메뉴 건너뛰기




Volumn 3, Issue 3, 2014, Pages 578-605

Dnmt3b prefers germ line genes and centromeric regions: Lessons from the ICF syndrome and cancer and implications for diseases

Author keywords

Cancer; Centromeric repeats; DNA methylation; DNMT3B; Germ line genes; ICF syndrome

Indexed keywords


EID: 84907555949     PISSN: None     EISSN: 20797737     Source Type: Journal    
DOI: 10.3390/biology3030578     Document Type: Article
Times cited : (28)

References (153)
  • 1
    • 0020851370 scopus 로고
    • DNA modification, differentiation, and transformation
    • Jones, P.A.; Taylor, S.M.; Wilson, V. DNA modification, differentiation, and transformation. J. Exp. Zool. 1983, 228, 287–295.
    • (1983) J. Exp. Zool , vol.228 , pp. 287-295
    • Jones, P.A.1    Taylor, S.M.2    Wilson, V.3
  • 3
    • 34047116826 scopus 로고    scopus 로고
    • Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
    • Weber, M.; Hellmann, I.; Stadler, M.B.; Ramos, L.; Paabo, S.; Rebhan, M.; Schubeler, D. Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat. Genet. 2007, 39, 457-466.
    • (2007) Nat. Genet , vol.39 , pp. 457-466
    • Weber, M.1    Hellmann, I.2    Stadler, M.B.3    Ramos, L.4    Paabo, S.5    Rebhan, M.6    Schubeler, D.7
  • 4
    • 34250188803 scopus 로고    scopus 로고
    • Genomic patterns of DNA methylation: Targets and function of an epigenetic mark
    • Weber, M.; Schubeler, D. Genomic patterns of DNA methylation: Targets and function of an epigenetic mark. Curr. Opin. Cell Biol. 2007, 19, 273-280.
    • (2007) Curr. Opin. Cell Biol , vol.19 , pp. 273-280
    • Weber, M.1    Schubeler, D.2
  • 6
    • 0025945632 scopus 로고
    • DNA methylation and gene expression
    • Razin, A.; Cedar, H. DNA methylation and gene expression. Microbiol. Rev. 1991, 55, 451-458.
    • (1991) Microbiol. Rev , vol.55 , pp. 451-458
    • Razin, A.1    Cedar, H.2
  • 7
    • 0033601073 scopus 로고    scopus 로고
    • Methylation-induced repression—Belts, braces, and chromatin
    • Bird, A.P.; Wolffe, A.P. Methylation-induced repression—Belts, braces, and chromatin. Cell 1999, 99, 451-454.
    • (1999) Cell , vol.99 , pp. 451-454
    • Bird, A.P.1    Wolffe, A.P.2
  • 10
    • 0026708177 scopus 로고
    • Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
    • Li, E.; Bestor, T.H.; Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 1992, 69, 915-926.
    • (1992) Cell , vol.69 , pp. 915-926
    • Li, E.1    Bestor, T.H.2    Jaenisch, R.3
  • 11
    • 0031662164 scopus 로고    scopus 로고
    • Transcription of IAP endogenous retroviruses is constrained by cytosine methylation. Nat
    • Walsh, C.P.; Chaillet, J.R.; Bestor, T.H. Transcription of IAP endogenous retroviruses is constrained by cytosine methylation. Nat. Genet. 1998, 20, 116-117.
    • (1998) Genet , vol.20 , pp. 116-117
    • Walsh, C.P.1    Chaillet, J.R.2    Bestor, T.H.3
  • 12
    • 0026781474 scopus 로고
    • Parental imprinting: Potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (IGF2) gene
    • Sasaki, H.; Jones, PA.; Chaillet, J.R.; Ferguson-Smith, A.C.; Barton, S.C.; Reik, W.; Surani, MA. Parental imprinting: Potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (IGF2) gene. Genes Dev. 1992, 6, 1843-1856.
    • (1992) Genes Dev , vol.6 , pp. 1843-1856
    • Sasaki, H.1    Jones, P.A.2    Chaillet, J.R.3    Ferguson-Smith, A.C.4    Barton, S.C.5    Reik, W.6    Surani, M.A.7
  • 13
    • 0027378582 scopus 로고
    • Role for DNA methylation in genomic imprinting
    • Li, E.; Beard, C; Jaenisch, R. Role for DNA methylation in genomic imprinting. Nature 1993, 366, 362-365.
    • (1993) Nature , vol.366 , pp. 362-365
    • Li, E.1    Beard, C.2    Jaenisch, R.3
  • 14
    • 0029956442 scopus 로고    scopus 로고
    • DNA hypomethylation can activate Xist expression and silence X-linked genes
    • Panning, B.; Jaenisch, R. DNA hypomethylation can activate Xist expression and silence X-linked genes. Genes Dev. 1996, 10, 1991-2002.
    • (1996) Genes Dev , vol.10 , pp. 1991-2002
    • Panning, B.1    Jaenisch, R.2
  • 15
    • 0031860739 scopus 로고    scopus 로고
    • Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
    • Okano, M.; Xie, S.; Li, E. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat. Genet. 1998, 19, 219-220.
    • (1998) Nat. Genet , vol.19 , pp. 219-220
    • Okano, M.1    Xie, S.2    Li, E.3
  • 16
    • 34648833002 scopus 로고    scopus 로고
    • Uhrf1 plays a role in maintaining DNA methylation in mammalian cells
    • Bostick, M.; Kim, J.K.; Esteve, P.O.; Clark, A.; Pradhan, S.; Jacobsen, S.E. Uhrf1 plays a role in maintaining DNA methylation in mammalian cells. Science 2007, 317, 1760-1764.
