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Volumn 47, Issue 9, 2014, Pages 727-737

Association among genetic predisposition, gut microbiota, and host immune response in the etiopathogenesis of inflammatory bowel disease

Author keywords

Crohn's disease; Etiology; Immune response; Inflammatory bowel disease; Microbiota; Ulcerative colitis

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CHEMOKINE RECEPTOR CCR6; CRYOPYRIN; INTERLEUKIN 12; INTERLEUKIN 23; THYMIC STROMAL LYMPHOPOIETIN; TOLL LIKE RECEPTOR; UVOMORULIN;

EID: 84906485586     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/1414-431X20143932     Document Type: Review
Times cited : (52)

References (90)
  • 1
    • 84874652518 scopus 로고    scopus 로고
    • Geographical variability and environmental risk factors in inflammatory bowel disease
    • doi: 10.1136/gutjnl-2012-303661
    • Ng SC, Bernstein CN, Vatn MH, Lakatos PL, Loftus EV Jr, Tysk C, et al. Geographical variability and environmental risk factors in inflammatory bowel disease. Gut 2013; 62: 630-649, doi: 10.1136/gutjnl-2012-303661.
    • (2013) Gut , vol.62 , pp. 630-649
    • Ng, S.C.1    Bernstein, C.N.2    Vatn, M.H.3    Lakatos, P.L.4    Loftus Jr., E.V.5    Tysk, C.6
  • 2
    • 66449106354 scopus 로고    scopus 로고
    • Incidence and prevalence rates of inflammatory bowel diseases, in midwestern of São Paulo State, Brazil
    • doi: 10.1590/S0004-28032009000100009
    • Victoria CR, Sassak LY, Nunes H.R. Incidence and prevalence rates of inflammatory bowel diseases, in midwestern of São Paulo State, Brazil. Arq Gastroenterol 2009; 46: 20-25, doi: 10.1590/S0004-28032009000100009.
    • (2009) Brazil. Arq Gastroenterol , vol.46 , pp. 20-25
    • Victoria, C.R.1    Sassak, L.Y.2    Nunes, H.R.3
  • 3
    • 34547459989 scopus 로고    scopus 로고
    • The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases
    • doi: 10.1038/sj.gene. 6364398
    • De Jager PL, Franchimont D, Waliszewska A, Bitton A, Cohen A, Langelier D, et al. The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases. Genes Immun 2007; 8: 387-397, doi: 10.1038/sj.gene. 6364398.
    • (2007) Genes Immun , vol.8 , pp. 387-397
    • de Jager, P.L.1    Franchimont, D.2    Waliszewska, A.3    Bitton, A.4    Cohen, A.5    Langelier, D.6
  • 4
    • 29744448927 scopus 로고    scopus 로고
    • Toll-like receptor-1,-2, and-6 polymorphisms influence disease extension in inflammatory bowel diseases
    • doi: 10.1097/01.MIB.0000195389.11645.ab
    • Pierik M, Joossens S, Van Steen K, Van Schuerbeek N, Vlietinck R, Rutgeerts P, et al. Toll-like receptor-1,-2, and-6 polymorphisms influence disease extension in inflammatory bowel diseases. Inflamm Bowel Dis 2006; 12: 1-8, doi: 10.1097/01.MIB.0000195389.11645.ab.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 1-8
    • Pierik, M.1    Joossens, S.2    van Steen, K.3    van Schuerbeek, N.4    Vlietinck, R.5    Rutgeerts, P.6
  • 5
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • doi: 10.1038/35079107
    • Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001; 411: 599-603, doi: 10.1038/35079107.
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3    Lesage, S.4    Cezard, J.P.5    Belaiche, J.6
  • 6
    • 79952195585 scopus 로고    scopus 로고
    • Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
    • doi: 10.1038/ng.764
    • Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 2011; 43: 246-252, doi: 10.1038/ng.764.
    • (2011) Nat Genet , vol.43 , pp. 246-252
    • Anderson, C.A.1    Boucher, G.2    Lees, C.W.3    Franke, A.4    D'Amato, M.5    Taylor, K.D.6
  • 7
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • doi: 10.1038/ng.717
    • Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 2010; 42: 1118-1125, doi: 10.1038/ng.717.
    • (2010) Nat Genet , vol.42 , pp. 1118-1125
    • Franke, A.1    McGovern, D.P.2    Barrett, J.C.3    Wang, K.4    Radford-smith, G.L.5    Ahmad, T.6
  • 8
    • 7244257312 scopus 로고    scopus 로고
    • NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression
    • doi: 10.1136/gut.2003.032805
    • Wehkamp J, Harder J, Weichenthal M, Schwab M, Schaffeler E, Schlee M, et al. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut 2004; 53: 1658-1664, doi: 10.1136/gut.2003.032805.
    • (2004) Gut , vol.53 , pp. 1658-1664
    • Wehkamp, J.1    Harder, J.2    Weichenthal, M.3    Schwab, M.4    Schaffeler, E.5    Schlee, M.6
  • 9
    • 58149159542 scopus 로고    scopus 로고
    • Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
    • doi: 10.1038/ng.285
    • Villani AC, Lemire M, Fortin G, Louis E, Silverberg MS, Collette C, et al. Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. Nat Genet 2009; 41: 71-76, doi: 10.1038/ng.285.
    • (2009) Nat Genet , vol.41 , pp. 71-76
    • Villani, A.C.1    Lemire, M.2    Fortin, G.3    Louis, E.4    Silverberg, M.S.5    Collette, C.6
  • 10
    • 66749106217 scopus 로고    scopus 로고
    • Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: A meta-analysis approach
    • doi: 10.1038/gene.2009.25
    • Palomino-Morales RJ, Oliver J, Gomez-Garcia M, Lopez-Nevot MA, Rodrigo L, Nieto A, et al. Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach. Genes Immun 2009; 10: 356-364, doi: 10.1038/gene.2009.25.
    • (2009) Genes Immun , vol.10 , pp. 356-364
    • Palomino-Morales, R.J.1    Oliver, J.2    Gomez-Garcia, M.3    Lopez-nevot, M.A.4    Rodrigo, L.5    Nieto, A.6
  • 11
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • doi: 10.1038/ng.175
    • Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008; 40: 955-962, doi: 10.1038/ng.175.
