메뉴 건너뛰기




Volumn 8, Issue AUG, 2014, Pages

Neuronal CC chemokines: The distinct roles of CCL21 and CCL2 in neuropathic pain

Author keywords

Chemokines; DRG neurons; LDV vesicles; Microglia reaction; Neuron microglia signaling; Neuropathic pain; Regulated release pathway

Indexed keywords


EID: 84905708649     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2014.00210     Document Type: Review
Times cited : (62)

References (119)
  • 1
    • 0037934294 scopus 로고    scopus 로고
    • Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2
    • doi: 10.1073/pnas.1331358100
    • Abbadie, C., Lindia, J. A., Cumiskey, A. M., Peterson, L. B., Mudgett, J. S., Bayne, E. K., et al. (2003). Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Proc. Natl. Acad. Sci. U S A 100, 7947-7952. doi: 10.1073/pnas.1331358100
    • (2003) Proc. Natl. Acad. Sci. U S A , vol.100 , pp. 7947-7952
    • Abbadie, C.1    Lindia, J.A.2    Cumiskey, A.M.3    Peterson, L.B.4    Mudgett, J.S.5    Bayne, E.K.6
  • 2
    • 33746902776 scopus 로고    scopus 로고
    • Permeability of injured and intact peripheral nerves and dorsal root ganglia
    • doi: 10.1097/00000542-200607000-00024
    • Abram, S. E., Yi, J., Fuchs, A., and Hogan, Q. H. (2006). Permeability of injured and intact peripheral nerves and dorsal root ganglia. Anesthesiology 105, 146-153. doi: 10.1097/00000542-200607000-00024
    • (2006) Anesthesiology , vol.105 , pp. 146-153
    • Abram, S.E.1    Yi, J.2    Fuchs, A.3    Hogan, Q.H.4
  • 3
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • doi: 10.1038/nn2014
    • Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W., and Rossi, F. M. (2007). Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat. Neurosci. 10, 1538-1543. doi: 10.1038/nn2014
    • (2007) Nat. Neurosci. , vol.10 , pp. 1538-1543
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    Tetzlaff, W.4    Rossi, F.M.5
  • 4
    • 77955745277 scopus 로고    scopus 로고
    • Glial cells in neuronal network function
    • doi: 10.1098/rstb.2009.0313
    • Araque, A., and Navarrete, M. (2010). Glial cells in neuronal network function. Philos. Trans. R. Soc. Lond. B Biol. Sci. 365, 2375-2381. doi: 10.1098/rstb.2009.0313
    • (2010) Philos. Trans. R. Soc. Lond. B Biol. Sci. , vol.365 , pp. 2375-2381
    • Araque, A.1    Navarrete, M.2
  • 5
    • 77958526530 scopus 로고    scopus 로고
    • Peripheral nerve injury and TRPV1-expressing primary afferent C-fibers cause opening of the blood-brain barrier
    • doi: 10.1186/1744-8069-6-74
    • Beggs, S., Liu, X. J., Kwan, C., and Salter, M. W. (2010). Peripheral nerve injury and TRPV1-expressing primary afferent C-fibers cause opening of the blood-brain barrier. Mol. Pain 6:74. doi: 10.1186/1744-8069-6-74
    • (2010) Mol. Pain , vol.6 , pp. 74
    • Beggs, S.1    Liu, X.J.2    Kwan, C.3    Salter, M.W.4
  • 7
    • 69749127051 scopus 로고    scopus 로고
    • Increased chemokine signaling in a model of HIV1-associated peripheral neuropathy
    • doi: 10.1186/1744-8069-5-48
    • Bhangoo, S. K., Ripsch, M. S., Buchanan, D. J., Miller, R. J., and White, F. A. (2009). Increased chemokine signaling in a model of HIV1-associated peripheral neuropathy. Mol. Pain 5:48. doi: 10.1186/1744-8069-5-48
    • (2009) Mol. Pain , vol.5 , pp. 48
    • Bhangoo, S.K.1    Ripsch, M.S.2    Buchanan, D.J.3    Miller, R.J.4    White, F.A.5
  • 8
    • 33644909854 scopus 로고    scopus 로고
    • Chemokines and their receptors in central nervous system disease
    • doi: 10.2174/138945006775270196
    • Biber, K., de Jong, E. K., van Weering, H. R., and Boddeke, H. W. (2006). Chemokines and their receptors in central nervous system disease. Curr. Drug Targets 7, 29-46. doi: 10.2174/138945006775270196
    • (2006) Curr. Drug Targets , vol.7 , pp. 29-46
    • Biber, K.1    de Jong, E.K.2    van Weering, H.R.3    Boddeke, H.W.4
  • 9
    • 35748939409 scopus 로고    scopus 로고
    • Neuronal 'On' and 'Off' signals control microglia
    • doi: 10.1016/j.tins.2007.08.007
    • Biber, K., Neumann, H., Inoue, K., and Boddeke, H. W. (2007). Neuronal 'On' and 'Off' signals control microglia. Trends Neurosci. 30, 596-602. doi: 10.1016/j.tins.2007.08.007
    • (2007) Trends Neurosci. , vol.30 , pp. 596-602
    • Biber, K.1    Neumann, H.2    Inoue, K.3    Boddeke, H.W.4
  • 10
    • 84898028606 scopus 로고    scopus 로고
    • What is microglia neurotoxicity (Not)?
    • doi: 10.1002/glia.22654
    • Biber, K., Owens, T., and Boddeke, E. (2014). What is microglia neurotoxicity (Not)? Glia 62, 841-854. doi: 10.1002/glia.22654
    • (2014) Glia , vol.62 , pp. 841-854
    • Biber, K.1    Owens, T.2    Boddeke, E.3
  • 11
    • 0035870604 scopus 로고    scopus 로고
    • Ischemia-induced neuronal expression of the microglia attracting chemokine Secondary Lymphoid-tissue Chemokine (SLC)
    • doi: 10.1002/glia.1047
    • Biber, K., Sauter, A., Brouwer, N., Copray, S. C., and Boddeke, H. W. (2001). Ischemia-induced neuronal expression of the microglia attracting chemokine Secondary Lymphoid-tissue Chemokine (SLC). Glia 34, 121-133. doi: 10.1002/glia.1047
    • (2001) Glia , vol.34 , pp. 121-133
    • Biber, K.1    Sauter, A.2    Brouwer, N.3    Copray, S.C.4    Boddeke, H.W.5
  • 12
    • 79955623602 scopus 로고    scopus 로고
    • Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development
    • doi: 10.1038/emboj.2011.89
    • Biber, K., Tsuda, M., Tozaki-Saitoh, H., Tsukamoto, K., Toyomitsu, E., Masuda, T., et al. (2011). Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development. EMBO J. 30, 1864-1873. doi: 10.1038/emboj.2011.89
    • (2011) EMBO J. , vol.30 , pp. 1864-1873
    • Biber, K.1    Tsuda, M.2    Tozaki-Saitoh, H.3    Tsukamoto, K.4    Toyomitsu, E.5    Masuda, T.6
  • 13
    • 47249120742 scopus 로고    scopus 로고
    • Neuron-microglia signaling: Chemokines as versatile messengers
    • doi: 10.1016/j.jneuroim.2008.04.012
    • Biber, K., Vinet, J., and Boddeke, H. W. (2008). Neuron-microglia signaling: chemokines as versatile messengers. J. Neuroimmunol. 198, 69-74. doi: 10.1016/j.jneuroim.2008.04.012
    • (2008) J. Neuroimmunol. , vol.198 , pp. 69-74
    • Biber, K.1    Vinet, J.2    Boddeke, H.W.3
  • 14
    • 0036462449 scopus 로고    scopus 로고
    • Chemokines in the brain: Neuroimmunology and beyond
    • doi: 10.1016/s1471-4892(01)00122-9
    • Biber, K., Zuurman, M. W., Dijkstra, I. M., and Boddeke, H. W. (2002). Chemokines in the brain: neuroimmunology and beyond. Curr. Opin. Pharmacol. 2, 63-68. doi: 10.1016/s1471-4892(01)00122-9
    • (2002) Curr. Opin. Pharmacol. , vol.2 , pp. 63-68
    • Biber, K.1    Zuurman, M.W.2    Dijkstra, I.M.3    Boddeke, H.W.4
  • 15
    • 77955501581 scopus 로고    scopus 로고
    • Is BDNF sufficient for information transfer between microglia and dorsal horn neurons during the onset of central sensitization?