    • (2007) Science , vol.317 , pp. 1760-1764
    • Bostick, M.1    Kim, J.K.2    Esteve, P.O.3    Clark, A.4    Pradhan, S.5    Jacobsen, S.E.6
  • 17
    • 9144256125 scopus 로고    scopus 로고
    • The Dnmt1 DNA-(cytosine-C5)-methyltransferase methylates DNA processively with high preference for hemimethylated target sites
    • Hermann, A.; Goyal, R.; Jeltsch, A. The Dnmt1 DNA-(cytosine-C5)-methyltransferase methylates DNA processively with high preference for hemimethylated target sites. J. Biol. Chem. 2004, 279, 48350-48359.
    • (2004) J. Biol. Chem , vol.279 , pp. 48350-48359
    • Hermann, A.1    Goyal, R.2    Jeltsch, A.3
  • 18
    • 0037168587 scopus 로고    scopus 로고
    • The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a
    • Chedin, F.; Lieber, M.R.; Hsieh, C.L. The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a. Proc. Natl. Acad. Sci. USA 2002, 99, 16916-16921.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 16916-16921
    • Chedin, F.1    Lieber, M.R.2    Hsieh, C.L.3
  • 19
    • 84872078429 scopus 로고    scopus 로고
    • Plasticity in Dnmt3L-dependent and -independent modes of de novo methylation in the developing mouse embryo
    • Guenatri, M.; Duffie, R.; Iranzo, J.; Fauque, P.; Bourc’his, D. Plasticity in Dnmt3L-dependent and -independent modes of de novo methylation in the developing mouse embryo. Development 2013, 140, 562-572.
    • (2013) Development , vol.140 , pp. 562-572
    • Guenatri, M.1    Duffie, R.2    Iranzo, J.3    Fauque, P.4    Bourc’his, D.5
  • 20
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • Okano, M.; Bell, D.W.; Haber, DA.; Li, E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999, 99, 247-257.
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 22
    • 0042132027 scopus 로고    scopus 로고
    • Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b
    • Chen, T.; Ueda, Y.; Dodge, J.E.; Wang, Z.; Li, E. Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b. Mol. Cell. Biol. 2003, 23, 5594–5605.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 5594-5605
    • Chen, T.1    Ueda, Y.2    Dodge, J.E.3    Wang, Z.4    Li, E.5
  • 23
    • 81055136654 scopus 로고    scopus 로고
    • Maintenance of DNA methylation: Dnmt3b joins the dance
    • Walton, E.L.; Francastel, C.; Velasco, G. Maintenance of DNA methylation: Dnmt3b joins the dance. Epigenetics 2011, 6, 1373–1377.
    • (2011) Epigenetics , vol.6 , pp. 1373-1377
    • Walton, E.L.1    Francastel, C.2    Velasco, G.3
  • 24
    • 4744366752 scopus 로고    scopus 로고
    • The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin
    • Chen, T.; Tsujimoto, N.; Li, E. The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin. Mol. Cell Biol. 2004, 24, 9048–9058.
    • (2004) Mol. Cell Biol , vol.24 , pp. 9048-9058
    • Chen, T.1    Tsujimoto, N.2    Li, E.3
  • 25
    • 0035943709 scopus 로고    scopus 로고
    • Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin
    • Bachman, K.E.; Rountree, M.R.; Baylin, S.B. Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin. J. Biol. Chem. 2001, 276, 32282–32287.
    • (2001) J. Biol. Chem , vol.276 , pp. 32282-32287
    • Bachman, K.E.1    Rountree, M.R.2    Baylin, S.B.3
  • 27
    • 84880442852 scopus 로고    scopus 로고
    • Inactive DNMT3B splice variants modulate de novo DNA methylation
    • Gordon, C.A.; Hartono, S.R.; Chedin, F. Inactive DNMT3B splice variants modulate de novo DNA methylation. PLoS One 2013, 8, e69486.
    • (2013) PLoS One , vol.8
    • Gordon, C.A.1    Hartono, S.R.2    Chedin, F.3
  • 30
    • 0037162542 scopus 로고    scopus 로고
    • Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3B4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis
    • Saito, Y.; Kanai, Y.; Sakamoto, M.; Saito, H.; Ishii, H.; Hirohashi, S. Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3B4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis. Proc. Natl. Acad. Sci. USA 2002, 99, 10060–10065.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 10060-10065
    • Saito, Y.1    Kanai, Y.2    Sakamoto, M.3    Saito, H.4    Ishii, H.5    Hirohashi, S.6
  • 31
    • 33749020195 scopus 로고    scopus 로고
    • A novel DNMT3B subfamily, deltaDNMT3B, is the predominant form of DNMT3B in non-small cell lung cancer
    • Wang, L.; Wang, J.; Sun, S.; Rodriguez, M.; Yue, P.; Jang, S.J.; Mao, L. A novel DNMT3B subfamily, deltaDNMT3B, is the predominant form of DNMT3B in non-small cell lung cancer. Int. J. Oncol. 2008, 29, 201–207.
    • (2008) Int. J. Oncol , vol.29 , pp. 201-207
    • Wang, L.1    Wang, J.2    Sun, S.3    Rodriguez, M.4    Yue, P.5    Jang, S.J.6    Mao, L.7
  • 33
    • 0037130945 scopus 로고    scopus 로고
    • Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells
    • Weisenberger, D.J.; Velicescu, M.; Preciado-Lopez, M.A.; Gonzales, F.A.; Tsai, Y.C.; Liang, G.; Jones, P.A. Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells. Gene 2002, 298, 91–99.
