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Volumn 234, Issue 2, 2012, Pages 354-361

ATP receptors gate microglia signaling in neuropathic pain

Author keywords

ATP; BDNF; Microglia; Nerve injury; Neuropathic pain; P2 purinoceptors; Spinal cord

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; INTERLEUKIN 1BETA; PURINERGIC P2 RECEPTOR; PURINERGIC P2X4 RECEPTOR; SECONDARY LYMPHOID TISSUE CHEMOKINE;

EID: 84858158249     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2011.11.012     Document Type: Review
Times cited : (125)

References (136)
  • 1
    • 26844528859 scopus 로고    scopus 로고
    • Regulation of microglia-potential new drug targets in the CNS
    • Aldskogius H. Regulation of microglia-potential new drug targets in the CNS. Expert Opin. Ther. Targets 2001, 5:655-668.
    • (2001) Expert Opin. Ther. Targets , vol.5 , pp. 655-668
    • Aldskogius, H.1
  • 3
    • 77956652648 scopus 로고    scopus 로고
    • Microglia-neuronal signalling in neuropathic pain hypersensitivity 2.0
    • Beggs S., Salter M.W. Microglia-neuronal signalling in neuropathic pain hypersensitivity 2.0. Curr. Opin. Neurobiol. 2010, 20:474-480.
    • (2010) Curr. Opin. Neurobiol. , vol.20 , pp. 474-480
    • Beggs, S.1    Salter, M.W.2
  • 4
    • 77958526530 scopus 로고    scopus 로고
    • Peripheral nerve injury and TRPV1-expressing primary afferent C-fibers cause opening of the blood-brain barrier
    • Beggs S., Liu X.J., Kwan C., Salter M.W. Peripheral nerve injury and TRPV1-expressing primary afferent C-fibers cause opening of the blood-brain barrier. Mol. Pain 2010, 6:74.
    • (2010) Mol. Pain , vol.6 , pp. 74
    • Beggs, S.1    Liu, X.J.2    Kwan, C.3    Salter, M.W.4
  • 7
    • 0034076537 scopus 로고    scopus 로고
    • Physiological properties of the lamina I spinoparabrachial neurons in the rat
    • Bester H., Chapman V., Besson J.M., Bernard J.F. Physiological properties of the lamina I spinoparabrachial neurons in the rat. J. Neurophysiol. 2000, 83:2239-2259.
    • (2000) J. Neurophysiol. , vol.83 , pp. 2239-2259
    • Bester, H.1    Chapman, V.2    Besson, J.M.3    Bernard, J.F.4
  • 10
    • 77955501581 scopus 로고    scopus 로고
    • Is BDNF sufficient for information transfer between microglia and dorsal horn neurons during the onset of central sensitization?
    • Biggs J.E., Lu V.B., Stebbing M.J., Balasubramanyan S., Smith P.A. Is BDNF sufficient for information transfer between microglia and dorsal horn neurons during the onset of central sensitization?. Mol. Pain 2010, 6:44.
    • (2010) Mol. Pain , vol.6 , pp. 44
    • Biggs, J.E.1    Lu, V.B.2    Stebbing, M.J.3    Balasubramanyan, S.4    Smith, P.A.5
  • 11
    • 0032761316 scopus 로고    scopus 로고
    • Identification of two persistently activated neurotrophin-regulated pathways in rat hippocampus
    • Blanquet P.R. Identification of two persistently activated neurotrophin-regulated pathways in rat hippocampus. Neuroscience 2000, 95:705-719.
    • (2000) Neuroscience , vol.95 , pp. 705-719
    • Blanquet, P.R.1
  • 12
    • 0037096435 scopus 로고    scopus 로고
    • P2X receptor trafficking in neurons is subunit specific
    • Bobanovic L.K., Royle S.J., Murrell-Lagnado R.D. P2X receptor trafficking in neurons is subunit specific. J. Neurosci. 2002, 22:4814-4824.
    • (2002) J. Neurosci. , vol.22 , pp. 4814-4824
    • Bobanovic, L.K.1    Royle, S.J.2    Murrell-Lagnado, R.D.3
  • 13
    • 0038053021 scopus 로고    scopus 로고
    • Purinergic receptors on microglial cells: functional expression in acute brain slices and modulation of microglial activation in vitro
    • Boucsein C., Zacharias R., Farber K., Pavlovic S., Hanisch U.K., Kettenmann H. Purinergic receptors on microglial cells: functional expression in acute brain slices and modulation of microglial activation in vitro. Eur. J. Neurosci. 2003, 17:2267-2276.
    • (2003) Eur. J. Neurosci. , vol.17 , pp. 2267-2276
    • Boucsein, C.1    Zacharias, R.2    Farber, K.3    Pavlovic, S.4    Hanisch, U.K.5    Kettenmann, H.6
  • 15
    • 67649395964 scopus 로고    scopus 로고
    • Analysis of assembly and trafficking of native P2X4 and P2X7 receptor complexes in rodent immune cells
    • Boumechache M., Masin M., Edwardson J.M., Gorecki D.C., Murrell-Lagnado R. Analysis of assembly and trafficking of native P2X4 and P2X7 receptor complexes in rodent immune cells. J. Biol. Chem. 2009, 284:13446-13454.
    • (2009) J. Biol. Chem. , vol.284 , pp. 13446-13454
    • Boumechache, M.1    Masin, M.2    Edwardson, J.M.3    Gorecki, D.C.4    Murrell-Lagnado, R.5
  • 16
    • 35248815474 scopus 로고    scopus 로고
    • P2X currents in peritoneal macrophages of wild type and P2X4-/- mice
    • Brone B., Moechars D., Marrannes R., Mercken M., Meert T. P2X currents in peritoneal macrophages of wild type and P2X4-/- mice. Immunol. Lett. 2007, 113:83-89.
    • (2007) Immunol. Lett. , vol.113 , pp. 83-89
    • Brone, B.1    Moechars, D.2    Marrannes, R.3    Mercken, M.4    Meert, T.5
  • 18
    • 0036200917 scopus 로고    scopus 로고
    • Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism
    • Brough D., Le Feuvre R.A., Iwakura Y., Rothwell N.J. Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism. Mol. Cell. Neurosci. 2002, 19:272-280.
