Neuropathology and HIV Dementia

Handbook of Clinical Neurology

Volumn 89, Issue , 2008, Pages 807-818

  Pelle, Marie Thérèse ^a   Bazille, Céline ^a   Gray, Françoise ^a  

^a HÔPITAL LARIBOISIÈRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; BRAIN; DRUG EFFECT; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV ASSOCIATED DEMENTIA; HUMAN; METHODOLOGY; PATHOLOGY; REVIEW; SCHILDER DISEASE; VIROLOGY;

AIDS DEMENTIA COMPLEX; ANIMALS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BRAIN; DIFFUSE CEREBRAL SCLEROSIS OF SCHILDER; HUMANS;

EID: 66049160860     PISSN: 00729752     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0072-9752(07)01270-5     Document Type: Review

References (87)

1. Adamson D.C., Wildemann B., Sasaki M., et al. Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41. Science 274 (1996) 1917-1921
2. Adle-Biassette H., Levy Y., Colombel M., et al. Neuronal apoptosis in HIV infection in adults. Neuropathol Appl Neurobiol 21 (1995) 218-227
3. Adle-Biassette H., Chretien F., Wingertsmann L., et al. Neuronal apoptosis does not correlate with dementia in HIV infection but is related to microglial activation and axonal damage. Neuropathol Appl Neurobiol 25 (1999) 123-133
4. An S.F., Ciardi A., Giometto B., et al. Investigation on the expression of major histocompatibility complex class II and cytokines and detection of HIV-1 DNA within brains of asymptomatic and symptomatic HIV-1-positive patients. Acta Neuropathol (Berl) 91 (1996) 494-503
5. An S.F., Giometto B., Groves M., et al. Axonal damage revealed by accumulation of beta-APP in HIV-positive individuals without AIDS. J Neuropathol Exp Neurol 56 (1997) 1262-1268
6. An S.F., Groves M., Giometto B., et al. Detection and localisation of HIV-1 DNA and RNA in fixed adult AIDS brain by polymerase chain reaction/in situ hybridisation technique. Acta Neuropathol (Berl) 98 (1999) 481-487
7. Anderson C.E., Tomlinson G.S., Pauly B., et al. Relationship of Nef-positive and GFAP-reactive astrocytes to drug use in early and late HIV infection. Neuropathol Appl Neurobiol 29 (2003) 378-388
8. Anthony I.C., Ramage S.N., Carnie F.W., et al. Influence of HAART on HIV-related CNS disease and neuroinflammation. J Neuropathol Exp Neurol 64 (2005) 529-536
9. Bell J.E., Brettle R.P., Chiswick A., et al. HIV encephalitis, proviral load and dementia in drug users and homosexuals with AIDS Effect of neocortical involvement. Brain 121 (1998) 2043-2052
10. Berger J.R., and Nath A. HIV dementia and the basal ganglia. Intervirology 40 (1997) 122-131
11. Bonnet F., Morlat P., Chene G., et al. Causes of death among HIV-infected patients in the era of highly active antiretroviral therapy, Bordeaux, France, 1998-1999. HIV Med 3 (2002) 195-199
12. Boven L.A., Gomes L., Hery C., et al. Increased peroxynitrite activity in AIDS dementia complex: implications for the neuropathogenesis of HIV-1 infection. J Immunol 162 (1999) 4319-4327
13. Boven L.A., Middel J., Verhoef J., et al. Monocyte infiltration is highly associated with loss of the tight junction protein zonula occludens in HIV-1-associated dementia. Neuropathol Appl Neurobiol 26 (2000) 356-360
14. Brew B.J. Evidence for a change in AIDS dementia complex in the era of highly active antiretroviral therapy and the possibility of new forms of AIDS dementia complex. Aids 18 (2004) S75-S78
15. Budka H. Multinucleated giant cells in brain: a hallmark of the acquired immune deficiency syndrome (AIDS). Acta Neuropathol (Berl) 69 (1986) 253-258
16. Budka H., Wiley C.A., Kleihues P., et al. HIV-associated disease of the nervous system: review of nomenclature and proposal for neuropathology-based terminology. Brain Pathol 1 (1991) 143-152
17. Chang L., Ernst T., Leonido-Yee M., et al. Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia. Neurology 53 (1999) 782-789
18. Cherner M., Masliah E., Ellis R.J., et al. Neurocognitive dysfunction predicts postmortem findings of HIV encephalitis. Neurology 59 (2002) 1563-1567
19. D'Arminio Monforte A., Duca P.G., Vago L., et al. Decreasing incidence of CNS AIDS-defining events associated with antiretroviral therapy. Neurology 54 (2000) 1856-1859
20. Dore G.J., Correll P.K., Li Y., et al. Changes to AIDS dementia complex in the era of highly active antiretroviral therapy. Aids 13 (1999) 1249-1253
21. Dreyer E.B., and Lipton S.A. The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid. Eur J Neurosci 7 (1995) 2502-2507
22. Everall I.P., Luthert P.J., and Lantos P.L. Neuronal loss in the frontal cortex in HIV infection. Lancet 337 (1991) 1119-1121
23. Everall I., Luthert P., and Lantos P. A review of neuronal damage in human immunodeficiency virus infection: its assessment, possible mechanism and relationship to dementia. J Neuropathol Exp Neurol 52 (1993) 561-566
24. Everall I.P., Glass J.D., McArthur J., et al. Neuronal density in the superior frontal and temporal gyri does not correlate with the degree of human immunodeficiency virus-associated dementia. Acta Neuropathol (Berl) 88 (1994) 538-544
25. Everall I., Barnes H., Spargo E., et al. Assessment of neuronal density in the putamen in human immunodeficiency virus (HIV) infection. Application of stereology and spatial analysis of quadrats. J Neurovirol 1 (1995) 126-129
26. Everall I.P., Heaton R.K., Marcotte T.D., et al. Cortical synaptic density is reduced in mild to moderate human immunodeficiency virus neurocognitive disorder. HNRC Group. HIV Neurobehavioral Research Center. Brain Pathol 9 (1999) 209-217
27. Ferrarese C., Aliprandi A., Tremolizzo L., et al. Increased glutamate in CSF and plasma of patients with HIV dementia. Neurology 57 (2001) 671-675
28. Fine S.M., Angel R.A., Perry S.W., et al. Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes. Implications for pathogenesis of HIV-1 dementia. J Biol Chem 271 (1996) 15303-15306
29. Geiger K.D., Stoldt P., Schlote W., et al. Ezrin immunoreactivity is associated with increasing malignancy of astrocytic tumors but is absent in oligodendrogliomas. Am J Pathol 157 (2000) 1785-1793
30. Gelbard H.A., James H.J., Sharer L.R., et al. Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy. Neuropathol Appl Neurobiol 21 (1995) 208-217
31. Giometto B., An S.F., Groves M., et al. Accumulation of beta-amyloid precursor protein in HIV encephalitis: relationship with neuropsychological abnormalities. Ann Neurol 42 (1997) 34-40
32. Glass J.D., Wesselingh S.L., Selnes O.A., et al. Clinical-neuropathologic correlation in HIV-associated dementia. Neurology 43 (1993) 2230-2237
33. Granon S., Cazalis F., Anton J.L., et al. Cognitive and motor disorders in neuroaids: early dignosis using functional MRI and neuropsychological tests. J Neurovirol 6 (2000) 268
34. Grant I., Atkinson J.H., Hesselink J.R., et al. Evidence for early central nervous system involvement in the acquired immunodeficiency syndrome (AIDS) and other human immunodeficiency virus (HIV) infections. Studies with neuropsychologic testing and magnetic resonance imaging. Ann Intern Med 107 (1987) 828-836
35. Gras G., Chrétien F., Vallat-Decouvelaere A.V., et al. Regulated expression of sodium-dependent glutamate transporters and synthetase: a neuroprotective role for activated microglia and macrophages in HIV infection?. Brain Pathol 13 (2003) 211-222
36. Gray F. Atlas of the Neuropathology of HIV Infection (1993), Oxford University Press, Oxford
37. Gray F., Haug H., Chimelli L., et al. Prominent cortical atrophy with neuronal loss as correlate of human immunodeficiency virus encephalopathy. Acta Neuropathol (Berl) 82 (1991) 229-233
38. Gray F., Scaravilli F., Everall I., et al. Neuropathology of early HIV-1 infection. Brain Pathol 6 (1996) 1-15
39. Gray F., Adle-Biassette H., Chrétien F., et al. Neuropathology and neurodegeneration in human immunodeficiency virus infection. Pathogenesis of HIV-induced lesions of the brain, correlations with HIV-associated disorders and modifications according to treatments. Clin Neuropathol 20 (2001) 146-155
40. Gray F., Chrétien F., Decouvelaere A.V., et al. Neuropathology of dementing illness: pathogenesis of HIV-induced lesions of the brain and correlations with HIV-associated cognitive disorders. Histopathology 41 (2002) 32-36
41. Gray F., Chrétien F., Vallat-Decouvelaere A.V., et al. The changing pattern of HIV neuropathology in the HAART era. J Neuropathol Exp Neurol 62 (2003) 429-440
