메뉴 건너뛰기




Volumn 74, Issue 6, 2003, Pages 1117-1124

HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling

Author keywords

cAMP; CREB; CXCR4; HIVenv

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 METHYLPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; CD4 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLYCOPROTEIN GP 120; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE LCK; STROMAL CELL DERIVED FACTOR 1ALPHA;

EID: 0348047538     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0503239     Document Type: Article
Times cited : (37)

References (54)
  • 1
    • 0024272153 scopus 로고
    • Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men: HIV affects the immune system before CD4+ T helper cell depletion occurs
    • Miedema, F., Petit, A. J., Terpstra, F. G., Schattenkerk, J. K., de Wolf, F., Al, B. J., Roos, M., Lange, J. M., Danner, S. A., Goudsmit, J. (1988) Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men: HIV affects the immune system before CD4+ T helper cell depletion occurs. J. Clin. Invest. 82, 1908-1914.
    • (1988) J. Clin. Invest. , vol.82 , pp. 1908-1914
    • Miedema, F.1    Petit, A.J.2    Terpstra, F.G.3    Schattenkerk, J.K.4    De Wolf, F.5    Al, B.J.6    Roos, M.7    Lange, J.M.8    Danner, S.A.9    Goudsmit, J.10
  • 2
    • 0024786954 scopus 로고
    • Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-sero-positive patients
    • Clerici, M., Stocks, N. I., Zajac, R. A., Boswell, R. N., Lucey, D. R., Via, C. S., Shearer, G. M. (1989) Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-sero-positive patients. J. Clin. Invest. 84, 1892-1899.
    • (1989) J. Clin. Invest. , vol.84 , pp. 1892-1899
    • Clerici, M.1    Stocks, N.I.2    Zajac, R.A.3    Boswell, R.N.4    Lucey, D.R.5    Via, C.S.6    Shearer, G.M.7
  • 4
    • 0033509509 scopus 로고    scopus 로고
    • Early and persistent human immunodeficiency virus type 1 (HIV-1) -specific T helper dysfunction in blood and lymph nodes following acute HIV-1 infection
    • Musey, L. K., Krieger, J. N., Hughes, J. P., Schacker, T. W., Corer, L., McElrath, M. J. (1999) Early and persistent human immunodeficiency virus type 1 (HIV-1)-specific T helper dysfunction in blood and lymph nodes following acute HIV-1 infection. J. Infect. Dis. 180, 278-284.
    • (1999) J. Infect. Dis. , vol.180 , pp. 278-284
    • Musey, L.K.1    Krieger, J.N.2    Hughes, J.P.3    Schacker, T.W.4    Corer, L.5    McElrath, M.J.6
  • 6
  • 7
    • 0026517545 scopus 로고
    • Activation-induced death by apoptosis in CD4+ T cells from HIV-1 infected asymptomatic individuals
    • Groux, W., Torpier, G., Monte, D., Mouton, Y., Capron, A., Ameisen, J. C. (1992) Activation-induced death by apoptosis in CD4+ T cells from HIV-1 infected asymptomatic individuals. J. Exp. Med. 175, 331-340.
    • (1992) J. Exp. Med. , vol.175 , pp. 331-340
    • Groux, W.1    Torpier, G.2    Monte, D.3    Mouton, Y.4    Capron, A.5    Ameisen, J.C.6
  • 9
    • 0032827437 scopus 로고    scopus 로고
    • Decreased expression of zeta molecules by T lymphocytes is correlated with disease progression in human immunodeficiency virus-infected persons
    • Geertsma, M. F., van Wengen-Stevenhagen, A., van Dam, E. M., Risberg, K., Kroon, F. P., Groeneveld, P. H., Nibbering, P. H. (1999) Decreased expression of zeta molecules by T lymphocytes is correlated with disease progression in human immunodeficiency virus-infected persons. J. Infect. Dis. 180, 649-658.
    • (1999) J. Infect. Dis. , vol.180 , pp. 649-658
    • Geertsma, M.F.1    Van Wengen-Stevenhagen, A.2    Van Dam, E.M.3    Risberg, K.4    Kroon, F.P.5    Groeneveld, P.H.6    Nibbering, P.H.7
  • 10
    • 0034628624 scopus 로고    scopus 로고
    • HIV type 1-induced inhibition of CD45 tyrosine phosphatase activity correlates with disease Progression anti apoptosis, but not with anti-CD3-induced cell proliferation
    • Giovannetti, A., Pierdominici, M., Mazzetta, F., Mazzone, A. M., Ricci, G., Prozzo, A., Pandolfi, F., Paganelli, R., Aiuti, F. (2000) HIV type 1-induced inhibition of CD45 tyrosine phosphatase activity correlates with disease Progression anti apoptosis, but not with anti-CD3-induced cell proliferation. AIDS Res. Hum. Retroviruses 16, 211-219.
    • (2000) AIDS Res. Hum. Retroviruses , vol.16 , pp. 211-219
    • Giovannetti, A.1    Pierdominici, M.2    Mazzetta, F.3    Mazzone, A.M.4    Ricci, G.5    Prozzo, A.6    Pandolfi, F.7    Paganelli, R.8    Aiuti, F.9
  • 11
    • 0029991451 scopus 로고    scopus 로고
    • CD4+ lymphocytes from HIV-infected patients display impaired CD45-associated tyrosine phosphatase activity which is enhanced by anti-oxidants
    • Cayota, A., Vuillier, R., Gonzalez, G., Dighiero, G. (1996) CD4+ lymphocytes from HIV-infected patients display impaired CD45-associated tyrosine phosphatase activity which is enhanced by anti-oxidants. Clin. Exp. Immunol. 104, 11-17.
    • (1996) Clin. Exp. Immunol. , vol.104 , pp. 11-17
    • Cayota, A.1    Vuillier, R.2    Gonzalez, G.3    Dighiero, G.4
  • 12
    • 0032501057 scopus 로고    scopus 로고
    • Impaired CD45-associated tyrosine phosphatase activity during HIV-1 infection: Implications for CD3 and CD4 receptor signalling
    • Guntermann, C., Amft, N., Murphy, B. J., Nye, K. E. (1998) Impaired CD45-associated tyrosine phosphatase activity during HIV-1 infection: implications for CD3 and CD4 receptor signalling. Biochem. Biophys. Res. Commun. 252, 69-77.
    • (1998) Biochem. Biophys. Res. Commun. , vol.252 , pp. 69-77
    • Guntermann, C.1    Amft, N.2    Murphy, B.J.3    Nye, K.E.4
  • 13
    • 0030952901 scopus 로고    scopus 로고
    • Human immunodeficiency virus infection abolishes CD4-dependent activation of ZAP-70 by inhibition of p56lck
    • Guntermann, C., Dye, J., Nye, K. E. (1997) Human immunodeficiency virus infection abolishes CD4-dependent activation of ZAP-70 by inhibition of p56lck. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 14, 204-212.
    • (1997) J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. , vol.14 , pp. 204-212
    • Guntermann, C.1    Dye, J.2    Nye, K.E.3
  • 14
    • 0031091744 scopus 로고    scopus 로고
    • Sequestration of p56 (lck) by gp120, a model for TCR desensitization
    • Goldman, F., Crabtree, J., Hollenback, C., Koretzky, G. (1997) Sequestration of p56 (lck) by gp120, a model for TCR desensitization. J. Immunol. 158, 2017-2024.
    • (1997) J. Immunol. , vol.158 , pp. 2017-2024
    • Goldman, F.1    Crabtree, J.2    Hollenback, C.3    Koretzky, G.4
  • 16
    • 0028208710 scopus 로고
    • Defective protein tyrosine phosphorylation and altered levels of p59fyn and p56lck in CD4 T cells from HIV-1 infected patients
    • Cayota, A., Vuillier, F., Siciliano, J., Dighiero, G. (1994) Defective protein tyrosine phosphorylation and altered levels of p59fyn and p56lck in CD4 T cells from HIV-1 infected patients. Int. Immunol 6, 611-621.