    • (2002) Mol. Cell. Neurosci. , vol.19 , pp. 272-280
    • Brough, D.1    Le Feuvre, R.A.2    Iwakura, Y.3    Rothwell, N.J.4
  • 19
    • 34250719722 scopus 로고    scopus 로고
    • Purine and pyrimidine receptors
    • Burnstock G. Purine and pyrimidine receptors. Cell. Mol. Life Sci. 2007, 64:1471-1483.
    • (2007) Cell. Mol. Life Sci. , vol.64 , pp. 1471-1483
    • Burnstock, G.1
  • 20
    • 80052855507 scopus 로고    scopus 로고
    • Purinergic signalling: from normal behaviour to pathological brain function
    • Burnstock G., Krugel U., Abbracchio M.P., Illes P. Purinergic signalling: from normal behaviour to pathological brain function. Prog. Neurobiol. 2011, 95(2):229-274.
    • (2011) Prog. Neurobiol. , vol.95 , Issue.2 , pp. 229-274
    • Burnstock, G.1    Krugel, U.2    Abbracchio, M.P.3    Illes, P.4
  • 21
    • 0036139877 scopus 로고    scopus 로고
    • Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains
    • Bushong E.A., Martone M.E., Jones Y.Z., Ellisman M.H. Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains. J. Neurosci. 2002, 22:183-192.
    • (2002) J. Neurosci. , vol.22 , pp. 183-192
    • Bushong, E.A.1    Martone, M.E.2    Jones, Y.Z.3    Ellisman, M.H.4
  • 22
    • 84858152101 scopus 로고    scopus 로고
    • The mechanisms of microgliosis and pain following peripheral nerve injury
    • in press
    • Calvo, M., Bennett, D.L., in press. The mechanisms of microgliosis and pain following peripheral nerve injury. Exp. Neurol.
    • Exp. Neurol.
    • Calvo, M.1    Bennett, D.L.2
  • 23
    • 79851498855 scopus 로고    scopus 로고
    • Following nerve injury neuregulin-1 drives microglial proliferation and neuropathic pain via the MEK/ERK pathway
    • Calvo M., Zhu N., Grist J., Ma Z., Loeb J.A., Bennett D.L. Following nerve injury neuregulin-1 drives microglial proliferation and neuropathic pain via the MEK/ERK pathway. Glia 2011, 59:554-568.
    • (2011) Glia , vol.59 , pp. 554-568
    • Calvo, M.1    Zhu, N.2    Grist, J.3    Ma, Z.4    Loeb, J.A.5    Bennett, D.L.6
  • 24
    • 42249104400 scopus 로고    scopus 로고
    • CNS-infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain
    • Cao L., DeLeo J.A. CNS-infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain. Eur. J. Immunol. 2008, 38:448-458.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 448-458
    • Cao, L.1    DeLeo, J.A.2
  • 25
  • 26
    • 0037092429 scopus 로고    scopus 로고
    • ADP and AMP induce interleukin-1beta release from microglial cells through activation of ATP-primed P2X7 receptor channels
    • Chakfe Y., Seguin R., Antel J.P., Morissette C., Malo D., Henderson D., Seguela P. ADP and AMP induce interleukin-1beta release from microglial cells through activation of ATP-primed P2X7 receptor channels. J. Neurosci. 2002, 22:3061-3069.
    • (2002) J. Neurosci. , vol.22 , pp. 3061-3069
    • Chakfe, Y.1    Seguin, R.2    Antel, J.P.3    Morissette, C.4    Malo, D.5    Henderson, D.6    Seguela, P.7
  • 29
    • 78349245841 scopus 로고    scopus 로고
    • Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor
    • Clark A.K., Wodarski R., Guida F., Sasso O., Malcangio M. Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor. Glia 2010, 58:1710-1726.
    • (2010) Glia , vol.58 , pp. 1710-1726
    • Clark, A.K.1    Wodarski, R.2    Guida, F.3    Sasso, O.4    Malcangio, M.5
  • 32
    • 67651048942 scopus 로고    scopus 로고
    • Neuropathic pain: a maladaptive response of the nervous system to damage
    • Costigan M., Scholz J., Woolf C.J. Neuropathic pain: a maladaptive response of the nervous system to damage. Annu. Rev. Neurosci. 2009, 32:1-32.
    • (2009) Annu. Rev. Neurosci. , vol.32 , pp. 1-32
    • Costigan, M.1    Scholz, J.2    Woolf, C.J.3
  • 35
    • 0032079675 scopus 로고    scopus 로고
    • Partial peripheral nerve injury leads to activation of astroglia and microglia which parallels the development of allodynic behavior
    • Coyle D.E. Partial peripheral nerve injury leads to activation of astroglia and microglia which parallels the development of allodynic behavior. Glia 1998, 23:75-83.
    • (1998) Glia , vol.23 , pp. 75-83
    • Coyle, D.E.1
  • 37
    • 23844452985 scopus 로고    scopus 로고
    • Vesicle-mediated transport and release of CCL21 in endangered neurons: a possible explanation for microglia activation remote from a primary lesion
    • de Jong E.K., Dijkstra I.M., Hensens M., Brouwer N., van A.M., Liem R.S., Boddeke H.W., Biber K. Vesicle-mediated transport and release of CCL21 in endangered neurons: a possible explanation for microglia activation remote from a primary lesion. J. Neurosci. 2005, 25:7548-7557.
    • (2005) J. Neurosci. , vol.25 , pp. 7548-7557
    • de Jong, E.K.1    Dijkstra, I.M.2    Hensens, M.3    Brouwer, N.4    van, A.M.5    Liem, R.S.6    Boddeke, H.W.7    Biber, K.8
  • 38
    • 33847008114 scopus 로고    scopus 로고
    • Altered chloride homeostasis in neurological disorders: a new target
    • De Koninck Y. Altered chloride homeostasis in neurological disorders: a new target. Curr. Opin. Pharmacol. 2007, 7:93-99.
