메뉴 건너뛰기




Volumn 5, Issue 7, 2014, Pages

Immortalised breast epithelia survive prolonged DNA replication stress and return to cycle from a senescent-Like state

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CHECKPOINT KINASE 1; CYCLIN D1; DNA DIRECTED DNA POLYMERASE ALPHA; HISTONE H2AX; PROTEIN P21; PROTEIN P53;

EID: 84905507784     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.315     Document Type: Article
Times cited : (17)

References (69)
  • 2
    • 50549218525 scopus 로고
    • Limited in vitro lifetime of human diploid cell strains
    • Hayflick L. Limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965; 37: 614.
    • (1965) Exp Cell Res , vol.37 , pp. 614
    • Hayflick, L.1
  • 3
    • 0018358261 scopus 로고
    • Senescent human diploid cells in culture-Survival, DNA synthesis and morphology
    • Matsumura T, Zerrudo Z, Hayflick L. Senescent human diploid cells in culture-Survival, DNA synthesis and morphology. J Gerontol 1979; 34: 328-334.
    • (1979) J Gerontol , vol.34 , pp. 328-334
    • Matsumura, T.1    Zerrudo, Z.2    Hayflick, L.3
  • 4
    • 84855888094 scopus 로고    scopus 로고
    • Regulation of senescence in cancer and aging
    • Kong Y, Cui H, Ramkumar C, Zhang H. Regulation of senescence in cancer and aging. J Aging Res 2011; 2011: 963172.
    • (2011) J Aging Res , vol.2011 , pp. 963172
    • Kong, Y.1    Cui, H.2    Ramkumar, C.3    Zhang, H.4
  • 5
    • 84873638532 scopus 로고    scopus 로고
    • Aging, cellular senescence, and cancer
    • Campisi J. Aging, cellular senescence, and cancer. Ann Rev Physiol 2013; 75: 685-705.
    • (2013) Ann Rev Physiol , vol.75 , pp. 685-705
    • Campisi, J.1
  • 6
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: When bad things happen to good cells
    • Campisi J, di Fagagna FD. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cel Biol 2007; 8: 729-740.
    • (2007) Nat Rev Mol Cel Biol , vol.8 , pp. 729-740
    • Campisi, J.1    Di Fagagna, F.D.2
  • 7
    • 0025787643 scopus 로고
    • Telomere loss-Mitotic clock or genetic time bomb
    • Harley CB. Telomere loss-Mitotic clock or genetic time bomb. Mut Res 1991; 256: 271-282.
    • (1991) Mut Res , vol.256 , pp. 271-282
    • Harley, C.B.1
  • 10
    • 45849099050 scopus 로고    scopus 로고
    • Living on a break: Cellular senescence as a DNA-Damage response
    • di Fagagna FD. Living on a break: cellular senescence as a DNA-Damage response. Nat Rev Cancer 2008; 8: 512-522.
    • (2008) Nat Rev Cancer , vol.8 , pp. 512-522
    • Di Fagagna, F.D.1
  • 11
    • 84876093576 scopus 로고    scopus 로고
    • DNA damage-Induced cell death: From specific DNA lesions to the DNA damage response and apoptosis
    • Roos WP, Kaina B. DNA damage-Induced cell death: from specific DNA lesions to the DNA damage response and apoptosis. Cancer Lett 2013; 332: 237-248.
    • (2013) Cancer Lett , vol.332 , pp. 237-248
    • Roos, W.P.1    Kaina, B.2
  • 12
    • 84887626721 scopus 로고    scopus 로고
    • Stressing the cell cycle in senescence and aging
    • Chandler H, Peters G. Stressing the cell cycle in senescence and aging. Curr Opin Cell Biol 2013; 25: 765-771.
    • (2013) Curr Opin Cell Biol , vol.25 , pp. 765-771
    • Chandler, H.1    Peters, G.2
  • 13
    • 0030609861 scopus 로고    scopus 로고
    • Bypass of senescence after disruption of p21(CIP1/WAF1) gene in normal diploid human fibroblasts
    • Brown JP, Wei WY, Sedivy JM. Bypass of senescence after disruption of p21(CIP1/WAF1) gene in normal diploid human fibroblasts. Science 1997; 277: 831-834.