    • doi: 10.1186/1744-8069-6-44
    • Biggs, J. E., Lu, V. B., Stebbing, M. J., Balasubramanyan, S., and Smith, P. A. (2010). Is BDNF sufficient for information transfer between microglia and dorsal horn neurons during the onset of central sensitization? Mol. Pain 6:44. doi: 10.1186/1744-8069-6-44
    • (2010) Mol. Pain , vol.6 , pp. 44
    • Biggs, J.E.1    Lu, V.B.2    Stebbing, M.J.3    Balasubramanyan, S.4    Smith, P.A.5
  • 16
    • 77953537217 scopus 로고    scopus 로고
    • Chemokine receptors intracellular trafficking
    • doi: 10.1016/j.pharmthera.2010.04.006
    • Borroni, E. M., Mantovani, A., Locati, M., and Bonecchi, R. (2010). Chemokine receptors intracellular trafficking. Pharmacol. Ther. 127, 1-8. doi: 10.1016/j.pharmthera.2010.04.006
    • (2010) Pharmacol. Ther. , vol.127 , pp. 1-8
    • Borroni, E.M.1    Mantovani, A.2    Locati, M.3    Bonecchi, R.4
  • 17
    • 84893745524 scopus 로고    scopus 로고
    • Identification of a unique TGF-β-dependent molecular and functional signature in microglia
    • doi: 10.1038/nn.3599
    • Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., et al. (2014). Identification of a unique TGF-β-dependent molecular and functional signature in microglia. Nat. Neurosci. 17, 131-143. doi: 10.1038/nn.3599
    • (2014) Nat. Neurosci. , vol.17 , pp. 131-143
    • Butovsky, O.1    Jedrychowski, M.P.2    Moore, C.S.3    Cialic, R.4    Lanser, A.J.5    Gabriely, G.6
  • 18
    • 33744492850 scopus 로고    scopus 로고
    • The chemokine SDF-1/CXCL12 modulates the firing pattern of vasopressin neurons and counteracts induced vasopressin release through CXCR4
    • doi: 10.1073/pnas.0602620103
    • Callewaere, C., Banisadr, G., Desarménien, M. G., Mechighel, P., Kitabgi, P., Rostène, W. H., et al. (2006). The chemokine SDF-1/CXCL12 modulates the firing pattern of vasopressin neurons and counteracts induced vasopressin release through CXCR4. Proc. Natl. Acad. Sci. U S A 103, 8221-8226. doi: 10.1073/pnas.0602620103
    • (2006) Proc. Natl. Acad. Sci. U S A , vol.103 , pp. 8221-8226
    • Callewaere, C.1    Banisadr, G.2    Desarménien, M.G.3    Mechighel, P.4    Kitabgi, P.5    Rostène, W.H.6
  • 19
    • 77950962921 scopus 로고    scopus 로고
    • Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury
    • doi: 10.1523/jneurosci.5169-09.2010
    • Calvo, M., Zhu, N., Tsantoulas, C., Ma, Z., Grist, J., Loeb, J. A., et al. (2010). Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury. J. Neurosci. 30, 5437-5450. doi: 10.1523/jneurosci.5169-09.2010.
    • (2010) J. Neurosci. , vol.30 , pp. 5437-5450
    • Calvo, M.1    Zhu, N.2    Tsantoulas, C.3    Ma, Z.4    Grist, J.5    Loeb, J.A.6
  • 20
    • 50849085193 scopus 로고    scopus 로고
    • Chemokines in and out of the central nervous system: Much more than chemotaxis and inflammation
    • doi: 10.1189/jlb.1107763
    • Cardona, A. E., Li, M., Liu, L., Savarin, C., and Ransohoff, R. M. (2008). Chemokines in and out of the central nervous system: much more than chemotaxis and inflammation. J. Leukoc. Biol. 84, 587-594. doi: 10.1189/jlb.1107763
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 587-594
    • Cardona, A.E.1    Li, M.2    Liu, L.3    Savarin, C.4    Ransohoff, R.M.5
  • 21
    • 84900475018 scopus 로고    scopus 로고
    • Fractalkine/CX3CR1 signaling during neuropathic pain
    • doi: 10.3389/fncel.2014.00121
    • Clark, A. K., and Malcangio, M. (2014). Fractalkine/CX3CR1 signaling during neuropathic pain. Front. Cell. Neurosci. 8:121. doi: 10.3389/fncel.2014.00121
    • (2014) Front. Cell. Neurosci. , vol.8 , pp. 121
    • Clark, A.K.1    Malcangio, M.2
  • 22
    • 84888175082 scopus 로고    scopus 로고
    • Neuropathic pain and cytokines: Current perspectives
    • doi: 10.2147/jpr.s53660
    • Clark, A. K., Old, E. A., and Malcangio, M. (2013). Neuropathic pain and cytokines: current perspectives. J. Pain Res. 6, 803-814. doi: 10.2147/jpr.s53660
    • (2013) J. Pain Res. , vol.6 , pp. 803-814
    • Clark, A.K.1    Old, E.A.2    Malcangio, M.3
  • 23
    • 74949123761 scopus 로고    scopus 로고
    • P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide
    • doi: 10.1523/jneurosci.3295-09.2010
    • Clark, A. K., Staniland, A. A., Marchand, F., Kaan, T. K., McMahon, S. B., and Malcangio, M. (2010). P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide. J. Neurosci. 30, 573-582. doi: 10.1523/jneurosci.3295-09.2010
    • (2010) J. Neurosci. , vol.30 , pp. 573-582
    • Clark, A.K.1    Staniland, A.A.2    Marchand, F.3    Kaan, T.K.4    McMahon, S.B.5    Malcangio, M.6
  • 24
    • 66149186748 scopus 로고    scopus 로고
    • The liberation of fractalkine in the dorsal horn requires microglial cathepsin S
    • doi: 10.1523/jneurosci.0828-09.2009
    • Clark, A. K., Yip, P. K., and Malcangio, M. (2009). The liberation of fractalkine in the dorsal horn requires microglial cathepsin S. J. Neurosci. 29, 6945-6954. doi: 10.1523/jneurosci.0828-09.2009
    • (2009) J. Neurosci. , vol.29 , pp. 6945-6954
    • Clark, A.K.1    Yip, P.K.2    Malcangio, M.3
  • 25
    • 0030859754 scopus 로고    scopus 로고
    • Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat
    • doi: 10.1016/s0165-5728(97)00119-7
    • Colburn, R. W., DeLeo, J. A., Rickman, A. J., Yeager, M. P., Kwon, P., and Hickey, W. F. (1997). Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat. J. Neuroimmunol. 79, 163-175. doi: 10.1016/s0165-5728(97)00119-7
    • (1997) J. Neuroimmunol. , vol.79 , pp. 163-175
    • Colburn, R.W.1    DeLeo, J.A.2    Rickman, A.J.3    Yeager, M.P.4    Kwon, P.5    Hickey, W.F.6
  • 26
    • 0032978701 scopus 로고    scopus 로고
    • The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior
    • doi: 10.1006/exnr.1999.7065
    • Colburn, R. W., Rickman, A. J., and DeLeo, J. A. (1999). The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior. Exp. Neurol. 157, 289-304. doi: 10.1006/exnr.1999.7065
    • (1999) Exp. Neurol. , vol.157 , pp. 289-304
    • Colburn, R.W.1    Rickman, A.J.2    DeLeo, J.A.3
  • 27
    • 0037175326 scopus 로고    scopus 로고
    • Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury
    • doi: 10.1186/1471-2202-3-16
    • Costigan, M., Befort, K., Karchewski, L., Griffin, R. S., D'Urso, D., Allchorne, A., et al. (2002). Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC Neurosci. 3:16. doi: 10.1186/1471-2202-3-16
    • (2002) BMC Neurosci. , vol.3 , pp. 16
    • Costigan, M.1    Befort, K.2    Karchewski, L.3    Griffin, R.S.4    D'Urso, D.5    Allchorne, A.6
  • 28
    • 67651048942 scopus 로고    scopus 로고
    • Neuropathic pain: A maladaptive response of the nervous system to damage
    • doi: 10.1146/annurev.neuro.051508.135531
    • Costigan, M., Scholz, J., and Woolf, C. J. (2009). Neuropathic pain: a maladaptive response of the nervous system to damage. Annu. Rev. Neurosci. 32, 1-32. doi: 10.1146/annurev.neuro.051508.135531
    • (2009) Annu. Rev. Neurosci. , vol.32 , pp. 1-32
    • Costigan, M.1    Scholz, J.2    Woolf, C.J.3
  • 29
    • 30744439794 scopus 로고    scopus 로고
    • BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
    • doi: 10.1038/nature04223
    • Coull, J. A., Beggs, S., Boudreau, D., Boivin, D., Tsuda, M., Inoue, K., et al. (2005). BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 438, 1017-1021. doi: 10.1038/nature04223
    • (2005) Nature , vol.438 , pp. 1017-1021
    • Coull, J.A.1    Beggs, S.2    Boudreau, D.3    Boivin, D.4    Tsuda, M.5    Inoue, K.6
  • 30
    • 33845901486 scopus 로고    scopus 로고
    • An SCN9A channelopathy causes congenital inability to experience pain
    • doi: 10.1038/nature05413
    • Cox, J. J., Reimann, F., Nicholas, A. K., Thornton, G., Roberts, E., Springell, K., et al. (2006). An SCN9A channelopathy causes congenital inability to experience pain. Nature 444, 894-898. doi: 10.1038/nature05413
    • (2006) Nature , vol.444 , pp. 894-898
    • Cox, J.J.1    Reimann, F.2    Nicholas, A.K.3    Thornton, G.4    Roberts, E.5    Springell, K.6
  • 31
    • 0032079675 scopus 로고    scopus 로고
    • Partial peripheral nerve injury leads to activation of astroglia and microglia which parallels the development of allodynic behavior
    • doi: 10.1002/(sici)1098-1136(199805)23:1<75::aid-glia7>3.0.co;2-3
    • Coyle, D. E. (1998). Partial peripheral nerve injury leads to activation of astroglia and microglia which parallels the development of allodynic behavior. Glia 23, 75-83. doi: 10.1002/(sici)1098-1136(199805)23:1<75::aid-glia7>3.0.co;2-3
    • (1998) Glia , vol.23 , pp. 75-83
    • Coyle, D.E.1
  • 32
    • 46749115222 scopus 로고    scopus 로고
    • Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS
    • doi: 10.1002/glia.20663
    • de Haas, A. H., Boddeke, H. W., and Biber, K. (2008). Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS. Glia 56, 888-894. doi: 10.1002/glia.20663
    • (2008) Glia , vol.56 , pp. 888-894
    • de Haas, A.H.1    Boddeke, H.W.2    Biber, K.3
  • 33
    • 38449090965 scopus 로고    scopus 로고
    • Neuronal chemokines: Versatile messengers in central nervous system cell interaction
    • doi: 10.1007/s12035-007-0036-8
    • de Haas, A. H., van Weering, H. R., de Jong, E. K., Boddeke, H. W., and Biber, K. P. (2007). Neuronal chemokines: versatile messengers in central nervous system cell interaction. Mol. Neurobiol. 36, 137-151. doi: 10.1007/s12035-007-0036-8
    • (2007) Mol. Neurobiol. , vol.36 , pp. 137-151
    • de Haas, A.H.1    van Weering, H.R.2    de Jong, E.K.3    Boddeke, H.W.4    Biber, K.P.5
  • 34
    • 23844452985 scopus 로고    scopus 로고
    • Vesicle-mediated transport and release of CCL21 in endangered neurons: A possible explanation for microglia activation remote from a primary lesion
    • doi: 10.1523/jneurosci.1019-05.2005
    • de Jong, E. K., Dijkstra, I. M., Hensens, M., Brouwer, N., van Amerongen, M., Liem, R. S., et al. (2005). Vesicle-mediated transport and release of CCL21 in endangered neurons: a possible explanation for microglia activation remote from a primary lesion. J. Neurosci. 25, 7548-7557. doi: 10.1523/jneurosci.1019-05.2005
    • (2005) J. Neurosci. , vol.25 , pp. 7548-7557
    • de Jong, E.K.1    Dijkstra, I.M.2    Hensens, M.3    Brouwer, N.4    van Amerongen, M.5    Liem, R.S.6
  • 35
    • 57349196489 scopus 로고    scopus 로고
    • Expression, transport and axonal sorting of neuronal CCL21 in large dense-core vesicles
    • doi: 10.1096/fj.07-101907
    • de Jong, E. K., Vinet, J., Stanulovic, V. S., Meijer, M., Wesseling, E., Sjollema, K., et al. (2008). Expression, transport and axonal sorting of neuronal CCL21 in large dense-core vesicles. FASEB J. 22, 4136-4145. doi: 10.1096/fj.07-101907
    • (2008) FASEB J. , vol.22 , pp. 4136-4145
    • de Jong, E.K.1    Vinet, J.2    Stanulovic, V.S.3    Meijer, M.4    Wesseling, E.5    Sjollema, K.6
  • 36
    • 0003434221 scopus 로고    scopus 로고
    • Intrathecal catheterization alone induces neuroimmune activation in the rat
    • doi: 10.1016/s1090-3801(97)90069-0
    • DeLeo, J. A., Colburn, R. W., Rickman, A. J., and Yeager, M. P. (1997). Intrathecal catheterization alone induces neuroimmune activation in the rat. Eur. J. Pain 1, 115-122. doi: 10.1016/s1090-3801(97)90069-0
    • (1997) Eur. J. Pain , vol.1 , pp. 115-122
    • DeLeo, J.A.1    Colburn, R.W.2    Rickman, A.J.3    Yeager, M.P.4
  • 37
    • 65449143227 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 (MCP-1) produced via NF-kappaB signaling pathway mediates migration of amoeboid microglia in the periventricular white matter in hypoxic neonatal rats
    • doi: 10.1002/glia.20790
    • Deng, Y. Y., Lu, J., Ling, E. A., and Kaur, C. (2009). Monocyte chemoattractant protein-1 (MCP-1) produced via NF-kappaB signaling pathway mediates migration of amoeboid microglia in the periventricular white matter in hypoxic neonatal rats. Glia 57, 604-621. doi: 10.1002/glia.20790
    • (2009) Glia , vol.57 , pp. 604-621
    • Deng, Y.Y.1    Lu, J.2    Ling, E.A.3    Kaur, C.4
  • 38
    • 33747206748 scopus 로고    scopus 로고
    • TRP ion channels and temperature sensation
    • doi: 10.1146/annurev.neuro.29.051605.112958
    • Dhaka, A., Viswanath, V., and Patapoutian, A. (2006). TRP ion channels and temperature sensation. Annu. Rev. Neurosci. 29, 135-161. doi: 10.1146/annurev.neuro.29.051605.112958
    • (2006) Annu. Rev. Neurosci. , vol.29 , pp. 135-161
    • Dhaka, A.1    Viswanath, V.2    Patapoutian, A.3
  • 39
    • 33750538482 scopus 로고    scopus 로고
    • Challenge with innate and protein antigens induces CCR7 expression by microglia in vitro and in vivo
    • doi: 10.1002/glia.20426
    • Dijkstra, I. M., de Haas, A. H., Brouwer, N., Boddeke, H. W., and Biber, K. (2006). Challenge with innate and protein antigens induces CCR7 expression by microglia in vitro and in vivo. Glia 54, 861-872. doi: 10.1002/glia.20426
    • (2006) Glia , vol.54 , pp. 861-872
    • Dijkstra, I.M.1    de Haas, A.H.2    Brouwer, N.3    Boddeke, H.W.4    Biber, K.5
  • 40
    • 0345445898 scopus 로고    scopus 로고
    • Advances in neuropathic pain: Diagnosis, mechanisms and treatment recommendations
    • doi: 10.1001/archneur.60.11.1524
    • Dworkin, R. H., Backonja, M., Rowbotham, M. C., Allen, R. R., Argoff, C. R., Bennett, G. J., et al. (2003). Advances in neuropathic pain: diagnosis, mechanisms and treatment recommendations. Arch. Neurol. 60, 1524-1534. doi: 10.1001/archneur.60.11.1524
    • (2003) Arch. Neurol. , vol.60 , pp. 1524-1534
    • Dworkin, R.H.1    Backonja, M.2    Rowbotham, M.C.3    Allen, R.R.4    Argoff, C.R.5    Bennett, G.J.6
  • 41
    • 35748943212 scopus 로고    scopus 로고
    • Pharmacologic management of neuropathic pain: Evidence-based recommendations
    • doi: 10.1016/j.pain.2007.08.033
    • Dworkin, R. H., O'Connor, A. B., Backonja, M., Farrar, J. T., Finnerup, N. B., Jensen, T. S., et al. (2007). Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain 132, 237-251. doi: 10.1016/j.pain.2007.08.033
    • (2007) Pain , vol.132 , pp. 237-251
    • Dworkin, R.H.1    O'Connor, A.B.2    Backonja, M.3    Farrar, J.T.4    Finnerup, N.B.5    Jensen, T.S.6
  • 42
    • 34147115541 scopus 로고    scopus 로고
    • Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease
    • doi: 10.1038/nm1555
    • El Khoury, J., Toft, M., Hickman, S. E., Means, T. K., Terada, K., Geula, C., et al. (2007). Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat. Med. 13, 432-438. doi: 10.1038/nm1555
    • (2007) Nat. Med. , vol.13 , pp. 432-438
    • El Khoury, J.1    Toft, M.2    Hickman, S.E.3    Means, T.K.4    Terada, K.5    Geula, C.6
  • 43
    • 0027428024 scopus 로고
    • A quantitative analysis of the microglial cell reaction in central primary sensory projection territories following peripheral nerve injury in the adult rat
    • doi: 10.1007/bf00230435
    • Eriksson, N. P., Persson, J. K., Svensson, M., Arvidsson, J., Molander, C., and Aldskogius, H. (1993). A quantitative analysis of the microglial cell reaction in central primary sensory projection territories following peripheral nerve injury in the adult rat. Exp. Brain Res. 96, 19-27. doi: 10.1007/bf00230435
    • (1993) Exp. Brain Res. , vol.96 , pp. 19-27
    • Eriksson, N.P.1    Persson, J.K.2    Svensson, M.3    Arvidsson, J.4    Molander, C.5    Aldskogius, H.6
  • 44
    • 77952423873 scopus 로고    scopus 로고
    • Contributions of astrocytes to synapse formation and maturation-Potential functions of the perisynaptic extracellular matrix
    • doi: 10.1016/j.brainresrev.2010.01.001