    • (2007) Curr. Opin. Pharmacol. , vol.7 , pp. 93-99
    • De Koninck, Y.1
  • 39
    • 0035805103 scopus 로고    scopus 로고
    • Gastrin-induced DNA synthesis requires p38-MAPK activation via PKC/Ca(2+) and Src-dependent mechanisms
    • Dehez S., Daulhac L., Kowalski-Chauvel A., Fourmy D., Pradayrol L., Seva C. Gastrin-induced DNA synthesis requires p38-MAPK activation via PKC/Ca(2+) and Src-dependent mechanisms. FEBS Lett. 2001, 496:25-30.
    • (2001) FEBS Lett. , vol.496 , pp. 25-30
    • Dehez, S.1    Daulhac, L.2    Kowalski-Chauvel, A.3    Fourmy, D.4    Pradayrol, L.5    Seva, C.6
  • 40
    • 0035252354 scopus 로고    scopus 로고
    • The role of neuroinflammation and neuroimmune activation in persistent pain
    • DeLeo J.A., Yezierski R.P. The role of neuroinflammation and neuroimmune activation in persistent pain. Pain 2001, 90:1-6.
    • (2001) Pain , vol.90 , pp. 1-6
    • DeLeo, J.A.1    Yezierski, R.P.2
  • 41
    • 0036899591 scopus 로고    scopus 로고
    • Relief of inflammatory pain in rats by local use of the selective P2X7 ATP receptor inhibitor, oxidized ATP
    • Dell'Antonio G., Quattrini A., Cin E.D., Fulgenzi A., Ferrero M.E. Relief of inflammatory pain in rats by local use of the selective P2X7 ATP receptor inhibitor, oxidized ATP. Arthritis Rheum. 2002, 46:3378-3385.
    • (2002) Arthritis Rheum. , vol.46 , pp. 3378-3385
    • Dell'Antonio, G.1    Quattrini, A.2    Cin, E.D.3    Fulgenzi, A.4    Ferrero, M.E.5
  • 42
    • 36349004825 scopus 로고    scopus 로고
    • Go it alone no more-P2X7 joins the society of heteromeric ATP-gated receptor channels
    • Dubyak G.R. Go it alone no more-P2X7 joins the society of heteromeric ATP-gated receptor channels. Mol. Pharmacol. 2007, 72:1402-1405.
    • (2007) Mol. Pharmacol. , vol.72 , pp. 1402-1405
    • Dubyak, G.R.1
  • 43
    • 38849178118 scopus 로고    scopus 로고
    • Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain
    • Echeverry S., Shi X.Q., Zhang J. Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain. Pain 2008, 135:37-47.
    • (2008) Pain , vol.135 , pp. 37-47
    • Echeverry, S.1    Shi, X.Q.2    Zhang, J.3
  • 44
    • 79960941570 scopus 로고    scopus 로고
    • Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway
    • Echeverry S., Shi X.Q., Rivest S., Zhang J. Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway. J. Neurosci. 2011, 31:10819-10828.
    • (2011) J. Neurosci. , vol.31 , pp. 10819-10828
    • Echeverry, S.1    Shi, X.Q.2    Rivest, S.3    Zhang, J.4
  • 46
    • 0027428024 scopus 로고
    • A quantitative analysis of the microglial cell reaction in central primary sensory projection territories following peripheral nerve injury in the adult rat
    • Eriksson N.P., Persson J.K., Svensson M., Arvidsson J., Molander C., Aldskogius H. A quantitative analysis of the microglial cell reaction in central primary sensory projection territories following peripheral nerve injury in the adult rat. Exp. Brain Res. 1993, 96:19-27.
    • (1993) Exp. Brain Res. , vol.96 , pp. 19-27
    • Eriksson, N.P.1    Persson, J.K.2    Svensson, M.3    Arvidsson, J.4    Molander, C.5    Aldskogius, H.6
  • 49
    • 0031201476 scopus 로고    scopus 로고
    • Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages
    • Ferrari D., Chiozzi P., Falzoni S., Dal S.M., Melchiorri L., Baricordi O.R., Di V.F. Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages. J. Immunol. 1997, 159:1451-1458.
    • (1997) J. Immunol. , vol.159 , pp. 1451-1458
    • Ferrari, D.1    Chiozzi, P.2    Falzoni, S.3    Dal, S.M.4    Melchiorri, L.5    Baricordi, O.R.6    Di, V.F.7
  • 50
    • 0031054641 scopus 로고    scopus 로고
    • Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin
    • Ferrari D., Chiozzi P., Falzoni S., Hanau S., Di V.F. Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin. J. Exp. Med. 1997, 185:579-582.
    • (1997) J. Exp. Med. , vol.185 , pp. 579-582
    • Ferrari, D.1    Chiozzi, P.2    Falzoni, S.3    Hanau, S.4    Di, V.F.5
  • 52
    • 33744960879 scopus 로고    scopus 로고
    • A C-terminal lysine that controls human P2X4 receptor desensitization
    • Fountain S.J., North R.A. A C-terminal lysine that controls human P2X4 receptor desensitization. J. Biol. Chem. 2006, 281:15044-15049.
    • (2006) J. Biol. Chem. , vol.281 , pp. 15044-15049
    • Fountain, S.J.1    North, R.A.2
  • 53
    • 79955671029 scopus 로고    scopus 로고
    • Exploiting powder X-ray diffraction for direct structure determination in structural biology: the P2X4 receptor trafficking motif YEQGL
    • Fujii K., Young M.T., Harris K.D. Exploiting powder X-ray diffraction for direct structure determination in structural biology: the P2X4 receptor trafficking motif YEQGL. J. Struct. Biol. 2011, 174(3):461-467.
    • (2011) J. Struct. Biol. , vol.174 , Issue.3 , pp. 461-467
    • Fujii, K.1    Young, M.T.2    Harris, K.D.3
  • 54
    • 0029068714 scopus 로고
    • Microglial turnover in the injured CNS: activated microglia undergo delayed DNA fragmentation following peripheral nerve injury
    • Gehrmann J., Banati R.B. Microglial turnover in the injured CNS: activated microglia undergo delayed DNA fragmentation following peripheral nerve injury. J. Neuropathol. Exp. Neurol. 1995, 54:680-688.