    • (1997) Science , vol.277 , pp. 831-834
    • Brown, J.P.1    Wei, W.Y.2    Sedivy, J.M.3
  • 14
    • 0033013980 scopus 로고    scopus 로고
    • Differential roles for cyclin-Dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
    • Stein GH, Drullinger LF, Soulard A, Dulic V. Differential roles for cyclin-Dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol Cell Biol 1999; 19: 2109-2117.
    • (1999) Mol Cell Biol , vol.19 , pp. 2109-2117
    • Stein, G.H.1    Drullinger, L.F.2    Soulard, A.3    Dulic, V.4
  • 15
    • 0029670840 scopus 로고    scopus 로고
    • Regulation of p16(CDKN2) expression and its implications for cell immortalization and senescence
    • Hara E, Smith R, Parry D, Tahara H, Stone S, Peters G. Regulation of p16(CDKN2) expression and its implications for cell immortalization and senescence. Mol Cell Biol 1996; 16: 859-867.
    • (1996) Mol Cell Biol , vol.16 , pp. 859-867
    • Hara, E.1    Smith, R.2    Parry, D.3    Tahara, H.4    Stone, S.5    Peters, G.6
  • 16
    • 0032487675 scopus 로고    scopus 로고
    • Both Rb/p16(INK4a) inactivation and telomerase activity are required to immortalize human epithelial cells
    • Kiyono T, Foster SA, Koop JI, McDougall JK, Galloway DA, Klingelhutz AJ. Both Rb/p16(INK4a) inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 1998; 396: 84-88.
    • (1998) Nature , vol.396 , pp. 84-88
    • Kiyono, T.1    Foster, S.A.2    Koop, J.I.3    McDougall, J.K.4    Galloway, D.A.5    Klingelhutz, A.J.6
  • 17
  • 18
    • 34648821257 scopus 로고    scopus 로고
    • Opinion-Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis
    • Stingl J, Caldas C. Opinion-Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis. Nat Rev Cancer 2007; 7: 791-799.
    • (2007) Nat Rev Cancer , vol.7 , pp. 791-799
    • Stingl, J.1    Caldas, C.2
  • 19
    • 77955287585 scopus 로고    scopus 로고
    • The ability to generate senescent progeny as a mechanism underlying breast cancer cell heterogeneity
    • Mumcuoglu M, Bagislar S, Yuzugullu H, Alotaibi H, Senturk S, Telkoparan P et al. The Ability to Generate Senescent Progeny as a Mechanism Underlying Breast Cancer Cell Heterogeneity. PLoS One 2010; 5: e11288.
    • (2010) PLoS One , vol.5
    • Mumcuoglu, M.1    Bagislar, S.2    Yuzugullu, H.3    Alotaibi, H.4    Senturk, S.5    Telkoparan, P.6
  • 20
    • 0035252089 scopus 로고    scopus 로고
    • Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
    • Romanov SR, Kozakiewicz BK, Holst CR, Stampfer MR, Haupt LM, Tlsty TD et al. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature 2001; 409: 633-637.
    • (2001) Nature , vol.409 , pp. 633-637
    • Romanov, S.R.1    Kozakiewicz, B.K.2    Holst, C.R.3    Stampfer, M.R.4    Haupt, L.M.5    Tlsty, T.D.6
  • 21
    • 84892731189 scopus 로고    scopus 로고
    • Cellular senescence and its effector programs
    • Salama R, Sadaie M, Hoare M, Narita M. Cellular senescence and its effector programs. Genes Dev 2014; 28: 99-114.
