Development of a PET/SPECT agent for amyloid imaging in alzheimer's disease

Journal of Molecular Neuroscience

Volumn 24, Issue 1, 2004, Pages 55-62

  Wang, Yanming ^a   Klunk, William E ^b   Debnath, Manik L ^b   Huang, Guo Feng ^b   Holt, Daniel P ^a,b   Shao, Li ^b   Mathis, Chester A ^b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; A peptides; Carbon 11; Iodine 125; PET; SPECT

Indexed keywords

2 (3' IODO 4' METHYLAMINOPHENYL) 6 HYDROXYBENZOTHIAZOLE C 11; 2 (3' IODO 4' METHYLAMINOPHENYL) 6 HYDROXYBENZOTHIAZOLE I 123; 2 (3' IODO 4' METHYLAMINOPHENYL) 6 HYDROXYBENZOTHIAZOLE I 125; 2 (3' IODO 4' METHYLAMINOPHENYL) 6 METHOXYBENZOTHIAZOLE; 2 (4' METHYLAMINOPHENYL) 6 METHANESULFONOXYBENZOTHIAZOLE; 2 (4' METHYLAMINOPHENYL) 6 METHANESULFONOXYBENZOTHIAZOLE SODIUM IODIDE I 125; 2 (4' METHYLAMINOPHENYL) 6 METHOXYBENZOTHIAZOLE; 2 AMINO 6 METHOXYBENZOTHIAZOLE; 6 HYDROXY 2 (4' METHYLAMINOPHENYL)BENZOTHIAZOLE; AMYLOID; BENZOTHIAZOLE DERIVATIVE; BIOLOGICAL MARKER; CARBON 11; IODINATED CONTRAST MEDIUM; METHYL IODIDE; RADIOLIGAND; SODIUM IODIDE I 125; TOSYLCHLORAMIDE SODIUM; TRACER; UNCLASSIFIED DRUG; 2 (3' IODO 4' METHYLAMINOPHENYL) 6 HYDROXYBENZOTHIAZOLE; 2-(3'-IODO-4'-METHYLAMINOPHENYL)-6-HYDROXYBENZOTHIAZOLE; AMYLOID BETA PROTEIN; ANILINE DERIVATIVE; BENZOTHIAZOLE; CARBON; DIAGNOSTIC AGENT; RADIOACTIVE IODINE; THIAZOLE DERIVATIVE;

AFFINITY LABELING; AGED; ALZHEIMER DISEASE; ANIMAL TISSUE; AUTOPSY; BINDING ASSAY; BRAIN HOMOGENATE; CEREBELLUM; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BINDING; DRUG CLEARANCE; DRUG PENETRATION; DRUG SYNTHESIS; EVALUATION; FEMALE; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; IODINATION; ISOTOPE LABELING; METHYLATION; MOUSE; NONHUMAN; PHOTON; POSITRON; POSITRON EMISSION TOMOGRAPHY; QUANTITATIVE ANALYSIS; RADIOLOGY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; ANIMAL; ARTICLE; BINDING COMPETITION; BRAIN; CHEMICAL STRUCTURE; DISEASE MODEL; FRONTAL LOBE; METABOLIC CLEARANCE RATE; METABOLISM; METHODOLOGY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RADIOASSAY; SCINTISCANNING; SENILE PLAQUE; SYNTHESIS; TRANSGENIC MOUSE;

AGED; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANILINE COMPOUNDS; ANIMALS; BENZOTHIAZOLES; BINDING, COMPETITIVE; BRAIN; CARBON RADIOISOTOPES; CEREBELLUM; DISEASE MODELS, ANIMAL; FEMALE; FRONTAL LOBE; HUMANS; IODINE RADIOISOTOPES; METABOLIC CLEARANCE RATE; MICE; MICE, TRANSGENIC; MOLECULAR STRUCTURE; POSITRON-EMISSION TOMOGRAPHY; RADIOLIGAND ASSAY; SENILE PLAQUES; THIAZOLES; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 16544371922     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/jmn:24:1:055     Document Type: Conference Paper

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