Lsh participates in DNA methylation and silencing of stem cell genes

Stem Cells

Volumn 27, Issue 11, 2009, Pages 2691-2702

  Xi, Sichuan ^a   Geiman, Theresa M ^a   Briones, Victorino ^a   Tao, Yong Guang ^a   Xu, Hong ^a   Muegge, Kathrin ^a  

^a SAIC FREDERICK INC   (United States)

Author keywords

Chromatin; Differentiation; DNA methylation; Epigenetics; Stem cell genes

Indexed keywords

DNA METHYLTRANSFERASE 3B; GENOMIC DNA; LSH PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SNF; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL STRUCTURE; CHROMATIN; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EPIGENETICS; GENE CONTROL; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; GENETIC MARKER; GENETIC TRANSCRIPTION; IN VITRO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PLURIPOTENT STEM CELL; PROMOTER REGION; PROTEIN DEPLETION; RETROPOSON; SOMATIC CELL;

ANIMALS; BLOTTING, SOUTHERN; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA HELICASES; DNA METHYLATION; EPIDERMAL GROWTH FACTOR; GENE SILENCING; GROWTH DIFFERENTIATION FACTOR 3; HOMEODOMAIN PROTEINS; MEMBRANE GLYCOPROTEINS; MICE; NEOPLASM PROTEINS; OCTAMER TRANSCRIPTION FACTOR-3; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REPRESSOR PROTEINS;

EID: 72849148752     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.183     Document Type: Article

References (58)