    • (2008) Nat Genet , vol.40 , pp. 955-962
    • Barrett, J.C.1    Hansoul, S.2    Nicolae, D.L.3    Cho, J.H.4    Duerr, R.H.5    Rioux, J.D.6
  • 12
    • 84858642947 scopus 로고    scopus 로고
    • PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background
    • doi: 10.1371/journal.pone.0033682
    • Glas J, Wagner J, Seiderer J, Olszak T, Wetzke M, Beigel F, et al. PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background. PLoS One 2012; 7: e33682, doi: 10.1371/journal.pone.0033682.
    • (2012) PLoS One , vol.7
    • Glas, J.1    Wagner, J.2    Seiderer, J.3    Olszak, T.4    Wetzke, M.5    Beigel, F.6
  • 13
    • 82755168804 scopus 로고    scopus 로고
    • Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype
    • doi: 10.1073/pnas.1106408108
    • Rausch P, Rehman A, Kunzel S, Hasler R, Ott SJ, Schreiber S, et al. Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype. Proc Natl Acad Sci U S A 2011; 108: 19030-19035, doi: 10.1073/pnas.1106408108.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 19030-19035
    • Rausch, P.1    Rehman, A.2    Kunzel, S.3    Hasler, R.4    Ott, S.J.5    Schreiber, S.6
  • 14
    • 2342442430 scopus 로고    scopus 로고
    • Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease
    • doi: 10.1136/gut.2003.025403
    • Ott SJ, Musfeldt M, Wenderoth DF, Hampe J, Brant O, Folsch UR, et al. Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease. Gut 2004; 53: 685-693, doi: 10.1136/gut.2003.025403.
    • (2004) Gut , vol.53 , pp. 685-693
    • Ott, S.J.1    Musfeldt, M.2    Wenderoth, D.F.3    Hampe, J.4    Brant, O.5    Folsch, U.R.6
  • 15
    • 78650973052 scopus 로고    scopus 로고
    • High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease
    • doi: 10.1186/1471-2180-11-7
    • Walker AW, Sanderson JD, Churcher C, Parkes GC, Hudspith BN, Rayment N, et al. High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease. BMC Microbiol 2011; 11: 7, doi: 10.1186/1471-2180-11-7.
    • (2011) BMC Microbiol , vol.11 , pp. 7
    • Walker, A.W.1    Sanderson, J.D.2    Churcher, C.3    Parkes, G.C.4    Hudspith, B.N.5    Rayment, N.6
  • 16
    • 66249129571 scopus 로고    scopus 로고
    • Twin studies reveal specific imbalances in the mucosa-associated microbiota of patients with ileal Crohn's disease
    • doi: 10.1002/ibd.20783
    • Willing B, Halfvarson J, Dicksved J, Rosenquist M, Jarnerot G, Engstrand L, et al. Twin studies reveal specific imbalances in the mucosa-associated microbiota of patients with ileal Crohn's disease. Inflamm Bowel Dis 2009; 15: 653-660, doi: 10.1002/ibd.20783.
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 653-660
    • Willing, B.1    Halfvarson, J.2    Dicksved, J.3    Rosenquist, M.4    Jarnerot, G.5    Engstrand, L.6
  • 17
    • 78650099360 scopus 로고    scopus 로고
    • Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases
    • doi: 10.1002/ibd.21339
    • Frank DN, Robertson CE, Hamm CM, Kpadeh Z, Zhang T, Chen H, et al. Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases. Inflamm Bowel Dis 2011; 17: 179-184, doi: 10.1002/ibd.21339.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 179-184
    • Frank, D.N.1    Robertson, C.E.2    Hamm, C.M.3    Kpadeh, Z.4    Zhang, T.5    Chen, H.6
  • 19
    • 0345830652 scopus 로고    scopus 로고
    • Dysbiosis in inflammatory bowel disease
    • doi: 10.1136/gut.53.1.1
    • Tamboli CP, Neut C, Desreumaux P, Colombel J.F. Dysbiosis in inflammatory bowel disease. Gut 2004; 53: 1-4, doi: 10.1136/gut.53.1.1.
    • (2004) Gut , vol.53 , pp. 1-4
    • Tamboli, C.P.1    Neut, C.2    Desreumaux, P.3    Colombel, J.F.4
  • 20
    • 84903376660 scopus 로고    scopus 로고
    • Gut microbiome composition and function in experimental colitis during active disease and treatmentinduced remission
    • Rooks MG, Veiga P, Wardwell-Scott LH, Tickle T, Segata N, Michaud M, et al. Gut microbiome composition and function in experimental colitis during active disease and treatmentinduced remission. ISME J 2014.
    • (2014) ISME J
    • Rooks, M.G.1    Veiga, P.2    Wardwell-Scott, L.H.3    Tickle, T.4    Segata, N.5    Michaud, M.6
  • 21
    • 22144476548 scopus 로고    scopus 로고
    • Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease
    • doi: 10.1128/JCM.43.7.3380-3389. 2005
    • Swidsinski A, Weber J, Loening-Baucke V, Hale LP, Lochs H. Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease. J Clin Microbiol 2005; 43: 3380-3389, doi: 10.1128/JCM.43.7.3380-3389. 2005.
    • (2005) J Clin Microbiol , vol.43 , pp. 3380-3389
    • Swidsinski, A.1    Weber, J.2    Loening-Baucke, V.3    Hale, L.P.4    Lochs, H.5
  • 22
    • 1442327302 scopus 로고    scopus 로고
    • Clindamycin, cephalosporins, fluoroquinolones, and Clostridium difficile-associated diarrhea: This is an antimicrobial resistance problem
    • doi: 10.1086/382084
    • Gerding D.N. Clindamycin, cephalosporins, fluoroquinolones, and Clostridium difficile-associated diarrhea: this is an antimicrobial resistance problem. Clin Infect Dis 2004; 38: 646-648, doi: 10.1086/382084.
    • (2004) Clin Infect Dis , vol.38 , pp. 646-648
    • Gerding, D.N.1
  • 23
    • 84890564250 scopus 로고    scopus 로고
    • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
    • doi: 10.1038/nature12721
    • Furusawa Y, Obata Y, Fukuda S, Endo TA, Nakato G, Takahashi D, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 2013; 504: 446-450, doi: 10.1038/nature12721.
    • (2013) Nature , vol.504 , pp. 446-450
    • Furusawa, Y.1    Obata, Y.2    Fukuda, S.3    Endo, T.A.4    Nakato, G.5    Takahashi, D.6
  • 24
    • 84890550163 scopus 로고    scopus 로고
    • Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
    • doi: 10.1038/nature12726
    • Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, deRoos P, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 2013; 504: 451-455, doi: 10.1038/nature12726.
