메뉴 건너뛰기




Volumn 104, Issue 7, 2009, Pages 1723-1733

Epistasis between toll-like receptor-9 polymorphisms and variants in NOD2 and IL23R modulates susceptibility to crohn's disease

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; INTERLEUKIN 23 RECEPTOR; TOLL LIKE RECEPTOR 9;

EID: 67650514274     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2009.184     Document Type: Article
Times cited : (66)

References (55)
  • 1
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leu-cine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot JP, Chamaillard M, Zouali H et al. Association of NOD2 leu-cine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001;411:599-603.
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3
  • 2
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y, Bonen DK, Inohara N et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001 ;411: 603-6.
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 3
    • 0035897904 scopus 로고    scopus 로고
    • Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations
    • Hampe J, Cuthbert A, Croucher PJ et al. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations. Lancet 2001;357:1925-8.
    • (2001) Lancet , vol.357 , pp. 1925-1928
    • Hampe, J.1    Cuthbert, A.2    Croucher, P.J.3
  • 4
    • 22644444207 scopus 로고    scopus 로고
    • Bacterial interactions with cells of the intestinal mucosa: Toll-like rceptors and NOD2
    • Cario E. Bacterial interactions with cells of the intestinal mucosa: toll-like rceptors and NOD2. Gut 2005;54:1182-93.
    • (2005) Gut , vol.54 , pp. 1182-1193
    • Cario, E.1
  • 5
    • 2942689466 scopus 로고    scopus 로고
    • Polymorphisms of the lipopolysaccha-ride-signaling complex in inflammatory bowel disease: Association of a mutation in the Toll-like receptor 4 gene with ulcerative colitis
    • Török HP, Glas J, Tonenchi L et al. Polymorphisms of the lipopolysaccha-ride-signaling complex in inflammatory bowel disease: association of a mutation in the Toll-like receptor 4 gene with ulcerative colitis. Clin Immunol 2004;112:85-91.
    • (2004) Clin Immunol , vol.112 , pp. 85-91
    • Török, H.P.1    Glas, J.2    Tonenchi, L.3
  • 6
    • 22044432709 scopus 로고    scopus 로고
    • The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease
    • Brand S, Staudinger T, Schnitzler F et al. The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease. Inflamm Bowel Dis 2005;11:645-52.
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 645-652
    • Brand, S.1    Staudinger, T.2    Schnitzler, F.3
  • 7
    • 35449000411 scopus 로고    scopus 로고
    • Has toll-like receptor 4 been prematurely dismissed as an inflammatory bowel disease gene? Association study combined with meta-analysis shows strong evidence for association
    • Browning BL, Huebner C, Petermann I et al. Has toll-like receptor 4 been prematurely dismissed as an inflammatory bowel disease gene? Association study combined with meta-analysis shows strong evidence for association. Am J Gastroenterol 2007;102:2504-12.
    • (2007) Am J Gastroenterol , vol.102 , pp. 2504-2512
    • Browning, B.L.1    Huebner, C.2    Petermann, I.3
  • 8
    • 34547459989 scopus 로고    scopus 로고
    • The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases
    • De Jager PL, Franchimont D, Waliszewska A et al. The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases. Genes Immun 2007;8:387-97.
    • (2007) Genes Immun , vol.8 , pp. 387-397
    • De Jager, P.L.1    Franchimont, D.2    Waliszewska, A.3
  • 9
    • 0012722659 scopus 로고    scopus 로고
    • Nod2 is a general sensor of pep-tidoglycan through muramyl dipeptide (MDP) detection
    • Girardin SE, Boneca IG, Viala J et al. Nod2 is a general sensor of pep-tidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 2003;278:8869-72.
    • (2003) J Biol Chem , vol.278 , pp. 8869-8872
    • Girardin, S.E.1    Boneca, I.G.2    Viala, J.3
  • 10
    • 0037458665 scopus 로고    scopus 로고
    • Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. 1
    • Inohara N, Ogura Y, Fontalba A et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. 1 Biol Chem 2003;278:5509-12.
