Crosstalk between autophagy and inflammasomes

Molecules and Cells

Volumn 36, Issue 5, 2013, Pages 393-399

  Yuk, Jae Min ^a   Jo, Eun Kyeong ^a  

^a Chungnam National University   (South Korea)

Author keywords

Autophagy; Host defense; Inflammasome; Inflammation; NLRP3

Indexed keywords

CRYOPYRIN; INFLAMMASOME;

AUTOPHAGY; CELL STRESS; HOST RESISTANCE; HUMAN; INFECTION; INFLAMMATION; INFLAMMATORY DISEASE; METABOLIC DISORDER; MOLECULAR INTERACTION; NONHUMAN; PROTEIN FUNCTION; PROTEIN STRUCTURE; SHORT SURVEY;

MUS;

ANIMALS; AUTOPHAGY; GENE EXPRESSION REGULATION; HUMANS; INFECTION; INFLAMMASOMES; INFLAMMATION; MICE; MODELS, ANIMAL; SIGNAL TRANSDUCTION;

EID: 84900420410     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.1007/s10059-013-0298-0     Document Type: Short Survey

References (72)

1. Bauernfeind, F.G., Horvath, G., Stutz, A., Alnemri, E.S., MacDonald, K., Speert, D., Fernandes-Alnemri, T., Wu, J., Monks, B.G., Fitzgerald, K.A., et al. (2009). Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 183, 787-791.
2. Bauernfeind, F., Ablasser, A., Bartok, E., Kim, S., Schmid-Burgk, J., Cavlar, T., and Hornung, V. (2011). Inflammasomes: current understanding and open questions. Cell. Mol. Life Sci. 68, 765-783.
3. Bergsbaken, T., Fink, S.L., and Cookson, B.T. (2009). Pyroptosis: host cell death and inflammation. Nat. Rev. Microbiol. 7, 99-109.
4. Cadwell, K., Liu, J.Y., Brown, S.L., Miyoshi, H., Loh, J., Lennerz, J.K., Kishi, C., Kc, W., Carrero, J.A., Hunt, S., et al. (2008). A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456, 259-263.
5. Cassel, S.L., Joly, S., and Sutterwala, F.S. (2009). The NLRP3 inflammasome: a sensor of immune danger signals. Semin. Immunol. 21, 194-198.
6. Chen, G.Y., and Nunez, G. (2010). Sterile inflammation: sensing and reacting to damage. Nat. Rev. Immunol. 10, 826-837.
7. Davis, B.K., Wen, H., and Ting, J.P. (2011). The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu. Rev. Immunol. 29, 707-735.
8. Deretic, V. (2011). Autophagy in immunity and cell-autonomous defense against intracellular microbes. Immunol. Rev. 240, 92-104.
9. Deretic, V. (2012a). Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors. Curr. Opin. Immunol. 24, 21-31.
10. Deretic, V. (2012b). Autophagy: an emerging immunological paradigm. J. Immunol. 189, 15-20.
11. Doherty, T.A., Brydges, S.D., and Hoffman, H.M. (2011). Autoinflammation: translating mechanism to therapy. J. Leukoc. Biol. 90, 37-47.
12. Dostert, C., Petrilli, V., Van Bruggen, R., Steele, C., Mossman, B.T., and Tschopp, J. (2008). Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320, 674-677. (Pubitemid 351928351)
13. Dowling, J.K., and O'Neill, L.A. (2012). Biochemical regulation of the inflammasome. Crit. Rev. Biochem. Mol. Biol. 47, 424-443.
14. Dupont, N., Jiang, S., Pilli, M., Ornatowski, W., Bhattacharya, D., and Deretic, V. (2011). Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1beta. EMBO J. 30, 4701-4711.
15. Dupont, N., Lacas-Gervais, S., Bertout, J., Paz, I., Freche, B., Van Nhieu, G.T., van der Goot, F.G., Sansonetti, P.J., and Lafont, F. (2009). Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy. Cell Host Microbe 6, 137-149.