    • (1994) Int. Immunol. , vol.6 , pp. 611-621
    • Cayota, A.1    Vuillier, F.2    Siciliano, J.3    Dighiero, G.4
  • 17
    • 0025218885 scopus 로고
    • Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA
    • Oyaizu, N., Chirmule, N., Kalyanaraman, V. S., Hall, W. W., Paliwa, W., Shuster, M., Palriva, S. (1990) Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA. Proc. Natl. Acad. Sci. USA 87, 2379-2383.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 2379-2383
    • Oyaizu, N.1    Chirmule, N.2    Kalyanaraman, V.S.3    Hall, W.W.4    Paliwa, W.5    Shuster, M.6    Palriva, S.7
  • 18
    • 0025608596 scopus 로고
    • Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway
    • Cefai, D., Debre, P., Kaezorek, M., Idziorek, T., Autran, B., Bismuth, G. (1990) Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. J. Clin. Invest. 86, 2117-2124.
    • (1990) J. Clin. Invest. , vol.86 , pp. 2117-2124
    • Cefai, D.1    Debre, P.2    Kaezorek, M.3    Idziorek, T.4    Autran, B.5    Bismuth, G.6
  • 19
    • 0025058349 scopus 로고
    • Inhibition of functional properties of tetanus antigen-specific T-cell clones by envelope glycoprotein GP120 of human immunodeficiency virus
    • Chirmule, N., Kalyanaranian, V. S., Oyaizu, N., Slade, H. B., Paliwa, S. (1990) Inhibition of functional properties of tetanus antigen-specific T-cell clones by envelope glycoprotein GP120 of human immunodeficiency virus. Blood 75, 152-159.
    • (1990) Blood , vol.75 , pp. 152-159
    • Chirmule, N.1    Kalyanaranian, V.S.2    Oyaizu, N.3    Slade, H.B.4    Paliwa, S.5
  • 20
    • 0029000768 scopus 로고
    • HIV-1 glycoprotein gp120 disrupts CD4-p56lck/CD3-T cell receptor interactions and inhibits CD3 signaling
    • Hubert, P., Bismuth, G., Korner, M., Debre, P. (1995) HIV-1 glycoprotein gp120 disrupts CD4-p56lck/CD3-T cell receptor interactions and inhibits CD3 signaling. Eur. J. Immunol. 25, 1417-1425.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 1417-1425
    • Hubert, P.1    Bismuth, G.2    Korner, M.3    Debre, P.4
  • 21
    • 0031054716 scopus 로고    scopus 로고
    • HIV glycoprotein gp120 inhibits TCH-CD3-mediated activation of fyn and lck
    • Morio, T., Chatila, T., Geha, R. S. (1997) HIV glycoprotein gp120 inhibits TCH-CD3-mediated activation of fyn and lck. Int. Immunol. 9, 53-64.
    • (1997) Int. Immunol. , vol.9 , pp. 53-64
    • Morio, T.1    Chatila, T.2    Geha, R.S.3
  • 22
    • 0031091744 scopus 로고    scopus 로고
    • Sequestration of p56(lck) by gp120, a model for TCH desensitization
    • Goldman, F., Crabtree, J., Hollenback, C., Koretzky, G. (1997) Sequestration of p56(lck) by gp120, a model for TCH desensitization. J. Immunol. 158, 2017-2024.
    • (1997) J. Immunol. , vol.158 , pp. 2017-2024
    • Goldman, F.1    Crabtree, J.2    Hollenback, C.3    Koretzky, G.4
  • 24
    • 0036136463 scopus 로고    scopus 로고
    • Molecular mechanisms for protein kinase A-mediated modulation of immune function
    • Torgersen, K. M., Vang, T., Abralhamsen, H., Yaqub, S., Tasken, K. (2002) Molecular mechanisms for protein kinase A-mediated modulation of immune function. Cell. Signal. 14, 1-9.
    • (2002) Cell. Signal. , vol.14 , pp. 1-9
    • Torgersen, K.M.1    Vang, T.2    Abralhamsen, H.3    Yaqub, S.4    Tasken, K.5
  • 25
    • 0035910759 scopus 로고    scopus 로고
    • Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor
    • Vaag, T., Torgersen, K. M., Sundvold, V., Saxena, M., Levy, F. O., Skalhegg, B. S., Hansson, V., Mustelin, T., Tasken, K. (2001) Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor. J. Exp. Med. 193, 497-507.
    • (2001) J. Exp. Med. , vol.193 , pp. 497-507
    • Vaag, T.1    Torgersen, K.M.2    Sundvold, V.3    Saxena, M.4    Levy, F.O.5    Skalhegg, B.S.6    Hansson, V.7    Mustelin, T.8    Tasken, K.9
  • 26
    • 0033840025 scopus 로고    scopus 로고
    • Suppression of T cell function: A potential role for transcriptional repressor ICER
    • Bodor, J., Bodorova, J., Gress, R. (2000) Suppression of T cell function: a potential role for transcriptional repressor ICER. J. Leukoc. Biol. 67, 774-799.
    • (2000) J. Leukoc. Biol. , vol.67 , pp. 774-799
    • Bodor, J.1    Bodorova, J.2    Gress, R.3
  • 27
    • 0037443547 scopus 로고    scopus 로고
    • The cyclic adenosine 5-monosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism
    • Tenbrock, K., Juang, Y-T., Tolnay, M., Tsokos, G. C. (2003) The cyclic adenosine 5-monosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism. J. Immunol. 170, 2971-2976.
    • (2003) J. Immunol. , vol.170 , pp. 2971-2976
    • Tenbrock, K.1    Juang, Y.-T.2    Tolnay, M.3    Tsokos, G.C.4
  • 28
    • 0027203061 scopus 로고
    • Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes
    • Hofmann, B., Nishanian, P., Nguyen, T., Insixiengmay, P., Fahey, J. L. (1993) Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes. Proc. Natl. Acad. Sci. USA 90, 6676-6680.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6676-6680
    • Hofmann, B.1    Nishanian, P.2    Nguyen, T.3    Insixiengmay, P.4    Fahey, J.L.5
  • 29
    • 0027312867 scopus 로고
    • Restoration of T-cell function in HIV infection by reduction of intracellular cAMP levels with adenosine analogues
    • Hofmann, B., Nishanian, P., Nguyen, T., Liu, M., Fahey, J. L. (1993) Restoration of T-cell function in HIV infection by reduction of intracellular cAMP levels with adenosine analogues. AIDS 7, 659-664.
    • (1993) AIDS , vol.7 , pp. 659-664
    • Hofmann, B.1    Nishanian, P.2    Nguyen, T.3    Liu, M.4    Fahey, J.L.5
  • 30
    • 0031748984 scopus 로고    scopus 로고
    • Protein kinase A type 1 antagonist restores Immune responses of T Cells from HIV-infected patients
    • Aandahl, E. M., Aukrust, P., Skalbegg, B. S., Muller, F., Froland, S. S., Hansson, V., Tasken, K. (1998) Protein kinase A type 1 antagonist restores Immune responses of T Cells from HIV-infected patients. FASEB J. 12, 855-862.
    • (1998) FASEB J. , vol.12 , pp. 855-862
    • Aandahl, E.M.1    Aukrust, P.2    Skalbegg, B.S.3    Muller, F.4    Froland, S.S.5    Hansson, V.6    Tasken, K.7
  • 31
    • 0028289244 scopus 로고
    • Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
    • Sallusto, F., Lanzavecchia, A. (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179, 1109-1118.
    • (1994) J. Exp. Med. , vol.179 , pp. 1109-1118
    • Sallusto, F.1    Lanzavecchia, A.2
  • 32
    • 0025797596 scopus 로고
    • Effect of human immunodeficiency virus gp120 glycoprotein on the association of the protein tyrosine kinase p56lck with CD4 ia human T lymphocytes
    • Juszezak, R. J., Turchin, H., Trimeh, A., Culp, J., Kassis, S. (1991) Effect of human immunodeficiency virus gp120 glycoprotein on the association of the protein tyrosine kinase p56lck with CD4 ia human T lymphocytes. J. Biol. Chem. 266, 11176-11183.