    • Faissner, A., Pyka, M., Geissler, M., Sobik, T., Frischknecht, R., Gundelfinger, E. D., et al. (2010). Contributions of astrocytes to synapse formation and maturation-Potential functions of the perisynaptic extracellular matrix. Brain Res. Rev. 63, 26-38. doi: 10.1016/j.brainresrev.2010.01.001
    • (2010) Brain Res. Rev. , vol.63 , pp. 26-38
    • Faissner, A.1    Pyka, M.2    Geissler, M.3    Sobik, T.4    Frischknecht, R.5    Gundelfinger, E.D.6
  • 45
    • 84858450937 scopus 로고    scopus 로고
    • Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke
    • doi: 10.1016/j.neuroscience.2012.01.008
    • Fernández-López, D., Faustino, J., Derugin, N., Wendland, M., Lizasoain, I., Moro, M. A., et al. (2012). Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke. Neuroscience207, 307-315. doi: 10.1016/j.neuroscience.2012.01.008
    • (2012) Neuroscience , vol.207 , pp. 307-315
    • Fernández-López, D.1    Faustino, J.2    Derugin, N.3    Wendland, M.4    Lizasoain, I.5    Moro, M.A.6
  • 46
    • 77957056575 scopus 로고    scopus 로고
    • Targeting astrocyte signaling for chronic pain
    • doi: 10.1016/j.nurt.2010.05.016
    • Gao, Y. J., and Ji, R. R. (2010). Targeting astrocyte signaling for chronic pain. Neurotherapeutics 7, 482-493. doi: 10.1016/j.nurt.2010.05.016
    • (2010) Neurotherapeutics , vol.7 , pp. 482-493
    • Gao, Y.J.1    Ji, R.R.2
  • 47
    • 65249114367 scopus 로고    scopus 로고
    • JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain
    • doi: 10.1523/jneurosci.3623-08.2009
    • Gao, Y. J., Zhang, L., Samad, O. A., Suter, M. R., Yasuhiko, K., Xu, Z. Z., et al. (2009). JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. J. Neurosci. 29, 4096-4108. doi: 10.1523/jneurosci.3623-08.2009
    • (2009) J. Neurosci. , vol.29 , pp. 4096-4108
    • Gao, Y.J.1    Zhang, L.2    Samad, O.A.3    Suter, M.R.4    Yasuhiko, K.5    Xu, Z.Z.6
  • 48
    • 75649138386 scopus 로고    scopus 로고
    • Astroglial networks: A step further in neuroglial and gliovascular interactions
    • doi: 10.1038/nrn2757
    • Giaume, C., Koulakoff, A., Roux, L., Holcman, D., and Rouach, N. (2010). Astroglial networks: a step further in neuroglial and gliovascular interactions. Nat. Rev. Neurosci. 11, 87-99. doi: 10.1038/nrn2757
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 87-99
    • Giaume, C.1    Koulakoff, A.2    Roux, L.3    Holcman, D.4    Rouach, N.5
  • 49
    • 78149360132 scopus 로고    scopus 로고
    • Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    • doi: 10.1126/science.1194637
    • Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., et al. (2010). Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330, 841-845. doi: 10.1126/science.1194637
    • (2010) Science , vol.330 , pp. 841-845
    • Ginhoux, F.1    Greter, M.2    Leboeuf, M.3    Nandi, S.4    See, P.5    Gokhan, S.6
  • 50
    • 84875965538 scopus 로고    scopus 로고
    • Origin and differentiation of microglia
    • doi: 10.3389/fncel.2013.00045
    • Ginhoux, F., Lim, S., Hoeffel, G., Low, D., and Huber, T. (2013). Origin and differentiation of microglia. Front. Cell. Neurosci. 7:45. doi: 10.3389/fncel.2013.00045
    • (2013) Front. Cell. Neurosci. , vol.7 , pp. 45
    • Ginhoux, F.1    Lim, S.2    Hoeffel, G.3    Low, D.4    Huber, T.5
  • 51
    • 28244464861 scopus 로고    scopus 로고
    • Constitutive expression of CCR2 chemokine receptor and inhibition by MCP-1/CCL2 of GABA-induced currents in spinal cord neurones
    • doi: 10.1111/j.1471-4159.2005.03431.x
    • Gosselin, R. D., Varela, C., Banisadr, G., Mechighel, P., Rostene, W., Kitabgi, P., et al. (2005). Constitutive expression of CCR2 chemokine receptor and inhibition by MCP-1/CCL2 of GABA-induced currents in spinal cord neurones. J. Neurochem. 95, 1023-1034. doi: 10.1111/j.1471-4159.2005.03431.x
    • (2005) J. Neurochem. , vol.95 , pp. 1023-1034
    • Gosselin, R.D.1    Varela, C.2    Banisadr, G.3    Mechighel, P.4    Rostene, W.5    Kitabgi, P.6
  • 52
    • 73349135323 scopus 로고    scopus 로고
    • BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses
    • doi: 10.1007/s00221-009-1994-z
    • Gottmann, K., Mittmann, T., and Lessmann, V. (2009). BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses. Exp. Brain Res. 199, 203-234. doi: 10.1007/s00221-009-1994-z
    • (2009) Exp. Brain Res. , vol.199 , pp. 203-234
    • Gottmann, K.1    Mittmann, T.2    Lessmann, V.3
  • 53
    • 34547865012 scopus 로고    scopus 로고
    • Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity
    • doi: 10.1523/jneurosci.2018-07.2007
    • Griffin, R. S., Costigan, M., Brenner, G. J., Ma, C. H., Scholz, J., Moss, A., et al. (2007). Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity. J. Neurosci. 27, 8699-8708. doi: 10.1523/jneurosci.2018-07.2007
    • (2007) J. Neurosci. , vol.27 , pp. 8699-8708
    • Griffin, R.S.1    Costigan, M.2    Brenner, G.J.3    Ma, C.H.4    Scholz, J.5    Moss, A.6
  • 54
    • 68049123116 scopus 로고    scopus 로고
    • Long term exposure to the chemokine CCL2 activates the nigrostriatal dopamine system: A novel mechanism for the control of dopamine release
    • doi: 10.1016/j.neuroscience.2009.05.048
    • Guyon, A., Skrzydelski, D., De Giry, I., Rovère, C., Conductier, G., Trocello, J. M., et al. (2009). Long term exposure to the chemokine CCL2 activates the nigrostriatal dopamine system: a novel mechanism for the control of dopamine release. Neuroscience 162, 1072-1080. doi: 10.1016/j.neuroscience.2009.05.048
    • (2009) Neuroscience , vol.162 , pp. 1072-1080
    • Guyon, A.1    Skrzydelski, D.2    De Giry, I.3    Rovère, C.4    Conductier, G.5    Trocello, J.M.6
  • 55
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
    • doi: 10.1038/nn1997
    • Hanisch, U. K., and Kettenmann, H. (2007). Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat. Neurosci. 10, 1387-1394. doi: 10.1038/nn1997
    • (2007) Nat. Neurosci. , vol.10 , pp. 1387-1394
    • Hanisch, U.K.1    Kettenmann, H.2
  • 57
    • 0035205827 scopus 로고    scopus 로고
    • Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): Mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor
    • doi: 10.1002/humu.1224
    • Indo, Y. (2001). Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor. Hum. Mutat.18, 462-471. doi: 10.1002/humu.1224
    • (2001) Hum. Mutat. , vol.18 , pp. 462-471
    • Indo, Y.1
  • 58
    • 58149512853 scopus 로고    scopus 로고
    • Expression of monocyte chemoattractant protein-1 in rat dorsal root ganglia and spinal cord in experimental models of neuropathic pain
    • doi: 10.1016/j.brainres.2008.11.046
    • Jeon, S. M., Lee, K. M., and Cho, H. J. (2009). Expression of monocyte chemoattractant protein-1 in rat dorsal root ganglia and spinal cord in experimental models of neuropathic pain. Brain Res. 1251, 103-111. doi: 10.1016/j.brainres.2008.11.046
    • (2009) Brain Res. , vol.1251 , pp. 103-111
    • Jeon, S.M.1    Lee, K.M.2    Cho, H.J.3
  • 59
    • 34447502253 scopus 로고    scopus 로고
    • Possible role of spinal astrocytes in maintaining chronic pain sensitization: Review of current evidence with focus on bFGF/JNK pathway
    • doi: 10.1017/s1740925x07000403
    • Ji, R. R., Kawasaki, Y., Zhuang, Z. Y., Wen, Y. R., and Decosterd, I. (2006). Possible role of spinal astrocytes in maintaining chronic pain sensitization: review of current evidence with focus on bFGF/JNK pathway. Neuron. Glia. Biol. 2, 259-269. doi: 10.1017/s1740925x07000403
    • (2006) Neuron. Glia. Biol. , vol.2 , pp. 259-269
    • Ji, R.R.1    Kawasaki, Y.2    Zhuang, Z.Y.3    Wen, Y.R.4    Decosterd, I.5
  • 60
    • 0037705314 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    • Jin, S. X., Zhuang, Z. Y., Woolf, C. J., and Ji, R. R. (2003). p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J. Neurosci. 23, 4017-4022.
