Brain aging in acquired immunodeficiency syndrome: Increased ubiquitin-protein conjugate is correlated with decreased synaptic protein but not amyloid plaque accumulation

Journal of NeuroVirology

Volumn 10, Issue 2, 2004, Pages 98-108

  Gelman, Benjamin B ^a   Schuenke, Kimberly ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Amyloid precursor protein; Autopsy; Diffuse plaque; Growth associated protein 43; HIV encephalitis; Proteasome; Synaptophysin; Ubiquitin; Western blotting

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; NEUROMODULIN; PROTEASOME; SYNAPTOPHYSIN; UBIQUITIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; AGE; AGED; AGING; ARTICLE; AUTOPSY; BRAIN REGION; CLINICAL ARTICLE; CLINICAL EXAMINATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DEATH; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; ENCEPHALITIS; ETHNIC DIFFERENCE; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR WEIGHT; NERVE CELL; NEUROPATHOLOGY; PREVALENCE; PRIORITY JOURNAL; PROTEIN METABOLISM; SENILE PLAQUE; SEX DIFFERENCE; TIME; WESTERN BLOTTING;

ADULT; AGED; AGING; AIDS DEMENTIA COMPLEX; AMYLOID BETA-PROTEIN; AMYLOIDOSIS; CYSTEINE ENDOPEPTIDASES; FEMALE; HUMANS; MALE; MIDDLE AGED; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX; SENILE PLAQUES; SYNAPSES; UBIQUITIN;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 1942422600     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.1080/13550280490279816     Document Type: Article

References (94)

1. Adle-Biassette H, Chretien F, Wingertsmann L, Hery C, Ereau T, Scaravilli F, Tardieu M, Gray F (1999). Neuronal apoptosis does not correlate with dementia in HIV infection but is related to microglial activation and axonal damage. Neuropathol Appl Neurobiol 25: 123-133.
2. Agarwal S, Sohal RS (1994). Aging and proteolysis of oxidized proteins. Arch Biochem Biophys 309: 24-28.
3. Ageta H, Kato A, Fukazawa Y, Inokuchi K, Sugiyama H (2001). Effects of proteasome inhibitors on the synaptic localization of Vesl-1S/Homer-1a proteins. Brain Res Mol Brain Res 97: 186-189.
4. An SF, Giometto B, Groves M, Miller RF, Beckett AA, Gray F, Tavolato B, Scaravilli F (1997). Axonal damage revealed by accumulation of beta-APP in HIV-positive individuals without AIDS. J Neuropathol Exp Neurol 56: 1262-1268.
5. Anderson JP, Esch FS, Keim PS, Sambamurti K, Lieberburg I, Robakis NK (1991). Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells. Neurosci Lett 128: 126-128.
6. Baker RT, Tobias JW, Varshavsky A (1992). Ubiquitin-specific proteases of Saccharomyces cerevisiae. Cloning of UBP2 and UBP3, and functional analysis of the UBP gene family. J Biol Chem 267: 23364-23375.
7. Band GP, Ridderinkhof KR, Segalowitz S (2002). Explaining neurocognitive aging: is one factor enough? Brain Cogn 49: 259-267.
8. Bence NF, Sampat RM, Kopito RR (2001). Impairment of the ubiquitin-proteasome system by protein aggregation. Science 292: 1552-1555.
9. Bennett MC, Bishop JF, Leng Y, Chock PB, Chase TN, Mouradian MM (1999). Degradation of alpha-synuclein by proteasome. J Biol Chem 274: 33855-33858.
10. Bulteau AL, Szweda LI, Friguet B (2002). Age-dependent declines in proteasome activity in the heart. Arch Biochem Biophys 397: 298-304.
11. Burbea M, Dreier L, Dittman JS, Grunwald ME, Kaplan JM (2002). Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans. Neuron 35: 107-120.
12. Buttner C, Sadtler S, Leyendecker A, Laube B, Griffon N, Betz H, Schmalzing G (2001). Ubiquitination precedes internalization and proteolytic cleavage of plasma membrane-bound glycine receptors. J Biol Chem 276: 42978-42985.
