Independent effects of HIV, aging, and HAART on brain volumetric measures

Journal of Acquired Immune Deficiency Syndromes

Volumn 59, Issue 5, 2012, Pages 469-477

  Ances, Beau M ^a   Ortega, Mario ^a   Vaida, Florin ^b   Heaps, Jodi ^c   Paul, Robert ^c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MISSOURI ST LOUIS   (United States)

Author keywords

Aging; Brain volume; HAART; HIV

Indexed keywords

ADULT; AGE; AGING; AMYGDALOID NUCLEUS; ARTICLE; BRAIN ATROPHY; BRAIN SIZE; CAUDATE NUCLEUS; CD4 LYMPHOCYTE COUNT; CLINICAL ASSESSMENT; CONTROLLED STUDY; CORPUS CALLOSUM; CORRELATIONAL STUDY; DISEASE DURATION; EXECUTIVE FUNCTION; FEMALE; GRAY MATTER; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIPPOCAMPUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; MEMORY; NEUROIMAGING; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; PSYCHOMOTOR PERFORMANCE; PUTAMEN; SEROCONVERSION; THALAMUS; VIRUS LOAD; VOLUMETRY; WHITE MATTER;

ADULT; AGING; ANALYSIS OF VARIANCE; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; ATROPHY; BRAIN; EXECUTIVE FUNCTION; FEMALE; HIV INFECTIONS; HUMANS; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MALE; MEMORY; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PSYCHOMOTOR PERFORMANCE;

EID: 84859751139     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0b013e318249db17     Document Type: Article

References (58)