    • (1995) J. Neuropathol. Exp. Neurol. , vol.54 , pp. 680-688
    • Gehrmann, J.1    Banati, R.B.2
  • 56
    • 33744997202 scopus 로고    scopus 로고
    • Chronic spinal nerve ligation induces microvascular permeability disturbances, astrocytic reaction, and structural changes in the rat spinal cord
    • Gordh T., Sharma H.S. Chronic spinal nerve ligation induces microvascular permeability disturbances, astrocytic reaction, and structural changes in the rat spinal cord. Acta Neurochir. Suppl. 2006, 96:335-340.
    • (2006) Acta Neurochir. Suppl. , vol.96 , pp. 335-340
    • Gordh, T.1    Sharma, H.S.2
  • 57
    • 80052707152 scopus 로고    scopus 로고
    • Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain
    • Grace P.M., Rolan P.E., Hutchinson M.R. Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain. Brain Behav. Immun. 2011, 25:1322-1332.
    • (2011) Brain Behav. Immun. , vol.25 , pp. 1322-1332
    • Grace, P.M.1    Rolan, P.E.2    Hutchinson, M.R.3
  • 59
    • 67349274699 scopus 로고    scopus 로고
    • Remote astrocytic and microglial activation modulates neuronal hyperexcitability and below-level neuropathic pain after spinal injury in rat
    • Gwak Y.S., Hulsebosch C.E. Remote astrocytic and microglial activation modulates neuronal hyperexcitability and below-level neuropathic pain after spinal injury in rat. Neuroscience 2009, 161:895-903.
    • (2009) Neuroscience , vol.161 , pp. 895-903
    • Gwak, Y.S.1    Hulsebosch, C.E.2
  • 60
    • 79952317307 scopus 로고    scopus 로고
    • "Gliopathy" maintains persistent hyperexcitability of spinal dorsal horn neurons after spinal cord injury: substrate of central neuropathic pain
    • Nova Science Publishers, Inc. A. Costa, E. Villalba (Eds.)
    • Gwak Y.S., Hulsebosch C.E. "Gliopathy" maintains persistent hyperexcitability of spinal dorsal horn neurons after spinal cord injury: substrate of central neuropathic pain. Horizons in Neuroscience Research 2010, Vol. 1:195-224. Nova Science Publishers, Inc. A. Costa, E. Villalba (Eds.).
    • (2010) Horizons in Neuroscience Research , vol.1 , pp. 195-224
    • Gwak, Y.S.1    Hulsebosch, C.E.2
  • 61
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: active sensor and versatile effector cells in the normal and pathologic brain
    • Hanisch U.K., Kettenmann H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat. Neurosci. 2007, 10:1387-1394.
    • (2007) Nat. Neurosci. , vol.10 , pp. 1387-1394
    • Hanisch, U.K.1    Kettenmann, H.2
  • 63
    • 0035869474 scopus 로고    scopus 로고
    • Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors
    • Honda S., Sasaki Y., Ohsawa K., Imai Y., Nakamura Y., Inoue K., Kohsaka S. Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J. Neurosci. 2001, 21:1975-1982.
    • (2001) J. Neurosci. , vol.21 , pp. 1975-1982
    • Honda, S.1    Sasaki, Y.2    Ohsawa, K.3    Imai, Y.4    Nakamura, Y.5    Inoue, K.6    Kohsaka, S.7
  • 66
    • 59649089153 scopus 로고    scopus 로고
    • Morphine enhances microglial migration through modulation of P2X4 receptor signaling
    • Horvath R.J., DeLeo J.A. Morphine enhances microglial migration through modulation of P2X4 receptor signaling. J. Neurosci. 2009, 29:998-1005.
    • (2009) J. Neurosci. , vol.29 , pp. 998-1005
    • Horvath, R.J.1    DeLeo, J.A.2
  • 67
    • 77954624044 scopus 로고    scopus 로고
    • Morphine tolerance attenuates the resolution of postoperative pain and enhances spinal microglial p38 and extracellular receptor kinase phosphorylation
    • Horvath R.J., Landry R.P., Romero-Sandoval E.A., DeLeo J.A. Morphine tolerance attenuates the resolution of postoperative pain and enhances spinal microglial p38 and extracellular receptor kinase phosphorylation. Neuroscience 2010, 169:843-854.
    • (2010) Neuroscience , vol.169 , pp. 843-854
    • Horvath, R.J.1    Landry, R.P.2    Romero-Sandoval, E.A.3    DeLeo, J.A.4
  • 68
    • 63449106099 scopus 로고    scopus 로고
    • Mechanisms of chronic central neuropathic pain after spinal cord injury
    • Hulsebosch C.E., Hains B.C., Crown E.D., Carlton S.M. Mechanisms of chronic central neuropathic pain after spinal cord injury. Brain Res. Rev. 2009, 60:202-213.
    • (2009) Brain Res. Rev. , vol.60 , pp. 202-213
    • Hulsebosch, C.E.1    Hains, B.C.2    Crown, E.D.3    Carlton, S.M.4
  • 69
    • 0030427101 scopus 로고    scopus 로고
    • Electrophysiological effects of ATP on brain neurones
    • Illes P., Nieber K., Norenberg W. Electrophysiological effects of ATP on brain neurones. J. Auton. Pharmacol. 1996, 16:407-411.
    • (1996) J. Auton. Pharmacol. , vol.16 , pp. 407-411
    • Illes, P.1    Nieber, K.2    Norenberg, W.3
  • 70
    • 0036848882 scopus 로고    scopus 로고
    • Microglial activation by purines and pyrimidines
    • Inoue K. Microglial activation by purines and pyrimidines. Glia 2002, 40:156-163.
    • (2002) Glia , vol.40 , pp. 156-163
    • Inoue, K.1
  • 71
    • 33745751533 scopus 로고    scopus 로고
    • The role of microglia and ATP receptors in a mechanism of neuropathic pain
    • Inoue K., Tsuda M. The role of microglia and ATP receptors in a mechanism of neuropathic pain. Nippon Yakurigaku Zasshi 2006, 127:14-17.