13. Carrard G, Bulteau AL, Petropoulos I, Friguet B (2002). Impairment of proteasome structure and function in aging. Int J Biochem Cell Biol 34: 1461-1474.
14. Chang L, Ernst T, Leonido-Yee M, Witt M, Speck O, Walot I, Miller EN (1999). Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia. Neurology 53: 782-789.
15. Chapman AP, Courtney SC, Smith SJ, Rider CC, Beesley PW (1992). Ubiquitin immunoreactivity of multiple polypeptides in rat brain synaptic membranes. Biochem Soc Trans 20: 155S.
16. Chapman AP, Smith SJ, Rider CC, Beesley PW (1994). Multiple ubiquitin conjugates are present in rat brain synaptic membranes and postsynaptic densities. Neurosci Lett 168: 238-242.
17. Chung KK, Dawson VL, Dawson TM (2001). The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders. Trends Neurosci 24: S7-S14.
18. Davies KJ (2001). Degradation of oxidized proteins by the 20S proteasome. Biochimie 83: 301-310.
19. DiAntonio A, Haghighi AP, Portman SL, Lee JD, Amaranto AM, Goodman CS (2001). Ubiquitination-dependent mechanisms regulate synaptic growth and function. Nature 412: 449-452.
20. Dickson DW (1997). The pathogenesis of senile plaques. J Neuropathol Exp Neurol 56: 321-339.
21. Dickson DW, Wertkin A, Kress Y, Ksiezak-Reding H, Yen SH (1990). Ubiquitin immunoreactive structures in normal human brains. Distribution and developmental aspects. Lab Invest 63: 87-99.
22. Dimakopoulos AC, Mayer RJ (2002). Aspects of neurodegeneration in the canine brain. J Nutr 132: 1579S-1582S.
23. Dore GJ, Correll PK, Li Y, Kaldor JM, Cooper DA, Brew BJ (1999). Changes to AIDS dementia complex in the era of highly active antiretroviral therapy. AIDS 13: 1249-1253.
24. Dougherty RH, Skolasky RL Jr, McArthur JC (2002). Progression of HIV-associated dementia treated with HAART. AIDS Read 12: 69-74.
25. Ehlers MD (2003). Ubiquitin and synaptic dysfunction: ataxic mice highlight new common themes in neurological disease. Trends Neurosci 26: 4-7.
26. Esiri MM, Biddolph SC, Morris CS (1998). Prevalence of Alzheimer plaques in AIDS. J Neurol Neurosurg Psychiatry 65: 29-33.
27. Figueiredo-Pereira ME, Li Z, Jansen M, Rockwell P (2002). N-acetylcysteine and celecoxib lessen cadmium cytotoxicity which is associated with cyclooxygenase-2 upregulation in mouse neuronal cells. J Biol Chem 277: 25283-25289.
28. Gelman BB, Wolf DA, Olano JP, Linthicum LC (1996). Incarceration and the acquired immunodeficiency syndrome: autopsy results in Texas prison inmates. Hum Pathol 27: 1282-1287.
29. Glass JD, Fedor H, Wesselingh SL, McArthur JC (1995). Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann Neurol 38: 755-762.
30. Goto S, Takahashi R, Araki S, Nakamoto H (2002). Dietary restriction initiated in late adulthood can reverse age-related alterations of protein and protein metabolism. Ann N Y Acad Sci 959: 50-56.
31. Goto S, Takahashi R, Kumiyama AA, Radak Z, Hayashi T, Takenouchi M, Abe R (2001). Implications of protein degradation in aging. Ann N Y Acad Sci 928: 54-64.
32. Gray F, Chretien F, Vallat-Decouvelaere AV, Scaravilli F (2003). The changing pattern of HIV neuropathology in the HAART era. J Neuropathol Exp Neurol 62: 429-440.