    • (2003) Biol Chem , vol.278 , pp. 5509-5512
    • Inohara, N.1    Ogura, Y.2    Fontalba, A.3
  • 11
    • 21144468350 scopus 로고    scopus 로고
    • Muramyl dipeptide and tolllike receptor sensitivity in NOD2-associated Crohn's disease
    • van Heel DA, Ghosh S, Butler M et al. Muramyl dipeptide and tolllike receptor sensitivity in NOD2-associated Crohn's disease. Lancet 2005;365:1794-6.
    • (2005) Lancet , vol.365 , pp. 1794-1796
    • van Heel, D.A.1    Ghosh, S.2    Butler, M.3
  • 12
    • 27444444603 scopus 로고    scopus 로고
    • KAetal. SynergybetweenTLR9andNOD2 innate immune responses is lost in genetic Crohn's disease
    • van Heel DA, Ghosh S, Hunt KAetal. SynergybetweenTLR9andNOD2 innate immune responses is lost in genetic Crohn's disease. Gut 2005;54: 1553-7.
    • (2005) Gut , vol.54 , pp. 1553-1557
    • van Heel, D.A.1    Ghosh, S.2    Hunt3
  • 13
    • 33751551466 scopus 로고    scopus 로고
    • Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells
    • Lee J, Mo JH, Katakura K etal. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat Cell Biol 2006;8:1327-36.
    • (2006) Nat Cell Biol , vol.8 , pp. 1327-1336
    • Lee, J.1    Mo, J.H.2    Katakura, K.3
  • 14
    • 0036241068 scopus 로고    scopus 로고
    • Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis
    • Rachmilewitz D, Karmeli F, Takabayashi K et al. Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis. Gastroenterol-ogy 2002;122:1428-41.
    • (2002) Gastroenterol-ogy , vol.122 , pp. 1428-1441
    • Rachmilewitz, D.1    Karmeli, F.2    Takabayashi, K.3
  • 15
    • 10744233159 scopus 로고    scopus 로고
    • Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis
    • Rachmilewitz D, Katakura K, Karmeli F et al. Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology 2004;126:520-8.
    • (2004) Gastroenterology , vol.126 , pp. 520-528
    • Rachmilewitz, D.1    Katakura, K.2    Karmeli, F.3
  • 16
    • 25444452680 scopus 로고    scopus 로고
    • In vivo CpG DNA/toll-like receptor 9 interaction induces regulatory properties in CD4+CD62L+ T cells which prevent intestinal inflammation in the SCID transfer model of colitis
    • Obermeier F, Strauch UG, Dunger N et al. In vivo CpG DNA/toll-like receptor 9 interaction induces regulatory properties in CD4+CD62L+ T cells which prevent intestinal inflammation in the SCID transfer model of colitis. Gut 2005;54:1428-36.
    • (2005) Gut , vol.54 , pp. 1428-1436
    • Obermeier, F.1    Strauch, U.G.2    Dunger, N.3
  • 17
    • 24144461193 scopus 로고    scopus 로고
    • CpG motifs of bacterial DNA essentially contribute to the perpetuation of chronic intestinal inflammation
    • Obermeier F, Dunger N, Strauch UG et al. CpG motifs of bacterial DNA essentially contribute to the perpetuation of chronic intestinal inflammation. Gastroenterology 2005;129:913-27.
    • (2005) Gastroenterology , vol.129 , pp. 913-927
    • Obermeier, F.1    Dunger, N.2    Strauch, U.G.3
  • 18
    • 0035125464 scopus 로고    scopus 로고
    • Fine mapping of the chromosome 3p susceptibility locus in inflammatory bowel disease
    • Hampe J, Lynch NJ, Daniels S et al. Fine mapping of the chromosome 3p susceptibility locus in inflammatory bowel disease. Gut 2001;48: 191-7.
