The class I HDAC inhibitor MGCD0103 induces cell cycle arrest and apoptosis in colon cancer initiating cells by upregulating Dickkopf-1 and non-canonical Wnt signaling.

Oncotarget

Volumn 1, Issue 7, 2010, Pages 596-605

  Sikandar, Shaheen ^a   Dizon, Diana ^b   Shen, Xiling ^b   Li, Zuomei ^b   Besterman, Jeffery ^b   Lipkin, Steven M ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BENZAMIDE DERIVATIVE; DKK1 PROTEIN, HUMAN; HISTONE DEACETYLASE INHIBITOR; N (2 AMINOPHENYL) 4 ((4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)METHYL)BENZAMIDE; N-(2-AMINOPHENYL)-4-((4-PYRIDIN-3-YLPYRIMIDIN-2-YLAMINO)METHYL)BENZAMIDE; PYRIMIDINE DERIVATIVE; SIGNAL PEPTIDE; WNT PROTEIN;

ANIMAL; APOPTOSIS; ARTICLE; CANCER STEM CELL; CARCINOMA; CELL CULTURE; CELL CYCLE; CELL STRAIN HT29; CELL TRANSFORMATION; CLASSIFICATION; COLON TUMOR; DRUG EFFECT; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; HELA CELL; HUMAN; METABOLISM; MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; APOPTOSIS; BENZAMIDES; CARCINOMA; CELL CYCLE; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; COLONIC NEOPLASMS; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HISTONE DEACETYLASE INHIBITORS; HT29 CELLS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NEOPLASTIC STEM CELLS; PYRIMIDINES; SIGNAL TRANSDUCTION; UP-REGULATION; WNT PROTEINS;

EID: 79957993618     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.194     Document Type: Article

References (0)