    • (2014) Genes Dev , vol.28 , pp. 99-114
    • Salama, R.1    Sadaie, M.2    Hoare, M.3    Narita, M.4
  • 22
    • 67749122294 scopus 로고    scopus 로고
    • Stress-Induced premature senescence of endothelial cells: A perilous state between recovery and point of no return
    • Goligorsky MS, Chen J, Patschan S. Stress-Induced premature senescence of endothelial cells: a perilous state between recovery and point of no return. Curr Opin Hematol 2009; 16: 215-219.
    • (2009) Curr Opin Hematol , vol.16 , pp. 215-219
    • Goligorsky, M.S.1    Chen, J.2    Patschan, S.3
  • 23
    • 50849121703 scopus 로고    scopus 로고
    • Temporal organization of the cell cycle
    • Tyson JJ, Novak B. Temporal organization of the cell cycle. Curr Biol 2008; 18: R759-R768.
    • (2008) Curr Biol , vol.18
    • Tyson, J.J.1    Novak, B.2
  • 24
    • 76049094188 scopus 로고    scopus 로고
    • Temporal self-Organization of the cyclin/Cdk network driving the mammalian cell cycle
    • Gerard C, Goldbeter A. Temporal self-Organization of the cyclin/Cdk network driving the mammalian cell cycle. Proc Natl Acad Sci USA 2009; 106: 21643-21648.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 21643-21648
    • Gerard, C.1    Goldbeter, A.2
  • 25
    • 3242890575 scopus 로고    scopus 로고
    • Mammalian cell cycle checkpoints: Signalling pathways and their organization in space and time
    • Lukas J, Lukas C, Bartek J. Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time. DNA Repair 2004; 3: 997-1007.
    • (2004) DNA Repair , vol.3 , pp. 997-1007
    • Lukas, J.1    Lukas, C.2    Bartek, J.3
  • 26
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-Damage response in human biology and disease
    • Jackson SP, Bartek J. The DNA-Damage response in human biology and disease. Nature 2009; 461: 1071-1078.
    • (2009) Nature , vol.461 , pp. 1071-1078
    • Jackson, S.P.1    Bartek, J.2
  • 27
    • 21344442139 scopus 로고    scopus 로고
    • Control of DNA replication: Regulation and activation of eukaryotic replicative helicase, MCM
    • Masai H, You ZY, Arai K. Control of DNA replication: regulation and activation of eukaryotic replicative helicase, MCM. IUBMB Life 2005; 57: 323-335.
    • (2005) IUBMB Life , vol.57 , pp. 323-335
    • Masai, H.1    You, Z.Y.2    Arai, K.3
  • 28
    • 70449512220 scopus 로고    scopus 로고
    • Towards a systems biology approach to mammalian cell cycle: Modeling the entrance into S phase of quiescent fibroblasts after serum stimulation
    • Alfieri R, Barberis M, Chiaradonna F, Gaglio D, Milanesi L, Vanoni M et al. Towards a systems biology approach to mammalian cell cycle: modeling the entrance into S phase of quiescent fibroblasts after serum stimulation. BMC Bioinformatics 2009; 10(Suppl 12): S16.
    • (2009) BMC Bioinformatics , vol.10 , Issue.SUPPL.12
    • Alfieri, R.1    Barberis, M.2    Chiaradonna, F.3    Gaglio, D.4    Milanesi, L.5    Vanoni, M.6
  • 29
    • 77951985216 scopus 로고    scopus 로고
    • Examination of the expanding pathways for the regulation of p21 expression and activity
    • Jung YS, Qian YJ, Chen XB. Examination of the expanding pathways for the regulation of p21 expression and activity. Cell Signal 2010; 22: 1003-1012.
    • (2010) Cell Signal , vol.22 , pp. 1003-1012
    • Jung, Y.S.1    Qian, Y.J.2    Chen, X.B.3
  • 30
    • 33947646873 scopus 로고    scopus 로고
    • Cdc25 phosphatases: Structure, specificity, and mechanism
    • Rudolph J. Cdc25 phosphatases: structure, specificity, and mechanism. Biochemistry 2007; 46: 3595-3604.
    • (2007) Biochemistry , vol.46 , pp. 3595-3604
    • Rudolph, J.1
  • 31
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 2004; 73: 39-85.