    • (2006) Nippon Yakurigaku Zasshi , vol.127 , pp. 14-17
    • Inoue, K.1    Tsuda, M.2
  • 72
    • 70450212126 scopus 로고    scopus 로고
    • Microglia and neuropathic pain
    • Inoue K., Tsuda M. Microglia and neuropathic pain. Glia 2009, 57:1469-1479.
    • (2009) Glia , vol.57 , pp. 1469-1479
    • Inoue, K.1    Tsuda, M.2
  • 73
    • 73449108381 scopus 로고    scopus 로고
    • The neural-glial purinergic receptor ensemble in chronic pain states
    • Jarvis M.F. The neural-glial purinergic receptor ensemble in chronic pain states. Trends Neurosci. 2010, 33:48-57.
    • (2010) Trends Neurosci. , vol.33 , pp. 48-57
    • Jarvis, M.F.1
  • 74
    • 58049127392 scopus 로고    scopus 로고
    • ATP-gated P2X cation-channels
    • Jarvis M.F., Khakh B.S. ATP-gated P2X cation-channels. Neuropharmacology 2009, 56:208-215.
    • (2009) Neuropharmacology , vol.56 , pp. 208-215
    • Jarvis, M.F.1    Khakh, B.S.2
  • 75
    • 67949117176 scopus 로고    scopus 로고
    • Crystal structure of the ATP-gated P2X(4) ion channel in the closed state
    • Kawate T., Michel J.C., Birdsong W.T., Gouaux E. Crystal structure of the ATP-gated P2X(4) ion channel in the closed state. Nature 2009, 460:592-598.
    • (2009) Nature , vol.460 , pp. 592-598
    • Kawate, T.1    Michel, J.C.2    Birdsong, W.T.3    Gouaux, E.4
  • 76
    • 36549088202 scopus 로고    scopus 로고
    • Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain
    • Keller A.F., Beggs S., Salter M.W., De Koninck Y. Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain. Mol. Pain 2007, 3:27.
    • (2007) Mol. Pain , vol.3 , pp. 27
    • Keller, A.F.1    Beggs, S.2    Salter, M.W.3    De Koninck, Y.4
  • 78
    • 40849089273 scopus 로고    scopus 로고
    • P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain
    • Kobayashi K., Yamanaka H., Fukuoka T., Dai Y., Obata K., Noguchi K. P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain. J. Neurosci. 2008, 28:2892-2902.
    • (2008) J. Neurosci. , vol.28 , pp. 2892-2902
    • Kobayashi, K.1    Yamanaka, H.2    Fukuoka, T.3    Dai, Y.4    Obata, K.5    Noguchi, K.6
  • 79
    • 0033216535 scopus 로고    scopus 로고
    • Ca2+-induced p38/SAPK signalling inhibited by the immunosuppressant cyclosporin A in human peripheral blood mononuclear cells
    • Kreideweiss S., Ahlers C., Nordheim A., Ruhlmann A. Ca2+-induced p38/SAPK signalling inhibited by the immunosuppressant cyclosporin A in human peripheral blood mononuclear cells. Eur. J. Biochem. 1999, 265:1075-1084.
    • (1999) Eur. J. Biochem. , vol.265 , pp. 1075-1084
    • Kreideweiss, S.1    Ahlers, C.2    Nordheim, A.3    Ruhlmann, A.4
  • 80
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: a sensor for pathological events in the CNS
    • Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996, 19:312-318.
    • (1996) Trends Neurosci. , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 81
    • 68949189686 scopus 로고    scopus 로고
    • Central sensitization: a generator of pain hypersensitivity by central neural plasticity
    • Latremoliere A., Woolf C.J. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J. Pain 2009, 10:895-926.
    • (2009) J. Pain , vol.10 , pp. 895-926
    • Latremoliere, A.1    Woolf, C.J.2
  • 82
    • 0025220976 scopus 로고
    • Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
    • Lawson L.J., Perry V.H., Dri P., Gordon S. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 1990, 39:151-170.
    • (1990) Neuroscience , vol.39 , pp. 151-170
    • Lawson, L.J.1    Perry, V.H.2    Dri, P.3    Gordon, S.4
  • 84
  • 85
    • 35348893821 scopus 로고    scopus 로고
    • Neuron type-specific effects of brain-derived neurotrophic factor in rat superficial dorsal horn and their relevance to 'central sensitization'
    • Lu V.B., Ballanyi K., Colmers W.F., Smith P.A. Neuron type-specific effects of brain-derived neurotrophic factor in rat superficial dorsal horn and their relevance to 'central sensitization'. J. Physiol. 2007, 584:543-563.
    • (2007) J. Physiol. , vol.584 , pp. 543-563
    • Lu, V.B.1    Ballanyi, K.2    Colmers, W.F.3    Smith, P.A.4
  • 86
    • 78649362101 scopus 로고    scopus 로고
    • Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn
    • Maeda M., Tsuda M., Tozaki-Saitoh H., Inoue K., Kiyama H. Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn. Glia 2010, 58:1838-1846.
    • (2010) Glia , vol.58 , pp. 1838-1846
    • Maeda, M.1    Tsuda, M.2    Tozaki-Saitoh, H.3    Inoue, K.4    Kiyama, H.5
  • 88
    • 57749200564 scopus 로고    scopus 로고
    • Pathological and protective roles of glia in chronic pain
    • Milligan E.D., Watkins L.R. Pathological and protective roles of glia in chronic pain. Nat. Rev. Neurosci. 2009, 10:23-36.
    • (2009) Nat. Rev. Neurosci. , vol.10 , pp. 23-36
    • Milligan, E.D.1    Watkins, L.R.2
  • 89
    • 0141769473 scopus 로고    scopus 로고
    • Activation of mouse microglial cells affects P2 receptor signaling
    • Moller T., Kann O., Verkhratsky A., Kettenmann H. Activation of mouse microglial cells affects P2 receptor signaling. Brain Res. 2000, 853:49-59.
