β-Cell inflammation in human type 2 diabetes and the role of autophagy

Diabetes, Obesity and Metabolism

Volumn 15, Issue S3, 2013, Pages 130-136

  Marselli, L ^a   Bugliani, M ^a   Suleiman, M ^a   Olimpico, F ^a   Masini, M ^a   Petrini, M ^a   Boggi, U ^a   Filipponi, F ^a   Syed, F ^a   Marchetti, P ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Autophagy; Inflammation; Pancreatic islets; Type 2 diabetes; cells

Indexed keywords

CHEMOKINE; CYTOKINE; IMATINIB;

APOPTOSIS; AUTOPHAGY; CELL INFILTRATION; CYTOTOXICITY; GENE EXPRESSION; HUMAN; IMMUNOCOMPETENT CELL; INFLAMMATION; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREATIC ISLET INFLAMMATION; PROTEIN EXPRESSION; REVIEW;

AUTOPHAGY; INFLAMMATION; PANCREATIC ISLETS; TYPE 2 DIABETES; Β-CELLS;

ANIMALS; AUTOPHAGY; DIABETES MELLITUS, TYPE 2; GENE EXPRESSION; HUMANS; INFLAMMATION; INSULIN-SECRETING CELLS; NEUTROPHIL INFILTRATION;

EID: 84883505832     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.12152     Document Type: Review

References (47)