1. Lima VD, Hogg RS, Harrigan PR, et al. Continued improvement in survival among HIV-infected individuals with newer forms of highly active antiretroviral therapy. AIDS. 2007;21:685-692. (Pubitemid 46568625)
2. Deeks SG. HIV infection, inflammation, immunosenescence, and aging. Annu Rev Med. 2011;62:141-155.
3. Effros RB, Fletcher CV, Gebo K, et al. Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions. Clin Infect Dis. 2008;47:542-553.
4. Desquilbet L, Jacobson LP, Fried LP, et al. HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty. J Gerontol A Biol Sci Med Sci. 2007;62:1279-1286. (Pubitemid 350287617)
5. Desquilbet L, Margolick JB, Fried LP, et al. Relationship between a frailty-related phenotype and progressive deterioration of the immune system in HIV-infected men. J Acquir Immune Defic Syndr. 2009;50: 299-306.
6. Onen NF, Overton ET. A review of premature frailty in HIV-infected persons; another manifestation of HIV-related accelerated aging. Curr Aging Sci. 2011;4:33-41.
7. Onen NF, Overton ET, Seyfried W, et al. Aging and HIV infection: a comparison between older HIV-infected persons and the general population. HIV Clin Trials. 2011;11:100-109.
8. Ances BM, Vaida F, Yeh MJ, et al. HIV infection and aging independently affect brain function as measured by functional magnetic resonance imaging. J Infect Dis. 2010;201:336-340.
9. Chang L, Andres M, Sadino J, et al. Impact of apolipoprotein E epsilon4 and HIV on cognition and brain atrophy: antagonistic pleiotropy and premature brain aging. Neuroimage. 2011;58:1017-1027.
10. Harezlak J, Buchthal S, Taylor M, et al. Persistence of HIV-associated cognitive impairment, inflammation, and neuronal injury in era of highly active antiretroviral treatment. AIDS. 2011;25:625-633.
11. Clark US, Cohen RA. Brain dysfunction in the era of combination anti-retroviral therapy: implications for the treatment of the aging population of HIV-infected individuals. Curr Opin Investig Drugs. 2011;11:884-900.
12. Aylward EH, Henderer JD, McArthur JC, et al. Reduced basal ganglia volume in HIV-1-associated dementia: results from quantitative neuro-imaging. Neurology. 1993;43:2099-2104. (Pubitemid 23318887)
13. Heindel WC, Jernigan TL, Archibald SL, et al. The relationship of quantitative brain magnetic resonance imaging measures to neuropathologic indexes of human immunodeficiency virus infection. Arch Neurol. 1994; 51:1129-1135. (Pubitemid 24352856)
14. Kieburtz KD, Ketonen L, Zettelmaier AE, et al. Magnetic resonance imaging findings in HIV cognitive impairment. Arch Neurol. 1990;47:643-645. (Pubitemid 20183571)
15. Post MJ, Berger JR, Duncan R, et al. Asymptomatic and neurologically symptomatic HIV-seropositive subjects: results of long-term MR imaging and clinical follow-up. Radiology. 1993;188:727-733. (Pubitemid 23254592)
16. Cohen RA, Harezlak J, Gongvatana A, et al. Cerebral metabolite abnormalities in human immunodeficiency virus are associated with cortical and subcortical volumes. J Neurovirol. 2010;16:435-444.
17. Cohen RA, Harezlak J, Schifitto G, et al. Effects of nadir CD4 count and duration of human immunodeficiency virus infection on brain volumes in the highly active antiretroviral therapy era. J Neurovirol. 2010;16:25-32.
18. Paul RH, Ernst T, Brickman AM, et al. Relative sensitivity of magnetic resonance spectroscopy and quantitative magnetic resonance imaging to cognitive function among nondemented individuals infected with HIV. J Int Neuropsychol Soc. 2008;14:725-733.
19. Paul RH, Yiannoutsos CT, Miller EN, et al. Proton MRS and neuro-psychological correlates in AIDS dementia complex: evidence of sub-cortical specificity. J Neuropsychiatry Clin Neurosci. 2007;19:283-292. (Pubitemid 47293901)
20. Archibald SL, Masliah E, Fennema-Notestine C, et al. Correlation of in vivo neuroimaging abnormalities with postmortem human immunodeficiency virus encephalitis and dendritic loss. Arch Neurol. 2004;61: 369-376. (Pubitemid 38327356)
21. Chiang MC, Dutton RA, Hayashi KM, et al. 3D pattern of brain atrophy in HIV/AIDS visualized using tensor-based morphometry. Neuroimage. 2007;34:44-60. (Pubitemid 44773796)
22. Klunder AD, Chiang MC, Dutton RA, et al. Mapping cerebellar degeneration in HIV/AIDS. Neuroreport. 2008;19:1655-1659.
23. Lepore N, Brun C, Chou YY, et al. Generalized tensor-based morphom-etry of HIV/AIDS using multivariate statistics on deformation tensors. IEEE Trans Med Imaging. 2008;27:129-141.
24. Becker JT, Maruca V, Kingsley LA, et al. Factors affecting brain structure in men with HIV disease in the post-HAART era. Neuroradiology. 2011;54:113-121.
25. Becker JT, Sanders J, Madsen SK, et al. Subcortical brain atrophy persists even in HAART-regulated HIV disease. Brain Imaging Behav. 2011;5:77-85.
26. Cysique LA, Brew BJ. Neuropsychological functioning and antiretroviral treatment in HIV/AIDS: a review. Neuropsychol Rev. 2009;19:169-185.
27. White MG, Wang Y, Akay C, et al. Parallel high throughput neuronal toxicity assays demonstrate uncoupling between loss of mitochondrial membrane potential and neuronal damage in a model of HIV-induced neurodegeneration. Neurosci Res. 2010;70:220-229.
28. Giunta B, Ehrhart J, Obregon DF, et al. Antiretroviral medications disrupt microglial phagocytosis of beta-amyloid and increase its production by neurons: implications for HIV-associated neurocognitive disorders. Mol Brain. 2011;4:23.