16. Fader, C.M., Sanchez, D., Furlan, M., and Colombo, M.I. (2008). Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in k562 cells. Traffic 9, 230-250.
17. Fader, C.M., Sanchez, D.G., Mestre, M.B., and Colombo, M.I. (2009). TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways. Biochim. Biophys. Acta 1793, 1901-1916.
18. Fésüs, L., Demeny, M.A., and Petrovski, G. (2011). Autophagy shapes inflammation. Antioxid. Redox Signal. 14, 2233-2243.
19. Franchi, L., Munoz-Planillo, R., and Nunez, G. (2012). Sensing and reacting to microbes through the inflammasomes. Nat. Immunol. 13, 325-332.
20. Furuta, N., Fujita, N., Noda, T., Yoshimori, T., and Amano, A. (2010). Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes. Mol. Biol. Cell 21, 1001-1010.
21. Halle, A., Hornung, V., Petzold, G.C., Stewart, C.R., Monks, B.G., Reinheckel, T., Fitzgerald, K.A., Latz, E., Moore, K.J., and Golenbock, D.T. (2008). The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat. Immunol. 9, 857-865.
22. Hamasaki, M., and Yoshimori, T. (2010). Where do they come from? Insights into autophagosome formation. FEBS Lett. 584, 1296-1301.
23. Hamasaki, M., Furuta, N., Matsuda, A., Nezu, A., Yamamoto, A., Fujita, N., Oomori, H., Noda, T., Haraguchi, T., Hiraoka, Y., et al. (2013). Autophagosomes form at ER-mitochondria contact sites. Nature 495, 389-393.
24. Harris, J., Hartman, M., Roche, C., Zeng, S.G., O'Shea, A., Sharp, F.A., Lambe, E.M., Creagh, E.M., Golenbock, D.T., Tschopp, J., et al. (2011). Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation. J. Biol. Chem. 286, 9587-9597.
25. Hornung, V., Bauernfeind, F., Halle, A., Samstad, E.O., Kono, H., Rock, K.L., Fitzgerald, K.A., and Latz, E. (2008). Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat. Immunol. 9, 847-856.
26. Hyttinen, J.M., Niittykoski, M., Salminen, A., and Kaarniranta, K. (2013). Maturation of autophagosomes and endosomes: a key role for Rab7. Biochim. Biophys. Acta 1833, 503-510.
27. Ichimura, Y., Kirisako, T., Takao, T., Satomi, Y., Shimonishi, Y., Ishihara, N., Mizushima, N., Tanida, I., Kominami, E., Ohsumi, M., et al. (2000). A ubiquitin-like system mediates protein lipidation. Nature 408, 488-492.
28. Itakura, E., Kishi-Itakura, C., and Mizushima, N. (2012). The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell 151, 1256-1269.
29. Jones, S.A., Mills, K.H., and Harris, J. (2013). Autophagy and inflammatory diseases. Immunol. Cell Biol. 91, 250-258.
30. Kamada, Y., Funakoshi, T., Shintani, T., Nagano, K., Ohsumi, M., and Ohsumi, Y. (2000). Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J. Cell Biol. 150, 1507-1513.
31. Kanneganti, T. (2010). Central roles of NLRs and inflammasomes in viral infection. Nat. Rev. Immunol. 10, 688-698.
32. Kraft, C., and Martens, S. (2012). Mechanisms and regulation of autophagosome formation. Curr. Opin. Cell Biol. 24, 496-501.
33. Lamkanfi, M., and Dixit, V.M. (2009). Inflammasomes: guardians of cytosolic sanctity. Immunol. Rev. 227, 95-105.
34. Lamkanfi, M., Walle, L.V., and Kanneganti, T.D. (2011). Deregulated inflammasome signaling in disease. Immunol. Rev. 243, 163-173.