    • (2002) Gene , vol.298 , pp. 91-99
    • Weisenberger, D.J.1    Velicescu, M.2    Preciado-Lopez, M.A.3    Gonzales, F.A.4    Tsai, Y.C.5    Liang, G.6    Jones, P.A.7
  • 34
    • 0942287087 scopus 로고    scopus 로고
    • Expression of mRNAs for DNA methyltransferases and methyl-CpG-binding proteins in the human female germ line, preimplantation embryos, and embryonic stem cells
    • Huntriss, J.; Hinkins, M.; Oliver, B.; Harris, S.E.; Beazley, J.C.; Rutherford, A.J.; Gosden, R.G.; Lanzendorf, S.E.; Picton, H.M. Expression of mRNAs for DNA methyltransferases and methyl-CpG-binding proteins in the human female germ line, preimplantation embryos, and embryonic stem cells. Mol. Reprod. Dev. 2004, 67, 323–336.
    • (2004) Mol. Reprod. Dev , vol.67 , pp. 323-336
    • Huntriss, J.1    Hinkins, M.2    Oliver, B.3    Harris, S.E.4    Beazley, J.C.5    Rutherford, A.J.6    Gosden, R.G.7    Lanzendorf, S.E.8    Picton, H.M.9
  • 35
    • 0033153303 scopus 로고    scopus 로고
    • The human DNA methyltransferases (DNMTs) 1, 3a and 3b: Coordinate mRNA expression in normal tissues and overexpression in tumors
    • Robertson, K.D.; Uzvolgyi, E.; Liang, G.; Talmadge, C.; Sumegi, J.; Gonzales, F.A.; Jones, P.A. The human DNA methyltransferases (DNMTs) 1, 3a and 3b: Coordinate mRNA expression in normal tissues and overexpression in tumors. Nucl. Acids Res. 1999, 27, 2291–2298.
    • (1999) Nucl. Acids Res. , vol.27 , pp. 2291-2298
    • Robertson, K.D.1    Uzvolgyi, E.2    Liang, G.3    Talmadge, C.4    Sumegi, J.5    Gonzales, F.A.6    Jones, P.A.7
  • 37
    • 4143099308 scopus 로고    scopus 로고
    • Mouse centric and pericentric satellite repeats form distinct functional heterochromatin
    • Guenatri, M.; Bailly, D.; Maison, C.; Almouzni, G. Mouse centric and pericentric satellite repeats form distinct functional heterochromatin. J. Cell. Biol. 2004, 166, 493–505.
    • (2004) J. Cell. Biol , vol.166 , pp. 493-505
    • Guenatri, M.1    Bailly, D.2    Maison, C.3    Almouzni, G.4
  • 38
    • 51649110069 scopus 로고    scopus 로고
    • Heterochromatin links to centromeric protection by recruiting shugoshin
    • Yamagishi, Y.; Sakuno, T.; Shimura, M.; Watanabe, Y. Heterochromatin links to centromeric protection by recruiting shugoshin. Nature 2008, 455, 251–255.
    • (2008) Nature , vol.455 , pp. 251-255
    • Yamagishi, Y.1    Sakuno, T.2    Shimura, M.3    Watanabe, Y.4
  • 39
    • 0004002022 scopus 로고    scopus 로고
    • Oxford University Press Inc.: New York, NY, USA
    • Choo, K.H. The Centromere; Oxford University Press Inc.: New York, NY, USA, 1997.
    • (1997) The Centromere
    • Choo, K.H.1
  • 41
    • 84979832497 scopus 로고    scopus 로고
    • Transcription of satellite DNAs in mammals
    • Vourc’h, C.; Biamonti, G. Transcription of satellite DNAs in mammals. Prog. Mol. Subcell. Biol. 2011, 51, 95–118.
    • (2011) Prog. Mol. Subcell. Biol , vol.51 , pp. 95-118
    • Vourc’h, C.1    Biamonti, G.2
  • 42
    • 0035431654 scopus 로고    scopus 로고
    • Domain organization at the centromere and neocentromere
    • Choo, K.H. Domain organization at the centromere and neocentromere. Dev. Cell. 2001, 1, 165–177.
    • (2001) Dev. Cell , vol.1 , pp. 165-177
    • Choo, K.H.1
  • 43
    • 0024892474 scopus 로고
    • Proteins of the inner and outer centromere of mitotic chromosomes
    • Earnshaw, W.C.; Cooke, C.A. Proteins of the inner and outer centromere of mitotic chromosomes. Genome 1989, 31, 541–552.
    • (1989) Genome , vol.31 , pp. 541-552
    • Earnshaw, W.C.1    Cooke, C.A.2
  • 44
    • 70349303348 scopus 로고    scopus 로고
    • The secret message of heterochromatin: New insights into the mechanisms and function of centromeric and pericentric repeat sequence transcription
    • Eymery, A.; Callanan, M.; Vourc’h, C. The secret message of heterochromatin: New insights into the mechanisms and function of centromeric and pericentric repeat sequence transcription. Int. J. Dev. Biol. 2009, 53, 259–268.
    • (2009) Int. J. Dev. Biol , vol.53 , pp. 259-268
    • Eymery, A.1    Callanan, M.2    Vourc’h, C.3
  • 45
    • 84864881695 scopus 로고    scopus 로고
    • Pericentric and centromeric transcription: A perfect balance required
    • Hall, L.E.; Mitchell, S.E.; O’Neill, R.J. Pericentric and centromeric transcription: A perfect balance required. Chromosom. Res. 2012, 20, 535–546.
    • (2012) Chromosom. Res , vol.20 , pp. 535-546
    • Hall, L.E.1    Mitchell, S.E.2    O’neill, R.J.3
  • 46
    • 33745036943 scopus 로고    scopus 로고
    • Accumulation of small murine minor satellite transcripts leads to impaired centromeric architecture and function
    • Bouzinba-Segard, H.; Guais, A.; Francastel, C. Accumulation of small murine minor satellite transcripts leads to impaired centromeric architecture and function. Proc. Natl. Acad. Sci. USA 2006, 103, 8709–8714.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 8709-8714
    • Bouzinba-Segard, H.1    Guais, A.2    Francastel, C.3
  • 47
    • 69849105566 scopus 로고    scopus 로고
    • Non-coding murine centromeric transcripts associate with and potentiate Aurora B kinase
    • Ferri, F.; Bouzinba-Segard, H.; Velasco, G.; Hubé, F.; Francastel, C. Non-coding murine centromeric transcripts associate with and potentiate Aurora B kinase. Nucl. Acids Res. 2009, 37, 5071–5080.
