APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant

EMBO Journal

Volumn 30, Issue 12, 2011, Pages 2501-2509

  Tamayev, Robert ^a   Matsuda, Shuji ^a   Giliberto, Luca ^a,d   Arancio, Ottavio ^b   D'Adamio, Luciano ^a,c  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NewYork Presbyterian Hospital   (United States)

^c CNR   (Italy)

^d FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

APP; BRI2 ITM2b; familial Alzheimer disease; familial Danish dementia; mouse model

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BRI2 PROTEIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ALLELE; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRI2 GENE; CONTROLLED STUDY; DEMENTIA; EXPERIMENTAL MODEL; FAMILIAL DANISH DEMENTIA; GENE; GENE MUTATION; HETEROZYGOSITY; KNOCKOUT MOUSE; MALE; MEMORY DISORDER; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; SYNAPTIC MEMBRANE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; DEMENTIA; DENMARK; DISEASE MODELS, ANIMAL; GENE KNOCK-IN TECHNIQUES; HETEROZYGOTE DETECTION; HUMANS; MALE; MEMBRANE PROTEINS; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTANT CHIMERIC PROTEINS; MUTATION; PEPTIDE FRAGMENTS;

MUS;

EID: 79958785727     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2011.161     Document Type: Article

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