    • (2001) Gut , vol.48 , pp. 191-197
    • Hampe, J.1    Lynch, N.J.2    Daniels, S.3
  • 19
    • 16044373177 scopus 로고    scopus 로고
    • Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12
    • Satsangi J, Parkes M, Louis E et al. Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. Nat Genet 1996;14:199-202.
    • (1996) Nat Genet , vol.14 , pp. 199-202
    • Satsangi, J.1    Parkes, M.2    Louis, E.3
  • 20
    • 0037289001 scopus 로고    scopus 로고
    • Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): Frequencies, pairwise linkage disequilibrium, and haplotypes in three US ethnic groups and exploratory case-control disease association studies
    • Lazarus R, Klimecki WT, Raby BA et al. Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three US ethnic groups and exploratory case-control disease association studies. Genomics 2003;81:85-91.
    • (2003) Genomics , vol.81 , pp. 85-91
    • Lazarus, R.1    Klimecki, W.T.2    Raby, B.A.3
  • 21
    • 3242732415 scopus 로고    scopus 로고
    • Crohn's disease is associated with a tolllike receptor-9 polymorphism
    • Török HP, Glas J, Tonenchi L et al. Crohn's disease is associated with a tolllike receptor-9 polymorphism. Gastroenterology 2004;127:365-6.
    • (2004) Gastroenterology , vol.127 , pp. 365-366
    • Török, H.P.1    Glas, J.2    Tonenchi, L.3
  • 22
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr RH, Taylor KD, Brant SR et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006;314:1461-3.
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3
  • 23
    • 33846627302 scopus 로고    scopus 로고
    • A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    • Hampe J, Franke A, Rosenstiel P et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 2007;39:207-11.
    • (2007) Nat Genet , vol.39 , pp. 207-211
    • Hampe, J.1    Franke, A.2    Rosenstiel, P.3
  • 24
    • 0034785352 scopus 로고    scopus 로고
    • Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease
    • Rioux JD, Daly MJ, Silverberg MS et al. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat Genet 2001;29:223-8.
    • (2001) Nat Genet , vol.29 , pp. 223-228
    • Rioux, J.D.1    Daly, M.J.2    Silverberg, M.S.3
  • 25
    • 2442585704 scopus 로고    scopus 로고
    • Functional variants of OCTN cation transporter genes are associated with Crohn disease
    • Peltekova VD, Wintle RF, Rubin LA et al. Functional variants of OCTN cation transporter genes are associated with Crohn disease. Nat Genet 2004;36:471-5.
    • (2004) Nat Genet , vol.36 , pp. 471-475
    • Peltekova, V.D.1    Wintle, R.F.2    Rubin, L.A.3
  • 26
    • 2442519456 scopus 로고    scopus 로고
    • Genetic variation in DLG5 is associated with inflammatory bowel disease
    • Stoll M, Corneliussen B, Costello CM et al. Genetic variation in DLG5 is associated with inflammatory bowel disease. Nat Genet 2004;36:476-80.
    • (2004) Nat Genet , vol.36 , pp. 476-480
    • Stoll, M.1    Corneliussen, B.2    Costello, C.M.3
  • 27
    • 33144468326 scopus 로고    scopus 로고
    • European evidence based consensus on the diagnosis and management of Crohn's disease: Definitions and diagnosis
    • il-15
    • Stange EF, Travis SP, Vermeire S et al. European evidence based consensus on the diagnosis and management of Crohn's disease: definitions and diagnosis. Gut 2006;55 (Suppl 1): il-15.
    • (2006) Gut , vol.55 , Issue.SUPPL. 1
    • Stange, E.F.1    Travis, S.P.2    Vermeire, S.3
  • 28
    • 33646778482 scopus 로고    scopus 로고
    • The Montreal classification of inflammatory bowel disease: Controversies, consensus, and implications
    • Satsangi J, Silverberg MS, Vermeire S et al. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut 2006;55:749-53.
