Histone deacetylase inhibition in the treatment of acute myeloid leukemia: The effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents

Clinical Epigenetics

Volumn 5, Issue 1, 2013, Pages

  Fredly, Hanne ^a   Gjertsen, Bjørn Tore ^a,b   Bruserud, Øystein ^a,b  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

Acute myeloid leukemia; Disease stabilization; Older patients; Valproic acid

Indexed keywords

4 PHENYLBUTYRIC ACID; 5 AZA 2' DEOXYCYTIDINE; ANTILEUKEMIC AGENT; AZACITIDINE; CYTARABINE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HYDROXYUREA; MERCAPTOPURINE; RETINOIC ACID; VALPROIC ACID;

ACUTE GRANULOCYTIC LEUKEMIA; BONE PAIN; CANCER SURVIVAL; CHRONIC MYELOID LEUKEMIA; CLINICAL EFFECTIVENESS; CONFUSION; DIARRHEA; DIZZINESS; DRUG BLOOD LEVEL; DRUG DOSE ESCALATION; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; DRUG METABOLISM; DRUG SAFETY; DRUG TOLERABILITY; ENZYME INHIBITION; EVIDENCE BASED MEDICINE; FATIGUE; FEBRILE NEUTROPENIA; FEVER; GASTROINTESTINAL TOXICITY; HEADACHE; HEART PALPITATION; HUMAN; INFECTION; LEUKEMIA CELL; LIVER TOXICITY; LOW DRUG DOSE; LUNG TOXICITY; MONOTHERAPY; MUCOSAL DRYNESS; MULTIPLE CYCLE TREATMENT; MYELODYSPLASTIC SYNDROME; NAUSEA; NEUROLOGIC DISEASE; NEUROTOXICITY; NONHUMAN; PLEURA EFFUSION; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; QUALITY OF LIFE; REVIEW; SKIN TOXICITY; TREMOR; VERTIGO;

EID: 84894797638     PISSN: 18687075     EISSN: 18687083     Source Type: Journal    
DOI: 10.1186/1868-7083-5-12     Document Type: Review

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