Limited role of macrophages in generation of nerve injury-induced mechanical allodynia

Physiology and Behavior

Volumn 71, Issue 3-4, 2000, Pages 225-235

  Rutkowski, Maria D ^a   Pahl, Janice L ^a   Sweitzer, Sarah ^a   Van Rooijen, Nico ^b   DeLeo, Joyce A ^a  

^a DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Astrocytes; CNI 1493; Glial fibrillary acidic protein (GFAP); Liposome encapsulated clodronate; Macrophages; Microglia; Neuropathic pain

Indexed keywords

CLODRONIC ACID; GLIAL FIBRILLARY ACIDIC PROTEIN; SEMAPIMOD;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CELL ACTIVATION; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MACROPHAGE MIGRATION INHIBITION; MALE; MICROGLIA; NERVE INJURY; NONHUMAN; PRIORITY JOURNAL; RAT; TECHNIQUE;

EID: 0034319204     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9384(00)00333-4     Document Type: Article

References (31)

1. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
2. Tactile allodynia, but not thermal hyperalgesia, of the hindlimbs is blocked by spinal transection in rats with nerve injury
3. Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazone
4. An inhibitor of macrophage arginine transport and nitric oxide production (CNI-1493) prevents acute inflammation and endotoxin lethality
5. Nociceptive integration: Does it have a peripheral component?
6. CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency
7. The effect of site vs. type of nerve injury on glial activity and behavior in the rat
8. Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat
9. The role of cytokines in nociception and chronic pain
10. Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury
11. Alterations in glial fibrillary acidic protein immunoreactivity in the upper dorsal horn of the rat spinal cord in the course of transganglionic atrophy and regenerative proliferation
12. Spinal glial activation and cytokine expression following lumbar root injury in the rat
13. Perivascular microglia are bone marrow derived and present antigen in vivo
14. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
15. Colchicine treatment of the sciatic nerve reduces neurogenic extravasation, but does not affect nociceptive thresholds or collateral sprouting in neuropathic or normal rats
16. Functional switching of macrophage responses to tumor necrosis factor-α (TNF-α) by IFNs: Implications for the pleiotropic activities of TNF-α
17. Liposome-mediated monocyte depletion reduces Wallerian degeneration and thermal hyperalgesia in rats with partial nerve injury
18. Prevention and treatment of experimental autoimmune encephalomyelitis by CNI-1493, a macrophage-deactivation agent
19. Possible chemical contribution from chromic gut sutures produces disorders of pain sensation like those seen in man
20. The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat
21. Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury
22. The control of pain in peripheral tissue by opioids
23. Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation
24. Biological and antigenic similarities of murine interferon-gamma and macrophage activating factor
25. Increased glial fibrillary protein synthesis in astrocytes during retrograde reaction of the rat facial nucleus
26. Depletion and repopulation of macrophages in spleen and liver of rat after intravenous treatment with liposome-encapsulated dichloromethylene diphosphonate
27. Liposome mediated depletion of macrophages: Mechanism of action, preparation of liposomes, and applications
28. Peripheral nerve pathology following sciatic cryoneurolysis: Relationship to neuropathic behaviors in the rat
29. Anti-inflammatory interleukin-10 therapy in CCI neuropathy decreases thermal hyperalgesia, macrophage recruitment, and endoneurial TNF-α expression
30. Endoneurial injection of TNF-alpha produces neuropathic pain behaviors
31. Schwann cells produce tumor necrosis factor alpha: Expression in injured and non-injured nerves