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Volumn 34, Issue 5, 2014, Pages 918-956

Involvement of Urokinase-Type Plasminogen Activator System in Cancer: An Overview

Author keywords

Cancer; Invasion; Metastasis; Prognosis; Urokinase

Indexed keywords

ALPHA 2 ANTIPLASMIN; CANCER GROWTH FACTOR; MATRIX METALLOPROTEINASE; PLASMIN; PLASMINOGEN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLASMINOGEN ACTIVATOR INHIBITOR 2; UROKINASE; UROKINASE RECEPTOR;

EID: 84905495495     PISSN: 01986325     EISSN: 10981128     Source Type: Journal    
DOI: 10.1002/med.21308     Document Type: Article
Times cited : (124)

References (353)
  • 2
    • 16444370452 scopus 로고    scopus 로고
    • Distribution of sympathetic tissue plasminogen activator (tPA) to a distant microvasculature
    • O'Rourke J, Jiang X, Hao Z, Cone RE, Hand AR. Distribution of sympathetic tissue plasminogen activator (tPA) to a distant microvasculature. J Neurosci Res 2005;79(6):727-733.
    • (2005) J Neurosci Res , vol.79 , Issue.6 , pp. 727-733
    • O'Rourke, J.1    Jiang, X.2    Hao, Z.3    Cone, R.E.4    Hand, A.R.5
  • 3
    • 34347265543 scopus 로고    scopus 로고
    • Urokinase receptor variants in tissue and body fluids
    • Hoyer-Hansen G, Lund IK. Urokinase receptor variants in tissue and body fluids. Adv Clin Chem 2007;44:65-102.
    • (2007) Adv Clin Chem , vol.44 , pp. 65-102
    • Hoyer-Hansen, G.1    Lund, I.K.2
  • 5
    • 0023223148 scopus 로고
    • The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases
    • Appella E, Robinson EA, Ullrich SJ, Stoppelli MP, Corti A, Cassani G, Blasi F. The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases. J Biol Chem 1987;262(10):4437-4440.
    • (1987) J Biol Chem , vol.262 , Issue.10 , pp. 4437-4440
    • Appella, E.1    Robinson, E.A.2    Ullrich, S.J.3    Stoppelli, M.P.4    Corti, A.5    Cassani, G.6    Blasi, F.7
  • 6
    • 0023784931 scopus 로고
    • One-chain urokinase-type plasminogen activator from human sarcoma cells is a proenzyme with little or no intrinsic activity
    • Petersen LC, Lund LR, Nielsen LS, Dano K, Skriver L. One-chain urokinase-type plasminogen activator from human sarcoma cells is a proenzyme with little or no intrinsic activity. J Biol Chem 1988;263(23):11189-11195.
    • (1988) J Biol Chem , vol.263 , Issue.23 , pp. 11189-11195
    • Petersen, L.C.1    Lund, L.R.2    Nielsen, L.S.3    Dano, K.4    Skriver, L.5
  • 8
    • 0031878668 scopus 로고    scopus 로고
    • Binding of human single chain urokinase to Chinese Hamster Ovary cells and cloning of hamster u-PAR
    • Fowler B, Mackman N, Parmer RJ, Miles LA. Binding of human single chain urokinase to Chinese Hamster Ovary cells and cloning of hamster u-PAR. Thromb Haemost 1998;80(1):148-154.
    • (1998) Thromb Haemost , vol.80 , Issue.1 , pp. 148-154
    • Fowler, B.1    Mackman, N.2    Parmer, R.J.3    Miles, L.A.4
  • 9
    • 0028010999 scopus 로고
    • Isolation and characterization of multiple isoforms of the rat urokinase receptor in osteoblasts
    • Rabbani SA, Rajwans N, Achbarou A, Murthy KK, Goltzman D. Isolation and characterization of multiple isoforms of the rat urokinase receptor in osteoblasts. FEBS Lett 1994;338(1):69-74.
    • (1994) FEBS Lett , vol.338 , Issue.1 , pp. 69-74
    • Rabbani, S.A.1    Rajwans, N.2    Achbarou, A.3    Murthy, K.K.4    Goltzman, D.5
  • 10
    • 0026063532 scopus 로고
    • Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol
    • Ploug M, Ronne E, Behrendt N, