Soluble amyloid precursor protein 770 is released from inflamed endothelial cells and activated platelets: A novel biomarker for acute coronary syndrome

Journal of Biological Chemistry

Volumn 287, Issue 48, 2012, Pages 40817-40825

  Kitazume, Shinobu ^a   Yoshihisa, Akiomi ^b   Yamaki, Takayoshi ^b   Oikawa, Masayoshi ^b   Tachida, Yuriko ^a   Ogawa, Kazuko ^a   Imamaki, Rie ^a   Hagiwara, Yoshiaki ^c   Kinoshita, Noriaki ^c   Takeishi, Yasuchika ^b   Furukawa, Katsutoshi ^d   Tomita, Naoki ^d   Arai, Hiroyuki ^d   Iwata, Nobuhisa ^e   Saido, Takaomi ^e   Yamamoto, Naomasa ^f   Taniguchi, Naoyuki ^a  

^a RIKEN   (Japan)

^b FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^c Immuno Biological Laboratories Co Ltd   (Japan)

^d TOHOKU UNIVERSITY   (Japan)

^e RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^f OHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PLATELETS; ACUTE CORONARY SYNDROMES; ACUTE MYOCARDIAL INFARCTION; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; BRAIN PARENCHYMA; CARDIAC ENZYMES; CLEAVAGE PRODUCTS; CLINICAL PRACTICES; ENDOTHELIAL DYSFUNCTION; INFLAMMATORY CYTOKINES; ISOFORMS; MYOCARDIAL INFARCTION; PLATELET ACTIVATION; PRECURSOR PROTEINS; THROMBUS FORMATION; VASCULAR ENDOTHELIAL CELLS;

BLOOD VESSELS; CEREBROSPINAL FLUID; ENDOTHELIAL CELLS; PLATELETS;

GLYCOPROTEINS;

AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN ALPHA; BIOLOGICAL MARKER; CREATINE KINASE; CYTOKINE; HEART ENZYME; SOLUBLE AMYLOID PRECURSOR PROTEIN 695; SOLUBLE AMYLOID PRECURSOR PROTEIN 751; SOLUBLE AMYLOID PRECURSOR PROTEIN 770; TROPONIN I; UNCLASSIFIED DRUG;

ACUTE CORONARY SYNDROME; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROTIC PLAQUE; BLOOD CLOTTING; CELLULAR SECRETION; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DIFFERENTIAL DIAGNOSIS; DISEASE MARKER; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; HEART INFARCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NERVE CELL; NEUROLOGIC DISEASE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN CLEAVAGE; PROTEIN SECRETION; RAT; THROMBOCYTE ACTIVATION; THROMBOCYTE DYSFUNCTION;

ACUTE CORONARY SYNDROME; AGED; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BIOLOGICAL MARKERS; BLOOD PLATELETS; CELLS, CULTURED; ENDOTHELIAL CELLS; FEMALE; HUMANS; MALE; PEPTIDE FRAGMENTS; PLATELET ACTIVATION; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 84869989953     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.398578     Document Type: Article

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