    • (2003) J. Neurosci. , vol.23 , pp. 4017-4022
    • Jin, S.X.1    Zhuang, Z.Y.2    Woolf, C.J.3    Ji, R.R.4
  • 61
    • 84875640002 scopus 로고    scopus 로고
    • Pain management mini-series. Part I. A review of management of acute pain
    • Johnson, Q., Borsheski, R. R., and Reeves-Viets, J. L. (2013). Pain management mini-series. Part I. A review of management of acute pain. Mo. Med. 110, 74-79.
    • (2013) Mo. Med. , vol.110 , pp. 74-79
    • Johnson, Q.1    Borsheski, R.R.2    Reeves-Viets, J.L.3
  • 62
    • 67649360008 scopus 로고    scopus 로고
    • Visualization of chemokine receptor activation in transgenic mice reveals peripheral activation of CCR2 receptors in states of neuropathic pain
    • doi: 10.1523/jneurosci.0485-09.2009
    • Jung, H., Bhangoo, S., Banisadr, G., Freitag, C., Ren, D., White, F. A., et al. (2009). Visualization of chemokine receptor activation in transgenic mice reveals peripheral activation of CCR2 receptors in states of neuropathic pain. J. Neurosci. 29, 8051-8062. doi: 10.1523/jneurosci.0485-09.2009
    • (2009) J. Neurosci. , vol.29 , pp. 8051-8062
    • Jung, H.1    Bhangoo, S.2    Banisadr, G.3    Freitag, C.4    Ren, D.5    White, F.A.6
  • 63
    • 37249022426 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons
    • Jung, H., Toth, P. T., White, F. A., and Miller, R. J. (2008). Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons. J. Neurochem. 104, 254-263.
    • (2008) J. Neurochem. , vol.104 , pp. 254-263
    • Jung, H.1    Toth, P.T.2    White, F.A.3    Miller, R.J.4
  • 64
    • 84875892857 scopus 로고    scopus 로고
    • Microglia emerge from erythromyeloid precursors via Pu.1-and Irf8-dependent pathways
    • doi: 10.1038/nn.3318
    • Kierdorf, K., Erny, D., Goldmann, T., Sander, V., Schulz, C., Perdiguero, E. G., et al. (2013). Microglia emerge from erythromyeloid precursors via Pu.1-and Irf8-dependent pathways. Nat. Neurosci. 16, 273-280. doi: 10.1038/nn.3318
    • (2013) Nat. Neurosci. , vol.16 , pp. 273-280
    • Kierdorf, K.1    Erny, D.2    Goldmann, T.3    Sander, V.4    Schulz, C.5    Perdiguero, E.G.6
  • 65
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • doi: 10.1016/0166-2236(96)10049-7
    • Kreutzberg, G. W. (1996). Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19, 312-318. doi: 10.1016/0166-2236(96)10049-7
    • (1996) Trends Neurosci. , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 66
    • 68949189686 scopus 로고    scopus 로고
    • Central sensitization: A generator of pain hypersensitivity by central neural plasticity
    • doi: 10.1016/j.jpain.2009.06.012
    • Latremoliere, A., and Woolf, C. J. (2009). Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J. Pain 10, 895-926. doi: 10.1016/j.jpain.2009.06.012
    • (2009) J. Pain , vol.10 , pp. 895-926
    • Latremoliere, A.1    Woolf, C.J.2
  • 67
    • 69349094004 scopus 로고    scopus 로고
    • CNS penetration of small molecules following local inflammation, widespread systemic inflammation or direct injury to the nervous system
    • doi: 10.1016/j.lfs.2009.07.009
    • Lu, P., Gonzales, C., Chen, Y., Adedoyin, A., Hummel, M., Kennedy, J. D., et al. (2009). CNS penetration of small molecules following local inflammation, widespread systemic inflammation or direct injury to the nervous system. Life Sci. 85, 450-456. doi: 10.1016/j.lfs.2009.07.009
    • (2009) Life Sci. , vol.85 , pp. 450-456
    • Lu, P.1    Gonzales, C.2    Chen, Y.3    Adedoyin, A.4    Hummel, M.5    Kennedy, J.D.6
  • 68
    • 70349984436 scopus 로고    scopus 로고
    • Current challenges in glia-pain biology
    • doi: 10.1016/j.neuron.2009.09.033
    • McMahon, S. B., and Malcangio, M. (2009). Current challenges in glia-pain biology. Neuron 64, 46-54. doi: 10.1016/j.neuron.2009.09.033
    • (2009) Neuron , vol.64 , pp. 46-54
    • McMahon, S.B.1    Malcangio, M.2
  • 69
    • 36448955070 scopus 로고    scopus 로고
    • Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
    • doi: 10.1038/nn2015
    • Mildner, A., Schmidt, H., Nitsche, M., Merkler, D., Hanisch, U. K., Mack, M., et al. (2007). Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions. Nat. Neurosci. 10, 1544-1553. doi: 10.1038/nn2015
    • (2007) Nat. Neurosci. , vol.10 , pp. 1544-1553
    • Mildner, A.1    Schmidt, H.2    Nitsche, M.3    Merkler, D.4    Hanisch, U.K.5    Mack, M.6
  • 70
    • 70349932472 scopus 로고    scopus 로고
    • Cytokine and chemokine regulation of sensory neuron function
    • doi: 10.1007/978-3-540-79090-7_12
    • Miller, R. J., Jung, H., Bhangoo, S. K., and White, F. A. (2009). Cytokine and chemokine regulation of sensory neuron function. Handb. Exp. Pharmacol. 194, 417-449. doi: 10.1007/978-3-540-79090-7_12
    • (2009) Handb. Exp. Pharmacol. , vol.194 , pp. 417-449
    • Miller, R.J.1    Jung, H.2    Bhangoo, S.K.3    White, F.A.4
  • 71
    • 58149349793 scopus 로고    scopus 로고
    • Chemokine action in the nervous system
    • doi: 10.1523/JNEUROSCI.3588-08.2008
    • Miller, R. J., Rostene, W., Apartis, E., Banisadr, G., Biber, K., Milligan, E. D., et al. (2008). Chemokine action in the nervous system. J. Neurosci. 28, 11792-11795. doi: 10.1523/JNEUROSCI.3588-08.2008
    • (2008) J. Neurosci. , vol.28 , pp. 11792-11795
    • Miller, R.J.1    Rostene, W.2    Apartis, E.3    Banisadr, G.4    Biber, K.5    Milligan, E.D.6
  • 72
    • 37149016394 scopus 로고    scopus 로고
    • Localization of S100A8 and S100A9 expressing neutrophils to spinal cord during peripheral tissue inflammation
    • doi: 10.1016/j.pain.2007.10.024
    • Mitchell, K., Yang, H. Y., Tessier, P. A., Muhly, W. T., Swaim, W. D., Szalayova, I., et al. (2008). Localization of S100A8 and S100A9 expressing neutrophils to spinal cord during peripheral tissue inflammation. Pain 134, 216-231. doi: 10.1016/j.pain.2007.10.024
    • (2008) Pain , vol.134 , pp. 216-231
    • Mitchell, K.1    Yang, H.Y.2    Tessier, P.A.3    Muhly, W.T.4    Swaim, W.D.5    Szalayova, I.6
  • 73
    • 84855384345 scopus 로고    scopus 로고
    • The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood
    • doi: 10.4049/jimmunol.1100421
    • Mizutani, M., Pino, P. A., Saederup, N., Charo, I. F., Ransohoff, R. M., and Cardona, A. E. (2012). The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood. J. Immunol.188, 29-36. doi: 10.4049/jimmunol.1100421
    • (2012) J. Immunol. , vol.188 , pp. 29-36
    • Mizutani, M.1    Pino, P.A.2    Saederup, N.3    Charo, I.F.4    Ransohoff, R.M.5    Cardona, A.E.6
  • 74
    • 84875897593 scopus 로고    scopus 로고