    • (2013) Nature , vol.504 , pp. 451-455
    • Arpaia, N.1    Campbell, C.2    Fan, X.3    Dikiy, S.4    van der Veeken, J.5    Deroos, P.6
  • 25
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal Th17 cells by segmented filamentous bacteria
    • doi: 10.1016/j.cell.2009.09.033
    • Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 2009; 139: 485-498, doi: 10.1016/j.cell.2009.09.033.
    • (2009) Cell , vol.139 , pp. 485-498
    • Ivanov, I.I.1    Atarashi, K.2    Manel, N.3    Brodie, E.L.4    Shima, T.5    Karaoz, U.6
  • 26
    • 74049122536 scopus 로고    scopus 로고
    • Enteric defensins are essential regulators of intestinal microbial ecology
    • doi: 10.1038/ni.1825
    • Salzman NH, Hung K, Haribhai D, Chu H, Karlsson-Sjoberg J, Amir E, et al. Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol 2010; 11: 76-83, doi: 10.1038/ni.1825.
    • (2010) Nat Immunol , vol.11 , pp. 76-83
    • Salzman, N.H.1    Hung, K.2    Haribhai, D.3    Chu, H.4    Karlsson-Sjoberg, J.5    Amir, E.6
  • 27
    • 84882668842 scopus 로고    scopus 로고
    • Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora
    • doi: 10.1016/j.immuni.2013.08.002
    • Qiu J, Guo X, Chen ZM, He L, Sonnenberg GF, Artis D, et al. Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora. Immunity 2013; 39: 386-399, doi: 10.1016/j.immuni.2013.08.002.
    • (2013) Immunity , vol.39 , pp. 386-399
    • Qiu, J.1    Guo, X.2    Chen, Z.M.3    He, L.4    Sonnenberg, G.F.5    Artis, D.6
  • 28
    • 79959271087 scopus 로고    scopus 로고
    • Intestinal homeostasis and its breakdown in inflammatory bowel disease
    • doi: 10.1038/nature10208
    • Maloy KJ, Powrie F. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature 2011; 474: 298-306, doi: 10.1038/nature10208.
    • (2011) Nature , vol.474 , pp. 298-306
    • Maloy, K.J.1    Powrie, F.2
  • 29
    • 79955839320 scopus 로고    scopus 로고
    • Increased intestinal permeability in inflammatory bowel diseases assessed by iohexol test
    • doi: 10.3748/wjg.v17.i17
    • Gerova VA, Stoynov SG, Katsarov DS, Svinarov D.A. Increased intestinal permeability in inflammatory bowel diseases assessed by iohexol test. World J Gastroenterol 2011; 17: 2211-2215, doi: 10.3748/wjg.v17.i17.
    • (2011) World J Gastroenterol , vol.17 , pp. 2211-2215
    • Gerova, V.A.1    Stoynov, S.G.2    Katsarov, D.S.3    Svinarov, D.A.4
  • 30
    • 84862880940 scopus 로고    scopus 로고
    • Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease
    • doi: 10.1136/gutjnl-2011-300695
    • Kiesslich R, Duckworth CA, Moussata D, Gloeckner A, Lim LG, Goetz M, et al. Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease. Gut 2012; 61: 1146-1153, doi: 10.1136/gutjnl-2011-300695.
    • (2012) Gut , vol.61 , pp. 1146-1153
    • Kiesslich, R.1    Duckworth, C.A.2    Moussata, D.3    Gloeckner, A.4    Lim, L.G.5    Goetz, M.6
  • 31
    • 0034122209 scopus 로고    scopus 로고
    • Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma
    • Mankertz J, Tavalali S, Schmitz H, Mankertz A, Riecken EO, Fromm M, et al. Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma. J Cell Sci 2000; 113 (Part 11): 2085-2090.
    • (2000) J Cell Sci , vol.113 , Issue.PART 11 , pp. 2085-2090
    • Mankertz, J.1    Tavalali, S.2    Schmitz, H.3    Mankertz, A.4    Riecken, E.O.5    Fromm, M.6
  • 32
    • 80052400212 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium
    • doi: 10.1074/jbc.M111.238147
    • Suzuki T, Yoshinaga N, Tanabe S. Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium. J Biol Chem 2011; 286: 31263-31271, doi: 10.1074/jbc.M111.238147.
    • (2011) J Biol Chem , vol.286 , pp. 31263-31271
    • Suzuki, T.1    Yoshinaga, N.2    Tanabe, S.3
  • 33
    • 0034823196 scopus 로고    scopus 로고
    • Mucin gene expression in intestinal epithelial cells in Crohn's disease
    • doi: 10.1136/gut.49.4.544
    • Buisine MP, Desreumaux P, Leteurtre E, Copin MC, Colombel JF, Porchet N, et al. Mucin gene expression in intestinal epithelial cells in Crohn's disease. Gut 2001; 49: 544-551, doi: 10.1136/gut.49.4.544.
    • (2001) Gut , vol.49 , pp. 544-551
    • Buisine, M.P.1    Desreumaux, P.2    Leteurtre, E.3    Copin, M.C.4    Colombel, J.F.5    Porchet, N.6
  • 34
    • 0034445697 scopus 로고    scopus 로고
    • Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease
    • doi: 10.1128/IAI.68.12.7010-7017.2000
    • Cario E, Podolsky D.K. Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun 2000; 68: 7010-7017, doi: 10.1128/IAI.68.12.7010-7017.2000.
    • (2000) Infect Immun , vol.68 , pp. 7010-7017
    • Cario, E.1    Podolsky, D.K.2
  • 35
    • 22344440495 scopus 로고    scopus 로고
    • Expression of Toll-like receptor 9 and response to bacterial CpG oligodeoxynucleotides in human intestinal epithelium
    • doi: 10.1111/j.1365-2249.2005.02848.x
    • Pedersen G, Andresen L, Matthiessen MW, Rask-Madsen J, Brynskov J. Expression of Toll-like receptor 9 and response to bacterial CpG oligodeoxynucleotides in human intestinal epithelium. Clin Exp Immunol 2005; 141: 298-306, doi: 10.1111/j.1365-2249.2005.02848.x.
    • (2005) Clin Exp Immunol , vol.141 , pp. 298-306
    • Pedersen, G.1    Andresen, L.2    Matthiessen, M.W.3    Rask-Madsen, J.4    Brynskov, J.5
  • 36
    • 0036080092 scopus 로고    scopus 로고
    • Toll-like receptors 2 and 4 are upregulated during intestinal inflammation
    • doi: 10.1053/gast.2002.33662
    • Hausmann M, Kiessling S, Mestermann S, Webb G, Spottl T, Andus T, et al. Toll-like receptors 2 and 4 are upregulated during intestinal inflammation. Gastroenterology 2002; 122: 1987-2000, doi: 10.1053/gast.2002.33662.