    • (2000) Brain Res. , vol.853 , pp. 49-59
    • Moller, T.1    Kann, O.2    Verkhratsky, A.3    Kettenmann, H.4
  • 90
    • 64849087753 scopus 로고    scopus 로고
    • The P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R pore
    • Monif M., Reid C.A., Powell K.L., Smart M.L., Williams D.A. The P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R pore. J. Neurosci. 2009, 29:3781-3791.
    • (2009) J. Neurosci. , vol.29 , pp. 3781-3791
    • Monif, M.1    Reid, C.A.2    Powell, K.L.3    Smart, M.L.4    Williams, D.A.5
  • 91
    • 0034866550 scopus 로고    scopus 로고
    • Microglia: activation and their significance in the central nervous system
    • Nakajima K., Kohsaka S. Microglia: activation and their significance in the central nervous system. J. Biochem. (Tokyo) 2001, 130:169-175.
    • (2001) J. Biochem. (Tokyo) , vol.130 , pp. 169-175
    • Nakajima, K.1    Kohsaka, S.2
  • 92
    • 33646259685 scopus 로고    scopus 로고
    • Possible involvement of increase in spinal fibronectin following peripheral nerve injury in upregulation of microglial P2X4, a key molecule for mechanical allodynia
    • Nasu-Tada K., Koizumi S., Tsuda M., Kunifusa E., Inoue K. Possible involvement of increase in spinal fibronectin following peripheral nerve injury in upregulation of microglial P2X4, a key molecule for mechanical allodynia. Glia 2006, 53:769-775.
    • (2006) Glia , vol.53 , pp. 769-775
    • Nasu-Tada, K.1    Koizumi, S.2    Tsuda, M.3    Kunifusa, E.4    Inoue, K.5
  • 93
    • 56049098367 scopus 로고    scopus 로고
    • Homotrimeric complexes are the dominant assembly state of native P2X7 subunits
    • Nicke A. Homotrimeric complexes are the dominant assembly state of native P2X7 subunits. Biochem. Biophys. Res. Commun. 2008, 377:803-808.
    • (2008) Biochem. Biophys. Res. Commun. , vol.377 , pp. 803-808
    • Nicke, A.1
  • 94
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A., Kirchhoff F., Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005, 308:1314-1318.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 95
    • 0028270927 scopus 로고
    • Characterization and possible function of adenosine 5'-triphosphate receptors in activated rat microglia
    • Norenberg W., Langosch J.M., Gebicke-Haerter P.J., Illes P. Characterization and possible function of adenosine 5'-triphosphate receptors in activated rat microglia. Br. J. Pharmacol. 1994, 111:942-950.
    • (1994) Br. J. Pharmacol. , vol.111 , pp. 942-950
    • Norenberg, W.1    Langosch, J.M.2    Gebicke-Haerter, P.J.3    Illes, P.4
  • 96
    • 0036788971 scopus 로고    scopus 로고
    • Molecular physiology of P2X receptors
    • North R.A. Molecular physiology of P2X receptors. Physiol. Rev. 2002, 82:1013-1067.
    • (2002) Physiol. Rev. , vol.82 , pp. 1013-1067
    • North, R.A.1
  • 98
    • 33947540584 scopus 로고    scopus 로고
    • Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis
    • Ohsawa K., Irino Y., Nakamura Y., Akazawa C., Inoue K., Kohsaka S. Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis. Glia 2007, 55:604-616.
    • (2007) Glia , vol.55 , pp. 604-616
    • Ohsawa, K.1    Irino, Y.2    Nakamura, Y.3    Akazawa, C.4    Inoue, K.5    Kohsaka, S.6
  • 102
    • 36549041874 scopus 로고    scopus 로고
    • Regulation of P2X4 receptors by lysosomal targeting, glycan protection and exocytosis
    • Qureshi O.S., Paramasivam A., Yu J.C., Murrell-Lagnado R.D. Regulation of P2X4 receptors by lysosomal targeting, glycan protection and exocytosis. J. Cell Sci. 2007, 120:3838-3849.
    • (2007) J. Cell Sci. , vol.120 , pp. 3838-3849
    • Qureshi, O.S.1    Paramasivam, A.2    Yu, J.C.3    Murrell-Lagnado, R.D.4
  • 103
    • 0141450468 scopus 로고    scopus 로고
    • Microglia and macrophage activation and the regulation of complement-receptor-3 (CR3/MAC-1)-mediated myelin phagocytosis in injury and disease
    • Rotshenker S. Microglia and macrophage activation and the regulation of complement-receptor-3 (CR3/MAC-1)-mediated myelin phagocytosis in injury and disease. J. Mol. Neurosci. 2003, 21:65-72.
    • (2003) J. Mol. Neurosci. , vol.21 , pp. 65-72
    • Rotshenker, S.1
  • 104
    • 0037144412 scopus 로고    scopus 로고
    • Identification of a non-canonical tyrosine-based endocytic motif in an ionotropic receptor
    • Royle S.J., Bobanovic L.K., Murrell-Lagnado R.D. Identification of a non-canonical tyrosine-based endocytic motif in an ionotropic receptor. J. Biol. Chem. 2002, 277:35378-35385.
    • (2002) J. Biol. Chem. , vol.277 , pp. 35378-35385
    • Royle, S.J.1    Bobanovic, L.K.2    Murrell-Lagnado, R.D.3
  • 105
    • 0036316688 scopus 로고    scopus 로고
    • Prostanoids and pain: unraveling mechanisms and revealing therapeutic targets
    • Samad T.A., Sapirstein A., Woolf C.J. Prostanoids and pain: unraveling mechanisms and revealing therapeutic targets. Trends Mol. Med. 2002, 8:390-396.
    • (2002) Trends Mol. Med. , vol.8 , pp. 390-396
    • Samad, T.A.1    Sapirstein, A.2    Woolf, C.J.3
  • 106
    • 0036829011 scopus 로고    scopus 로고
    • Can we conquer pain?
    • Scholz J., Woolf C.J. Can we conquer pain?. Nat. Neurosci. 2002, 5:1062-1067. Suppl.