    • (2009) Nucl. Acids Res , vol.37 , pp. 5071-5080
    • Ferri, F.1    Bouzinba-Segard, H.2    Velasco, G.3    Hubé, F.4    Francastel, C.5
  • 48
    • 77957857693 scopus 로고    scopus 로고
    • A strand-specific burst in transcription of pericentric satellites is required for chromocenter formation and early mouse development
    • Probst, A.V.; Okamoto, I.; Casanova, M.; El Marjou, F.; Le Baccon, P.; Almouzni, G. A strand-specific burst in transcription of pericentric satellites is required for chromocenter formation and early mouse development. Dev. Cell. 2010, 19, 625–638.
    • (2010) Dev. Cell , vol.19 , pp. 625-638
    • Probst, A.V.1    Okamoto, I.2    Casanova, M.3    El Marjou, F.4    Le Baccon, P.5    Almouzni, G.6
  • 51
    • 0032694084 scopus 로고    scopus 로고
    • DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter
    • De Smet, C.; Lurquin, C.; Lethe, B.; Martelange, V.; Boon, T. DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. Mol. Cell. Biol. 1999, 19, 7327–7335.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 7327-7335
    • De Smet, C.1    Lurquin, C.2    Lethe, B.3    Martelange, V.4    Boon, T.5
  • 52
    • 33749396836 scopus 로고    scopus 로고
    • DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages
    • Maatouk, D.M.; Kellam, L.D.; Mann, M.R.; Lei, H.; Li, E.; Bartolomei, M.S.; Resnick, J.L. DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages. Development 2006, 133, 3411–3418.
    • (2006) Development , vol.133 , pp. 3411-3418
    • Maatouk, D.M.1    Kellam, L.D.2    Mann, M.R.3    Lei, H.4    Li, E.5    Bartolomei, M.S.6    Resnick, J.L.7
  • 54
    • 0035201141 scopus 로고    scopus 로고
    • Methylation of the FSHD syndrome-linked subtelomeric repeat in normal and FSHD cell cultures and tissues
    • Tsien, F.; Sun, B.; Hopkins, N.E.; Vedanarayanan, V.; Figlewicz, D.; Winokur, S.; Ehrlich, M. Methylation of the FSHD syndrome-linked subtelomeric repeat in normal and FSHD cell cultures and tissues. Mol. Genet. Metab. 2001, 74, 322–331.
    • (2001) Mol. Genet. Metab , vol.74 , pp. 322-331
    • Tsien, F.1    Sun, B.2    Hopkins, N.E.3    Vedanarayanan, V.4    Figlewicz, D.5    Winokur, S.6    Ehrlich, M.7
  • 58
    • 50849099769 scopus 로고    scopus 로고
    • Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions
    • Yehezkel, S.; Segev, Y.; Viegas-Pequignot, E.; Skorecki, K.; Selig, S. Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions. Hum. Mol. Genet. 2008, 17, 2776–2789.
    • (2008) Hum. Mol. Genet , vol.17 , pp. 2776-2789
    • Yehezkel, S.1    Segev, Y.2    Viegas-Pequignot, E.3    Skorecki, K.4    Selig, S.5
  • 59
    • 0032714089 scopus 로고    scopus 로고
    • Densely methylated sequences that are preferentially localized at telomere-proximal regions of human chromosomes
    • Brock, G.J.; Charlton, J.; Bird, A. Densely methylated sequences that are preferentially localized at telomere-proximal regions of human chromosomes. Gene 1999, 240, 269–277.
    • (1999) Gene , vol.240 , pp. 269-277
    • Brock, G.J.1    Charlton, J.2    Bird, A.3
  • 60
    • 0344668731 scopus 로고    scopus 로고
    • Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns
    • Craig, J.M.; Earle, E.; Canham, P.; Wong, L.H.; Anderson, M.; Choo, K.H. Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns. Hum. Mol. Genet. 2003, 12, 3109–3121.
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 3109-3121
    • Craig, J.M.1    Earle, E.2    Canham, P.3    Wong, L.H.4    Anderson, M.5    Choo, K.H.6
  • 61
    • 33645735015 scopus 로고    scopus 로고
    • Roles for Dnmt3b in mammalian development: A mouse model for the ICF syndrome
    • Ueda, Y.; Okano, M.; Williams, C.; Chen, T.; Georgopoulos, K.; Li, E. Roles for Dnmt3b in mammalian development: A mouse model for the ICF syndrome. Development 2006, 133, 1183–1192.
    • (2006) Development , vol.133 , pp. 1183-1192
    • Ueda, Y.1    Okano, M.2    Williams, C.3    Chen, T.4    Georgopoulos, K.5    Li, E.6
  • 63
    • 66149123748 scopus 로고    scopus 로고
    • The nuclear DNA base 5-hydroxymethylcytosine is present in purkinje neurons and the brain
    • Kriaucionis, S.; Heintz, N. The nuclear DNA base 5-hydroxymethylcytosine is present in purkinje neurons and the brain. Science 2009, 324, 929–930.
    • (2009) Science , vol.324 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 66
    • 84876343136 scopus 로고    scopus 로고
    • Functions of DNA methylation and hydroxymethylation in mammalian development
    • Guibert, S.; Weber, M. Functions of DNA methylation and hydroxymethylation in mammalian development. Curr. Top. Dev. Biol. 2013, 104, 47–83.