33. Grune T (2000). Oxidative stress, aging and the proteasomal system. Biogerontology 1: 31-40.
34. Hegde AN, DiAntonio A (2002). Ubiquitin and the synapse. Nat Rev Neurosci 3: 854-861.
35. Hogg RS, O'Shaughnessy MV, Gataric N, Yip B, Craib K, Schechter MT, Montaner JS (1997). Decline in deaths from AIDS due to new antiretrovirals. Lancet 349: 1294.
36. Izycka-Swieszewska E, Zoltowska A, Rzepko R, Gross M, Borowska-Lehman J (2000). Vasculopathy and amyloid beta reactivity in brains of patients with acquired immune deficiency (AIDS). Folia Neuropathol 38: 175-182.
37. Jellinger KA, Setinek U, Drlicek M, Bohm G, Steurer A, Lintner F (2000). Neuropathology and general autopsy findings in AIDS during the last 15 years. Acta Neuropathol (Berl) 100: 213-220.
38. Jiang YH, Armstrong D, Albrecht U, Atkins CM, Noebels JL, Eichele G, Sweatt JD, Beaudet AL (1998). Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. Neuron 21: 799-811.
39. Kanemaru K, Meckelein B, Marshall DC, Sipe JD, Abraham CR (1996). Synthesis and secretion of active alpha 1-antichymotrypsin by murine primary astrocytes. Neurobiol Aging 17: 767-771.
40. Keck S, Nitsch R, Grune T, Ullrich O (2003). Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease. J Neurochem 85: 115-122.
41. Keller JN, Gee J, Ding Q (2002). The proteasome in brain aging. Ageing Res Rev 1: 279-293.
42. Keller JN, Hanni KB, Kindy MS (2000a). Oxidized high-density lipoprotein induces neuron death. Exp Neurol 161: 621-630.
43. Keller JN, Hanni KB, Markesbery WR (2000b). Impaired proteasome function in Alzheimer's disease. J Neurochem 75: 436-439.
44. Keller JN, Hanni KB, Markesbery WR (2000c). Possible involvement of proteasome inhibition in aging: implications for oxidative stress. Mech Ageing Dev 113: 61-70.
45. Keller JN, Huang FF, Markesbery WR (2000d). Decreased levels of proteasome activity and proteasome expression in aging spinal cord. Neuroscience 98: 149-156.
46. Keller JN, Markesbery WR (2000). Proteasome inhibition results in increased poly-ADP-ribosylation: implications for neuron death. J Neurosci Res 61: 436-442.
47. Klimaschewski L (2003). Ubiquitin-dependent proteolysis in neurons. News Physiol Sci 18: 29-33.
48. Lennox G, Lowe J, Morrell K, Landon M, Mayer RJ (1988). Ubiquitin is a component of neurofibrillary tangles in a variety of neurodegenerative diseases. Neurosci Lett 94: 211-217.
49. Li Z, Jansen M, Pierre SR, Figueiredo-Pereira ME (2003). Neurodegeneration: linking ubiquitin/proteasome pathway impairment with inflammation. Int J Biochem Cell Biol 35: 547-552.
50. Licastro F, Campbell IL, Kincaid C, Veinbergs I, Van Uden E, Rockenstein E, Mallory M, Gilbert JR, Masliah E (1999). A role for apoE in regulating the levels of alpha-1-antichymotrypsin in the aging mouse brain and in Alzheimer's disease. Am J Pathol 155: 869-875.
51. Lopez-Salon M, Alonso M, Vianna MR, Viola H, Mello e Souza T, Izquierdo I, Pasquini JM, Medina JH (2001). The ubiquitin-proteasome cascade is required for mammalian long-term memory formation. Eur J Neurosci 14: 1820-1826.
52. Lowe J, Blanchard A, Morrell K, Lennox G, Reynolds L, Billett M, Landon M, Mayer RJ (1988). Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease. J Pathol 155: 9-15.
53. Lowe J, Mayer J, Landon M, Layfield R (2001). Ubiquitin and the molecular pathology of neurodegenerative diseases. Adv Exp Med Biol 487: 169-186.
54. Ma J, Wollmann R, Lindquist S (2002). Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol. Science 298: 1781-1785.