    • (2006) Gut , vol.55 , pp. 749-753
    • Satsangi, J.1    Silverberg, M.S.2    Vermeire, S.3
  • 29
    • 39649106413 scopus 로고    scopus 로고
    • rsl004819 is the main disease-associated IL23R variant in German Crohn's disease patients: Combined analysis of IL23R, CARD15, and OCTN1/2 variants
    • Glas J, Seiderer J, Wetzke M et al. rsl004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants. PLoS ONE 2007;2:e819.
    • (2007) PLoS ONE , vol.2
    • Glas, J.1    Seiderer, J.2    Wetzke, M.3
  • 30
    • 40949112379 scopus 로고    scopus 로고
    • The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population
    • Glas J, Konrad A, Schmechel S et al. The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population. Am J Gastroenterol 2008;103:682-91.
    • (2008) Am J Gastroenterol , vol.103 , pp. 682-691
    • Glas, J.1    Konrad, A.2    Schmechel, S.3
  • 31
    • 21344449654 scopus 로고    scopus 로고
    • Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease
    • Török HP, Glas J, Tonenchi L et al. Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease. Gut 2005;54: 1421-7.
    • (2005) Gut , vol.54 , pp. 1421-1427
    • Török, H.P.1    Glas, J.2    Tonenchi, L.3
  • 32
    • 33751561942 scopus 로고    scopus 로고
    • Predictive value of the CARD15 variant 1007fs for the diagnosis of intestinal stenoses and the need for surgery in Crohn's disease in clinical practice: Results of a prospective study
    • Seiderer J, Brand S, Herrmann KA et al. Predictive value of the CARD15 variant 1007fs for the diagnosis of intestinal stenoses and the need for surgery in Crohn's disease in clinical practice: results of a prospective study. Inflamm Bowel Dis 2006;12:1114-21.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 1114-1121
    • Seiderer, J.1    Brand, S.2    Herrmann, K.A.3
  • 33
    • 38349113447 scopus 로고    scopus 로고
    • Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts
    • Browning BL, Annese V, Barclay ML et al. Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts. J Med Genet 2008;45:36-42.
    • (2008) J Med Genet , vol.45 , pp. 36-42
    • Browning, B.L.1    Annese, V.2    Barclay, M.L.3
  • 34
    • 11144279151 scopus 로고    scopus 로고
    • Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: A metaanalysis
    • Economou M, Trikalinos TA, Loizou KT et al. Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis. Am J Gastroenterol 2004;99:2393-404.
    • (2004) Am J Gastroenterol , vol.99 , pp. 2393-2404
    • Economou, M.1    Trikalinos, T.A.2    Loizou, K.T.3
  • 35
    • 3242810387 scopus 로고    scopus 로고
    • Degranulation of paneth cells via tolllike receptor 9
    • Rumio C, Besusso D, Palazzo M et al. Degranulation of paneth cells via tolllike receptor 9. Am J Pathol 2004;165:373-81.
    • (2004) Am J Pathol , vol.165 , pp. 373-381
    • Rumio, C.1    Besusso, D.2    Palazzo, M.3
  • 36
    • 0038109983 scopus 로고    scopus 로고
    • Crohn's disease and the NOD2 gene: A role for paneth cells
    • Lala S, Ogura Y, Osborne C et al. Crohn's disease and the NOD2 gene: a role for paneth cells. Gastroenterology 2003;125:47-57.
    • (2003) Gastroenterology , vol.125 , pp. 47-57
    • Lala, S.1    Ogura, Y.2    Osborne, C.3
  • 37
    • 7244257312 scopus 로고    scopus 로고
    • NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression
    • Wehkamp J, Harder J, Weichenthal M et al. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut 2004;53:1658-64.
    • (2004) Gut , vol.53 , pp. 1658-1664
    • Wehkamp, J.1    Harder, J.2    Weichenthal, M.3
  • 38
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Wellcome Trust Case Control Consortium
    • Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007;447:661-78.
    • (2007) Nature , vol.447 , pp. 661-678
  • 39
    • 33646397611 scopus 로고    scopus 로고
    • IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    • Yen D, Cheung J, Scheerens H et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 2006;116:1310-6.
    • (2006) J Clin Invest , vol.116 , pp. 1310-1316
    • Yen, D.1    Cheung, J.2    Scheerens, H.3
  • 40
    • 42449084096 scopus 로고    scopus 로고
    • Role of the novel Th 17 cytokine IL-17F in inflammatory bowel disease (IBD): Upregulated colonic IL-17F expression in active crohn's disease and analysis of the IL17F p.His161 Arg polymorphism in IBD
    • Seiderer J, Elben I, Diegelmann J et al. Role of the novel Th 17 cytokine IL-17F in inflammatory bowel disease (IBD): Upregulated colonic IL-17F expression in active crohn's disease and analysis of the IL17F p.His161 Arg polymorphism in IBD. Inflamm Bowel Dis 2008;14:437-45.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 437-445
    • Seiderer, J.1    Elben, I.2    Diegelmann, J.3
  • 41
    • 33645829078 scopus 로고    scopus 로고
    • IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration
    • Brand S, Beigel F, Olszak T et al. IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration. Am J Physiol Gastrointest Liver Physiol 2006;290:G827-38.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Brand, S.1    Beigel, F.2    Olszak, T.3
  • 42
    • 61949124982 scopus 로고    scopus 로고
    • The novel IL-10 related cytokine IL-26 is increased in active inflammatory bowel disease and intestinal epithelial cells express the functional IL-26 receptor complex
    • Dambacher J, Beigel F, Golluscio R et al. The novel IL-10 related cytokine IL-26 is increased in active inflammatory bowel disease and intestinal epithelial cells express the functional IL-26 receptor complex. Gastroenterology 2006;130:A196.
    • (2006) Gastroenterology , vol.130
    • Dambacher, J.1    Beigel, F.2    Golluscio, R.3
  • 43
    • 33645005339 scopus 로고    scopus 로고
    • Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells
    • Brand S, Olszak T, Beigel F et al. Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells. J Cell Biochem 2006;97:709-23.
    • (2006) J Cell Biochem , vol.97 , pp. 709-723
    • Brand, S.1    Olszak, T.2    Beigel, F.3
  • 44
    • 34848850085 scopus 로고    scopus 로고
    • The genetics of inflammatory bowel disease
    • Cho JH, Weaver CT. The genetics of inflammatory bowel disease. Gastroenterology 2007;133:1327-39.
    • (2007) Gastroenterology , vol.133 , pp. 1327-1339
    • Cho, J.H.1    Weaver, C.T.2
  • 45
    • 49849096752 scopus 로고    scopus 로고
    • NOD2/CARD15 genotype influences MDP-induced cytokine release and basal IL-12p40 levels in primary isolated peripheral blood monocytes
    • Beynon V, Cotofana S, Brand S et al. NOD2/CARD15 genotype influences MDP-induced cytokine release and basal IL-12p40 levels in primary isolated peripheral blood monocytes. Inflamm Bowel Dis 2008;14:1033-40.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 1033-1040
    • Beynon, V.1    Cotofana, S.2    Brand, S.3
  • 46
    • 8344284998 scopus 로고    scopus 로고
    • Anti-interleukin-12 antibody for active Crohn's disease
    • Mannon PJ, Fuss IT, Mayer L et al. Anti-interleukin-12 antibody for active Crohn's disease. N Engl J Med 2004;351:2069-79.
    • (2004) N Engl J Med , vol.351 , pp. 2069-2079
    • Mannon, P.J.1    Fuss, I.T.2    Mayer, L.3
  • 47
    • 34548527714 scopus 로고    scopus 로고
    • Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype
    • Cummings JR, Ahmad T, Geremia A et al. Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype. Inflamm Bowel Dis 2007;13:1063-8.