    • (2013) Curr. Top. Dev. Biol , vol.104 , pp. 47-83
    • Guibert, S.1    Weber, M.2
  • 70
    • 84870368555 scopus 로고    scopus 로고
    • DNA methylation profiles define stem cell identity and reveal a tight embryonic-extraembryonic lineage boundary
    • Senner, C.E.; Krueger, F.; Oxley, D.; Andrews, S.; Hemberger, M. DNA methylation profiles define stem cell identity and reveal a tight embryonic-extraembryonic lineage boundary. Stem Cells 2012, 30, 2732–2745.
    • (2012) Stem Cells , vol.30 , pp. 2732-2745
    • Senner, C.E.1    Krueger, F.2    Oxley, D.3    Andrews, S.4    Hemberger, M.5
  • 76
  • 77
    • 84859519339 scopus 로고    scopus 로고
    • Global profiling of DNA methylation erasure in mouse primordial germ cells
    • Guibert, S.; Forne, T.; Weber, M. Global profiling of DNA methylation erasure in mouse primordial germ cells. Genome Res. 2012, 22, 633–641.
    • (2012) Genome Res , vol.22 , pp. 633-641
    • Guibert, S.1    Forne, T.2    Weber, M.3
  • 79
    • 0037710466 scopus 로고    scopus 로고
    • Methylation dynamics of repetitive DNA elements in the mouse germ cell lineage
    • Lees-Murdock, D.J.; de Felici, M.; Walsh, C.P. Methylation dynamics of repetitive DNA elements in the mouse germ cell lineage. Genomics 2003, 82, 230–237.
    • (2003) Genomics , vol.82 , pp. 230-237
    • Lees-Murdock, D.J.1    De Felici, M.2    Walsh, C.P.3
  • 80
    • 1842499716 scopus 로고    scopus 로고
    • Windows for sex-specific methylation marked by DNA methyltransferase expression profiles in mouse germ cells
    • La Salle, S.; Mertineit, C.; Taketo, T.; Moens, P.B.; Bestor, T.H.; Trasler, J.M. Windows for sex-specific methylation marked by DNA methyltransferase expression profiles in mouse germ cells. Dev. Biol. 2004, 268, 403–415.
    • (2004) Dev. Biol , vol.268 , pp. 403-415
    • La Salle, S.1    Mertineit, C.2    Taketo, T.3    Moens, P.B.4    Bestor, T.H.5    Trasler, J.M.6
  • 81
    • 36549069302 scopus 로고    scopus 로고
    • Centromeric DNA hypomethylation as an epigenetic signature discriminates between germ and somatic cell lineages
    • Yamagata, K.; Yamazaki, T.; Miki, H.; Ogonuki, N.; Inoue, K.; Ogura, A.; Baba, T. Centromeric DNA hypomethylation as an epigenetic signature discriminates between germ and somatic cell lineages. Dev. Biol. 2007, 312, 419–426.
    • (2007) Dev. Biol , vol.312 , pp. 419-426
    • Yamagata, K.1    Yamazaki, T.2    Miki, H.3    Ogonuki, N.4    Inoue, K.5    Ogura, A.6    Baba, T.7
  • 84
    • 0027960055 scopus 로고
    • Sp1 sites in the mouse Aprt gene promoter are required to prevent methylation of the CpG island
    • Macleod, D.; Charlton, J.; Cullins, J.; Bird, A.P. Sp1 sites in the mouse Aprt gene promoter are required to prevent methylation of the CpG island. Genes Dev. 1994, 8, 2282–2292.
    • (1994) Genes Dev , vol.8 , pp. 2282-2292
    • Macleod, D.1    Charlton, J.2    Cullins, J.3    Bird, A.P.4
  • 85
    • 80054994283 scopus 로고    scopus 로고
    • Identification of genetic elements that autonomously determine DNA methylation states
    • Lienert, F.; Wirbelauer, C.; Som, I.; Dean, A.; Mohn, F.; Schubeler, D. Identification of genetic elements that autonomously determine DNA methylation states. Nat. Genet. 2011, 43, 1091–1097.
    • (2011) Nat. Genet , vol.43 , pp. 1091-1097
    • Lienert, F.1    Wirbelauer, C.2    Som, I.3    Dean, A.4    Mohn, F.5    Schubeler, D.6
  • 86
    • 78049415018 scopus 로고    scopus 로고
    • Dnmt3L modulates significant and distinct flanking sequence preference for DNA methylation by Dnmt3a and Dnmt3b in vivo
    • Wienholz, B.L.; Kareta, M.S.; Moarefi, A.H.; Gordon, C.A.; Ginno, P.A.; Chedin, F. Dnmt3L modulates significant and distinct flanking sequence preference for DNA methylation by Dnmt3a and Dnmt3b in vivo. PLoS Genet. 2010, 6, 1001106.
    • PLoS Genet , vol.6 , pp. 2010
    • Wienholz, B.L.1    Kareta, M.S.2    Moarefi, A.H.3    Gordon, C.A.4    Ginno, P.A.5    Chedin, F.6
  • 87
    • 73449113904 scopus 로고    scopus 로고
    • Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation
    • Hervouet, E.; Vallette, F.M.; Cartron, P.F. Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation. Epigenetics 2009, 4, 487–499.
    • (2009) Epigenetics , vol.4 , pp. 487-499
    • Hervouet, E.1    Vallette, F.M.2    Cartron, P.F.3
  • 89
    • 68749117667 scopus 로고    scopus 로고
    • DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions
    • Gopalakrishnan, S.; Sullivan, B.A.; Trazzi, S.; Della Valle, G.; Robertson, K.D. DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions. Hum. Mol. Genet. 2009, 18, 3178–3193.