    • (2002) Gastroenterology , vol.122 , pp. 1987-2000
    • Hausmann, M.1    Kiessling, S.2    Mestermann, S.3    Webb, G.4    Spottl, T.5    Andus, T.6
  • 37
    • 20844463064 scopus 로고    scopus 로고
    • A synthetic TLR4 antagonist has antiinflammatory effects in two murine models of inflammatory bowel disease
    • doi: 10.4049/jimmunol.174.10.6416
    • Fort MM, Mozaffarian A, Stover AG, Correia JS, Johnson DA, Crane RT, et al. A synthetic TLR4 antagonist has antiinflammatory effects in two murine models of inflammatory bowel disease. J Immunol 2005; 174: 6416-6423, doi: 10.4049/jimmunol.174.10.6416.
    • (2005) J Immunol , vol.174 , pp. 6416-6423
    • Fort, M.M.1    Mozaffarian, A.2    Stover, A.G.3    Correia, J.S.4    Johnson, D.A.5    Crane, R.T.6
  • 38
    • 67650514274 scopus 로고    scopus 로고
    • Epistasis between Toll-like receptor-9 polymorphisms and variants in NOD2 and IL23R modulates susceptibility to Crohn's disease
    • doi: 10.1038/ajg.2009.184
    • Torok HP, Glas J, Endres I, Tonenchi L, Teshome MY, Wetzke M, et al. Epistasis between Toll-like receptor-9 polymorphisms and variants in NOD2 and IL23R modulates susceptibility to Crohn's disease. Am J Gastroenterol 2009; 104: 1723-1733, doi: 10.1038/ajg.2009.184.
    • (2009) Am J Gastroenterol , vol.104 , pp. 1723-1733
    • Torok, H.P.1    Glas, J.2    Endres, I.3    Tonenchi, L.4    Teshome, M.Y.5    Wetzke, M.6
  • 39
    • 73849151394 scopus 로고    scopus 로고
    • NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
    • doi: 10.1038/nm.2069
    • Cooney R, Baker J, Brain O, Danis B, Pichulik T, Allan P, et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med 2010; 16: 90-97, doi: 10.1038/nm.2069.
    • (2010) Nat Med , vol.16 , pp. 90-97
    • Cooney, R.1    Baker, J.2    Brain, O.3    Danis, B.4    Pichulik, T.5    Allan, P.6
  • 40
    • 84888123097 scopus 로고    scopus 로고
    • Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes
    • doi: 10.1084/jem.20122490
    • Jiang W, Wang X, Zeng B, Liu L, Tardivel A, Wei H, et al. Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes. J Exp Med 2013; 210: 2465-2476, doi: 10.1084/jem.20122490.
    • (2013) J Exp Med , vol.210 , pp. 2465-2476
    • Jiang, W.1    Wang, X.2    Zeng, B.3    Liu, L.4    Tardivel, A.5    Wei, H.6
  • 41
  • 42
    • 84895098842 scopus 로고    scopus 로고
    • Nod2 deficiency is associated with an increased mucosal immunoregulatory response to commensal microorganisms
    • doi: 10.1038/mi. 2013.58
    • Amendola A, Butera A, Sanchez M, Strober W, Boirivant M. Nod2 deficiency is associated with an increased mucosal immunoregulatory response to commensal microorganisms. Mucosal Immunol 2014; 7: 391-404, doi: 10.1038/mi. 2013.58.
    • (2014) Mucosal Immunol , vol.7 , pp. 391-404
    • Amendola, A.1    Butera, A.2    Sanchez, M.3    Strober, W.4    Boirivant, M.5
  • 43
    • 12244297799 scopus 로고    scopus 로고
    • CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance
    • doi: 10.1126/science.1102901
    • Niess JH, Brand S, Gu X, Landsman L, Jung S, McCormick BA, et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 2005; 307: 254-258, doi: 10.1126/science.1102901.
    • (2005) Science , vol.307 , pp. 254-258
    • Niess, J.H.1    Brand, S.2    Gu, X.3    Landsman, L.4    Jung, S.5    McCormick, B.A.6
  • 44
    • 77952794397 scopus 로고    scopus 로고
    • Securing the immune tightrope: Mononuclear phagocytes in the intestinal lamina propria
    • doi: 10.1038/nri2778
    • Varol C, Zigmond E, Jung S. Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria. Nat Rev Immunol 2010; 10: 415-426, doi: 10.1038/nri2778.
    • (2010) Nat Rev Immunol , vol.10 , pp. 415-426
    • Varol, C.1    Zigmond, E.2    Jung, S.3
  • 45
    • 26844468978 scopus 로고    scopus 로고
    • Essential role for CD103 in the T cell-mediated regulation of experimental colitis
    • doi: 10.1084/jem.20040662
    • Annacker O, Coombes JL, Malmstrom V, Uhlig HH, Bourne T, Johansson-Lindbom B, et al. Essential role for CD103 in the T cell-mediated regulation of experimental colitis. J Exp Med 2005; 202: 1051-1061, doi: 10.1084/jem.20040662.
    • (2005) J Exp Med , vol.202 , pp. 1051-1061
    • Annacker, O.1    Coombes, J.L.2    Malmstrom, V.3    Uhlig, H.H.4    Bourne, T.5    Johansson-Lindbom, B.6
  • 46
    • 77951934151 scopus 로고    scopus 로고
    • E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis
    • doi: 10.1016/j.immuni.2010.03.017
    • Siddiqui KR, Laffont S, Powrie F. E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. Immunity 2010; 32: 557-567, doi: 10.1016/j.immuni.2010.03.017.
    • (2010) Immunity , vol.32 , pp. 557-567
    • Siddiqui, K.R.1    Laffont, S.2    Powrie, F.3
  • 47
    • 67651233961 scopus 로고    scopus 로고
    • Exaggerated inflammatory response of primary human myeloid dendritic cells to lipopolysaccharide in patients with inflammatory bowel disease
    • doi: 10.1111/j.1365-2249. 2009.03981.x
    • Baumgart DC, Thomas S, Przesdzing I, Metzke D, Bielecki C, Lehmann SM, et al. Exaggerated inflammatory response of primary human myeloid dendritic cells to lipopolysaccharide in patients with inflammatory bowel disease. Clin Exp Immunol 2009; 157: 423-436, doi: 10.1111/j.1365-2249. 2009.03981.x.