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 1063-1068
    • Cummings, J.R.1    Ahmad, T.2    Geremia, A.3
  • 48
    • 67650557755 scopus 로고    scopus 로고
    • The first two Crohn's disease susceptibility loci with a high degree of epistasis: PTGER4-expression-modulating polymorphisms in the 5pl3.1 region enhance ATG16L1-associated susceptibility to Crohn's disease
    • Seiderer J, Glas J, Diegelmann J et al. The first two Crohn's disease susceptibility loci with a high degree of epistasis: PTGER4-expression-modulating polymorphisms in the 5pl3.1 region enhance ATG16L1-associated susceptibility to Crohn's disease. Gastroenterology 2008;134:A456.
    • (2008) Gastroenterology , vol.134
    • Seiderer, J.1    Glas, J.2    Diegelmann, J.3
  • 49
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • Barrett JC, Hansoul S, Nicolae DL et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008;40:955-62.
    • (2008) Nat Genet , vol.40 , pp. 955-962
    • Barrett, J.C.1    Hansoul, S.2    Nicolae, D.L.3
  • 50
    • 31144442966 scopus 로고    scopus 로고
    • TLR9 activation is defective in common variable immune deficiency
    • Cunningham-Rundles C, Radigan L, Knight AK et al. TLR9 activation is defective in common variable immune deficiency. J Immunol 2006;176:1978-87.
    • (2006) J Immunol , vol.176 , pp. 1978-1987
    • Cunningham-Rundles, C.1    Radigan, L.2    Knight, A.K.3
  • 51
    • 34250627117 scopus 로고    scopus 로고
    • Putative association of a TLR9 promoter polymorphism with atopic eczema
    • Novak N, Yu CF, Bussmann C et al. Putative association of a TLR9 promoter polymorphism with atopic eczema. Allergy 2007;62:766-72.
    • (2007) Allergy , vol.62 , pp. 766-772
    • Novak, N.1    Yu, C.F.2    Bussmann, C.3
  • 52
    • 1542285261 scopus 로고    scopus 로고
    • An association study of asthma and total serum immunoglobin E levels for Toll-like receptor polymorphisms in a Japanese population
    • Noguchi E, Nishimura F, Fukai H et al. An association study of asthma and total serum immunoglobin E levels for Toll-like receptor polymorphisms in a Japanese population. Clin Exp Allergy 2004;34:177-83.
    • (2004) Clin Exp Allergy , vol.34 , pp. 177-183
    • Noguchi, E.1    Nishimura, F.2    Fukai, H.3
  • 53
    • 35148851549 scopus 로고    scopus 로고
    • Lack of association of Toll-like receptor 9 gene polymorphism with Behcet's disease in Japanese patients
    • Ito A, Ota M, Katsuyama Y et al. Lack of association of Toll-like receptor 9 gene polymorphism with Behcet's disease in Japanese patients. Tissue Antigens 2007;70:423-6.
    • (2007) Tissue Antigens , vol.70 , pp. 423-426
    • Ito, A.1    Ota, M.2    Katsuyama, Y.3
  • 54
    • 14844291442 scopus 로고    scopus 로고
    • Association study of Toll-like receptor 9 gene polymorphism in Korean patients with systemic lupus erythematosus
    • Hur JW, Shin HD, Park BL et al. Association study of Toll-like receptor 9 gene polymorphism in Korean patients with systemic lupus erythematosus. Tissue Antigens 2005;65:266-70.
    • (2005) Tissue Antigens , vol.65 , pp. 266-270
    • Hur, J.W.1    Shin, H.D.2    Park, B.L.3
  • 55
    • 33646340664 scopus 로고    scopus 로고
    • Genetic variation in toll-like receptor 9 and susceptibility to systemic lupus erythematosus
    • De Jager PL, Richardson A, Vyse TJ et al. Genetic variation in toll-like receptor 9 and susceptibility to systemic lupus erythematosus. Arthritis Rheum 2006;54:1279-82.
    • (2006) Arthritis Rheum , vol.54 , pp. 1279-1282
    • De Jager, P.L.1    Richardson, A.2    Vyse, T.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.