1. Li B, Carey M, Workman JL. The role of chromatin during transcription. Cell 2007;128:707-719.
2. Murry CE, Keller G. Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell 2008;132:661-680. (Pubitemid 351260059)
3. Bernstein BE, Mikkelsen TS, Xie X et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006;125:315-326.
4. Guenther MG, Levine SS, Boyer LA et al. A chromatin landmark and transcription initiation at most promoters in human cells. Cell 2007;130:77-88.
5. Chambers I, Colby D, Robertson M et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003;113:643-655. (Pubitemid 36694189)
6. Nichols J, Zevnik B, Anastassiadis K et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 1998;95:379-391. (Pubitemid 28507326)
7. Rideout WM 3rd, Eggan K, Jaenisch R. Nuclear cloning and epigenetic reprogramming of the genome. Science 2001;293:1093-1098.
8. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-676. (Pubitemid 44233629)
9. Wilmut I, Schnieke AE, McWhir J et al. Viable offspring derived from fetal and adult mammalian cells. Nature 1997;385:810-813. (Pubitemid 27106068)
10. Yamanaka S. Pluripotency and nuclear reprogramming. Philos Trans R Soc Lond B Biol Sci 2008;363:2079-2087.
11. Freberg CT, Dahl JA, Timoskainen S et al. Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract. Mol Biol Cell 2007;18:1543-1553. (Pubitemid 46717539)
12. Bird A. DNA methylation patterns and epigenetic memory. Genes Dev 2002;16:6-21. (Pubitemid 34049633)
13. Chen T, Li E. Establishment and maintenance of DNA methylation patterns in mammals. Curr Top Microbiol Immunol 2006;301:179-201. (Pubitemid 43022672)
14. Feinberg AP, Cui H, Ohlsson R. DNA methylation and genomic imprinting: insights from cancer into epigenetic mechanisms. Semin Cancer Biol 2002;12:389-398.
15. Lees-Murdock DJ, Walsh CP. DNA methylation reprogramming in the germ line. Adv Exp Med Biol 2008;626:1-15.
16. Gidekel S, Bergman Y. A unique developmental pattern of Oct-3/4 DNA methylation is controlled by a cis-demodification element. J Biol Chem 2002;277:34521-34530. (Pubitemid 35056276)
17. Deb-Rinker P, Ly D, Jezierski A et al. Sequential DNA methylation of the Nanog and Oct-4 upstream regions in human NT2 cells during neuronal differentiation. J Biol Chem 2005;280:6257-6260. (Pubitemid 40341170)
18. Feldman N, Gerson A, Fang J et al. G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nat Cell Biol 2006;8:188-194.
19. Hattori N, Nishino K, Ko YG et al. Epigenetic control of mouse Oct- 4 gene expression in embryonic stem cells and trophoblast stem cells. J Biol Chem 2004;279:17063-17069. (Pubitemid 38560461)
20. Blelloch R, Wang Z, Meissner A et al. Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus. Stem Cells 2006;24:2007-2013. (Pubitemid 44477125)
21. Simonsson S, Gurdon J. DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei. Nat Cell Biol 2004;6:984-990. (Pubitemid 39359851)
22. Goll MG, Bestor TH. Eukaryotic cytosine methyltransferases. Annu Rev Biochem 2005;74:481-514.
23. Jeltsch A. On the enzymatic properties of Dnmt1: specificity, processivity, mechanism of linear diffusion and allosteric regulation of the enzyme. Epigenetics 2006;1:63-66.
24. Bostick M, Kim JK, Esteve PO et al. UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science 2007;317:1760-1764. (Pubitemid 47461842)
25. Sharif J, Muto M, Takebayashi S et al. The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA. Nature 2007;450:908-912. (Pubitemid 350231331)
26. Okano M, Bell DW, Haber DA et al. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999;99:247-257. (Pubitemid 29519904)
27. Geiman TM, Tessarollo L, Anver MR et al. Lsh, a SNF2 family member, is required for normal murine development. Biochim Biophys Acta 2001;1526:211-220. (Pubitemid 32452257)
28. Jarvis CD, Geiman T, Vila-Storm MP et al. A novel putative helicase produced in early murine lymphocytes. Gene 1996;169:203-207. (Pubitemid 26092265)
29. De La Fuente R, Baumann C, Fan T et al. Lsh is required for meiotic chromosome synapsis and retrotransposon silencing in female germ cells. Nat Cell Biol 2006;8:1448-1454. (Pubitemid 44835121)
30. Dennis K, Fan T, Geiman T et al. Lsh, a member of the SNF2 family, is required for genome-wide methylation. Genes Dev 2001;15:2940-2944. (Pubitemid 33078944)
31. Huang J, Fan T, Yan Q et al. Lsh, an epigenetic guardian of repetitive elements. Nucleic Acids Res 2004;32:5019-5028. (Pubitemid 39445488)
32. Zhu H, Geiman TM, Xi S et al. Lsh is involved in de novo methylation of DNA. EMBO J 2006;25:335-345. (Pubitemid 43152854)
33. Myant K, Stancheva I. LSH cooperates with DNA methyltransferases to repress transcription. Mol Cell Biol 2008;28:215-226.
34. Xi S, Zhu H, Xu H et al. Lsh controls Hox gene silencing during development. Proc Natl Acad Sci U S A 2007;104:14366-14371. (Pubitemid 350003267)
35. Fan T, Hagan JP, Kozlov SV et al. Lsh controls silencing of the imprinted Cdkn1c gene. Development 2005;132:635-644. (Pubitemid 40352824)
36. Geiman TM, Muegge K. Lsh, an SNF2/helicase family member, is required for proliferation of mature T lymphocytes. Proc Natl Acad Sci U S A 2000;97:4772-4777. (Pubitemid 30238633)
37. Muegge K. Lsh, a guardian of heterochromatin at repeat elements. Biochem Cell Biol 2005;83:548-554. (Pubitemid 41626773)
38. Weber M, Davies JJ, Wittig D et al. Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet 2005;37:853-862. (Pubitemid 41077111)
39. McBurney MW, Rogers BJ. Isolation of male embryonal carcinoma cells and their chromosome replication patterns. Dev Biol 1982;89:503-508.
40. Jones-Villeneuve EM, McBurney MW, Rogers KA et al. Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells. J Cell Biol 1982;94:253-262.
41. McBurney MW, Jones-Villeneuve EM, Edwards MK et al. Control of muscle and neuronal differentiation in a cultured embryonal carcinoma cell line. Nature 1982;299:165-167. (Pubitemid 12056794)
42. Assou S, Le Carrour T, Tondeur S et al. A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas. Stem Cells 2007;25:961-973. (Pubitemid 46572593)
43. Strickland S, Smith KK, Marotti KR. Hormonal induction of differentiation in teratocarcinoma stem cells: generation of parietal endoderm by retinoic acid and dibutyryl cAMP. Cell 1980;21:347-355. (Pubitemid 10047088)
44. Fan T, Schmidtmann A, Xi S et al. DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development. Epigenetics 2008;3:134-142.
45. Mohn F, Weber M, Rebhan M et al. Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. Mol Cell 2008;30:755-766.
46. Jackson M, Krassowska A, Gilbert N et al. Severe global DNA hypomethylation blocks differentiation and induces histone hyperacetylation in embryonic stem cells. Mol Cell Biol 2004;24:8862-8871. (Pubitemid 39313892)
47. Fouse SD, Shen Y, Pellegrini M et al. Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell 2008;2:160-169.
48. Kang ES, Park CW, Chung JH. Dnmt3b, de novo DNA methyltransferase, interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1. Biochem Biophys Res Commun 2001;289:862-868.
49. Ling Y, Sankpal UT, Robertson AK et al. Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription. Nucleic Acids Res 2004;32:598-610. (Pubitemid 38263051)
50. Jia D, Jurkowska RZ, Zhang X et al. Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature 2007;449:248-251. (Pubitemid 47402375)
51. Ooi SK, Qiu C, Bernstein E et al. DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature 2007;448:714-717. (Pubitemid 47236857)
52. Métivier R, Gallais R, Tiffoche C et al. Cyclical DNA methylation of a transcriptionally active promoter. Nature 2008;452:45-50. (Pubitemid 351355084)
53. Yeom YI, Fuhrmann G, Ovitt CE et al. Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells. Development 1996;122:881-894. (Pubitemid 26095994)
54. Fuhrmann G, Chung AC, Jackson KJ et al. Mouse germline restriction of Oct4 expression by germ cell nuclear factor. Dev Cell 2001;1:377-387. (Pubitemid 33586087)
55. Chew JL, Loh YH, Zhang W et al. Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol 2005;25:6031-6046. (Pubitemid 40946556)
56. Babaie Y, Herwig R, Greber B et al. Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells. Stem Cells 2007;25:500-510. (Pubitemid 46232806)
57. Loh YH, Wu Q, Chew JL et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 2006;38:431-440.
58. National Research Council. Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press, 1996.