    • (2004) Annu Rev Biochem , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Unsal-Kacmaz, K.3    Linn, S.4
  • 33
    • 62849118995 scopus 로고    scopus 로고
    • Sophisticated framework between cell cycle arrest and apoptosis induction based on p53 dynamics
    • Hamada H, Tashima Y, Kisaka Y, Iwamoto K, Hanai T, Eguchi Y et al. Sophisticated framework between cell cycle arrest and apoptosis induction based on p53 dynamics. PLoS One 2009; 4: e4795.
    • (2009) PLoS One , vol.4
    • Hamada, H.1    Tashima, Y.2    Kisaka, Y.3    Iwamoto, K.4    Hanai, T.5    Eguchi, Y.6
  • 34
    • 34250010317 scopus 로고    scopus 로고
    • Chk1 regulates the density of active replication origins during the vertebrate S phase
    • Maya-Mendoza A, Petermann E, Gillespie DAF, Caldecott KW, Jackson DA. Chk1 regulates the density of active replication origins during the vertebrate S phase. Embo J 2007; 26: 2719-2731.
    • (2007) Embo J , vol.26 , pp. 2719-2731
    • Maya-Mendoza, A.1    Petermann, E.2    Gillespie, D.A.F.3    Caldecott, K.W.4    Jackson, D.A.5
  • 35
    • 78650724206 scopus 로고    scopus 로고
    • Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories
    • Ge XQ, Blow JJ. Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories. J Cell Biol 2010; 191: 1285-1297.
    • (2010) J Cell Biol , vol.191 , pp. 1285-1297
    • Ge, X.Q.1    Blow, J.J.2
  • 36
    • 37249025795 scopus 로고    scopus 로고
    • Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress
    • Ge XQ, Jackson DA, Blow JJ. Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. Genes Dev 2007; 21: 3331-3341.
    • (2007) Genes Dev , vol.21 , pp. 3331-3341
    • Ge, X.Q.1    Jackson, D.A.2    Blow, J.J.3
  • 37
    • 79961170861 scopus 로고    scopus 로고
    • How dormant origins promote complete genome replication
    • Blow JJ, Ge XQ, Jackson DA. How dormant origins promote complete genome replication. Trends Biochem Sci 2011; 36: 405-414.
    • (2011) Trends Biochem Sci , vol.36 , pp. 405-414
    • Blow, J.J.1    Ge, X.Q.2    Jackson, D.A.3
  • 38
    • 74749095240 scopus 로고    scopus 로고
    • Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins
    • Ilves I, Petojevic T, Pesavento JJ, Botchan MR. Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins. Mol Cell 2010; 37: 247-258.
    • (2010) Mol Cell , vol.37 , pp. 247-258
    • Ilves, I.1    Petojevic, T.2    Pesavento, J.J.3    Botchan, M.R.4
  • 39
    • 20344396122 scopus 로고    scopus 로고
    • Preventing re-Replication of chromosomal DNA
    • Blow JJ, Dutta A. Preventing re-Replication of chromosomal DNA. Nat Rev Mol Cell Biol 2005; 6: 476-486.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 476-486
    • Blow, J.J.1    Dutta, A.2
  • 40
    • 33947127410 scopus 로고    scopus 로고
    • Strength in numbers: Preventing rereplication via multiple mechanisms in eukaryotic cells
    • Arias EE, Walter JC. Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells. Genes Dev 2007; 21: 497-518.
    • (2007) Genes Dev , vol.21 , pp. 497-518
    • Arias, E.E.1    Walter, J.C.2
  • 41
    • 79951468998 scopus 로고    scopus 로고
    • Prevention of DNA re-Replication in eukaryotic cells
    • Truong LN, Wu XH. Prevention of DNA re-Replication in eukaryotic cells. J Mol Cell Biol 2011; 3: 13-22.
