y Lin Q Fujio Y Kunisada K Leventaki V Das P Rassidakis GZ Cutler C Medeiros LJ Lai R Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma Oncogene 2004, 23:5426-5434. 15184887
29. Cory S Huang DC Adams JM The Bcl-2 family: Roles in cell survival and oncogenesis Oncogene 2003, 22:8590-8607. 14634621
30. Adams JM Cory S Apoptosomes: Engines for caspase activation Curr Opin Cell Biol 2002, 14:715-720. 12473344
31. Cory S Adams JM The Bcl2 family: Regulators of the cellular life-or-death switch Nat Rev Cancer 2002, 2:647-656. 12209154
32. Ashkenazi A Dixit VM Apoptosis control by death and decoy receptors Curr Opin Cell Biol 1999, 11:255-260. 10209153
33. Ivanov VN Bhoumik A Ronai Z Death receptors and melanoma resistance to apoptosis Oncogene 2003, 22:3152-3161. 12789291
34. Shivapurkar N Toyooka S Toyooka KO Reddy J Miyajima K Suzuki M Shigematsu H Takahashi T Parikh G Pass HI Chaudhary PM Gazdar AF Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types Int J Cancer 2004, 109:786-792. 14999791
35. Butcher BA Kim L Panopoulos AD Watowich SS Murray PJ Denkers EY IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages J Immunol 2005, 174:3148-3152. 15749841
36. Nishiki S Hato F Kamata N Sakamoto E Hasegawa T Kimura-Eto A Hino M Kitagawa S Selective activation of STAT3 in human monocytes stimulated by G-CSF: Implication in inhibition of LPS-induced TNF-alpha production Am J Physiol Cell Physiol 2004, 286:C1302-1311. 14736711
37. Niu G Shain KH Huang M Ravi R Bedi A Dalton WS Jove R Yu H Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest Cancer Res 2001, 61:3276-3280. 11309279
38. Lee JI Choi DY Chung HS Seo HG Woo HJ Choi BT Choi YH beta-lapachone induces growth inhibition and apoptosis in bladder cancer cells by modulation of Bcl-2 family and activation of caspases Exp Oncol 2006, 28:30-35. 16614704
39. Cho HJ Kim JK Kim KD Yoon HK Cho MY Park YP Jeon JH Lee ES Byun SS Lim HM Song EY Lim JS Yoon DY Lee HG Choe YK Upregulation of Bcl-2 is associated with cisplatin-resistance via inhibition of Bax translocation in human bladder cancer cells Cancer Lett 2006, 237(1):56-66. 16009487
40. Calvin D Nam S Buettner R Sekharam M Torres-Roca J Jove R Inhibition of STAT3 activity with STAT3 antisense oligonucleotide (STAT3-ASO) enhances radiation-induced apoptosis in DU145 prostate cancer cells Int J Radiat Oncol Biol Phys 2003, 57:S297.
41. Lee SO Lou W Qureshi KM Mehraein-Ghomi F Trump DL Gao AC RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells Prostate 2004, 60:303-309. 15264241
42. Turkson J Zhang S Mora LB Burns A Sebti S Jove R A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells J Biol Chem 2005, 280:32979-32988. 16046414
43. Leong P Andrews G Johnson D Dyer K Xi S Mai J Robbins P Gadiparthi S Burke N Watkins S Grandis J Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth Proc Natl Acad Sci USA 2003, 100:4138-4143. 153061 12640143
44. Wu R Sun S Steinberg BM Requirement of STAT3 activation for differentiation of mucosal stratified squamous epithelium Mol Med 2003, 9:77-84. 1430729 12865943
45. Bhattacharya S Ray RM Johnson LR STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells Biochem J 2005, 392:335-344. 1316269 16048438
46. Masuda M Suzui M Lim JT Deguchi A Soh JW Weinstein IB Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR-related pathways of signal transduction J Exp Ther Oncol 2002, 2:350-359. 12440226
47. Real PJ Sierra A De Juan A Segovia JC Lopez-Vega JM Fernandez-Luna JL Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells Oncogene 2002, 21:7611-7618. 12400004
48. Burke WM Jin X Lin HJ Huang M Liu R Reynolds RK Lin J Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells Oncogene 2001, 20:7925-7934. 11753675
49. Hsieh FC Cheng G Lin J Evaluation of potential Stat3-regulated genes in human breast cancer Biochem Biophys Res Commun 2005, 335:292-299. 16081048
50. Chen C-L Hsieh F-C Brown J Chan C Wallaca JA Cheng G Hall BM Lin J Stat3 activation in human endometrial and cervical cancers Br J Cancer 2007, 96(4):591-599. 17311011