    • (2009) Hum. Mol. Genet , vol.18 , pp. 3178-3193
    • Gopalakrishnan, S.1    Sullivan, B.A.2    Trazzi, S.3    Della Valle, G.4    Robertson, K.D.5
  • 90
    • 0035890090 scopus 로고    scopus 로고
    • Lsh, a member of the SNF2 family, is required for genome-wide methylation
    • Dennis, K.; Fan, T.; Geiman, T.; Yan, Q.; Muegge, K. Lsh, a member of the SNF2 family, is required for genome-wide methylation. Genes Dev. 2001, 15, 2940–2944.
    • (2001) Genes Dev , vol.15 , pp. 2940-2944
    • Dennis, K.1    Fan, T.2    Geiman, T.3    Yan, Q.4    Muegge, K.5
  • 95
    • 72849148752 scopus 로고    scopus 로고
    • Lsh participates in DNA methylation and silencing of stem cell genes
    • Xi, S.; Geiman, T.M.; Briones, V.; Guang Tao, Y.; Xu, H.; Muegge, K. Lsh participates in DNA methylation and silencing of stem cell genes. Stem Cells 2009, 27, 2691–2702.
    • (2009) Stem Cells , vol.27 , pp. 2691-2702
    • Xi, S.1    Geiman, T.M.2    Briones, V.3    Guang Tao, Y.4    Xu, H.5    Muegge, K.6
  • 97
    • 37549061829 scopus 로고    scopus 로고
    • Lsh cooperates with DNA methyltransferases to repress transcription
    • Myant, K.; Stancheva, I. Lsh cooperates with DNA methyltransferases to repress transcription. Mol. Cell. Biol. 2008, 28, 215–226.
    • (2008) Mol. Cell. Biol , vol.28 , pp. 215-226
    • Myant, K.1    Stancheva, I.2
  • 98
    • 34248160438 scopus 로고    scopus 로고
    • Developmentally regulated piRNA clusters implicate MILI in transposon control
    • Aravin, A.A.; Sachidanandam, R.; Girard, A.; Fejes-Toth, K.; Hannon, G.J. Developmentally regulated piRNA clusters implicate MILI in transposon control. Science 2007, 316, 744–747.
    • (2007) Science , vol.316 , pp. 744-747
    • Aravin, A.A.1    Sachidanandam, R.2    Girard, A.3    Fejes-Toth, K.4    Hannon, G.J.5
  • 99
    • 77958576363 scopus 로고    scopus 로고
    • Interaction of noncoding RNA with the rDNA promoter mediates recruitment of Dnmt3b and silencing of rRNA genes
    • Schmitz, K.M.; Mayer, C.; Postepska, A.; Grummt, I. Interaction of noncoding RNA with the rDNA promoter mediates recruitment of Dnmt3b and silencing of rRNA genes. Genes Dev. 2010, 24, 2264–2269.
    • (2010) Genes Dev , vol.24 , pp. 2264-2269
    • Schmitz, K.M.1    Mayer, C.2    Postepska, A.3    Grummt, I.4
  • 100
    • 0037072661 scopus 로고    scopus 로고
    • Regulation of heterochromatic silencing and histone h3 lysine-9 methylation by RNAi
    • Volpe, T.A.; Kidner, C.; Hall, I.M.; Teng, G.; Grewal, S.I.; Martienssen, R.A. Regulation of heterochromatic silencing and histone h3 lysine-9 methylation by RNAi. Science 2002, 297, 1833–1837.
    • (2002) Science , vol.297 , pp. 1833-1837
    • Volpe, T.A.1    Kidner, C.2    Hall, I.M.3    Teng, G.4    Grewal, S.I.5    Martienssen, R.A.6
  • 103
    • 22844457491 scopus 로고    scopus 로고
    • DNA methylation and human disease
    • Robertson, K.D. DNA methylation and human disease. Nat. Rev. Genet. 2005, 6, 597–610.
    • (2005) Nat. Rev. Genet , vol.6 , pp. 597-610
    • Robertson, K.D.1
  • 104
    • 36549056015 scopus 로고    scopus 로고
    • Epigenetic changes in cancer
    • Gronbaek, K.; Hother, C.; Jones, P.A. Epigenetic changes in cancer. APMIS 2007, 115, 1039–1059.
    • (2007) APMIS , vol.115 , pp. 1039-1059
    • Gronbaek, K.1    Hother, C.2    Jones, P.A.3
  • 105
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • Feinberg, A.P.; Vogelstein, B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 1983, 301, 89–92.
    • (1983) Nature , vol.301 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 106
    • 77954661906 scopus 로고    scopus 로고
    • DNA hypomethylation in cancer cells
    • Ehrlich, M. DNA hypomethylation in cancer cells. Epigenomics 2009, 1, 239–259.
    • (2009) Epigenomics , vol.1 , pp. 239-259
    • Ehrlich, M.1
  • 107
    • 0020627846 scopus 로고
    • Hypomethylation of Ras oncogenes in primary human cancers
    • Feinberg, A.P.; Vogelstein, B. Hypomethylation of Ras oncogenes in primary human cancers. Biochem. Biophys. Res. Commun. 1983, 111, 47–54.
    • (1983) Biochem. Biophys. Res. Commun , vol.111 , pp. 47-54
    • Feinberg, A.P.1    Vogelstein, B.2
  • 108
    • 0036813331 scopus 로고    scopus 로고
    • Cancer/testis antigens: An expanding family of targets for cancer immunotherapy
    • Scanlan, M.J.; Gure, A.O.; Jungbluth, A.A.; Old, L.J.; Chen, Y.T. Cancer/testis antigens: An expanding family of targets for cancer immunotherapy. Immunol. Rev. 2002, 188, 22–32.
    • (2002) Immunol. Rev , vol.188 , pp. 22-32
    • Scanlan, M.J.1    Gure, A.O.2    Jungbluth, A.A.3    Old, L.J.4    Chen, Y.T.5
  • 109
    • 79851510814 scopus 로고    scopus 로고
    • DNA methylation and cancer: Ghosts and angels above the genes
    • Sincic, N.; Herceg, Z. DNA methylation and cancer: Ghosts and angels above the genes. Curr. Opin. Oncol. 2011, 23, 69–76.