    • (1991) J. Biol. Chem. , vol.266 , pp. 11176-11183
    • Juszezak, R.J.1    Turchin, H.2    Trimeh, A.3    Culp, J.4    Kassis, S.5
  • 33
    • 0026652806 scopus 로고
    • Internalization of HIV glycoprotein gp120 is associated with down-modulation of membrane CD4 and p56lck together with impairment of T cell activation
    • Cefai, D., Ferrer, M., Serpente, N., Idziorek, T., Dautry-Varsat, A., Debre, P., Bismuth, G. (1992) Internalization of HIV glycoprotein gp120 is associated with down-modulation of membrane CD4 and p56lck together with impairment of T cell activation. J. Immunol. 149, 285-294.
    • (1992) J. Immunol. , vol.149 , pp. 285-294
    • Cefai, D.1    Ferrer, M.2    Serpente, N.3    Idziorek, T.4    Dautry-Varsat, A.5    Debre, P.6    Bismuth, G.7
  • 34
    • 0026784923 scopus 로고
    • Crosslinking CD4 by human immonodeficiency virus gp 120 primes T cells for activation-induced apoptosis
    • Banda, N. K., Bernier, J., Kurahara, D. K., Kurrle, R., Haigwood, N., Sekaly, R. P., Finkel, T. H. (1992) Crosslinking CD4 by human immonodeficiency virus gp 120 primes T cells for activation-induced apoptosis. J. Exp. Med. 176, 1099-1106.
    • (1992) J. Exp. Med. , vol.176 , pp. 1099-1106
    • Banda, N.K.1    Bernier, J.2    Kurahara, D.K.3    Kurrle, R.4    Haigwood, N.5    Sekaly, R.P.6    Finkel, T.H.7
  • 35
    • 0030815339 scopus 로고    scopus 로고
    • Signals transduced through the CD4 molecule interfere with TCR/CD3-mediated ras activation leading to T cell anergy/apoptosis
    • Tamma, S. M., Chirmule, N., McCloskey, T. W., Oyaizu, N., Kalyanaraman, V. S., Pahwa, S. (1997) Signals transduced through the CD4 molecule interfere with TCR/CD3-mediated ras activation leading to T cell anergy/apoptosis. Clin. Immunopathol. 85, 195-201.
    • (1997) Clin. Immunopathol. , vol.85 , pp. 195-201
    • Tamma, S.M.1    Chirmule, N.2    McCloskey, T.W.3    Oyaizu, N.4    Kalyanaraman, V.S.5    Pahwa, S.6
  • 36
    • 0032543307 scopus 로고    scopus 로고
    • Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and neutralizing human antibody
    • Kwong, P. D., Wyatt, R., Robinson, J., Sweet, W., Sodroski, J., Hendrickson, W. (1998) Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and neutralizing human antibody. Nature 393, 648-659.
    • (1998) Nature , vol.393 , pp. 648-659
    • Kwong, P.D.1    Wyatt, R.2    Robinson, J.3    Sweet, W.4    Sodroski, J.5    Hendrickson, W.6
  • 37
    • 0034633829 scopus 로고    scopus 로고
    • Exploitation of cellular signaling by HIV-1: Unwelcome guests with master keys that signal their entry
    • Popik, W., Pitha, P.M. (2000) Exploitation of cellular signaling by HIV-1: unwelcome guests with master keys that signal their entry. Virology 276, 1-6.
    • (2000) Virology , vol.276 , pp. 1-6
    • Popik, W.1    Pitha, P.M.2
  • 38
    • 0035340992 scopus 로고    scopus 로고
    • HIV-1 gp120 stimulates the production of b-chemokines in human peripheral blood monocytes through a CD4-independent mechanism
    • Fantuzzi, L., Canini, I., Belardelli, F., Gessani, S. (2001) HIV-1 gp120 stimulates the production of b-chemokines in human peripheral blood monocytes through a CD4-independent mechanism. J. Immunol. 166, 5381-5387.