    • (2011) J Mol Cell Biol , vol.3 , pp. 13-22
    • Truong, L.N.1    Wu, X.H.2
  • 42
    • 67651089806 scopus 로고    scopus 로고
    • Phosphorylation of Mcm2 by Cdc7 promotes pre-Replication complex assembly during cellcycle re-Entry
    • Chuang LC, Teixeira LK, Wohlschlegel JA, Henze M, Yates JR, Méndez J et al. Phosphorylation of Mcm2 by Cdc7 promotes pre-Replication complex assembly during cellcycle re-Entry. Mol Cell 2009; 35: 206-216.
    • (2009) Mol Cell , vol.35 , pp. 206-216
    • Chuang, L.C.1    Teixeira, L.K.2    Wohlschlegel, J.A.3    Henze, M.4    Yates, J.R.5    Méndez, J.6
  • 43
    • 61949262034 scopus 로고    scopus 로고
    • Integrins and cell-Fate determination
    • Streuli CH. Integrins and cell-Fate determination. J Cell Sci 2009; 122: 171-177.
    • (2009) J Cell Sci , vol.122 , pp. 171-177
    • Streuli, C.H.1
  • 44
    • 79953228481 scopus 로고    scopus 로고
    • Cellular microenvironment influences the ability of mammary epithelia to undergo cell cycle
    • Jeanes AI, Maya-Mendoza A, Streuli CH. Cellular microenvironment influences the ability of mammary epithelia to undergo cell cycle. PLoS One 2011; 6: e18144.
    • (2011) PLoS One , vol.6
    • Jeanes, A.I.1    Maya-Mendoza, A.2    Streuli, C.H.3
  • 45
    • 0025129726 scopus 로고
    • Isolation and characterization of a spontaneously immortalized human breast eoithelial cell line MCF-10
    • Soule HD, Maloney TM, Wolman SR, Peterson Jr WD, Brenz R, McGrath CM et al. Isolation and characterization of a spontaneously immortalized human breast eoithelial cell line, MCF-10. Cancer Res 1990; 50: 6075-6086.
    • (1990) Cancer Res , vol.50 , pp. 6075-6086
    • Soule, H.D.1    Maloney, T.M.2    Wolman, S.R.3    Peterson, Jr.W.D.4    Brenz, R.5    McGrath, C.M.6
  • 47
    • 0037099009 scopus 로고    scopus 로고
    • Prolonged arrest of mammalian cells at the G1/S boundary results in permanent S phase stasis
    • Borel F, Lacroix FB, Margolis RL. Prolonged arrest of mammalian cells at the G1/S boundary results in permanent S phase stasis. J Cell Sci 2002; 115: 2829-2838.
    • (2002) J Cell Sci , vol.115 , pp. 2829-2838
    • Borel, F.1    Lacroix, F.B.2    Margolis, R.L.3
  • 48
    • 33847737716 scopus 로고    scopus 로고
    • DNA damage checkpoints: From initiation to recovery or adaptation
    • Bartek J, Lukas J. DNA damage checkpoints: from initiation to recovery or adaptation. Curr Opin Cell Biol 2007; 19: 238-245.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 238-245
    • Bartek, J.1    Lukas, J.2
  • 49
    • 79952268809 scopus 로고    scopus 로고
    • Interplay between oncogene-Induced DNA damage response and heterochromatin in senescence and cancer
    • Di Micco R, Sulli G, Dobreva M, Liontos M, Botrugno OA, Gargiulo G et al. Interplay between oncogene-Induced DNA damage response and heterochromatin in senescence and cancer. Nat Cell Biol 2011; 13: 292-U244.
    • (2011) Nat Cell Biol , vol.13
    • Di Micco, R.1    Sulli, G.2    Dobreva, M.3    Liontos, M.4    Botrugno, O.A.5    Gargiulo, G.6
  • 50
    • 79952281751 scopus 로고    scopus 로고
    • 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress
    • Lukas C, Savic V, Bekker-Jensen S, Doil C, Neumann B, Pedersen RS et al. 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nat Cell Biol 2011; 13: 243-U380.