1. Donath MY, Böni-Schnetzler M, Ellingsgaard H, Ehses JA. Islet inflammation impairs the pancreatic β-cell in type 2 diabetes. Physiology 2009; 24: 325-331.
2. Donath MY, Ehses JA, Maedler K et al. Mechanisms of β-cell death in type 2 diabetes. Diabetes 2005; 54(Suppl. 2): S108-113.
3. Marchetti P, Lupi R, Del Guerra S et al. Goals of treatment for type 2 diabetes: β-cell preservation for glycemic control. Diabetes Care 2009; 32(Suppl. 2): S178-183.
4. Weir GC, Marselli L, Marchetti P et al. Towards better understanding of the contributions of overwork and glucotoxicity to the β-cell inadequacy of type 2 diabetes. Diabetes Obes Metab 2009; 11(Suppl. 4): 82-90.
5. Zhou XJ, Zhang H. Autophagy in immunity: implications in etiology of autoimmune/autoinflammatory diseases. Autophagy 2012; 8: 1286-1299.
6. Kuballa P, Nolte WM, Castoreno AB, Xavier RJ. Autophagy and the immune system. Annu Rev Immunol 2012; 30: 611-646.
7. Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med 2013; 368: 651-662.
8. Todde V, Veenhuis M, van der Klei IJ. Autophagy: principles and significance in health and disease. Biochim Biophys Acta 2009; 1792: 3-13.
9. Huang J, Klionsky DJ. Autophagy and human disease. Cell Cycle 2007; 6: 1837-1849.
10. Saitoh T, Fujita N, Jang MH et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production. Nature 2008; 456: 264-268.
11. Meng Q, Cai D. Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase β (IKKβ)/NF-kappaB pathway. J Biol Chem 2011; 286: 32324-32332.
12. Choi AJ, Ryter SW. Autophagy in inflammatory diseases. Int J Cell Biol 2011; 2011: 732798.
13. Salminen A, Kaarniranta K, Kauppinen A. Inflammaging: disturbed interplay between autophagy and inflammasomes. Aging 2012; 4: 166-175.
14. Gonzalez CD, Lee MS, Marchetti P et al. The emerging role of autophagy in the pathophysiology of diabetes mellitus. Autophagy 2011; 7: 2-11.
15. Masini M, Bugliani M, Lupi R et al. Autophagy in human type 2 diabetes pancreatic β cells. Diabetologia 2009; 52: 1083-1086.
16. Ehses JA, Perren A, Eppler E et al. Increased number of islet-associated macrophages in type 2 diabetes. Diabetes 2007; 56: 2356-2370.
17. Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG. Islet-associated macrophages in type 2 diabetes. Diabetologia 2009; 52: 1686-1688.
18. Rowe PA, Campbell-Thompson ML, Schatz DA, Atkinson MA. The pancreas in human type 1 diabetes. Semin Immunopathol 2011; 33: 29-43.
19. Skog O, Korsgren S, Melhus A, Korsgren O. Revisiting the notion of type 1 diabetes being a T-cell-mediated autoimmune disease. Curr Opin Endocrinol Diabetes Obes 2013; 20: 118-123.
20. Gunton JE, Kulkarni RN, Yim S et al. Loss of ARNT/HIF1β mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell 2005; 122: 337-349.
21. Taneera J, Lang S, Sharma A et al. A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets. Cell Metab 2012; 16: 122-134.
22. Mahdi T, Hänzelmann S, Salehi A et al. Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes. Cell Metab 2012; 16: 625-633.
23. Bugliani M, Liechti R, Cheon H et al. Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic β cell dysfunction. Mol Cell Endocrinol 2013; 367: 1-10.
24. Welsh N, Cnop M, Kharroubi I et al. Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets? Diabetes 2005; 54: 3238-3244.
25. Johansson U, Olsson A, Gabrielsson S, Nilsson B, Korsgren O. Inflammatory mediators expressed in human islets of Langerhans: implications for islet transplantation. Biochem Biophys Res Commun 2003; 308: 474-479.
26. Huang X, Moore DJ, Ketchum RJ et al. Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation. Endocr Rev 2008; 29: 603-630.
27. Negi S, Jetha A, Aikin R, Hasilo C, Sladek R, Paraskevas S. Analysis of β-cell gene expression reveals inflammatory signaling and evidence of dedifferentiation following human islet isolation and culture. PLoS One 2012; 7: e30415.
28. Erbel S, Reers C, Nawroth PP, Ritzel RA. Prolonged culture of human islets induces ER stress. Exp Clin Endocrinol Diabetes 2010; 118: 81-86.
29. Cabrera O, Berman DM, Kenyon NS, Ricordi C, Berggren PO, Caicedo A. The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci U S A 2006; 103: 2334-2339.
30. Kilimnik G, Jo J, Periwal V, Zielinski MC, Hara M. Quantification of islet size and architecture. Islets 2012; 4: 167-172.
31. Marselli L, Sgroi DC, Bonner-Weir S, Weir GC. Laser capture microdissection of human pancreatic β-cells and RNA preparation for gene expression profiling. Methods Mol Biol 2009; 560: 87-98.
32. Marselli L, Thorne J, Dahiya S et al. Gene expression profiles of β-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes. PLoS One 2010; 5: e11499.
33. Böni-Schnetzler M, Thorne J, Parnaud G et al. Increased interleukin (IL)-1β messenger ribonucleic acid expression in β-cells of individuals with type 2 diabetes and regulation of IL-1β in human islets by glucose and autostimulation. J Clin Endocrinol Metab 2008; 93: 4065-4074.
34. Maedler K, Sergeev P, Ris F et al. Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets. J Clin Invest 2002; 110: 851-860.
35. Igoillo-Esteve M, Marselli L, Cunha DA et al. Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by β cells in type 2 diabetes. Diabetologia 2010; 53: 1395-1405.
36. Jung HS, Chung KW, Won Kim J et al. Loss of autophagy diminishes pancreatic β cell mass and function with resultant hyperglycemia. Cell Metab 2008; 8: 318-324.
37. Ebato C, Uchida T, Arakawa M et al. Autophagy is important in islet homeostasis and compensatory increase of β cell mass in response to high-fat diet. Cell Metab 2008; 8: 325-332.
38. Eizirik DL, Colli ML, Ortis F. The role of inflammation in insulitis and β-cell loss in type 1 diabetes. Nat Rev Endocrinol 2009; 5: 219-226.
39. Banerjee M, Saxena M. Interleukin-1 (IL-1) family of cytokines: role in type 2 diabetes. Clin Chim Acta 2012; 413: 1163-1170.
40. Gump JM, Thorburn A. Autophagy and apoptosis: what is the connection? Trends Cell Biol 2011; 21: 387-392.
41. Moscat J, Diaz-Meco MT. p62 at the crossroads of autophagy, apoptosis, and cancer. Cell 2010; 137: 1001-1004.
42. Chipuk JE, Moldoveanu T, Llambi F, Parsons MJ, Green DR. The BCL-2 family reunion. Mol Cell 2010; 37: 299-310.
43. Pattingre S, Tassa A, Qu X et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122: 927-939.
44. Luo S, Rubinsztein DC. Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. Cell Death Differ 2010; 17: 268-277.
45. Efficace F, Cardoni A, Cottone F, Vignetti M, Mandelli F. Tyrosine-kinase inhibitors and patient-reported outcomes in chronic myeloid leukemia: a systematic review. Leuk Res 2013; 37: 206-213.
46. Elzinga BM, Nyhan MJ, Crowley LC, O'Donovan TR, Cahill MR, McKenna SL. Induction of autophagy by imatinib sequesters Bcr-Abl in autophagosomes and down-regulates Bcr-Abl protein. Am J Hematol 2013; 14: 454-460.
47. Welsh N. Does the small tyrosine kinase inhibitor Imatinib mesylate counteract diabetes by affecting pancreatic islet amyloidosis and fibrosis? Expert Opin Investig Drugs 2012; 21: 1743-1750.