    • (2001) J. Immunol. , vol.166 , pp. 5381-5387
    • Fantuzzi, L.1    Canini, I.2    Belardelli, F.3    Gessani, S.4
  • 39
    • 0033563171 scopus 로고    scopus 로고
    • T cell-tropic HIV gp120 mediates CD4 and CD8 cell chemotaxis through CXCR4 independent of CD4: Implications for HIV pathogenesis
    • Iyengar, U., Schwartz, D. H., Hildreth, J. E. K. (1999) T cell-tropic HIV gp120 mediates CD4 and CD8 cell chemotaxis through CXCR4 independent of CD4: implications for HIV pathogenesis. J. Immunol. 162, 6263-6267.
    • (1999) J. Immunol. , vol.162 , pp. 6263-6267
    • Iyengar, U.1    Schwartz, D.H.2    Hildreth, J.E.K.3
  • 40
    • 0029655470 scopus 로고    scopus 로고
    • The role of CD4 in HIV envelope-mediated pathogenesis
    • Siliciano, R. F. (1996) The role of CD4 in HIV envelope-mediated pathogenesis. Curr. Top. Microbiol. Immunol. 205, 159-179.
    • (1996) Curr. Top. Microbiol. Immunol. , vol.205 , pp. 159-179
    • Siliciano, R.F.1
  • 41
    • 0036785396 scopus 로고    scopus 로고
    • gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes
    • Kinet, S., Bernard, F., Mongellaz, C., Perreau, M., Goldman, F. D., Taylor, N. (2002) gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes. Blood 100, 2546-2553.
    • (2002) Blood , vol.100 , pp. 2546-2553
    • Kinet, S.1    Bernard, F.2    Mongellaz, C.3    Perreau, M.4    Goldman, F.D.5    Taylor, N.6
  • 42
    • 0036148171 scopus 로고    scopus 로고
    • Segregation of CD4 and CXCR4 into distinct lipid microdomains in T lymphocytes suggests a mechanism for membrane destabilization by human immunodeficiency virus
    • Kozak, S. L., Heard, J. M., Kabat, D. (2002) Segregation of CD4 and CXCR4 into distinct lipid microdomains in T lymphocytes suggests a mechanism for membrane destabilization by human immunodeficiency virus. J. Virol. 76, 1802-1815.
    • (2002) J. Virol. , vol.76 , pp. 1802-1815
    • Kozak, S.L.1    Heard, J.M.2    Kabat, D.3
  • 43
    • 0036498797 scopus 로고    scopus 로고
    • Lipid raft heterogeneity in human peripheral blood T lymphoblasts: A mechanism for regulating the initiation of TCR signal transduction
    • Schade, A. E., Levine, A. D. (2002) Lipid raft heterogeneity in human peripheral blood T lymphoblasts: a mechanism for regulating the initiation of TCR signal transduction. J. Immunol. 168, 2233-2239.
    • (2002) J. Immunol. , vol.168 , pp. 2233-2239
    • Schade, A.E.1    Levine, A.D.2
  • 44
    • 0030453582 scopus 로고    scopus 로고
    • Exclusion of CD45 inhibits activity of p56lck associated with glycolipid-enriched membrane domains
    • Rodgers, W., Rose, J. K. (1996) Exclusion of CD45 inhibits activity of p56lck associated with glycolipid-enriched membrane domains. J. Cell Biol. 135, 1515-1523.
    • (1996) J. Cell Biol. , vol.135 , pp. 1515-1523
    • Rodgers, W.1    Rose, J.K.2
  • 45
    • 0032101348 scopus 로고    scopus 로고
    • Membrane compartmentation is required for efficient T cell activation
    • Xavier, R., Brennan, T., Li, Q., McCormack, C., Seed, B. (1998) Membrane compartmentation is required for efficient T cell activation. Immunity 8, 723-773.