    • Brain microglia: Watchdogs with pedigree
    • doi: 10.1038/nn.3338
    • Neumann, H., and Wekerle, H. (2013). Brain microglia: watchdogs with pedigree. Nat. Neurosci. 16, 253-255. doi: 10.1038/nn.3338
    • (2013) Nat. Neurosci. , vol.16 , pp. 253-255
    • Neumann, H.1    Wekerle, H.2
  • 75
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • doi: 10.1126/science.1110647
    • Nimmerjahn, A., Kirchhoff, F., and Helmchen, F. (2005). Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308, 1314-1318. doi: 10.1126/science.1110647
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 76
    • 0036184216 scopus 로고    scopus 로고
    • Regulation of calcium currents by chemokines and their receptors
    • doi: 10.1016/s0165-5728(01)00485-4
    • Oh, S. B., Endoh, T., Simen, A. A., Ren, D., and Miller, R. J. (2002). Regulation of calcium currents by chemokines and their receptors. J. Neuroimmunol. 123, 66-75. doi: 10.1016/s0165-5728(01)00485-4
    • (2002) J. Neuroimmunol. , vol.123 , pp. 66-75
    • Oh, S.B.1    Endoh, T.2    Simen, A.A.3    Ren, D.4    Miller, R.J.5
  • 77
    • 83055184202 scopus 로고    scopus 로고
    • Identification of a microglia phenotype supportive of remyelination
    • doi: 10.1002/glia.21266
    • Olah, M., Amor, S., Brouwer, N., Vinet, J., Eggen, B., Biber, K., et al. (2012). Identification of a microglia phenotype supportive of remyelination. Glia 60, 306-321. doi: 10.1002/glia.21266
    • (2012) Glia , vol.60 , pp. 306-321
    • Olah, M.1    Amor, S.2    Brouwer, N.3    Vinet, J.4    Eggen, B.5    Biber, K.6
  • 78
    • 78650233802 scopus 로고    scopus 로고
    • Microglia in the CNS: Immigrants from another world
    • doi: 10.1002/glia.21104
    • Prinz, M., and Mildner, A. (2011). Microglia in the CNS: immigrants from another world. Glia 59, 177-187. doi: 10.1002/glia.21104
    • (2011) Glia , vol.59 , pp. 177-187
    • Prinz, M.1    Mildner, A.2
  • 79
    • 84875660631 scopus 로고    scopus 로고
    • Effects of 56Fe radiation on hippocampal function in mice deficient in chemokine receptor 2 (CCR2)
    • doi: 10.1016/j.bbr.2013.03.003
    • Raber, J., Allen, A. R., Rosi, S., Sharma, S., Dayger, C., Davis, M. J., et al. (2013). Effects of 56Fe radiation on hippocampal function in mice deficient in chemokine receptor 2 (CCR2). Behav. Brain Res. 246, 69-75. doi: 10.1016/j.bbr.2013.03.003
    • (2013) Behav. Brain Res. , vol.246 , pp. 69-75
    • Raber, J.1    Allen, A.R.2    Rosi, S.3    Sharma, S.4    Dayger, C.5    Davis, M.J.6
  • 80
    • 78149435065 scopus 로고    scopus 로고
    • The myeloid cells of the central nervous system parenchyma
    • doi: 10.1038/nature09615
    • Ransohoff, R. M., and Cardona, A. E. (2010). The myeloid cells of the central nervous system parenchyma. Nature468, 253-262. doi: 10.1038/nature09615
    • (2010) Nature , vol.468 , pp. 253-262
    • Ransohoff, R.M.1    Cardona, A.E.2
  • 81
    • 70449525704 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors: Standing at the crossroads of immunobiology and neurobiology
    • doi: 10.1016/j.immuni.2009.09.010
    • Ransohoff, R. M. (2009). Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology. Immunity 31, 711-721. doi: 10.1016/j.immuni.2009.09.010
    • (2009) Immunity , vol.31 , pp. 711-721
    • Ransohoff, R.M.1
  • 82
    • 67650966680 scopus 로고    scopus 로고
    • Microglial physiology: Unique stimuli, specialized responses
    • doi: 10.1146/annurev.immunol.021908.132528
    • Ransohoff, R. M., and Perry, V. H. (2009). Microglial physiology: unique stimuli, specialized responses. Annu. Rev. Immunol. 27, 119-145. doi: 10.1146/annurev.immunol.021908.132528
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 119-145
    • Ransohoff, R.M.1    Perry, V.H.2
  • 83
    • 4744355622 scopus 로고    scopus 로고
    • CXCR3-dependent microglial recruitment is essential for dendrite loss after brain lesion
    • doi: 10.1523/jneurosci.2451-04.2004
    • Rappert, A., Bechmann, I., Pivneva, T., Mahlo, J., Biber, K., Nolte, C., et al. (2004). CXCR3-dependent microglial recruitment is essential for dendrite loss after brain lesion. J. Neurosci. 24, 8500-8509. doi: 10.1523/jneurosci.2451-04.2004
    • (2004) J. Neurosci. , vol.24 , pp. 8500-8509
    • Rappert, A.1    Bechmann, I.2    Pivneva, T.3    Mahlo, J.4    Biber, K.5    Nolte, C.6
  • 84
    • 0036533514 scopus 로고    scopus 로고
    • Partial peripheral nerve injury leads to activation of astroglia and microglia which parallels the development of allodynic behavior
    • doi: 10.4049/jimmunol.168.7.3221
    • Rappert, A., Biber, K., Nolte, C., Lipp, M., Schubel, A., Lu, B., et al. (2002). Partial peripheral nerve injury leads to activation of astroglia and microglia which parallels the development of allodynic behavior. J. Immunol. 168, 3221-3226. doi: 10.4049/jimmunol.168.7.3221
    • (2002) J. Immunol. , vol.168 , pp. 3221-3226
    • Rappert, A.1    Biber, K.2    Nolte, C.3    Lipp, M.4    Schubel, A.5    Lu, B.6
  • 85
    • 78149357276 scopus 로고    scopus 로고
    • Interactions between the immune and nervous systems in pain
    • doi: 10.1038/nm.2234
    • Ren, K., and Dubner, R. (2010). Interactions between the immune and nervous systems in pain. Nat. Med. 16, 1267-1276. doi: 10.1038/nm.2234
    • (2010) Nat. Med. , vol.16 , pp. 1267-1276
    • Ren, K.1    Dubner, R.2
  • 87
    • 0034319204 scopus 로고    scopus 로고
    • Limited role of macrophages in generation of nerve injury-induced mechanical allodynia
    • doi: 10.1016/s0031-9384(00)00333-4
    • Rutkowski, M. D., Pahl, J. L., Sweitzer, S., van Rooijen, N., and DeLeo, J. A. (2000). Limited role of macrophages in generation of nerve injury-induced mechanical allodynia. Physiol. Behav. 71, 225-235. doi: 10.1016/s0031-9384(00)00333-4
    • (2000) Physiol. Behav. , vol.71 , pp. 225-235
    • Rutkowski, M.D.1    Pahl, J.L.2    Sweitzer, S.3    van Rooijen, N.4    DeLeo, J.A.5
  • 88
    • 33748997942 scopus 로고    scopus 로고
    • Neuropeptides as synaptic transmitters
    • doi: 10.1007/s00441-006-0268-3
    • Salio, C., Lossi, L., Ferrini, F., and Merighi, A. (2006). Neuropeptides as synaptic transmitters. Cell Tissue Res. 326, 583-598. doi: 10.1007/s00441-006-0268-3
    • (2006) Cell Tissue Res. , vol.326 , pp. 583-598
    • Salio, C.1    Lossi, L.2    Ferrini, F.3    Merighi, A.4
  • 89
    • 0345701254 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons
    • Schäfers, M., Svensson, C. I., Sommer, C., and Sorkin, L. S. (2003). Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons. J. Neurosci. 23, 2517-2521.