    • (2009) Clin Exp Immunol , vol.57 , pp. 423-436
    • Baumgart, D.C.1    Thomas, S.2    Przesdzing, I.3    Metzke, D.4    Bielecki, C.5    Lehmann, S.M.6
  • 48
    • 75949104055 scopus 로고    scopus 로고
    • TGFbeta1 gene-modified, immature dendritic cells delay the development of inflammatory bowel disease by inducing CD4(+)Foxp3(+) regulatory T cells
    • doi: 10.1038/cmi.2009.107
    • Cai Z, Zhang W, Li M, Yue Y, Yang F, Yu L, et al. TGFbeta1 gene-modified, immature dendritic cells delay the development of inflammatory bowel disease by inducing CD4(+)Foxp3(+) regulatory T cells. Cell Mol Immunol 2010; 7: 35-43, doi: 10.1038/cmi.2009.107.
    • (2010) Cell Mol Immunol , vol.7 , pp. 35-43
    • Cai, Z.1    Zhang, W.2    Li, M.3    Yue, Y.4    Yang, F.5    Yu, L.6
  • 49
    • 84876349699 scopus 로고    scopus 로고
    • Resident and pro-inflammatory macrophages in the colon represent alternative contextdependent fates of the same Ly6Chi monocyte precursors
    • doi: 10.1038/mi. 2012.89
    • Bain CC, Scott CL, Uronen-Hansson H, Gudjonsson S, Jansson O, Grip O, et al. Resident and pro-inflammatory macrophages in the colon represent alternative contextdependent fates of the same Ly6Chi monocyte precursors. Mucosal Immunol 2013; 6: 498-510, doi: 10.1038/mi. 2012.89.
    • (2013) Mucosal Immunol , vol.6 , pp. 498-510
    • Bain, C.C.1    Scott, C.L.2    Uronen-Hansson, H.3    Gudjonsson, S.4    Jansson, O.5    Grip, O.6
  • 50
    • 34948821265 scopus 로고    scopus 로고
    • TREM-1-expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases
    • doi: 10.1172/JCI30602
    • Schenk M, Bouchon A, Seibold F, Mueller C. TREM-1-expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J Clin Invest 2007; 117: 3097-3106, doi: 10.1172/JCI30602.
    • (2007) J Clin Invest , vol.117 , pp. 3097-3106
    • Schenk, M.1    Bouchon, A.2    Seibold, F.3    Mueller, C.4
  • 51
    • 66149159613 scopus 로고    scopus 로고
    • Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease
    • doi: 10.1002/ibd.20923
    • Liu Z, Yang L, Cui Y, Wang X, Guo C, Huang Z, et al. Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease. Inflamm Bowel Dis 2009; 15: 1133-1144, doi: 10.1002/ibd.20923.
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 1133-1144
    • Liu, Z.1    Yang, L.2    Cui, Y.3    Wang, X.4    Guo, C.5    Huang, Z.6
  • 52
    • 77956190936 scopus 로고    scopus 로고
    • Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease
    • doi: 10.1053/j.gastro. 2010.05.040
    • Takayama T, Kamada N, Chinen H, Okamoto S, Kitazume MT, Chang J, et al. Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease. Gastroenterology 2010; 139: 882-92, 892, doi: 10.1053/j.gastro. 2010.05.040.
    • Gastroenterology , vol.2010 , Issue.139
    • Takayama, T.1    Kamada, N.2    Chinen, H.3    Okamoto, S.4    Kitazume, M.T.5    Chang, J.6
  • 53
    • 57849131584 scopus 로고    scopus 로고
    • Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells
    • doi: 10.1038/ni.1668
    • Cupedo T, Crellin NK, Papazian N, Rombouts EJ, Weijer K, Grogan JL, et al. Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells. Nat Immunol 2009; 10: 66-74, doi: 10.1038/ni.1668.
    • (2009) Nat Immunol , vol.10 , pp. 66-74
    • Cupedo, T.1    Crellin, N.K.2    Papazian, N.3    Rombouts, E.J.4    Weijer, K.5    Grogan, J.L.6
  • 54
    • 77951878587 scopus 로고    scopus 로고
    • Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
    • doi: 10.1038/nature08949
    • Buonocore S, Ahern PP, Uhlig HH, Ivanov II, Littman DR, Maloy KJ, et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 2010; 464: 1371-1375, doi: 10.1038/nature08949.
    • (2010) Nature , vol.464 , pp. 1371-1375
    • Buonocore, S.1    Ahern, P.P.2    Uhlig, H.H.3    Ivanov, I.I.4    Littman, D.R.5    Maloy, K.J.6
  • 55
    • 84855917402 scopus 로고    scopus 로고
    • AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch
    • doi: 10.1038/ni.2187
    • Lee JS, Cella M, McDonald KG, Garlanda C, Kennedy GD, Nukaya M, et al. AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nat Immunol 2012; 13: 144-151, doi: 10.1038/ni.2187.
    • (2012) Nat Immunol , vol.13 , pp. 144-151
    • Lee, J.S.1    Cella, M.2    McDonald, K.G.3    Garlanda, C.4    Kennedy, G.D.5    Nukaya, M.6
  • 56
    • 79952986650 scopus 로고    scopus 로고
    • RORgammat+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota
    • doi: 10.1038/ni.2002
    • Sawa S, Lochner M, Satoh-Takayama N, Dulauroy S, Berard M, Kleinschek M, et al. RORgammat+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota. Nat Immunol 2011; 12: 320-326, doi: 10.1038/ni.2002.
    • (2011) Nat Immunol , vol.12 , pp. 320-326
    • Sawa, S.1    Lochner, M.2    Satoh-Takayama, N.3    Dulauroy, S.4    Berard, M.5    Kleinschek, M.6
  • 57
    • 57449090428 scopus 로고    scopus 로고
    • Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
    • doi: 10.1016/j.immuni. 2008.11.003
    • Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, Flavell R.A. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 2008; 29: 947-957, doi: 10.1016/j.immuni. 2008.11.003.
    • (2008) Immunity , vol.29 , pp. 947-957
    • Zenewicz, L.A.1    Yancopoulos, G.D.2    Valenzuela, D.M.3    Murphy, A.J.4    Stevens, S.5    Flavell, R.A.6
  • 58
    • 0030209985 scopus 로고    scopus 로고
    • Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • Fuss IJ, Neurath M, Boirivant M, Klein JS, de la Motte C, Strong SA, et al. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 1996; 157: 1261-1270.