35. Latz, E. (2010). The inflammasomes: mechanisms of activation and function. Curr. Opin. Immunol. 22, 28-33.
36. Lee, M.S. (2009). Role of autophagy in the control of cell death and inflammation. Immune Network 9, 8-11.
37. Leemans, J.C., Cassel, S.L., and Sutterwala, F.S. (2011). Sensing damage by the NLRP3 inflammasome. Immunol. Rev. 243, 152-162.
38. Levine, B., Sinha, S., and Kroemer, G. (2008). Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy 4, 600-606.
39. Levine, B., Mizushima, N., and Virgin, H.W. (2011). Autophagy in immunity and inflammation. Nature 469, 323-335.
40. Liang, C., Lee, J.S., Inn, K.S., Gack, M.U., Li, Q., Roberts, E.A., Vergne, I., Deretic, V., Feng, P., Akazawa, C., et al. (2008). Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat. Cell Biol. 10, 776-787. (Pubitemid 351927707)
41. Martinon, F., Mayor, A., and Tschopp, J. (2009). The inflammasomes: guardians of the body. Annu. Rev. Immunol. 27, 229-265.
42. Mehrpour, M., Esclatine, A., Beau, I., and Codogno, P. (2010). Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview. Am. J. Physiol. Cell Physiol. 298, C776-785.
43. Meissner, F., Molawi, K., and Zychlinsky, A. (2010a). Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis. Proc. Natl. Acad. Sci. USA 107, 13046-13050.
44. Meissner, F., Seger, R.A., Moshous, D., Fischer, A., Reichenbach, J., and Zychlinsky, A. (2010b). Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease. Blood 116, 1570-1573.
45. Menu, P., and Vince, J.E. (2011). The NLRP3 inflammasome in health and disease: the good, the bad and the ugly. Clin. Exp. Immunol. 166, 1-15.
46. Mizushima, N., Noda, T., Yoshimori, T., Tanaka, Y., Ishii, T., George, M.D., Klionsky, D.J., Ohsumi, M., and Ohsumi, Y. (1998). A protein conjugation system essential for autophagy. Nature 395, 395-398. (Pubitemid 28450691)
47. Mizushima, N., Yoshimori, T., and Ohsumi, Y. (2011). The role of Atg proteins in autophagosome formation. Annu. Rev. Cell Dev. Biol. 27, 107-132.
48. Moreau, K., Ravikumar, B., Renna, M., Puri, C., and Rubinsztein, D.C. (2011). Autophagosome precursor maturation requires homo-typic fusion. Cell 146, 303-317.
49. Muñoz-Planillo, R., Kuffa, P., Martinez-Colon, G., Smith, B.L., Rajendiran, T.M., and Nunez, G. (2013). K(+) efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity 38, 1142-1153.
50. Nair, U., Jotwani, A., Geng, J., Gammoh, N., Richerson, D., Yen, W. L., Griffith, J., Nag, S., Wang, K., Moss, T., et al. (2011). SNARE proteins are required for macroautophagy. Cell 146, 290-302.
51. Nakahira, K., Haspel, J.A., Rathinam, V.A., Lee, S.J., Dolinay, T., Lam, H.C., Englert, J.A., Rabinovitch, M., Cernadas, M., Kim, H.P., et al. (2011). Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat. Immunol. 12, 222-230.
52. Parkhitko, A.A., Favorova, O.O., and Henske, E.P. (2013). Autophagy: mechanisms, regulation, and its role in tumorigenesis. Biochemistry 78, 355-367.
53. Pelegrin, P., and Surprenant, A. (2006). Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J. 25, 5071-5082. (Pubitemid 44658525)
54. Peral de Castro, C., Jones, S.A., Ni Cheallaigh, C., Hearnden, C.A., Williams, L., Winter, J., Lavelle, E.C., Mills, K.H., and Harris, J. (2012). Autophagy regulates IL-23 secretion and innate T cell responses through effects on IL-1 secretion. J. Immunol. 189, 4144-4153.