    • (2011) Nat Cell Biol , vol.13
    • Lukas, C.1    Savic, V.2    Bekker-Jensen, S.3    Doil, C.4    Neumann, B.5    Pedersen, R.S.6
  • 51
    • 34547108336 scopus 로고    scopus 로고
    • What's taking so long? S-Phase entry from quiescence versus proliferation
    • Coller HA. What's taking so long? S-Phase entry from quiescence versus proliferation. Nat Rev Mol Cell Biol 2007; 8: 667-670.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 667-670
    • Coller, H.A.1
  • 52
    • 77955735894 scopus 로고    scopus 로고
    • S-Phase lengthening induced by p16(INK4a) overexpression in malignant cells with wild-Type pRb and p53
    • Chien WW, Domenech C, Catallo R, Salles G, Ffrench M. S-Phase lengthening induced by p16(INK4a) overexpression in malignant cells with wild-Type pRb and p53. Cell Cycle 2010; 9: 3286-3296.
    • (2010) Cell Cycle , vol.9 , pp. 3286-3296
    • Chien, W.W.1    Domenech, C.2    Catallo, R.3    Salles, G.4    Ffrench, M.5
  • 53
    • 84864926277 scopus 로고    scopus 로고
    • New insights into p53 signaling and cancer cell response to DNA damage: Implications for cancer therapy
    • Mirzayans R, Andrais B, Scott A, Murray D. New insights into p53 signaling and cancer cell response to DNA damage: implications for cancer therapy. J Biomed Biotechnol 2012; 2012: 170325.
    • (2012) J Biomed Biotechnol , vol.2012 , pp. 170325
    • Mirzayans, R.1    Andrais, B.2    Scott, A.3    Murray, D.4
  • 54
    • 17644368915 scopus 로고    scopus 로고
    • Evasion of a single-Step, chemotherapyinduced senescence in breast cancer cells: Implications for treatment response
    • Elmore LW, Di X, Dumur C, Holt SE, Gewirtz DA. Evasion of a single-Step, chemotherapyinduced senescence in breast cancer cells: Implications for treatment response. Clin Cancer Res 2005; 11: 2637-2643.
    • (2005) Clin Cancer Res , vol.11 , pp. 2637-2643
    • Elmore, L.W.1    Di, X.2    Dumur, C.3    Holt, S.E.4    Gewirtz, D.A.5
  • 55
    • 16844373387 scopus 로고    scopus 로고
    • Escape from therapy-Induced accelerated cellular senescence in p53-Null lung cancer cells and in human lung cancers
    • Roberson RS, Kussick SJ, Vallieres E, Chen SYJ, Wu DY. Escape from therapy-Induced accelerated cellular senescence in p53-Null lung cancer cells and in human lung cancers. Cancer Res 2005; 65: 2795-2803.
    • (2005) Cancer Res , vol.65 , pp. 2795-2803
    • Roberson, R.S.1    Kussick, S.J.2    Vallieres, E.3    Chen, S.Y.J.4    Wu, D.Y.5
  • 57
    • 34548253635 scopus 로고    scopus 로고
    • Checkpoint adaptation in human cells
    • Syljuasen RG. Checkpoint adaptation in human cells. Oncogene 2007; 26: 5833-5839.
    • (2007) Oncogene , vol.26 , pp. 5833-5839
    • Syljuasen, R.G.1
  • 58
    • 76849109722 scopus 로고    scopus 로고
    • Hydroxyurea-Stalled replication forks become progressively inactivated and require two different RAD51-Mediated pathways for restart and repair
    • Petermann E, Orta ML, Issaeva N, Schultz N, Helleday T. Hydroxyurea-Stalled replication forks become progressively inactivated and require two different RAD51-Mediated pathways for restart and repair. Mol Cell 2010; 37: 492-502.
    • (2010) Mol Cell , vol.37 , pp. 492-502
    • Petermann, E.1    Orta, M.L.2    Issaeva, N.3    Schultz, N.4    Helleday, T.5
  • 60
    • 40449120350 scopus 로고    scopus 로고
    • An oncogene-Induced DNA damage model for cancer development
    • Halazonetis TD, Gorgoulis VG, Bartek J. An oncogene-Induced DNA damage model for cancer development. Science 2008; 319: 1352-1355.
