Epigenetic drugs against cancer: An evolving landscape

Archives of Toxicology

Volumn 88, Issue 9, 2014, Pages 1651-1668

  Di Costanzo, Antonella ^a   Del Gaudio, Nunzio ^a   Migliaccio, Antimo ^a   Altucci, Lucia ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Cancer; Chromatin modulation; Drug discovery; Epigenetics

Indexed keywords

AGK 2; ANTINEOPLASTIC AGENT; BUTYRIC ACID DERIVATIVE; CAMBINOL; DNA METHYLTRANSFERASE INHIBITOR; ENTINOSTAT; EPIGENETIC DRUG; HISTONE; HISTONE ACETYLTRANSFERASE INHIBITOR; HISTONE DEACETYLASE INHIBITOR; HISTONE METHYLTRANSFERASE INHIBITOR; HISTONE READER; INDOLE; JUMONJI C CONTAINING DEMETHYLASE INHIBITOR; LYSINE SPECIFIC DEMETHYLASE INHIBITOR; MOCETINOSTAT; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE DERIVATIVE; PANOBINOSTAT; RESVERATROL; ROMIDEPSIN; SIRTUIN; SPLITOMICIN; SRT 1460; SRT 1720; SRT 2183; SRT1460; SRT1720; SRT2183; SURAMIN; TRICHOSTATIN A; UNCLASSIFIED DRUG; VALPROIC ACID; VORINOSTAT; NEW DRUG; TUMOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; CANCER CHEMOTHERAPY; DNA METHYLATION; DRUG MECHANISM; EPIGENETICS; HISTONE METHYLATION; HUMAN; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; REVIEW; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; CHROMATIN ASSEMBLY AND DISASSEMBLY; DRUG DESIGN; DRUG DEVELOPMENT; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; MEDICAL RESEARCH; METABOLISM; MOLECULARLY TARGETED THERAPY; NEOPLASMS; TRENDS;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOMEDICAL RESEARCH; CHROMATIN ASSEMBLY AND DISASSEMBLY; DRUG DESIGN; DRUG DISCOVERY; DRUGS, INVESTIGATIONAL; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MODELS, BIOLOGICAL; MOLECULAR TARGETED THERAPY; NEOPLASM PROTEINS; NEOPLASMS;

EID: 84906231124     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1315-6     Document Type: Review

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