    • (2002) Nat. Neurosci. , vol.5 , Issue.SUPPL. , pp. 1062-1067
    • Scholz, J.1    Woolf, C.J.2
  • 108
    • 0034814542 scopus 로고    scopus 로고
    • Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5
    • Shigemoto-Mogami Y., Koizumi S., Tsuda M., Ohsawa K., Kohsaka S., Inoue K. Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5. J. Neurochem. 2001, 78:1339-1349.
    • (2001) J. Neurochem. , vol.78 , pp. 1339-1349
    • Shigemoto-Mogami, Y.1    Koizumi, S.2    Tsuda, M.3    Ohsawa, K.4    Kohsaka, S.5    Inoue, K.6
  • 110
    • 0032937860 scopus 로고    scopus 로고
    • The role of microglia and macrophages in the pathophysiology of the CNS
    • Stoll G., Jander S. The role of microglia and macrophages in the pathophysiology of the CNS. Prog. Neurobiol. 1999, 58:233-247.
    • (1999) Prog. Neurobiol. , vol.58 , pp. 233-247
    • Stoll, G.1    Jander, S.2
  • 111
    • 0036844372 scopus 로고    scopus 로고
    • Focal peripheral nerve injury induces leukocyte trafficking into the central nervous system: potential relationship to neuropathic pain
    • Sweitzer S.M., Hickey W.F., Rutkowski M.D., Pahl J.L., DeLeo J.A. Focal peripheral nerve injury induces leukocyte trafficking into the central nervous system: potential relationship to neuropathic pain. Pain 2002, 100:163-170.
    • (2002) Pain , vol.100 , pp. 163-170
    • Sweitzer, S.M.1    Hickey, W.F.2    Rutkowski, M.D.3    Pahl, J.L.4    DeLeo, J.A.5
  • 112
    • 0036228048 scopus 로고    scopus 로고
    • The differential role of spinal MHC class II and cellular adhesion molecules in peripheral inflammatory versus neuropathic pain in rodents
    • Sweitzer S.M., White K.A., Dutta C., DeLeo J.A. The differential role of spinal MHC class II and cellular adhesion molecules in peripheral inflammatory versus neuropathic pain in rodents. J. Neuroimmunol. 2002, 125:82-93.
    • (2002) J. Neuroimmunol. , vol.125 , pp. 82-93
    • Sweitzer, S.M.1    White, K.A.2    Dutta, C.3    DeLeo, J.A.4
  • 113
    • 0347814979 scopus 로고    scopus 로고
    • Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain
    • Tanga F.Y., Raghavendra V., DeLeo J.A. Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain. Neurochem. Int. 2004, 45:397-407.
    • (2004) Neurochem. Int. , vol.45 , pp. 397-407
    • Tanga, F.Y.1    Raghavendra, V.2    DeLeo, J.A.3
  • 114
    • 31044446583 scopus 로고    scopus 로고
    • Functional properties of internalization-deficient P2X4 receptors reveal a novel mechanism of ligand-gated channel facilitation by ivermectin
    • Toulme E., Soto F., Garret M., Boue-Grabot E. Functional properties of internalization-deficient P2X4 receptors reveal a novel mechanism of ligand-gated channel facilitation by ivermectin. Mol. Pharmacol. 2006, 69:576-587.
    • (2006) Mol. Pharmacol. , vol.69 , pp. 576-587
    • Toulme, E.1    Soto, F.2    Garret, M.3    Boue-Grabot, E.4
  • 115
    • 44949147139 scopus 로고    scopus 로고
    • P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury
    • Tozaki-Saitoh H., Tsuda M., Miyata H., Ueda K., Kohsaka S., Inoue K. P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury. J. Neurosci. 2008, 28:4949-4956.
    • (2008) J. Neurosci. , vol.28 , pp. 4949-4956
    • Tozaki-Saitoh, H.1    Tsuda, M.2    Miyata, H.3    Ueda, K.4    Kohsaka, S.5    Inoue, K.6
  • 116
    • 63849192564 scopus 로고    scopus 로고
    • P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation
    • Trang T., Beggs S., Wan X., Salter M.W. P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation. J. Neurosci. 2009, 29:3518-3528.
    • (2009) J. Neurosci. , vol.29 , pp. 3518-3528
    • Trang, T.1    Beggs, S.2    Wan, X.3    Salter, M.W.4
  • 118
    • 13144276331 scopus 로고    scopus 로고
    • Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia
    • Tsuda M., Inoue K., Salter M.W. Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia. Trends Neurosci. 2005, 28:101-107.
    • (2005) Trends Neurosci. , vol.28 , pp. 101-107
    • Tsuda, M.1    Inoue, K.2    Salter, M.W.3
  • 119
    • 44949248511 scopus 로고    scopus 로고
    • Fibronectin/integrin system is involved in P2X(4) receptor upregulation in the spinal cord and neuropathic pain after nerve injury
    • Tsuda M., Toyomitsu E., Komatsu T., Masuda T., Kunifusa E., Nasu-Tada K., Koizumi S., Yamamoto K., Ando J., Inoue K. Fibronectin/integrin system is involved in P2X(4) receptor upregulation in the spinal cord and neuropathic pain after nerve injury. Glia 2008, 56:579-585.
    • (2008) Glia , vol.56 , pp. 579-585
    • Tsuda, M.1    Toyomitsu, E.2    Komatsu, T.3    Masuda, T.4    Kunifusa, E.5    Nasu-Tada, K.6    Koizumi, S.7    Yamamoto, K.8    Ando, J.9    Inoue, K.10
  • 120
    • 36448966388 scopus 로고    scopus 로고
    • Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury
    • Tsuda M., Tozaki-Saitoh H., Masuda T., Toyomitsu E., Tezuka T., Yamamoto T., Inoue K. Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury. Glia 2008, 56:50-58.
    • (2008) Glia , vol.56 , pp. 50-58
    • Tsuda, M.1    Tozaki-Saitoh, H.2    Masuda, T.3    Toyomitsu, E.4    Tezuka, T.5    Yamamoto, T.6    Inoue, K.7
  • 121
    • 67650222417 scopus 로고    scopus 로고
    • Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays
    • Tsuda M., Kuboyama K., Inoue T., Nagata K., Tozaki-Saitoh H., Inoue K. Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays. Mol. Pain 2009, 5:28.
