BRI2 inhibits amyloid β-peptide precursor protein processing by interfering with the docking of secretases to the substrate

Journal of Neuroscience

Volumn 28, Issue 35, 2008, Pages 8668-8676

  Matsuda, Shuji ^a   Giliberto, Luca ^a,d   Matsuda, Yukiko ^a   McGowan, Eileen M ^b   D'Adamio, Luciano ^a,c  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d UNIVERSITY OF GENOA   (Italy)

Author keywords

Alzheimer's disease; Amyloid ; BRI2; Familial dementia; Mice; Synaptic plasticity

Indexed keywords

ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA SECRETASE; MEMBRANE PROTEIN; PROTEIN BRI2; SECRETASE; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; ENZYME INHIBITOR; ITM2B PROTEIN, HUMAN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; IMMUNOPRECIPITATION; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; ANIMAL; BRAIN; CELL LINE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; METHODOLOGY; MUTATION; PHYSIOLOGY; PROTEIN BINDING; TRANSGENIC MOUSE;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN; CELL LINE; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HUMANS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MUTATION; PROTEIN BINDING; TRANSFECTION;

EID: 52049089901     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2094-08.2008     Document Type: Article

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