Activation of TRPML1 clears intraneuronal Aβ in preclinical models of HIV infection

Journal of Neuroscience

Volumn 34, Issue 34, 2014, Pages 11485-11503

  Bae, Mihyun ^a   Patel, Neha ^a   Xu, Haoxing ^b   Lee, Mingwaoh ^c   Tominaga Yamanaka, Kumiko ^e   Nath, Avindra ^c   Geiger, Jonathan ^d   Gorospe, Myriam ^e   Mattson, Mark P ^e   Haughey, Norman J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^d UNIVERSITY OF NORTH DAKOTA   (United States)

^e NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Amyloid; Dementia; Endosome; HIV; Lysosome; Neuron

Indexed keywords

ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; BETA SECRETASE 1; GAMMA SECRETASE; GLYCOPROTEIN GP 120; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SPHINGOMYELIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL M1; ENZYME INHIBITOR; GP120 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; MCOLN1 PROTEIN, HUMAN; PRESENILIN 1; PSEN1 PROTEIN, HUMAN; TRANSIENT RECEPTOR POTENTIAL CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BRAIN; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NERVE CELL; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; VIROLOGY;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HUMANS; LYSOSOMES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS; PRESENILIN-1; RATS; SIGNAL TRANSDUCTION; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84906273987     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0210-14.2014     Document Type: Article

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