    • (2009) Mol. Pain , vol.5 , pp. 28
    • Tsuda, M.1    Kuboyama, K.2    Inoue, T.3    Nagata, K.4    Tozaki-Saitoh, H.5    Inoue, K.6
  • 123
    • 77449099299 scopus 로고    scopus 로고
    • Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways
    • Tsuda M., Toyomitsu E., Kometani M., Tozaki-Saitoh H., Inoue K. Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways. J. Cell. Mol. Med. 2009, 13:3251-3259.
    • (2009) J. Cell. Mol. Med. , vol.13 , pp. 3251-3259
    • Tsuda, M.1    Toyomitsu, E.2    Kometani, M.3    Tozaki-Saitoh, H.4    Inoue, K.5
  • 125
    • 77954886436 scopus 로고    scopus 로고
    • P2X4 receptors mediate PGE2 release by tissue-resident macrophages and initiate inflammatory pain
    • Ulmann L., Hirbec H., Rassendren F. P2X4 receptors mediate PGE2 release by tissue-resident macrophages and initiate inflammatory pain. EMBO J. 2010, 29:2290-2300.
    • (2010) EMBO J. , vol.29 , pp. 2290-2300
    • Ulmann, L.1    Hirbec, H.2    Rassendren, F.3
  • 126
    • 79952199138 scopus 로고    scopus 로고
    • When does acute pain become chronic?
    • Voscopoulos C., Lema M. When does acute pain become chronic?. Br. J. Anaesth. 2010, 105(Suppl. 1):i69-i85.
    • (2010) Br. J. Anaesth. , vol.105 , Issue.SUPPL. 1
    • Voscopoulos, C.1    Lema, M.2
  • 127
    • 0027426013 scopus 로고
    • Extracellular ATP activates a cation conductance and a K+ conductance in cultured microglial cells from mouse brain
    • Walz W., Ilschner S., Ohlemeyer C., Banati R., Kettenmann H. Extracellular ATP activates a cation conductance and a K+ conductance in cultured microglial cells from mouse brain. J. Neurosci. 1993, 13:4403-4411.
    • (1993) J. Neurosci. , vol.13 , pp. 4403-4411
    • Walz, W.1    Ilschner, S.2    Ohlemeyer, C.3    Banati, R.4    Kettenmann, H.5
  • 128
    • 0347169249 scopus 로고    scopus 로고
    • Glia: a novel drug discovery target for clinical pain
    • Watkins L.R., Maier S.F. Glia: a novel drug discovery target for clinical pain. Nat. Rev. Drug Discov. 2003, 2:973-985.
    • (2003) Nat. Rev. Drug Discov. , vol.2 , pp. 973-985
    • Watkins, L.R.1    Maier, S.F.2
  • 129
    • 0035426434 scopus 로고    scopus 로고
    • Glial activation: a driving force for pathological pain
    • Watkins L.R., Milligan E.D., Maier S.F. Glial activation: a driving force for pathological pain. Trends Neurosci. 2001, 24:450-455.
    • (2001) Trends Neurosci. , vol.24 , pp. 450-455
    • Watkins, L.R.1    Milligan, E.D.2    Maier, S.F.3
  • 130
    • 34547563162 scopus 로고    scopus 로고
    • Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model
    • Wen Y.R., Suter M.R., Kawasaki Y., Huang J., Pertin M., Kohno T., Berde C.B., Decosterd I., Ji R.R. Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model. Anesthesiology 2007, 107:312-321.
    • (2007) Anesthesiology , vol.107 , pp. 312-321
    • Wen, Y.R.1    Suter, M.R.2    Kawasaki, Y.3    Huang, J.4    Pertin, M.5    Kohno, T.6    Berde, C.B.7    Decosterd, I.8    Ji, R.R.9
  • 131
    • 0034625770 scopus 로고    scopus 로고
    • Neuronal plasticity: increasing the gain in pain
    • Woolf C.J., Salter M.W. Neuronal plasticity: increasing the gain in pain. Science 2000, 288:1765-1769.
    • (2000) Science , vol.288 , pp. 1765-1769
    • Woolf, C.J.1    Salter, M.W.2
  • 132
    • 77951591750 scopus 로고    scopus 로고
    • Role of mast cell activation in inducing microglial cells to release neurotrophin
    • Yuan H., Zhu X., Zhou S., Chen Q., Zhu X., Ma X., He X., Tian M., Shi X. Role of mast cell activation in inducing microglial cells to release neurotrophin. J. Neurosci. Res. 2010, 88:1348-1354.
    • (2010) J. Neurosci. Res. , vol.88 , pp. 1348-1354
    • Yuan, H.1    Zhu, X.2    Zhou, S.3    Chen, Q.4    Zhu, X.5    Ma, X.6    He, X.7    Tian, M.8    Shi, X.9
  • 133
    • 33645850108 scopus 로고    scopus 로고
    • Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury
    • Zhang J., De Koninck Y. Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury. J. Neurochem. 2006, 97:772-783.
    • (2006) J. Neurochem. , vol.97 , pp. 772-783
    • Zhang, J.1    De Koninck, Y.2
  • 134
    • 36048991728 scopus 로고    scopus 로고
    • Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain
    • Zhang J., Shi X.Q., Echeverry S., Mogil J.S., De Koninck Y., Rivest S. Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain. J. Neurosci. 2007, 27:12396-12406.
    • (2007) J. Neurosci. , vol.27 , pp. 12396-12406
    • Zhang, J.1    Shi, X.Q.2    Echeverry, S.3    Mogil, J.S.4    De Koninck, Y.5    Rivest, S.6
  • 136
    • 0035840825 scopus 로고    scopus 로고
    • Pathobiology of neuropathic pain
    • Zimmermann M. Pathobiology of neuropathic pain. Eur. J. Pharmacol. 2001, 429:23-37.
    • (2001) Eur. J. Pharmacol. , vol.429 , pp. 23-37
    • Zimmermann, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.