Hypersensitivity to radiation-induced non-apoptotic and apoptotic death in cell lines from patients with the ICF chromosome instability syndrome

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 456, Issue 1-2, 2000, Pages 1-15

  Narayan, Ajita ^a   Tuck Muller, Cathy ^b   Weissbecker, Karen ^a   Smeets, Dominique ^c   Ehrlich, Melanie ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTH ALABAMA   (United States)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Apoptosis; Cell cycle checkpoints; Chromosomal instability; Hypomethylation; ICF; Ionizing radiation

Indexed keywords

DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 3B; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; ATAXIA TELANGIECTASIA; CARCINOGENESIS; CELL CYCLE; CELL DEATH; CELL LINE; CELL VIABILITY; CENTROMERE; CHROMOSOMAL INSTABILITY; CHROMOSOME 1; CHROMOSOME 16; CHROMOSOME ANALYSIS; CHROMOSOME BREAKAGE; CHROMOSOME DISORDER; CHROMOSOME REARRANGEMENT; CLONOGENIC ASSAY; CONTROLLED STUDY; DNA METHYLATION; FACE MALFORMATION; GENOME; GENOTOXICITY; HUMAN; HUMAN CELL; HYPERSENSITIVITY; ICF SYNDROME; IMMUNE DEFICIENCY; IONIZING RADIATION; LYMPHOBLASTOID CELL LINE; NIJMEGEN BREAKAGE SYNDROME; PRIORITY JOURNAL; RADIOSENSITIVITY; RECESSIVE INHERITANCE; REGULATOR GENE;

APOPTOSIS; CELL CYCLE; CELL DEATH; CELL DIVISION; CELL LINE, TRANSFORMED; CHROMOSOMES, HUMAN; COLONY-FORMING UNITS ASSAY; DNA DAMAGE; DNA METHYLATION; FACIAL BONES; GAMMA RAYS; GENES, RECESSIVE; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; RADIATION TOLERANCE; SYNDROME;

ATAXIA; ATAXIA TELANGIECTASIA;

EID: 0034736268     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(00)00103-2     Document Type: Article

References (42)

1. The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome
2. DNA methyltransferases DNMT3A and DNMT3B are essential for de novo methylation and mammalian development
3. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene
4. ICF syndrome: a new case and review of the literature
5. Chromosome instability in ICF syndrome: formation of micronuclei from multibranched chromosome 1 demonstrated by fluorescence in situ hybridization
6. DNA hypomethylation and unusual chromosome instability in cell lines from ICF syndrome patients
7. An embryonic-like methylation pattern of classical satellite DNA is observed in ICF syndrome
8. Alpha-satellite DNA methylation in normal individuals and in ICF patients: heterogeneous methylation of constitutive heterochromatin in adult and fetal tissues
9. Chromosome instability syndromes: lessons for carcinogenesis
10. Cell cycle checkpoints and DNA repair in Nijmegen breakage syndrome
11. Variable immunodeficiency with abnormal condensation of the heterochromatin of chromosomes 1, 9, and 16
12. Initial chromosome damage but not DNA damage is greater in ataxia telangiectasia cells
13. The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage
14. Radiosensitivity in ataxia-telangiectasia: anomalies in radiation-induced cell cycle delay
15. Biochemical and molecular mechanisms regulating apoptosis
16. Apoptosis, oncosis, and necrosis: an overview of cell death
17. Cell cycle arrest following exposure of EBV-immortalised B-cells to gamma irradiation correlates with inhibition of cdk2 activity
18. Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines
19. Defective control of apoptosis, radiosensitivity, and spindle checkpoint in ataxia telangiectasia
20. Whole-genome methylation scan in ICF syndrome: hypomethylation of non-satellite DNA repeats D4Z4 and NBL2
21. Expression of full-length NBS1 protein restores normal radiation responses in cells from Nijmegen breakage syndrome patients
22. Induction, repair and biological relevance of radiation-induced DNA lesions in eukaryotic cells
23. The effect of chromatin decondensation on DNA damage and repair
24. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
25. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
26. Apoptosis after γ irradiation. Is it an important cell death modality?
27. Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism
28. Increased initial levels of chromosome damage and heterogeneous chromosome repair in ataxia telangiectasia heterozygote cells
29. Defective control of apoptosis and mitotic spindle checkpoint in heterozygous carriers of ATM mutations
30. Low level of DNA repair in human chromosome 1 heterochromatin
31. Cloning, expression and chromosome locations of the human DNMT3 gene family
32. Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1
33. The response of proliferating cell nuclear antigen to ionizing radiation in human lymphoblastoid cell lines is dependent on p53
34. Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype
35. Mitogen-activated protein kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation
36. Epstein-Barr virus efficiently immortalizes human B cells without neutralizing the function of p53
37. p53 inhibits entry into mitosis when DNA synthesis is blocked
38. Satellite DNA hypomethylation vs. overall genomic hypomethylation in ovarian epithelial tumors of different malignant potential
39. Frequent hypomethylation in Wilms tumors of pericentromeric DNA in chromosomes 1 and 16
40. Hypomethylation of pericentromeric DNA in breast adenocarcinomas
41. The 5-methylcytosine content of DNA from human tumors