APP is cleaved by bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, viaIts intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Del Prete, Dolores ^a   Lombino, Franco ^a   Liu, Xinran ^b   D'Adamio, Luciano ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SOLUBLE NSF ATTACHMENT PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; BETA SOLUBLE NSF ATTACHMENT PROTEIN; COMPLEXIN; GAMMA SECRETASE; GAMMA SOLUBLE NSF ATTACHMENT PROTEIN; MEMBRANE PROTEIN; MUNC18 PROTEIN; N ETHYLMALEIMIDE SENSITIVE FACTOR; SYNAPTOBREVIN 1; SYNAPTOBREVIN 2; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNAPTOSOMAL ASSOCIATED PROTEIN 47; SYNAPTOTAGMIN I; SYNAPTOTAGMIN II; SYNTAXIN 1A; SYNTAXIN 1B; UNCLASSIFIED DRUG; ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; NERVE PROTEIN; SECRETASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; IN VIVO STUDY; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRESYNAPTIC INTERACTOME; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEOMICS; SYNAPSE VESICLE; ANIMAL; C57BL MOUSE; CELL FRACTIONATION; CHEMISTRY; DEFICIENCY; ENDOCYTOSIS; EXOCYTOSIS; HIPPOCAMPUS; IMMUNOELECTRON MICROSCOPY; KNOCKOUT MOUSE; METABOLISM; NERVE ENDING; PHYSIOLOGY; PROCEDURES; PROTEIN TERTIARY STRUCTURE; ULTRASTRUCTURE;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CELL FRACTIONATION; ENDOCYTOSIS; EXOCYTOSIS; HIPPOCAMPUS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, IMMUNOELECTRON; NERVE TISSUE PROTEINS; PRESYNAPTIC TERMINALS; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; SUBCELLULAR FRACTIONS; SYNAPTIC VESICLES;

EID: 84907478709     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108576     Document Type: Article

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