42. Gray F., Bazille C., Adle-Biassette H., et al. Central nervous system immune reconstitution disease in acquired immunodeficiency syndrome patients receiving highly active antiretroviral treatment. J Neurovirol 11 (2005) 16-22
43. Haughey N.J., Nath A., Mattson M.P., et al. HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity. J Neurochem 78 (2001) 457-467
44. Heyes M.P., Brew B.J., Martin A., et al. Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status. Ann Neurol 29 (1991) 202-209
45. Janssen R.S., Cornblath D.R., Epstein L.G., et al. Nomenclature and research case definitions for neurological manifestations of human immunodeficiency virus type-1 (HIV-1) infection. Report of a Working group of the American Academy of Neurology AIDS Task Force. Neurology 41 (1991) 778-785
46. Janssen R.S., Nwanyanwu O.C., Selik R.M., et al. Epidemiology of human immunodeficiency virus encephalopathy in the United States. Neurology 42 (1992) 1472-1476
47. Johnson R.T., Glass J.D., McArthur J.C., et al. Quantitation of human immunodeficiency virus in brains of demented and nondemented patients with acquired immunodeficiency syndrome. Ann Neurol 39 (1996) 392-395
48. Kaul M., Garden G.A., and Lipton S.A. Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 410 (2001) 988-994
49. Ketzler S., Weis S., Haug H., et al. Loss of neurons in the frontal cortex in AIDS brains. Acta Neuropathol (Berl) 80 (1990) 92-94
50. Kleihues P., Lang W., Burger P.C., et al. Progressive diffuse leukoencephalopathy in patients with acquired immune deficiency syndrome (AIDS). Acta Neuropathol (Berl) 68 (1985) 333-339
51. Koralnik I.J., Beaumanoir A., Hausler R., et al. A controlled study of early neurologic abnormalities in men with asymptomatic human immunodeficiency virus infection. N Engl J Med 323 (1990) 864-870
52. Langford T.D., Letendre S.L., Marcotte T.D., et al. Severe, demyelinating leukoencephalopathy in AIDS patients on antiretroviral therapy. Aids 16 (2002) 1019-1029
53. Lazarini F., Seilhean D., Rosenblum O., et al. Human immunodeficiency virus type 1 DNA and RNA load in brains of demented and nondemented patients with acquired immunodeficiency syndrome. J Neurovirol 3 (1997) 299-303
54. Lipton S.A., Sucher N.J., Kaiser P.K., et al. Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity. Neuron 7 (1991) 111-118
55. Maschke M., Kastrup O., Esser S., et al. Incidence and prevalence of neurological disorders associated with HIV since the introduction of highly active antiretroviral therapy (HAART). J Neurol Neurosurg Psychiatry 69 (2000) 376-380
56. Masliah E., Heaton R.K., Marcotte T.D., et al. Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders. HNRC Group. The HIV Neurobehavioral Research Center. Ann Neurol 42 (1997) 963-972
57. Miller R.F., Isaacson P.G., Hall-Craggs M., et al. Cerebral CD8+ lymphocytosis in HIV-1 infected patients with immune restoration induced by HAART. Acta Neuropathol (Berl) 108 (2004) 17-23
58. Petito C.K., and Cash K.S. Blood-brain barrier abnormalities in the acquired immunodeficiency syndrome: immunohistochemical localization of serum proteins in postmortem brain. Ann Neurol 32 (1992) 658-666
59. Petito C.K., and Roberts B. Evidence of apoptotic cell death in HIV encephalitis. Am J Pathol 146 (1995) 1121-1130
60. Petito C.K., Roberts B., Cantando J.D., et al. Hippocampal injury and alterations in neuronal chemokine co-receptor expression in patients with AIDS. J Neuropathol Exp Neurol 60 (2001) 377-385
61. Power C., Kong P.A., Crawford T.O., et al. Cerebral white matter changes in acquired immunodeficiency syndrome dementia: alterations of the blood-brain barrier. Ann Neurol 34 (1993) 339-350
62. Price R.W., Sidtis J.J., and Brew B.J. AIDS dementia complex and HIV-1 infection: a view from the clinic. Brain Pathol 1 (1991) 155-162
63. Raja F., Sherriff F.E., Morris C.S., et al. Cerebral white matter damage in HIV infection demonstrated using beta-amyloid precursor protein immunoreactivity. Acta Neuropathol (Berl) 93 (1997) 184-189
64. Rimaniol A.C., Mialocq P., Clayette P., et al. Role of glutamate transporters in the regulation of glutathione levels in human macrophages. Am J Physiol Cell Physiol 281 (2001) C1964-C1970