    • (2008) Science , vol.319 , pp. 1352-1355
    • Halazonetis, T.D.1    Gorgoulis, V.G.2    Bartek, J.3
  • 61
    • 33845269825 scopus 로고    scopus 로고
    • Oncogene-Induced senescence is a DNA damage response triggered by DNA hyperreplication
    • Di Micco R, Fumagalli M, Cicalese A, Piccinin S, Gasparini P, Luise C et al. Oncogene-Induced senescence is a DNA damage response triggered by DNA hyperreplication. Nature 2006; 444: 638-642.
    • (2006) Nature , vol.444 , pp. 638-642
    • Di Micco, R.1    Fumagalli, M.2    Cicalese, A.3    Piccinin, S.4    Gasparini, P.5    Luise, C.6
  • 62
    • 33845235459 scopus 로고    scopus 로고
    • Oncogene-Induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
    • Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N et al. Oncogene-Induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 2006; 444: 633-637.
    • (2006) Nature , vol.444 , pp. 633-637
    • Bartkova, J.1    Rezaei, N.2    Liontos, M.3    Karakaidos, P.4    Kletsas, D.5    Issaeva, N.6
  • 63
    • 79955525482 scopus 로고    scopus 로고
    • Nucleotide deficiency promotes genomic instability in early stages of cancer development
    • Bester AC, Roniger M, Oren YS, Im MM, Sarni D, Chaoat M et al. Nucleotide deficiency promotes genomic instability in early stages of cancer development. Cell 2011; 145: 435-446.
    • (2011) Cell , vol.145 , pp. 435-446
    • Bester, A.C.1    Roniger, M.2    Oren, Y.S.3    Im, M.M.4    Sarni, D.5    Chaoat, M.6
  • 66
    • 62549160352 scopus 로고    scopus 로고
    • Cellular quiescence in mammary stem cells and breast tumor stem cells: Got testable hypotheses?
    • Harmes DC, DiRenzo J. Cellular quiescence in mammary stem cells and breast tumor stem cells: got testable hypotheses? J Mammary Gland Biol Neoplasia 2009; 14: 19-27.
    • (2009) J Mammary Gland Biol Neoplasia , vol.14 , pp. 19-27
    • Harmes, D.C.1    Direnzo, J.2
  • 67
    • 84860851412 scopus 로고    scopus 로고
    • Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks
    • Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, MacBeath G et al. Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell 2012; 149: 780-794.
    • (2012) Cell , vol.149 , pp. 780-794
    • Lee, M.J.1    Ye, A.S.2    Gardino, A.K.3    Heijink, A.M.4    Sorger, P.K.5    Macbeath, G.6
  • 68
    • 0024306070 scopus 로고
    • Keratin expression in human mammary epithelial cells cultured from normal and malignant tissue-Relation to in vivo phenotypes and influence of medium
    • Taylorpapadimitriou J, Stampfer M, Bartek J, Lewis A, Boshell M, Lane EB et al. Keratin expression in human mammary epithelial cells cultured from normal and malignant tissue-Relation to in vivo phenotypes and influence of medium. J Cell Sci 1989; 94: 403-413.
    • (1989) J Cell Sci , vol.94 , pp. 403-413
    • Taylorpapadimitriou, J.1    Stampfer, M.2    Bartek, J.3    Lewis, A.4    Boshell, M.5    Lane, E.B.6
  • 69
    • 0032559794 scopus 로고    scopus 로고
    • Replicon clusters are stable units of chromosome structure: Evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells
    • Jackson DA, Pombo A. Replicon clusters are stable units of chromosome structure: Evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells. J Cell Biol 1998; 140: 1285-1295.
    • (1998) J Cell Biol , vol.140 , pp. 1285-1295
    • Jackson, D.A.1    Pombo, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.