    • (1996) J Immunol , vol.157 , pp. 1261-1270
    • Fuss, I.J.1    Neurath, M.2    Boirivant, M.3    Klein, J.S.4    de la Motte, C.5    Strong, S.A.6
  • 59
    • 84862190159 scopus 로고    scopus 로고
    • Compartmentalized expression of Th1 and Th17 cytokines in pediatric inflammatory bowel diseases
    • doi: 10.1002/ibd.21905
    • Verdier J, Begue B, Cerf-Bensussan N, Ruemmele F.M. Compartmentalized expression of Th1 and Th17 cytokines in pediatric inflammatory bowel diseases. Inflamm Bowel Dis 2012; 18: 1260-1266, doi: 10.1002/ibd.21905.
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 1260-1266
    • Verdier, J.1    Begue, B.2    Cerf-Bensussan, N.3    Ruemmele, F.M.4
  • 60
    • 0028861975 scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • doi: 10.1084/jem.182.5.1281
    • Neurath MF, Fuss I, Kelsall BL, Stuber E, Strober W. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 1995; 182: 1281-1290, doi: 10.1084/jem.182.5.1281.
    • (1995) J Exp Med , vol.182 , pp. 1281-1290
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3    Stuber, E.4    Strober, W.5
  • 61
    • 84893739015 scopus 로고    scopus 로고
    • Comparison of experimental mouse models of inflammatory bowel disease
    • Oh SY, Cho KA, Kang JL, Kim KH, Woo S.Y. Comparison of experimental mouse models of inflammatory bowel disease. Int J Mol Med 2014; 33: 333-340.
    • (2014) Int J Mol Med , vol.33 , pp. 333-340
    • Oh, S.Y.1    Cho, K.A.2    Kang, J.L.3    Kim, K.H.4    Woo, S.Y.5
  • 62
    • 84873735168 scopus 로고    scopus 로고
    • Increased levels of circulating Th17 cells in quiescent versus active Crohn's disease
    • doi: 10.1016/j.crohns.2012.06.015
    • Dige A, Stoy S, Rasmussen TK, Kelsen J, Hvas CL, Sandahl TD, et al. Increased levels of circulating Th17 cells in quiescent versus active Crohn's disease. J Crohns Colitis 2013; 7: 248-255, doi: 10.1016/j.crohns.2012.06.015.
    • (2013) J Crohns Colitis , vol.7 , pp. 248-255
    • Dige, A.1    Stoy, S.2    Rasmussen, T.K.3    Kelsen, J.4    Hvas, C.L.5    Sandahl, T.D.6
  • 63
    • 54449102022 scopus 로고    scopus 로고
    • Involvement of IL-17A in the pathogenesis of DSSinduced colitis in mice
    • doi: 10.1016/j.bbrc.2008.09.019
    • Ito R, Kita M, Shin-Ya M, Kishida T, Urano A, Takada R, et al. Involvement of IL-17A in the pathogenesis of DSSinduced colitis in mice. Biochem Biophys Res Commun 2008; 377: 12-16, doi: 10.1016/j.bbrc.2008.09.019.
    • (2008) Biochem Biophys Res Commun , vol.377 , pp. 12-16
    • Ito, R.1    Kita, M.2    Shin-Ya, M.3    Kishida, T.4    Urano, A.5    Takada, R.6
  • 64
    • 41349121555 scopus 로고    scopus 로고
    • Regulation of gut inflammation and th17 cell response by interleukin-21
    • doi: 10.1053/j.gastro.2008.01.041
    • Fina D, Sarra M, Fantini MC, Rizzo A, Caruso R, Caprioli F, et al. Regulation of gut inflammation and th17 cell response by interleukin-21. Gastroenterology 2008; 134: 1038-1048, doi: 10.1053/j.gastro.2008.01.041.
    • (2008) Gastroenterology , vol.134 , pp. 1038-1048
    • Fina, D.1    Sarra, M.2    Fantini, M.C.3    Rizzo, A.4    Caruso, R.5    Caprioli, F.6
  • 65
    • 33750505009 scopus 로고    scopus 로고
    • Interleukin-23 drives innate and T cellmediated intestinal inflammation
    • doi: 10.1084/jem.20061099
    • Hue S, Ahern P, Buonocore S, Kullberg MC, Cua DJ, McKenzie BS, et al. Interleukin-23 drives innate and T cellmediated intestinal inflammation. J Exp Med 2006; 203: 2473-2483, doi: 10.1084/jem.20061099.
    • (2006) J Exp Med , vol.203 , pp. 2473-2483
    • Hue, S.1    Ahern, P.2    Buonocore, S.3    Kullberg, M.C.4    Cua, D.J.5    McKenzie, B.S.6
  • 66
    • 34250026960 scopus 로고    scopus 로고
    • Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice
    • doi: 10.1053/j.gastro.2007.03.104
    • Elson CO, Cong Y, Weaver CT, Schoeb TR, McClanahan TK, Fick RB, et al. Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology 2007; 132: 2359-2370, doi: 10.1053/j.gastro.2007.03.104.
    • (2007) Gastroenterology , vol.132 , pp. 2359-2370
    • Elson, C.O.1    Cong, Y.2    Weaver, C.T.3    Schoeb, T.R.4    McClanahan, T.K.5    Fick, R.B.6
  • 67
    • 77956222219 scopus 로고    scopus 로고
    • Human Th17 cells comprise heterogeneous subsets including IFNgamma-producing cells with distinct properties from the Th1 lineage
    • doi: 10.4049/jimmunol.1000366
    • Boniface K, Blumenschein WM, Brovont-Porth K, McGeachy MJ, Basham B, Desai B, et al. Human Th17 cells comprise heterogeneous subsets including IFNgamma-producing cells with distinct properties from the Th1 lineage. J Immunol 2010; 185: 679-687, doi: 10.4049/jimmunol.1000366.
    • (2010) J Immunol , vol.185 , pp. 679-687
    • Boniface, K.1    Blumenschein, W.M.2    Brovont-Porth, K.3    McGeachy, M.J.4    Basham, B.5    Desai, B.6
  • 68
    • 0032538915 scopus 로고    scopus 로고
    • Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4
    • doi: 10.1084/jem.188.10.1929
    • Boirivant M, Fuss IJ, Chu A, Strober W. Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J Exp Med 1998; 188: 1929-1939, doi: 10.1084/jem.188.10.1929.
    • (1998) J Exp Med , vol.188 , pp. 1929-1939
    • Boirivant, M.1    Fuss, I.J.2    Chu, A.3    Strober, W.4
  • 69
    • 0036850908 scopus 로고    scopus 로고
    • Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells
    • doi: 10.1016/S1074-7613(02) 00453-3
    • Heller F, Fuss IJ, Nieuwenhuis EE, Blumberg RS, Strober W. Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity 2002; 17: 629-638, doi: 10.1016/S1074-7613(02) 00453-3.
    • (2002) Immunity , vol.17 , pp. 629-638
    • Heller, F.1    Fuss, I.J.2    Nieuwenhuis, E.E.3    Blumberg, R.S.4    Strober, W.5
  • 70
    • 84856235126 scopus 로고    scopus 로고
    • Dysregulation of CD1d-restricted type ii natural killer T cells leads to spontaneous development of colitis in mice
    • doi: 10.1053/j.gastro.2011.10.030
    • Liao CM, Zimmer MI, Shanmuganad S, Yu HT, Cardell SL, Wang C.R. dysregulation of CD1d-restricted type ii natural killer T cells leads to spontaneous development of colitis in mice. Gastroenterology 2012; 142: 326-334, doi: 10.1053/j.gastro.2011.10.030.
    • (2012) Gastroenterology , vol.142 , pp. 326-334
    • Liao, C.M.1    Zimmer, M.I.2    Shanmuganad, S.3    Yu, H.T.4    Cardell, S.L.5    Wang, C.R.6
  • 71
    • 85047690640 scopus 로고    scopus 로고
    • Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
    • doi: 10.1172/JCI19836
    • Fuss IJ, Heller F, Boirivant M, Leon F, Yoshida M, Fichtner-Feigl S, et al. Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest 2004; 113: 1490-1497, doi: 10.1172/JCI19836.
    • (2004) J Clin Invest , vol.113 , pp. 1490-1497
    • Fuss, I.J.1    Heller, F.2    Boirivant, M.3    Leon, F.4    Yoshida, M.5    Fichtner-feigl, S.6
  • 72
    • 84877742439 scopus 로고    scopus 로고
    • Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota
    • doi: 10.1038/nature12079
    • Cebula A, Seweryn M, Rempala GA, Pabla SS, McIndoe RA, Denning TL, et al. Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota. Nature 2013; 497: 258-262, doi: 10.1038/nature12079.
    • (2013) Nature , vol.497 , pp. 258-262
    • Cebula, A.1    Seweryn, M.2    Rempala, G.A.3    Pabla, S.S.4    McIndoe, R.A.5    Denning, T.L.6
  • 73
    • 0037446531 scopus 로고    scopus 로고
    • Cutting edge: Cure of colitis by CD4+CD25+ regulatory T cells
    • doi: 10.4049/jimmunol.170.8.3939
    • Mottet C, Uhlig HH, Powrie F. Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol 2003; 170: 3939-3943, doi: 10.4049/jimmunol.170.8.3939.
    • (2003) J Immunol , vol.170 , pp. 3939-3943
    • Mottet, C.1    Uhlig, H.H.2    Powrie, F.3
  • 74
    • 84873990764 scopus 로고    scopus 로고
    • Tregs are dysfunctional in vivo in a spontaneous murine model of Crohn's disease
    • doi: 10.1038/mi.2012.67
    • Ishikawa D, Okazawa A, Corridoni D, Jia LG, Wang XM, Guanzon M, et al. Tregs are dysfunctional in vivo in a spontaneous murine model of Crohn's disease. Mucosal Immunol 2013; 6: 267-275, doi: 10.1038/mi.2012.67.
    • (2013) Mucosal Immunol , vol.6 , pp. 267-275
    • Ishikawa, D.1    Okazawa, A.2    Corridoni, D.3    Jia, L.G.4    Wang, X.M.5    Guanzon, M.6
  • 75
    • 0029956024 scopus 로고    scopus 로고
    • A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells
    • doi: 10.1084/jem.183.6.2669
    • Powrie F, Carlino J, Leach MW, Mauze S, Coffman R.L. A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J Exp Med 1996; 183: 2669-2674, doi: 10.1084/jem.183.6.2669.
    • (1996) J Exp Med , vol.183 , pp. 2669-2674
    • Powrie, F.1    Carlino, J.2    Leach, M.W.3    Mauze, S.4    Coffman, R.L.5
  • 76
    • 33750375612 scopus 로고    scopus 로고
    • Characterization of Foxp3CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis
    • doi: 10.4049/jimmunol.177.9.5852
    • Uhlig HH, Coombes J, Mottet C, Izcue A, Thompson C, Fanger A, et al. Characterization of Foxp3CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis. J Immunol 2006; 177: 5852-5860, doi: 10.4049/jimmunol.177.9.5852.
    • (2006) J Immunol , vol.177 , pp. 5852-5860
    • Uhlig, H.H.1    Coombes, J.2    Mottet, C.3    Izcue, A.4    Thompson, C.5    Fanger, A.6
  • 77
    • 0034131557 scopus 로고    scopus 로고
    • Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
    • doi: 10.1016/S1074-7613(00)80170-3
    • Gorelik L, Flavell R.A. Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 2000; 12: 171-181, doi: 10.1016/S1074-7613(00)80170-3.
    • (2000) Immunity , vol.12 , pp. 171-181
    • Gorelik, L.1    Flavell, R.A.2
  • 78
    • 62949223226 scopus 로고    scopus 로고
    • Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression
    • doi: 10.1053/j.gastro.2008.12.053
    • Fantini MC, Rizzo A, Fina D, Caruso R, Sarra M, Stolfi C, et al. Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression. Gastroenterology 2009; 136: 1308-1316, doi: 10.1053/j.gastro.2008.12.053.
    • (2009) Gastroenterology , vol.136 , pp. 1308-1316
    • Fantini, M.C.1    Rizzo, A.2    Fina, D.3    Caruso, R.4    Sarra, M.5    Stolfi, C.6
  • 79
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • doi: 10.1016/0092-8674(93)80068-P
    • Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993; 75: 263-274, doi: 10.1016/0092-8674(93)80068-P.
    • (1993) Cell , vol.75 , pp. 263-274
    • Kuhn, R.1    Lohler, J.2    Rennick, D.3    Rajewsky, K.4    Muller, W.5
  • 80
    • 70949087383 scopus 로고    scopus 로고
    • Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
    • doi: 10.1056/NEJMoa0907206
    • Glocker EO, Kotlarz D, Boztug K, Gertz EM, Schaffer AA, Noyan F, et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med 2009; 361: 2033-2045, doi: 10.1056/NEJMoa0907206.
    • (2009) N Engl J Med , vol.361 , pp. 2033-2045
    • Glocker, E.O.1    Kotlarz, D.2    Boztug, K.3    Gertz, E.M.4    Schaffer, A.A.5    Noyan, F.6
  • 81
    • 57249097253 scopus 로고    scopus 로고
    • Clinical and molecular profile of a new series of patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: Inconsistent correlation between forkhead box protein 3 expression and disease severity
    • doi: 10.1016/j.jaci.2008.09.027
    • Gambineri E, Perroni L, Passerini L, Bianchi L, Doglioni C, Meschi F, et al. Clinical and molecular profile of a new series of patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: inconsistent correlation between forkhead box protein 3 expression and disease severity. J Allergy Clin Immunol 2008; 122: 1105-1112, doi: 10.1016/j.jaci.2008.09.027.
    • (2008) J Allergy Clin Immunol , vol.122 , pp. 1105-1112
    • Gambineri, E.1    Perroni, L.2    Passerini, L.3    Bianchi, L.4    Doglioni, C.5    Meschi, F.6
  • 82
    • 77249137663 scopus 로고    scopus 로고
    • Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease
    • doi: 10.1007/s10875-009-9345-1
    • Eastaff-Leung N, Mabarrack N, Barbour A, Cummins A, Barry S. Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease. J Clin Immunol 2010; 30: 80-89, doi: 10.1007/s10875-009-9345-1.
    • (2010) J Clin Immunol , vol.30 , pp. 80-89
    • Eastaff-Leung, N.1    Mabarrack, N.2    Barbour, A.3    Cummins, A.4    Barry, S.5
  • 83
    • 84888333449 scopus 로고    scopus 로고
    • Increased prevalence of circulating novel IL-17 secreting Foxp3 expressing CD4+ T cells and defective suppressive function of circulating Foxp3+ regulatory cells support plasticity between Th17 and regulatory T cells in inflammatory bowel disease patients
    • doi: 10.1097/MIB.0b013e3182a85709
    • Ueno A, Jijon H, Chan R, Ford K, Hirota C, Kaplan GG, et al. Increased prevalence of circulating novel IL-17 secreting Foxp3 expressing CD4+ T cells and defective suppressive function of circulating Foxp3+ regulatory cells support plasticity between Th17 and regulatory T cells in inflammatory bowel disease patients. Inflamm Bowel Dis 2013; 19: 2522-2534, doi: 10.1097/MIB.0b013e3182a85709.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 2522-2534
    • Ueno, A.1    Jijon, H.2    Chan, R.3    Ford, K.4    Hirota, C.5    Kaplan, G.G.6
  • 84
    • 80052573212 scopus 로고    scopus 로고
    • Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNFalpha treatment
    • doi: 10.1136/gut.2010.217117
    • Veltkamp C, Anstaett M, Wahl K, Moller S, Gangl S, Bachmann O, et al. Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNFalpha treatment. Gut 2011; 60: 1345-1353, doi: 10.1136/gut.2010.217117.
    • (2011) Gut , vol.60 , pp. 1345-1353
    • Veltkamp, C.1    Anstaett, M.2    Wahl, K.3    Moller, S.4    Gangl, S.5    Bachmann, O.6
  • 85
    • 33846375082 scopus 로고    scopus 로고
    • Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells
    • doi: 10.1002/eji.200636435
    • Wang J, Ioan-Facsinay A, van d, V, Huizinga TW, Toes R.E. Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells. Eur J Immunol 2007; 37: 129-138, doi: 10.1002/eji.200636435.
    • (2007) Eur J Immunol , vol.37 , pp. 129-138
    • Wang, J.1    Ioan-Facsinay, A.2    van d, V.3    Huizinga, T.W.4    Toes, R.E.5
  • 86
    • 49849094011 scopus 로고    scopus 로고
    • Natural and TGF-betainduced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other
    • doi: 10.1016/j.it.2008.06.005
    • Horwitz DA, Zheng SG, Gray J.D. Natural and TGF-betainduced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other. Trends Immunol 2008; 29: 429-435, doi: 10.1016/j.it.2008.06.005.
    • (2008) Trends Immunol , vol.29 , pp. 429-435
    • Horwitz, D.A.1    Zheng, S.G.2    Gray, J.D.3
  • 87
    • 65549136983 scopus 로고    scopus 로고
    • Mechanisms of foxp3+ T regulatory cellmediated suppression
    • doi: 10.1016/j.immuni.2009.04.010
    • Shevach E.M. Mechanisms of foxp3+ T regulatory cellmediated suppression. Immunity 2009; 30: 636-645, doi: 10.1016/j.immuni.2009.04.010.
    • (2009) Immunity , vol.30 , pp. 636-645
    • Shevach, E.M.1
  • 88
    • 79954620910 scopus 로고    scopus 로고
    • Th17 cells express interleukin-10 receptor and are controlled by Foxp3(-) and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner
    • doi: 10.1016/j.immuni.2011.01.020
    • Huber S, Gagliani N, Esplugues E, O'Connor W Jr, Huber FJ, Chaudhry A, et al. Th17 cells express interleukin-10 receptor and are controlled by Foxp3(-) and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity 2011; 34: 554-565, doi: 10.1016/j.immuni.2011.01.020.
    • (2011) Immunity , vol.34 , pp. 554-565
    • Huber, S.1    Gagliani, N.2    Esplugues, E.3    O'Connor Jr., W.4    Huber, F.J.5    Chaudhry, A.6
  • 89
    • 84863643114 scopus 로고    scopus 로고
    • Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon
    • doi: 10.1371/journal.ppat.1002714
    • Jeon SG, Kayama H, Ueda Y, Takahashi T, Asahara T, Tsuji H, et al. Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon. PLoS Pathog 2012; 8: e1002714, doi: 10.1371/journal.ppat.1002714.
    • (2012) PLoS Pathog , vol.8
    • Jeon, S.G.1    Kayama, H.2    Ueda, Y.3    Takahashi, T.4    Asahara, T.5    Tsuji, H.6
  • 90
    • 77954738601 scopus 로고    scopus 로고
    • Inducible Foxp3+ regulatory Tcell development by a commensal bacterium of the intestinal microbiota
    • doi: 10.1073/pnas.0909122107
    • Round JL, Mazmanian S.K. Inducible Foxp3+ regulatory Tcell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci U S A 2010; 107: 12204-12209, doi: 10.1073/pnas.0909122107.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 12204-12209
    • Round, J.L.1    Mazmanian, S.K.2


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