29. Liner KJ II, Ro MJ, Robertson KR. HIV, antiretroviral therapies, and the brain. Curr HIV/AIDS Rep. 2010;7:85-91.
30. Marra CM, Zhao Y, Clifford DB, et al. Impact of combination antire-troviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance. AIDS. 2009;23:1359-1366.
31. Robertson KR, Su Z, Margolis DM, et al. Neurocognitive effects of treatment interruption in stable HIV-positive participants in an observational cohort. Neurology. 2010;74:1260-1266.
32. Ciccarelli N, Fabbiani M, Di Giambenedetto S, et al. Efavirenz associated with cognitive disorders in otherwise asymptomatic HIV-infected participants. Neurology. 2011;76:1403-1409.
33. Ernst T, Jiang CS, Nakama H, et al. Lower brain glutamate is associated with cognitive deficits in HIV participants: a new mechanism for HIV-associated neurocognitive disorder. J Magn Reson Imaging. 2010;32:1045-1053.
34. Van Gorp WG, Miller EN, Satz P, et al. Neuropsychological performance in HIV-1 immunocompromised participants: a preliminary report. J Clin Exp Neuropsychol. 1989;11:763-773.
35. Heaton RK, Franklin DR, Ellis RJ, et al. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J Neurovirol. 2011;17:3-16.
36. Letendre SL, Ellis RJ, Ances BM, McCutchan JA. Neurologic complications of HIV disease and their treatment. Top HIV Med. 2010;18:45-55.
37. Fischl B, Salat DH, Busa E, et al. Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron. 2002; 33:341-355. (Pubitemid 34162530)
38. Fischl B, Salat DH, van der Kouwe AJ, et al. Sequence-independent segmentation of magnetic resonance images. Neuroimage. 2004;23 (suppl 1):S69-S84. (Pubitemid 39429376)
39. Messina D, Cerasa A, Condino F, et al. Patterns of brain atrophy in Parkinson's disease, progressive supranuclear palsy and multiple system atrophy. Parkinsonism Relat Disord. 2011;17:172-176.
40. Labate A, Cerasa A, Aguglia U, et al. Voxel-based morphometry of sporadic epileptic participants with mesiotemporal sclerosis. Epilepsia. 2010;51:506-510.
41. Raz N, Rodrigue KM, Kennedy KM, et al. Differential aging of the human striatum: longitudinal evidence. AJNR Am J Neuroradiol. 2003; 24:1849-1856. (Pubitemid 37280536)
42. Westfall PH, Troendle JF. Multiple testing with minimal assumptions. Biom J. 2008;50:745-755.
43. Cleveland W. Robust locally weighted regression and smoothing scatter-plots. J Am Stat Assoc. 1979;74:829-883.
44. Vieth E. Fitting piecewise linear regression functions to biological responses. J Appl Physiol. 1989;67:390-396. (Pubitemid 19196496)
45. Lindsey JK, Jones B. Choosing among generalized linear models applied to medical data. Stat Med. 1998;17:59-68. (Pubitemid 28020208)
46. Dewey J, Hana G, Russell T, et al. Reliability and validity of MRI-based automated volumetry software relative to auto-assisted manual measurement of subcortical structures in HIV-infected participants from a multi-site study. Neuroimage. 2010;51:1334-1344.
47. Masliah E, Heaton RK, Marcotte TD, et al. Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders. HNRC Group. The HIV Neurobehavioral Research Center. Ann Neurol. 1997;42:963-972. (Pubitemid 28008427)
48. Brew BJ, Rosenblum M, Cronin K, et al. AIDS dementia complex and HIV-1 brain infection: clinical-virological correlations. Ann Neurol. 1995;38:563-570.
49. Fujimura RK, Goodkin K, Petito CK, et al. HIV-1 proviral DNA load across neuroanatomic regions of individuals with evidence for HIV-1-associated dementia. J Acquir Immune Defic Syndr Hum Retrovirol. 1997;16:146-152.
50. Langford D, Marquie-Beck J, de Almeida S, et al. Relationship of anti-retroviral treatment to postmortem brain tissue viral load in human immunodeficiency virus-infected participants. J Neurovirol. 2006;12:100-107. (Pubitemid 44574601)
51. Ances BM, Roc AC, Wang J, et al. Caudate blood flow and volume are reduced in HIV1 neurocognitively impaired participants. Neurology. 2006;66:862-866. (Pubitemid 43739761)
52. Jernigan TL, Archibald S, Hesselink JR, et al. Magnetic resonance imaging morphometric analysis of cerebral volume loss in human immunodeficiency virus infection. The HNRC Group. Arch Neurol. 1993;50:250-255. (Pubitemid 23069608)
53. Cardenas VA, Meyerhoff DJ, Studholme C, et al. Evidence for ongoing brain injury in human immunodeficiency virus-positive participants treated with antiretroviral therapy. J Neurovirol. 2009;15:324-333.
54. Di Sclafani V, Mackay RD, Meyerhoff DJ, et al. Brain atrophy in HIV infection is more strongly associated with CDC clinical stage than with cognitive impairment. J Int Neuropsychol Soc. 1997;3:276-287. (Pubitemid 27220046)
55. Jernigan TL, Archibald SL, Fennema-Notestine C, et al. Clinical factors related to brain structure in HIV: the CHARTER study. J Neurovirol. 2011;17:248-257.
56. Stout JC, Ellis RJ, Jernigan TL, et al. Progressive cerebral volume loss in human immunodeficiency virus infection: a longitudinal volumetric magnetic resonance imaging study. HIV Neurobehavioral Research Center Group. Arch Neurol. 1998;55:161-168.
57. Pfefferbaum A, Rosenbloom MJ, Rohlfing T, et al. Contribution of alcoholism to brain dysmorphology in HIV infection: effects on the ventricles and corpus callosum. Neuroimage. 2006;33:239-251. (Pubitemid 44397579)
58. Thompson PM, Dutton RA, Hayashi KM, et al. 3D mapping of ventricular and corpus callosum abnormalities in HIV/AIDS. Neuroimage. 2006;31:12-23. (Pubitemid 44250877)