55. Mahler HR (1969). Protein turnover and synthesis: relation to synaptic function. Adv Biochem Psychopharmacol 1: 49-69.
56. Marzban G, Grillari J, Reisinger E, Hemetsberger T, Grabherr R, Katinger H (2002). Age-related alterations in the protein expression profile of C57BL/6J mouse pituitaries. Exp Gerontol 37: 1451-1460.
57. Masliah E, DeTeresa RM, Mallory ME, Hansen LA (2000). Changes in pathological findings at autopsy in AIDS cases for the last 15 years. AIDS 14: 69-74.
58. Masliah E, Heaton RK, Marcotte TD, Ellis RJ, Wiley CA, Mallory M, Achim CL, McCutchan JA, Nelson JA, Atkinson JH, Grant I (1997). Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders. HNRC Group. The HIV Neurobehavioral Research Center. Ann Neurol 42: 963-972.
59. McGeer PL, McGeer EG (2001). Inflammation, autotoxicity and Alzheimer disease. Neurobiol Aging 22: 799-809.
60. Merker K, Grune T (2000). Proteolysis of oxidised proteins and cellular senescence. Exp Gerontol 35: 779-786.
61. Merker K, Stolzing A, Grune T (2001). Proteolysis, caloric restriction and aging. Mech Ageing Dev 122: 595-615.
62. Merrill JE, Koyanagi Y, Zack J, Thomas L, Martin F, Chen IS (1992). Induction of interleukin-1 and tumor necrosis factor alpha in brain cultures by human immunodeficiency virus type 1. J Virol 66: 2217-2225.
63. Mezey E, Dehejia A, Harta G, Papp MI, Polymeropoulos MH, Brownstein MJ (1998). Alpha synuclein in neurodegenerative disorders: murderer or accomplice? Nat Med 4: 755-757.
64. Mirra SS, Hart MN, Terry RD (1993). Making the diagnosis of Alzheimer's disease. A primer for practicing pathologists. Arch Pathol Lab Med 117: 132-144.
65. Mizuno Y, Hattori N, Matsumine H (1998). Neurochemical and neurogenetic correlates of Parkinson's disease. J Neurochem 71: 893-902.
66. Morgello S, Mahboob R, Yakoushina T, Khan S, Hague K (2002). Autopsy findings in a human immunodeficiency virus-infected population over 2 decades: influences of gender, ethnicity, risk factors, and time. Arch Pathol Lab Med 126: 182-190.
67. Navia BA, Cho ES, Petito CK, Price RW (1986). The AIDS dementia complex: II. Neuropathology. Ann Neurol 19: 525-535.
68. Ohtsuka H, Takahashi R, Goto S (1995). Age-related accumulation of high-molecular-weight ubiquitin protein conjugates in mouse brains. J Gerontol A Biol Sci Med Sci 50: B277-B281.
69. Pappolla MA, Omar R, Saran B (1989). The "normal" brain. "Abnormal" ubiquitinilated deposits highlight an age-related protein change. Am J Pathol 135: 585-591.
70. Petito CK (1993). Neuropathology of Acquired Immunodeficiency Syndrome. In: Principles and practice of neuropathology. Nelson JS, Parisi JE, Schochet SS (eds). St. Louis: Mosby-Year Book, pp 88-108.
71. Raasi S, Schmidtke G, de Giuli R, Groettrup M (1999). A ubiquitin-like protein which is synergistically inducible by interferon-gamma and tumor necrosis factor-alpha. Eur J Immunol 29: 4030-4036.
72. Roberts ES, Zandonatti MA, Watry DD, Madden LJ, Henriksen SJ, Taffe MA, Fox HS (2003). Induction of pathogenic sets of genes in macrophages and neurons in NeuroAIDS. Am J Pathol 162: 2041-2057.
73. Ryazanov AG, Nefsky BS (2002). Protein turnover plays a key role in aging. Mech Ageing Dev 123: 207-213.
74. Sacktor N, Lyles RH, Skolasky R, Kleeberger C, Selnes OA, Miller EN, Becker JT, Cohen B, McArthur JC (2001). HIV-associated neurologic disease incidence changes: Multicenter AIDS Cohort Study, 1990-1998. Neurology 56: 257-260.