    • (1998) Immunity , vol.8 , pp. 723-773
    • Xavier, R.1    Brennan, T.2    Li, Q.3    McCormack, C.4    Seed, B.5
  • 48
    • 1842295122 scopus 로고    scopus 로고
    • Requirement of a second signal via protein kinase C or protein kinase A for maximal expression of CD40 ligand: Involvement of transcriptional and posttranscriptional mechanisms
    • Suárez, A., Mozo, L., Gayo, A., Zamorano, J., Gutiérrez, C. (1997) Requirement of a second signal via protein kinase C or protein kinase A for maximal expression of CD40 ligand: involvement of transcriptional and posttranscriptional mechanisms. Eur. J. Immunol. 27, 2822-2830.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2822-2830
    • Suárez, A.1    Mozo, L.2    Gayo, A.3    Zamorano, J.4    Gutiérrez, C.5
  • 49
    • 0034663811 scopus 로고    scopus 로고
    • Defective Th function induced by a dominant-negative cAMP response element binding protein mutation is reversed by Bcl-2
    • Zhang, F., Rincon, M., Flavell, R. A., Aune, T. M. (2000) Defective Th function induced by a dominant-negative cAMP response element binding protein mutation is reversed by Bcl-2. J. Immunol. 165, 1762-1767.
    • (2000) J. Immunol. , vol.165 , pp. 1762-1767
    • Zhang, F.1    Rincon, M.2    Flavell, R.A.3    Aune, T.M.4
  • 50
    • 0027336504 scopus 로고
    • Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes
    • Snijdewint, F. G. M., Kalinski, P., Wierenga, E. A., Bos, J. D., Kapsenberg, L. (1993) Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes. J. Immunol. 150, 5321-5326.
    • (1993) J. Immunol. , vol.150 , pp. 5321-5326
    • Snijdewint, F.G.M.1    Kalinski, P.2    Wierenga, E.A.3    Bos, J.D.4    Kapsenberg, L.5
  • 52
    • 0033121116 scopus 로고    scopus 로고
    • Downregulation of JACK3 protein levels in T lymphocytes by prostaglandin E2 and other cyclic adenosine monophosphate-elevating agents: Impact on interleukin-2 receptor signalling pathway
    • Kolenko, V., Rayman, P., Ray, B., Catheart, M. K., O'Shea, J., Tubbs, R., Rybicki, L., Bukowski, R., Finke, J. (1999) Downregulation of JACK3 protein levels in T lymphocytes by prostaglandin E2 and other cyclic adenosine monophosphate-elevating agents: impact on interleukin-2 receptor signalling pathway. Blood 93, 2308-2314.
    • (1999) Blood , vol.93 , pp. 2308-2314
    • Kolenko, V.1    Rayman, P.2    Ray, B.3    Catheart, M.K.4    O'Shea, J.5    Tubbs, R.6    Rybicki, L.7    Bukowski, R.8    Finke, J.9
  • 53
    • 0034670044 scopus 로고    scopus 로고
    • Cyclic AMP activates p38 mitogen-activated protein kinase in Th2 cells: Phosphorylation of GATA-3 and stimulation of Th2 cytokine gene expression
    • Chen, C., Zhang, D., LaPorte, J. M., Ray, A. (2000) Cyclic AMP activates p38 mitogen-activated protein kinase in Th2 cells: phosphorylation of GATA-3 and stimulation of Th2 cytokine gene expression. J. Immunol. 165, 5597-5602.
    • (2000) J. Immunol. , vol.165 , pp. 5597-5602
    • Chen, C.1    Zhang, D.2    LaPorte, J.M.3    Ray, A.4
  • 54
    • 0036681792 scopus 로고    scopus 로고
    • Generation of CD4(+)D45RA(+) effector T cells by stimulation in the presence of cyclic adenosinc 5′-monophosphate-elevating agents
    • Suarez, A., Mozo, L., Gutierrez, C. (2002) Generation of CD4(+)D45RA(+) effector T cells by stimulation in the presence of cyclic adenosinc 5′-monophosphate-elevating agents. J. Immunol. 169, 1159-1167.
    • (2002) J. Immunol. , vol.169 , pp. 1159-1167
    • Suarez, A.1    Mozo, L.2    Gutierrez, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.