    • (2003) J. Neurosci. , vol.23 , pp. 2517-2521
    • Schäfers, M.1    Svensson, C.I.2    Sommer, C.3    Sorkin, L.S.4
  • 90
    • 68649107955 scopus 로고    scopus 로고
    • The role of CC chemokine receptor 2 on microglia activation and blood-borne cell recruitment after transient focal cerebral ischemia in mice
    • doi: 10.1016/j.brainres.2009.06.054
    • Schilling, M., Strecker, J. K., Ringelstein, E. B., Schäbitz, W. R., and Kiefer, R. (2009a). The role of CC chemokine receptor 2 on microglia activation and blood-borne cell recruitment after transient focal cerebral ischemia in mice. Brain Res. 1289, 79-84. doi: 10.1016/j.brainres.2009.06.054
    • (2009) Brain Res. , vol.1289 , pp. 79-84
    • Schilling, M.1    Strecker, J.K.2    Ringelstein, E.B.3    Schäbitz, W.R.4    Kiefer, R.5
  • 91
    • 65749106380 scopus 로고    scopus 로고
    • Effects of monocyte chemoattractant protein 1 on blood-borne cell recruitment after transient focal cerebral ischemia in mice
    • doi: 10.1016/j.neuroscience.2009.04.025
    • Schilling, M., Strecker, J. K., Schäbitz, W. R., Ringelstein, E. B., and Kiefer, R. (2009b). Effects of monocyte chemoattractant protein 1 on blood-borne cell recruitment after transient focal cerebral ischemia in mice. Neuroscience 161, 806-812. doi: 10.1016/j.neuroscience.2009.04.025
    • (2009) Neuroscience , vol.161 , pp. 806-812
    • Schilling, M.1    Strecker, J.K.2    Schäbitz, W.R.3    Ringelstein, E.B.4    Kiefer, R.5
  • 92
    • 35548937457 scopus 로고    scopus 로고
    • The neuropathic pain triad: Neurons, immune cells and glia
    • doi: 10.1038/nn1992
    • Scholz, J., and Woolf, C. J. (2007). The neuropathic pain triad: neurons, immune cells and glia. Nat. Neurosci. 10, 1361-1368. doi: 10.1038/nn1992
    • (2007) Nat. Neurosci. , vol.10 , pp. 1361-1368
    • Scholz, J.1    Woolf, C.J.2
  • 93
    • 84859508307 scopus 로고    scopus 로고
    • A lineage of myeloid cells independent of Myb and hematopoietic stem cells
    • doi: 10.1126/science.1219179
    • Schulz, C., Gomez Perdiguero, E., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., et al. (2012). A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science 336, 86-90. doi: 10.1126/science.1219179
    • (2012) Science , vol.336 , pp. 86-90
    • Schulz, C.1    Gomez Perdiguero, E.2    Chorro, L.3    Szabo-Rogers, H.4    Cagnard, N.5    Kierdorf, K.6
  • 94
    • 32044442102 scopus 로고    scopus 로고
    • Microglial phenotype: Is the commitment reversible?
    • doi: 10.1016/j.tins.2005.12.005
    • Schwartz, M., Butovsky, O., Brück, W., and Hanisch, U. K. (2006). Microglial phenotype: is the commitment reversible? Trends Neurosci. 29, 68-74. doi: 10.1016/j.tins.2005.12.005
    • (2006) Trends Neurosci. , vol.29 , pp. 68-74
    • Schwartz, M.1    Butovsky, O.2    Brück, W.3    Hanisch, U.K.4
  • 95
    • 76749152880 scopus 로고    scopus 로고
    • Chemokines and their receptors: Orchestrating a fine balance between health and disease
    • doi: 10.1080/07388550903187418
    • Sharma, M. (2010). Chemokines and their receptors: orchestrating a fine balance between health and disease. Crit. Rev. Biotechnol. 30, 1-22. doi: 10.1080/07388550903187418
    • (2010) Crit. Rev. Biotechnol. , vol.30 , pp. 1-22
    • Sharma, M.1
  • 96
    • 0036847816 scopus 로고    scopus 로고
    • Microglia as neuroprotective, immunocompetent cells of the CNS
    • doi: 10.1002/glia.10154
    • Streit, W. J. (2002). Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 40, 133-139. doi: 10.1002/glia.10154
    • (2002) Glia , vol.40 , pp. 133-139
    • Streit, W.J.1
  • 97
    • 76349102800 scopus 로고    scopus 로고
    • Spinal astrocytes in pain processing: Non-neuronal cells as therapeutic targets
    • doi: 10.1124/mi.10.1.6
    • Svensson, C. I., and Brodin, E. (2010). Spinal astrocytes in pain processing: non-neuronal cells as therapeutic targets. Mol. Interv. 10, 25-38. doi: 10.1124/mi.10.1.6
    • (2010) Mol. Interv. , vol.10 , pp. 25-38
    • Svensson, C.I.1    Brodin, E.2
  • 98
    • 34248138496 scopus 로고    scopus 로고
    • The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
    • doi: 10.1038/nrd2280
    • Szallasi, A., Cortright, D. N., Blum, C. A., and Eid, S. R. (2007). The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat. Rev. Drug Discov. 6, 357-372. doi: 10.1038/nrd2280
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 357-372
    • Szallasi, A.1    Cortright, D.N.2    Blum, C.A.3    Eid, S.R.4
  • 99
    • 1642404488 scopus 로고    scopus 로고
    • Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: Possible involvement in the development of neuropathic pain
    • doi: 10.1016/j.neures.2004.01.004
    • Tanaka, T., Minami, M., Nakagawa, T., and Satoh, M. (2004). Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: possible involvement in the development of neuropathic pain. Neurosci. Res. 48, 463-469. doi: 10.1016/j.neures.2004.01.004
    • (2004) Neurosci. Res. , vol.48 , pp. 463-469
    • Tanaka, T.1    Minami, M.2    Nakagawa, T.3    Satoh, M.4
  • 100
    • 43949146604 scopus 로고    scopus 로고
    • Activation of microglia and p38 mitogen-activated protein kinase in the dorsal column nucleus contributes to tactile allodynia following peripheral nerve injury
    • doi: 10.1016/j.neuroscience.2008.03.041
    • Terayama, R., Omura, S., Fujisawa, N., Yamaai, T., Ichikawa, H., and Sugimoto, T. (2008). Activation of microglia and p38 mitogen-activated protein kinase in the dorsal column nucleus contributes to tactile allodynia following peripheral nerve injury. Neuroscience 153, 1245-1255. doi: 10.1016/j.neuroscience.2008.03.041
    • (2008) Neuroscience , vol.153 , pp. 1245-1255
    • Terayama, R.1    Omura, S.2    Fujisawa, N.3    Yamaai, T.4    Ichikawa, H.5    Sugimoto, T.6
  • 101
    • 60949105934 scopus 로고    scopus 로고
    • CCL2 is a key mediator of microglia activation in neuropathic pain states
    • doi: 10.1016/j.ejpain.2008.04.017
    • Thacker, M. A., Clark, A. K., Bishop, T., Grist, J., Yip, P. K., Moon, L. D., et al. (2009). CCL2 is a key mediator of microglia activation in neuropathic pain states. Eur. J. Pain 13, 263-272. doi: 10.1016/j.ejpain.2008.04.017
    • (2009) Eur. J. Pain , vol.13 , pp. 263-272
    • Thacker, M.A.1    Clark, A.K.2    Bishop, T.3    Grist, J.4    Yip, P.K.5    Moon, L.D.6
  • 102
    • 84858158249 scopus 로고    scopus 로고
    • ATP receptors gate microglia signaling in neuropathic pain
    • doi: 10.1016/j.expneurol.2011.11.012
    • Trang, T., Beggs, S., and Salter, M. W. (2012). ATP receptors gate microglia signaling in neuropathic pain. Exp. Neurol. 234, 354-361. doi: 10.1016/j.expneurol.2011.11.012
    • (2012) Exp. Neurol. , vol.234 , pp. 354-361
    • Trang, T.1    Beggs, S.2    Salter, M.W.3
  • 103
    • 84874130784 scopus 로고    scopus 로고
    • Microglial regulation of neuropathic pain
    • doi: 10.1254/jphs.12r14cp
    • Tsuda, M., Masuda, T., Tozaki-Saitoh, H., and Inoue, K. (2013). Microglial regulation of neuropathic pain. J. Pharmacol. Sci. 121, 89-94. doi: 10.1254/jphs.12r14cp
    • (2013) J. Pharmacol. Sci. , vol.121 , pp. 89-94
    • Tsuda, M.1    Masuda, T.2    Tozaki-Saitoh, H.3    Inoue, K.4
  • 104
    • 0042968804 scopus 로고    scopus 로고
    • P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
    • doi: 10.1038/nature01786
