Prolonged arrest of mammalian cells at the G1/S boundary results in permanent S phase stasis

Journal of Cell Science

Volumn 115, Issue 14, 2002, Pages 2829-2838

  Borel, Franck ^a   Lacroix, Françoise B ^a   Margolis, Robert L ^a  

^a CEA GRENOBLE   (France)

Author keywords

Aphidicolin; Hydroxyurea; Mammalian; MCM proteins; S phase; S phase stasis

Indexed keywords

APHIDICOLIN; BIOLOGICAL MARKER; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE 2; HYDROXYUREA; MINICHROMOSOME MAINTENANCE PROTEIN; PROTEIN P21; PROTEIN P27; PROTEIN P53;

ANIMAL CELL; ARTICLE; CELL AGING; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL DIVISION; CELL NUCLEUS; CELL TRANSFORMATION; CHROMATIN; CONTACT INHIBITION; CONTROLLED STUDY; CYTOSTASIS; DNA REPLICATION; DNA REPLICATION ORIGIN; FIBROBLAST CULTURE; GENE REPRESSION; GENETIC PROCEDURES; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOLATION PROCEDURE; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; APHIDICOLIN; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLINS; DNA; DNA REPLICATION; DNA-BINDING PROTEINS; ENZYME INHIBITORS; EUKARYOTIC CELLS; FETUS; FIBROBLASTS; G1 PHASE; HELA CELLS; HUMANS; HYDROXYUREA; NOCODAZOLE; NUCLEAR PROTEINS; RATS; S PHASE; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; MAMMALIA;

EID: 0037099009     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Microtubule dependency of p34cdc2 inactivation and mitotic exit in mammalian cells
2. Telophase disc: A new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis
3. Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1
4. Components and dynamics of DNA replication complexes in S. cerevisiae: Redistribution of MCM proteins and Cdc45p during S phase
5. Cell cycle. A new check on issuing the licence
6. Mutations of mitotic checkpoint genes in human cancers
7. The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts
8. Chromatin-bound Cdc6 persists in S and G2 phases in human cells, while soluble Cdc6 is destroyed in a cyclin A-cdk2 dependent process
9. Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: Studies in Xenopus
10. Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast
11. Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement
12. p53-dependent of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
13. WAF1, a potential mediator of p53 tumor suppression
14. A model of DNA aneuploidization and evolution in colorectal cancer
15. Nucleoplasmin-mediated chromatin remodelling is required for Xenopus sperm nuclei to become licensed for DNA replication
16. p53 accumulates but is functionally impaired when DNA synthesis is blocked
17. The pathogenesis and management of essential thrombocythaemia
18. Phosphorylation of MCM4 by cdc2 protein kinase inhibits the activity of the minichromosome maintenance complex
19. Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-alpha
20. Megakaryocyte endomitosis: A review
21. Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication
22. Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
23. Expression of the v-Src oncoprotein in fibroblasts disrupts normal regulation of the CDK inhibitor p27 and inhibits quiescence
24. A Cdc7p-Dbf4p protein kinase activity is conserved from yeast to humans
25. Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation
26. Regulation of chromosome replication
27. Human replication proteins hCdc21, hCdc46 and P1Mcm3 bind chromatin uniformly before S-phase and are displaced locally during DNA replication
28. Cyclin/Cdk-dependent initiation of DNA replication in a human cell-free system
29. Genetic instability in colorectal cancers
30. Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair
31. Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants
32. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
33. SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family
34. XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis
35. Geminin, an inhibitor of DNA replication, is degraded during mitosis
36. The Cdt1 protein is required to license DNA for replication in fission yeast
37. The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase
38. G1 events and regulation of cell proliferation
39. Simian virus 40 large tumor antigen alone or two cooperating oncogenes convert REF52 cells to a state permissive for gene amplification
40. Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization
41. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
42. Progression to cancer in Barrett's esophagus is associated with genomic instability
43. Mammalian cell fusion: Studies on the regulation of DNA synthesis and mitosis
44. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta
45. Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase
46. Chromosome markers and progression in bladder cancer
47. Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells
48. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
49. Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin
50. Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs
51. Hydroxyurea
52. The cdk2 kinase is required for the G1-to-S transition in mammalian cells
53. MCM proteins in DNA replication
54. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
55. Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
56. The ability of simian virus 40 large T antigen to immortalize primary mouse embryo fibroblasts cosegregates with its ability to bind to p53
57. Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin