Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease

Gut

Volumn 61, Issue 8, 2012, Pages 1146-1153

  Kiesslich, R ^a   Duckworth, C A ^b   Moussata, D ^c   Gloeckner, A ^a   Lim, L G ^d   Goetz, M ^a   Pritchard, D M ^b   Galle, P R ^a   Neurath, M F ^e   Watson, A J M ^f  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c UNIVERSITÉ LYON 1   (France)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^f UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE;

ANIMAL EXPERIMENT; ARTICLE; CELL DAMAGE; CONFOCAL LASER MICROSCOPY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CROHN DISEASE; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; DISEASE CLASSIFICATION; DISEASE EXACERBATION; ENTERITIS; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; INTESTINE INJURY; INTESTINE MUCOSA; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RELAPSE; REMISSION; SENSITIVITY AND SPECIFICITY; ULCERATIVE COLITIS;

ADULT; DISEASE PROGRESSION; ENDOSCOPY, GASTROINTESTINAL; FEMALE; FLUORESCEIN; FLUORESCENT DYES; HUMANS; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; PILOT PROJECTS; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES; RECURRENCE;

EID: 84862880940     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2011-300695     Document Type: Article

References (40)

1. Duerksen DR, Wilhelm-Boyles C, Parry DM. Intestinal permeability in long-term follow-up of patients with celiac disease on a gluten-free diet. Dig Dis Sci 2005;50:785-90.
2. Berkes J, Viswanathan VK, Savkovic SD, et al. Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation. Gut 2003;52:439-51.
3. Meddings J. The significance of the gut barrier in disease. Gut 2008;57: 438-40.
4. Marchiando AM, Graham WV, Turner JR. Epithelial barriers in homeostasis and disease. Annu Rev Pathol 2010;5:119-44.
5. Peeters M, Ghoos Y, Maes B, et al. Increased permeability of macroscopically normal small bowel in Crohn's disease. Dig Dis Sci 1994;39:2170-6.
6. Peeters M, Geypens B, Claus D, et al. Clustering of increased small intestinal permeability in families with Crohn's disease. Gastroenterology 1997;113:802-7.
7. May GR, Sutherland LR, Meddings JB. Is small intestinal permeability really increased in relatives of patients with Crohn's disease? Gastroenterology 1993;104:1627-32.
8. Wyatt J, Vogelsang H, Hubl W, et al. Intestinal permeability and the prediction of relapse in Crohn's disease. Lancet 1993;341:1437-9.
9. Zeissig S, Burgel N, Gunzel D, et al. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 2007;56:61-72.
10. Marchiando AM, Shen L, Graham WV, et al. Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. J Cell Biol 2010;189:111-26.
11. Su L, Shen L, Clayburgh DR, et al. Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. Gastroenterology 2009;136:551-63.
12. Arrieta MC, Madsen K, Doyle J, et al. Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse. Gut 2009;58:41-8.
13. Guan Y, Watson AJ, Marchiando AM, et al. Redistribution of the tight junction protein ZO-1 during physiologic shedding of mouse intestinal epithelial cells. Am J Physiol Cell Physiol 2011;300:C1404-14.
14. Kiesslich R, Goetz M, Angus EM, et al. Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy. Gastroenterology 2007;133:1769-78.
15. Watson AJ, Duckworth CA, Guan Y, et al. Mechanisms of epithelial cell shedding in the Mammalian intestine and maintenance of barrier function. Ann N Y Acad Sci 2009;1165:135-42.
16. Marchiando AM, Shen L, Graham VW, et al. The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. Gastroenterology 2011;140:1208-18.
17. Liu JJ, Wong K, Thiesen AL, et al. Increased epithelial gaps in the small intestines of patients with inflammatory bowel disease: density matters. Gastrointest Endosc 2011;73:1174-80.
18. Arrieta MC, Bistritz L, Meddings JB. Alterations in intestinal permeability. Gut 2006;55:1512-20.
19. Meddings JB, Sutherland LR, Byles NI, et al. Sucrose: a novel permeability marker for gastroduodenal disease. Gastroenterology 1993;104:1619-26.
20. Hilsden RJ, Meddings JB, Sutherland LR. Intestinal permeability changes in response to acetylsalicylic acid in relatives of patients with Crohn's disease. Gastroenterology 1996;110:1395-403.
21. Munkholm P, Langholz E, Hollander D, et al. Intestinal permeability in patients with Crohn's disease and ulcerative colitis and their first degree relatives. Gut 1994;35:68-72.
22. Schulzke JD, Fromm M, Bentzel CJ, et al. Adaptation of the jejunal mucosa in the experimental blind loop syndrome: changes in paracellular conductance and tight junction structure. Gut 1987;28:159-64.
23. Kroesen AJ, Dullat S, Schulzke JD, et al. Permanently increased mucosal permeability in patients with backwash ileitis after ileoanal pouch for ulcerative colitis. Scand J Gastroenterol 2008;43:704-11.
24. Fromm M, Krug SM, Zeissig S, et al. High-resolution analysis of barrier function. Ann N Y Acad Sci 2009;1165:74-81.
25. Gitter AH, Wullstein F, Fromm M, et al. Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging. Gastroenterology 2001;121:1320-8.
26. Watson AJ, Chu S, Sieck L, et al. Epithelial barrier function in vivo is sustained despite gaps in epithelial layers. Gastroenterology 2005;129:902-12.
27. Gunzel D, Florian P, Richter JF, et al. Restitution of single-cell defects in the mouse colon epithelium differs from that of cultured cells. Am J Physiol Regul Integr Comp Physiol 2006;290:R1496-507.
28. Vermeire S, Schreiber S, Sandborn WJ, et al. Correlation between the Crohn's disease activity and Harvey-Bradshaw indices in assessing Crohn's disease severity. Clin Gastroenterol Hepatol 2010;8:357-63.
29. Hirai F, Matsui T, Aoyagi K, et al. Validity of activity indices in ulcerative colitis: comparison of clinical and endoscopic indices. Dig Endosc 2010;22:39-44.
30. Shen L, Weber CR, Raleigh DR, et al. Tight junction pore and leak pathways: a dynamic duo. Annu Rev Physiol 2011;73:283-309.
31. Bullen TF, Forrest S, Campbell F, et al. Characterization of epithelial cell shedding from human small intestine. Lab Invest 2006;86:1052-63.
32. Gitter AH, Bertog M, Schulzke J, et al. Measurement of paracellular epithelial conductivity by conductance scanning. Pflugers Arch 1997;434:830-40.
33. Epple HJ, Schneider T, Troeger H, et al. Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients. Gut 2009;58:220-7.
34. Salim SY, Soderholm JD. Importance of disrupted intestinal barrier in inflammatory bowel diseases. Inflamm Bowel Dis 2011;17:362-81.
35. Fritz T, Niederreiter L, Adolph T, et al. Crohn's disease: NOD2, autophagy and ER stress converge. Gut 2011;60:1580-8.
36. Lee JS. Contraction of villi and fluid transport in dog jejunal mucosa in vitro. Am J Physiol 1971;221:488-95.
37. Lee JS. Epithelial cell extrusion during fluid transport in canine small intestine. Am J Physiol 1977;232:E408-14.
38. Moore R, Carlson S, Madara JL. Villus contraction aids repair of intestinal epithelium after injury. Am J Physiol 1989;257:G274-83.
39. Ahmed T, Rieder F, Fiocchi C, et al. Pathogenesis of postoperative recurrence in Crohn's disease. Gut 2011;60:553-62.
40. Su L, Nalle SC, Sullivan EA, et al. Genetic ablation of myosin light chain kinase limits epithelial barrier dysfunction and attenuates experimental inflammatory bowel disease. Gastroenterology 2009;136:abstract.