    • (2011) Curr. Opin. Oncol , vol.23 , pp. 69-76
    • Sincic, N.1    Herceg, Z.2
  • 111
    • 79958074728 scopus 로고    scopus 로고
    • Modulation of Dnmt3b function in vitro by interactions with Dnmt3l, Dnmt3a and Dnmt3b splice variants
    • Van Emburgh, B.O.; Robertson, K.D. Modulation of Dnmt3b function in vitro by interactions with Dnmt3l, Dnmt3a and Dnmt3b splice variants. Nucl. Acids Res. 2011, 39, 4984–5002.
    • (2011) Nucl. Acids Res , vol.39 , pp. 4984-5002
    • Van Emburgh, B.O.1    Robertson, K.D.2
  • 114
    • 0019434304 scopus 로고
    • Centromeric instability of chromosomes 1, 9, and 16 associated with combined immunodeficiency
    • Fryns, J.P.; Azou, M.; Jaeken, J.; Eggermont, E.; Pedersen, J.C.; van den Berghe, H. Centromeric instability of chromosomes 1, 9, and 16 associated with combined immunodeficiency. Hum. Genet. 1981, 57, 108–110.
    • (1981) Hum. Genet. , vol.57 , pp. 108-110
    • Fryns, J.P.1    Azou, M.2    Jaeken, J.3    Eggermont, E.4    Pedersen, J.C.5    Van Den Berghe, H.6
  • 115
    • 0018672228 scopus 로고
    • Multibranched chromosomes 1, 9, and 16 in a patient with combined IgA and IgE deficiency
    • Tiepolo, L.; Maraschio, P.; Gimelli, G.; Cuoco, C.; Gargani, G.F.; Romano, C. Multibranched chromosomes 1, 9, and 16 in a patient with combined IgA and IgE deficiency. Hum. Genet. 1979, 51, 127–137.
    • (1979) Hum. Genet , vol.51 , pp. 127-137
    • Tiepolo, L.1    Maraschio, P.2    Gimelli, G.3    Cuoco, C.4    Gargani, G.F.5    Romano, C.6
  • 118
    • 0023890497 scopus 로고
    • Variable immunodeficiency with abnormal condensation of the heterochromatin of chromosomes 1, 9, and 16
    • Carpenter, N.J.; Filipovich, A.; Blaese, R.M.; Carey, T.L.; Berkel, A.I. Variable immunodeficiency with abnormal condensation of the heterochromatin of chromosomes 1, 9, and 16. J. Pediatr. 1988, 112, 757–760.
    • (1988) J. Pediatr , vol.112 , pp. 757-760
    • Carpenter, N.J.1    Filipovich, A.2    Blaese, R.M.3    Carey, T.L.4    Berkel, A.I.5
  • 119
    • 0023848337 scopus 로고
    • Immunodeficiency, centromeric heterochromatin instability of chromosomes 1, 9, and 16, and facial anomalies: The ICF syndrome
    • Maraschio, P.; Zuffardi, O.; Dalla Fior, T.; Tiepolo, L. Immunodeficiency, centromeric heterochromatin instability of chromosomes 1, 9, and 16, and facial anomalies: The ICF syndrome. J. Med. Genet. 1988, 25, 173–180.
    • (1988) J. Med. Genet , vol.25 , pp. 173-180
    • Maraschio, P.1    Zuffardi, O.2    Dalla Fior, T.3    Tiepolo, L.4
  • 125
    • 0037036468 scopus 로고    scopus 로고
    • Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases
    • Gowher, H.; Jeltsch, A. Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases. J. Biol. Chem. 2002, 277, 20409–20414.
    • (2002) J. Biol. Chem , vol.277 , pp. 20409-20414
    • Gowher, H.1    Jeltsch, A.2
  • 126
    • 79958071640 scopus 로고    scopus 로고
    • ICF syndrome mutations cause a broad spectrum of biochemical defects in Dnmt3b-mediated de novo DNA methylation
    • Moarefi, A.H.; Chedin, F. ICF syndrome mutations cause a broad spectrum of biochemical defects in Dnmt3b-mediated de novo DNA methylation. J. Mol. Biol. 2011, 409, 758–772.
    • (2011) J. Mol. Biol , vol.409 , pp. 758-772
    • Moarefi, A.H.1    Chedin, F.2
  • 128
    • 84859709154 scopus 로고    scopus 로고
    • Pok/zbtb proteins: An emerging family of proteins that regulate lymphoid development and function
    • Lee, S.U.; Maeda, T. Pok/zbtb proteins: An emerging family of proteins that regulate lymphoid development and function. Immunol. Rev. 2012, 247, 107–119.
    • (2012) Immunol. Rev , vol.247 , pp. 107-119
    • Lee, S.U.1    Maeda, T.2
  • 130
    • 84899978054 scopus 로고    scopus 로고
    • Germline genes hypomethylation and expression define a molecular signature in peripheral blood of ICF patients: Implications for diagnosis and etiology
    • Velasco, G.; Walton, E.L.; Sterlin, D.; Hedouin, S.; Nitta, H.; Yuya, I.; Fouyssac, F.; Megarbane, A.; Sasaki, H.; Picard, C.; et al. Germline genes hypomethylation and expression define a molecular signature in peripheral blood of ICF patients: Implications for diagnosis and etiology. Orphanet. J. Rare Dis. 2014, 9, 56.