    • Tsuda, M., Shigemoto-Mogami, Y., Koizumi, S., Mizokoshi, A., Kohsaka, S., Salter, M. W., et al. (2003). P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 424, 778-783. doi: 10.1038/nature01786
    • (2003) Nature , vol.424 , pp. 778-783
    • Tsuda, M.1    Shigemoto-Mogami, Y.2    Koizumi, S.3    Mizokoshi, A.4    Kohsaka, S.5    Salter, M.W.6
  • 105
    • 67349164309 scopus 로고    scopus 로고
    • Mode of action of cytokines on nociceptive neurons
    • doi: 10.1007/s00221-009-1755-z
    • Uçeyler, N., Schäfers, M., and Sommer, C. (2009). Mode of action of cytokines on nociceptive neurons. Exp. Brain Res. 196, 67-78. doi: 10.1007/s00221-009-1755-z
    • (2009) Exp. Brain Res. , vol.196 , pp. 67-78
    • Uçeyler, N.1    Schäfers, M.2    Sommer, C.3
  • 106
    • 5444256254 scopus 로고    scopus 로고
    • Microglia
    • doi: 10.1023/B:MEBR.0000043984.73063.d8
    • van Rossum, D., and Hanisch, U. K. (2004). Microglia. Metab. Brain Dis. 19, 393-411. doi: 10.1023/B:MEBR.0000043984.73063.d8
    • (2004) Metab. Brain Dis. , vol.19 , pp. 393-411
    • van Rossum, D.1    Hanisch, U.K.2
  • 107
    • 79955769305 scopus 로고    scopus 로고
    • CCL2 released from neuronal synaptic vesicles in the spinal cord is a major mediator of local inflammation and pain after peripheral nerve injury
    • doi: 10.1523/JNEUROSCI.5986-10.2011
    • Van Steenwinckel, J., Reaux-Le Goazigo, A., Pommier, B., Mauborgne, A., Dansereau, M. A., Kitabgi, P., et al. (2011). CCL2 released from neuronal synaptic vesicles in the spinal cord is a major mediator of local inflammation and pain after peripheral nerve injury. J. Neurosci. 31, 5865-5875. doi: 10.1523/JNEUROSCI.5986-10.2011
    • (2011) J. Neurosci. , vol.31 , pp. 5865-5875
    • Van Steenwinckel, J.1    Reaux-Le Goazigo, A.2    Pommier, B.3    Mauborgne, A.4    Dansereau, M.A.5    Kitabgi, P.6
  • 109
    • 77953611864 scopus 로고    scopus 로고
    • CCL21-induced calcium transients and proliferation in primary mouse astrocytes: CXCR3-dependent and independent responses
    • doi: 10.1016/j.bbi.2009.04.007
    • van Weering, H. R., de Jong, A. P., de Haas, A. H., Biber, K. P., and Boddeke, H. W. (2010). CCL21-induced calcium transients and proliferation in primary mouse astrocytes: CXCR3-dependent and independent responses. Brain Behav. Immun. 24, 768-775. doi: 10.1016/j.bbi.2009.04.007
    • (2010) Brain Behav. Immun. , vol.24 , pp. 768-775
    • van Weering, H.R.1    de Jong, A.P.2    de Haas, A.H.3    Biber, K.P.4    Boddeke, H.W.5
  • 110
    • 0028805882 scopus 로고
    • Immune activation: The role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states
    • doi: 10.1016/0304-3959(95)00186-7
    • Watkins, L. R., Maier, S. F., and Goehler, L. E. (1995). Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states. Pain 63, 289-302. doi: 10.1016/0304-3959(95)00186-7
    • (1995) Pain , vol.63 , pp. 289-302
    • Watkins, L.R.1    Maier, S.F.2    Goehler, L.E.3
  • 111
    • 0034882399 scopus 로고    scopus 로고
    • Spinal cord glia: New players in pain
    • doi: 10.1016/s0304-3959(01)00359-1
    • Watkins, L. R., Milligan, E. D., and Maier, S. F. (2001). Spinal cord glia: new players in pain. Pain 93, 201-205. doi: 10.1016/s0304-3959(01)00359-1
    • (2001) Pain , vol.93 , pp. 201-205
    • Watkins, L.R.1    Milligan, E.D.2    Maier, S.F.3
  • 112
    • 0028136937 scopus 로고
    • Characterization of cytokine-induced hyperalgesia
    • doi: 10.1016/0006-8993(94)91566-0
    • Watkins, L. R., Wiertelak, E. P., Goehler, L. E., Smith, K. P., Martin, D., and Maier, S. F. (1994). Characterization of cytokine-induced hyperalgesia. Brain Res. 654, 15-26. doi: 10.1016/0006-8993(94)91566-0
    • (1994) Brain Res. , vol.654 , pp. 15-26
    • Watkins, L.R.1    Wiertelak, E.P.2    Goehler, L.E.3    Smith, K.P.4    Martin, D.5    Maier, S.F.6
  • 113
    • 25444490392 scopus 로고    scopus 로고
    • Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion
    • doi: 10.1073/pnas.0503496102
    • White, F. A., Sun, J., Waters, S. M., Ma, C., Ren, D., Ripsch, M., et al. (2005). Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion. Proc. Natl. Acad. Sci. U S A 102, 14092-14097. doi: 10.1073/pnas.0503496102
    • (2005) Proc. Natl. Acad. Sci. U S A , vol.102 , pp. 14092-14097
    • White, F.A.1    Sun, J.2    Waters, S.M.3    Ma, C.4    Ren, D.5    Ripsch, M.6
  • 114
    • 35448972399 scopus 로고    scopus 로고
    • Peripheral inflammation increases Scya2 expression in sensory ganglia and cytokine and endothelial related gene expression in inflamed tissue
    • doi: 10.1111/j.1471-4159.2007.04874.x
    • Yang, H. Y., Mitchell, K., Keller, J. M., and Iadarola, M. J. (2007). Peripheral inflammation increases Scya2 expression in sensory ganglia and cytokine and endothelial related gene expression in inflamed tissue. J. Neurochem. 103, 1628-1643. doi: 10.1111/j.1471-4159.2007.04874.x
    • (2007) J. Neurochem. , vol.103 , pp. 1628-1643
    • Yang, H.Y.1    Mitchell, K.2    Keller, J.M.3    Iadarola, M.J.4
  • 115
    • 84859704700 scopus 로고    scopus 로고
    • The CCL2-CCR2 system affects the progression and clearance of intracerebral hemorrhage
    • doi: 10.1002/glia.22323
    • Yao, Y., and Tsirka, S. E. (2012). The CCL2-CCR2 system affects the progression and clearance of intracerebral hemorrhage. Glia 60, 908-918. doi: 10.1002/glia.22323
    • (2012) Glia , vol.60 , pp. 908-918
    • Yao, Y.1    Tsirka, S.E.2
  • 116
    • 76849102925 scopus 로고    scopus 로고
    • Sorting of neuropeptides and neuropeptide receptors into secretory pathways
    • doi: 10.1016/j.pneurobio.2009.10.011
    • Zhang, X., Bao, L., and Ma, G. Q. (2010). Sorting of neuropeptides and neuropeptide receptors into secretory pathways. Prog. Neurobiol. 90, 276-283. doi: 10.1016/j.pneurobio.2009.10.011
    • (2010) Prog. Neurobiol. , vol.90 , pp. 276-283
    • Zhang, X.1    Bao, L.2    Ma, G.Q.3
  • 117
    • 33645850108 scopus 로고    scopus 로고
    • Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury
    • doi: 10.1111/j.1471-4159.2006.03746.x
    • Zhang, J., and De Koninck, Y. (2006). Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury. J. Neurochem. 97, 772-783. doi: 10.1111/j.1471-4159.2006.03746.x
    • (2006) J. Neurochem. , vol.97 , pp. 772-783
    • Zhang, J.1    De Koninck, Y.2
  • 118
    • 36048991728 scopus 로고    scopus 로고
    • Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain
    • doi: 10.1523/jneurosci.3016-07.2007
    • Zhang, J., Shi, X. Q., Echeverry, S., Mogil, J. S., De Koninck, Y., and Rivest, S. (2007). Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain. J. Neurosci. 27, 12396-12406. doi: 10.1523/jneurosci.3016-07.2007
    • (2007) J. Neurosci. , vol.27 , pp. 12396-12406
    • Zhang, J.1    Shi, X.Q.2    Echeverry, S.3    Mogil, J.S.4    De Koninck, Y.5    Rivest, S.6
  • 119
    • 0037338288 scopus 로고    scopus 로고
    • LPS-induced expression of a novel chemokine receptor (L-CCR) in mouse glial cells in vitro and in vivo
    • doi: 10.1002/glia.10156
    • Zuurman, M. W., Heeroma, J., Brouwer, N., Boddeke, H. W., and Biber, K. (2003). LPS-induced expression of a novel chemokine receptor (L-CCR) in mouse glial cells in vitro and in vivo. Glia 41, 327-336. doi: 10.1002/glia.10156
    • (2003) Glia , vol.41 , pp. 327-336
    • Zuurman, M.W.1    Heeroma, J.2    Brouwer, N.3    Boddeke, H.W.4    Biber, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.