65. Sacktor N.C., Lyles R.H., Skolasky R.L., et al. Combination antiretroviral therapy improves psychomotor speed performance in HIV-seropositive homosexual men. Multicenter AIDS Cohort Study (MACS). Neurology 52 (1999) 1640-1647
66. Sacktor N.C., Skolasky R.L., Lyles R.H., et al. Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors. J Neurovirol 6 (2000) 84-88
67. Sacktor N., McDermott M.P., Marder K., et al. HIV-associated cognitive impairment before and after the advent of combination therapy. J Neurovirol 8 (2002) 136-142
68. Saito Y., Sharer L.R., Epstein L.G., et al. Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues. Neurology 44 (1994) 474-481
69. Seilhean D., Duyckaerts C., Vazeux R., et al. HIV-1-associated cognitive/motor complex: absence of neuronal loss in the cerebral neocortex. Neurology 43 (1993) 1492-1499
70. Seilhean D., Dzia-Lepfoundzou A., Sazdovitch V., et al. Astrocytic adhesion molecules are increased in HIV-1-associated cognitive/motor complex. Neuropathol Appl Neurobiol 23 (1997) 83-92
71. Sharer L.R., Cho E.S., and Epstein L.G. Multinucleated giant cells and HTLV-III in AIDS encephalopathy. Hum Pathol 16 (1985) 760
72. Shelburne III S.A., Hamill R.J., Rodriguez-Barradas M.C., et al. Immune reconstitution inflammatory syndrome: emergence of a unique syndrome during highly active antiretroviral therapy. Medicine (Baltimore) 81 (2002) 213-227
73. Shi B., De Girolami U., He J., et al. Apoptosis induced by HIV-1 infection of the central nervous system. J Clin Invest 98 (1996) 1979-1990
74. Shi B., Raina J., Lorenzo A., et al. Neuronal apoptosis induced by HIV-1 Tat protein and TNF-alpha: potentiation of neurotoxicity mediated by oxidative stress and implications for HIV-1 dementia. J Neurovirol 4 (1998) 281-290
75. Smith T.W., DeGirolami U., Henin D., et al. Human immunodeficiency virus (HIV) leukoencephalopathy and the microcirculation. J Neuropathol Exp Neurol 49 (1990) 357-370
76. Sung J.H., Shin S.A., Park H.K., et al. Protective effect of glutathione in HIV-1 lytic peptide 1-induced cell death in human neuronal cells. J Neurovirol 7 (2001) 454-465
77. Tornatore C., Chandra R., Berger J.R., et al. HIV-1 infection of subcortical astrocytes in the pediatric central nervous system. Neurology 44 (1994) 481-487
78. Tozzi V., Balestra P., Galgani S., et al. Changes in neurocognitive performance in a cohort of patients treated with HAART for 3 years. J Acquir Immune Defic Syndr 28 (2001) 19-27
79. Vallat A.V., De Girolami U., He J., et al. Localization of HIV-1 co-receptors CCR5 and CXCR4 in the brain of children with AIDS. Am J Pathol 152 (1998) 167-178
80. Vallat-Decouvelaere A.V., Chrétien F., Gras G., et al. Expression of excitatory amino acid transporter-1 in brain macrophages and microglia of HIV-infected patients. A neuroprotective role for activated microglia?. J Neuropathol Exp Neurol 62 (2003) 475-485
81. Vallat-Decouvelaere A.V., Chrétien F., Lorin de la Grandmaison G., et al. [The neuropathology of HIV infection in the era of highly active antiretroviral therapy]. Ann Pathol 23 (2003) 408-423
82. Vallat-Decouvelaere A.V., Gray F., Chrétien F., et al. [Neurotoxicity and neuroprotection, two aspects of microglial activation in human immunodeficiency virus (HIV) infection]. Ann Pathol 24 (2004) 31-44
83. Van der Ven A.J., van Oostenbrugge R.J., Kubat B., et al. Cerebral vasculitis after initiation antiretroviral therapy. Aids 16 (2002) 2362-2364
84. Vendrely A., Bienvenu B., Gasnault J., et al. Fulminant inflammatory leukoencephalopathy associated with HAART-induced immune restoration in AIDS-related progressive multifocal leukoencephalopathy. Acta Neuropathol (Berl) 109 (2005) 449-455
85. Weis S., Haug H., and Budka H. Neuronal damage in the cerebral cortex of AIDS brains: a morphometric study. Acta Neuropathol (Berl) 85 (1993) 185-189
86. Wiley C.A., and Achim C. Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome. Ann Neurol 36 (1994) 673-676
87. Wiley C.A., Masliah E., Morey M., et al. Neocortical damage during HIV infection. Ann Neurol 29 (1991) 651-657