    • (2014) Orphanet. J. Rare Dis , vol.9 , pp. 56
    • Velasco, G.1    Walton, E.L.2    Sterlin, D.3    Hedouin, S.4    Nitta, H.5    Yuya, I.6    Fouyssac, F.7    Megarbane, A.8    Sasaki, H.9    Picard, C.10
  • 132
    • 79951961768 scopus 로고    scopus 로고
    • Angiosarcoma in a patient with immunodeficiency, centromeric region instability, facial anomalies (ICF) syndrome
    • Van den Brand, M.; Flucke, U.E.; Bult, P.; Weemaes, C.M.; van Deuren, M. Angiosarcoma in a patient with immunodeficiency, centromeric region instability, facial anomalies (ICF) syndrome. Am. J. Med. Genet. 2011, 155A, 622–625.
    • (2011) Am. J. Med. Genet , vol.155A , pp. 622-625
    • Van Den Brand, M.1    Flucke, U.E.2    Bult, P.3    Weemaes, C.M.4    Van Deuren, M.5
  • 133
    • 0034736268 scopus 로고    scopus 로고
    • Hypersensitivity to radiation-induced non-apoptotic and apoptotic death in cell lines from patients with the ICF chromosome instability syndrome
    • Narayan, A.; Tuck-Muller, C.; Weissbecker, K.; Smeets, D.; Ehrlich, M. Hypersensitivity to radiation-induced non-apoptotic and apoptotic death in cell lines from patients with the ICF chromosome instability syndrome. Mutat. Res. 2000, 456, 1–15.
    • (2000) Mutat. Res , vol.456 , pp. 1-15
    • Narayan, A.1    Tuck-Muller, C.2    Weissbecker, K.3    Smeets, D.4    Ehrlich, M.5
  • 135
    • 84881532232 scopus 로고    scopus 로고
    • Cancer hallmarks sustained by ectopic activations of placenta/male germline genes
    • Rousseaux, S.; Wang, J.; Khochbin, S. Cancer hallmarks sustained by ectopic activations of placenta/male germline genes. Cell. Cycle 2013, 12, 2331–2332.
    • (2013) Cell. Cycle , vol.12 , pp. 2331-2332
    • Rousseaux, S.1    Wang, J.2    Khochbin, S.3
  • 138
    • 78650631610 scopus 로고    scopus 로고
    • Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila
    • Janic, A.; Mendizabal, L.; Llamazares, S.; Rossell, D.; Gonzalez, C. Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila. Science 2010, 330, 1824–1827.
    • (2010) Science , vol.330 , pp. 1824-1827
    • Janic, A.1    Mendizabal, L.2    Llamazares, S.3    Rossell, D.4    Gonzalez, C.5
  • 139
    • 0029240544 scopus 로고
    • Transcripts from opposite strands of gamma satellite DNA are differentially expressed during mouse development
    • Rudert, F.; Bronner, S.; Garnier, J.M.; Dolle, P. Transcripts from opposite strands of gamma satellite DNA are differentially expressed during mouse development. Mamm. Genome 1995, 6, 76–83.
    • (1995) Mamm. Genome , vol.6 , pp. 76-83
    • Rudert, F.1    Bronner, S.2    Garnier, J.M.3    Dolle, P.4
  • 141
    • 35948951117 scopus 로고    scopus 로고
    • Proliferation-dependent and cell cycle regulated transcription of mouse pericentric heterochromatin
    • Lu, J.; Gilbert, D.M. Proliferation-dependent and cell cycle regulated transcription of mouse pericentric heterochromatin. J. Cell Biol. 2007, 179, 411–421.
    • (2007) J. Cell Biol , vol.179 , pp. 411-421
    • Lu, J.1    Gilbert, D.M.2
  • 145
    • 34848878368 scopus 로고    scopus 로고
    • Human chromosome 1 satellite 3 DNA is decondensed, demethylated and transcribed in senescent cells and in A431 epithelial carcinoma cells
    • Enukashvily, N.I.; Donev, R.; Waisertreiger, I.S.; Podgornaya, O.I. Human chromosome 1 satellite 3 DNA is decondensed, demethylated and transcribed in senescent cells and in A431 epithelial carcinoma cells. Cytogenet. Genome Res. 2007, 118, 42–54.
    • (2007) Cytogenet. Genome Res , vol.118 , pp. 42-54
    • Enukashvily, N.I.1    Donev, R.2    Waisertreiger, I.S.3    Podgornaya, O.I.4
  • 148
    • 45349089291 scopus 로고    scopus 로고
    • Centromere mitotic recombination in mammalian cells
    • Jaco, I.; Canela, A.; Vera, E.; Blasco, M.A. Centromere mitotic recombination in mammalian cells. J. Cell Biol. 2008, 181, 885–892.
    • (2008) J. Cell Biol , vol.181 , pp. 885-892
    • Jaco, I.1    Canela, A.2    Vera, E.3    Blasco, M.A.4
  • 150
    • 0036532237 scopus 로고    scopus 로고
    • Gene silencing, cell fate and nuclear organisation
    • Fisher, A.G.; Merkenschlager, M. Gene silencing, cell fate and nuclear organisation. Curr. Opin. Genet. Dev. 2002, 12, 193–197.
    • (2002) Curr. Opin. Genet. Dev , vol.12 , pp. 193-197
    • Fisher, A.G.1    Merkenschlager, M.2
  • 153
    • 0035662541 scopus 로고    scopus 로고
    • High frequencies of ICF syndrome-like pericentromeric heterochromatin decondensation and breakage in chromosome 1 in a chorionic villus sample
    • Ehrlich, M.; Tsien, F.; Herrera, D.; Blackman, V.; Roggenbuck, J.; Tuck-Muller, C.M. High frequencies of ICF syndrome-like pericentromeric heterochromatin decondensation and breakage in chromosome 1 in a chorionic villus sample. J. Med. Genet. 2001, 38, 882–884.
    • (2001) J. Med. Genet , vol.38 , pp. 882-884
    • Ehrlich, M.1    Tsien, F.2    Herrera, D.3    Blackman, V.4    Roggenbuck, J.5    Tuck-Muller, C.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.