55. Perry, V.H., Cunningham, C., and Holmes, C. (2007). Systemic infections and inflammation affect chronic neurodegeneration. Nat. Rev. Imunol. 7, 161-167. (Pubitemid 46174862)
56. Pétrilli, V., Papin, S., Dostert, C., Mayor, A., Martinon, F., and Tschopp, J. (2007). Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ. 14, 1583-1589. (Pubitemid 47278844)
57. Rathinam, V.A., Vanaja, S.K., and Fitzgerald, K.A. (2012). Regulation of inflammasome signaling. Nat. Immunol. 13, 333-332.
58. Rodgers, M.A., Bowman, J.W., Liang, Q., and Jung, J.U. (2013). Regulation where autophagy intersects the inflammasome. Antioxid. Redox Signal. [Epub ahead of print]
59. Qu, Y., Misaghi, S., Newton, K., Gilmour, L.L., Louie, S., Cupp, J.E., Dubyak, G.R., Hackos, D., and Dixit, V.M. (2011). Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation. J. Immunol. 186, 6553-6561.
60. Saitoh, T., Fujita, N., Jang, M.H., Uematsu, S., Yang, B.G., Satoh, T., Omori, H., Noda, T., Yamamoto, N., Komatsu, M., et al. (2008). Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 456, 264-268.
61. Schroder, K., and Tschopp, J. (2010). The inflammasomes. Cell 140, 821-832.
62. Schroder, K., Zhou, R., and Tschopp, J. (2010). The NLRP3 inflammasome: a sensor for metabolic danger? Science 327, 296-300.
63. Shaw, P.J., McDermott, M.F., and Kanneganti, T.D. (2011). Inflammasomes and autoimmunity. Trends Mol. Med. 17, 57-64.
64. Shi, C.S., Shenderov, K., Huang, N.N., Kabat, J., Abu-Asab, M., Fitzgerald, K.A., Sher, A., and Kehrl, J.H. (2012). Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction. Nat. Immunol. 13, 255-263.
65. Suzuki, T., Franchi, L., Toma, C., Ashida, H., Ogawa, M., Yoshikawa, Y., Mimuro, H., Inohara, N., Sasakawa, C., and Nunez, G. (2007). Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathogens 3, e111.
66. van de Veerdonk, F.L., Smeekens, S.P., Joosten, L.A., Kullberg, B. J., Dinarello, C.A., van der Meer, J.W., and Netea, M.G. (2010). Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease. Proc. Natl. Acad. Sci. USA 107, 3030-3033.
67. Vladimer, G.I., Marty-Roix, R., Ghosh, S., Weng, D., and Lien, E. (2013). Inflammasomes and host defenses against bacterial infections. Curr. Opin. Microbiol. 16, 23-31.
68. Wang, Y., Li, Y.B., Yin, J.J., Wang, Y., Zhu, L.B., Xie, G.Y., and Pan, S.H. (2013). Autophagy regulates inflammation following oxidative injury in diabetes. Autophagy 9, 272-277.
69. Weidberg, H., Shvets, E., and Elazar, Z. (2011). Biogenesis and cargo selectivity of autophagosomes. Annu. Rev. Biochem. 80, 125-156.
70. Yin, Y., Pastrana, J.L., Li, X., Huang, X., Mallilankaraman, K., Choi, E.T., Madesh, M., Wang, H., and Yang, X.F. (2013). Inflammasomes: sensors of metabolic stresses for vascular inflammation. Front. Biosci. 18, 638-649.
71. Zhou, R., Tardivel, A., Thorens, B., Choi, I., and Tschopp, J. (2010). Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat. Immunol. 11, 136-140.
72. Zhou, R., Yazdi, A.S., Menu, P., and Tschopp, J. (2011). A role for mitochondria in NLRP3 inflammasome activation. Nature 469, 221-225.