75. Sacktor NC, Lyles RH, Skolasky RL, Anderson DE, McArthur JC, McFarlane G, Selnes OA, Becker JT, Cohen B, Wesch J, Miller EN (1999). Combination antiretroviral therapy improves psychomotor speed performance in HIV-seropositive homosexual men. Multicenter AIDS Cohort Study (MACS). Neurology 52: 1640-1647.
76. Sacktor NC, Skolasky RL, Lyles RH, Esposito D, Selnes OA, McArthur JC (2000). Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors. J Neuro Virol 6: 84-88.
77. Schreiber G, Aldred AR (1993). Extrahepatic synthesis of acute phase proteins. In: Acute phase proteins: molecular biology, biochemistry, and clinical applications. Mackiewicz A, Kushner I, Baumann H (eds). Boca Raton: CRC Press, pp 39-76.
78. Sherman MY, Goldberg AL (2001). Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases. Neuron 29: 15-32.
79. Shimura H, Hattori N, Kubo S, Mizuno Y, Asakawa S, Minoshima S, Shimizu N, Iwai K, Chiba T, Tanaka K, Suzuki T (2000). Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet 25: 302-305.
80. Stolzing A, Grune T (2001). The proteasome and its function in the ageing process. Clin Exp Dermatol 26: 566-572.
81. Taylor JP, Tanaka F, Robitschek J, Sandoval CM, Taye A, Markovic-Plese S, Fischbeck KH (2003). Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein. Hum Mol Genet 12: 749-757.
82. Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R (1991). Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30: 572-580.
83. Thal DR, Rub U, Schultz C, Sassin I, Ghebremedhin E, Del Tredici K, Braak E, Braak H (2000). Sequence of Abeta-protein deposition in the human medial temporal lobe. J Neuropathol Exp Neurol 59: 733-748.
84. Tozzi V, Balestra P, Galgani S, Narciso P, Sampaolesi A, Antinori A, Giulianelli M, Serraino D, Ippolito G (2001). Changes in neurocognitive performance in a cohort of patients treated with HAART for 3 years. J Acquir Immune Defic Syndr 28: 19-27.
85. Tsuji T, Shimohama S (2002). Protein degradation in Alzheimer's disease and aging of the brain. Prog Mol Subcell Biol 29: 43-60.
86. Vogelgesang S, Cascorbi I, Schroeder E, Pahnke J, Kroemer HK, Siegmund W, Kunert-Keil C, Walker LC, Warzok RW (2002). Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans. Pharmacogenetics 12: 535-541.
87. Walker DG, Kim SU, McGeer PL (1995). Complement and cytokine gene expression in cultured microglial derived from postmortem human brains. J Neurosci Res 40: 478-493.
88. Ward WF (2000). The relentless effects of the aging process on protein turnover. Biogerontology 1: 195-199.
89. Wiley CA, Achim C (1994). Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome. Ann Neurol 36: 673-676.
90. Williams KC, Hickey WF (2002). Central nervous system damage, monocytes and macrophages, and neurological disorders in AIDS. Annu Rev Neurosci 25: 537-562.
91. Wilson SM, Bhattacharyya B, Rachel RA, Coppola V, Tessarollo L, Householder DB, Fletcher CF, Miller RJ, Copeland NG, Jenkins NA (2002). Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease. Nat Genet 32: 420-425.
92. Wolf DA, Dholakia SR, Keherly MJ, Rodriguez-Wolf MG, Cloyd MW, Gelman BB (1997). Proteolysis in the myelopathy of acquired immunodeficiency syndrome: preferential loss of the C-8 component of myelin basic protein. Lab Invest 77: 513-523.
93. Wyss-Coray T, Mucke L (2002). Inflammation in neurodegenerative disease - a double-edged sword. Neuron 35: 419-432.
94. Yamaguchi H, Sugihara S, Ogawa A, Oshima N, Ihara Y (2001). Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects. J Neuropathol Exp Neurol 60: 731-739.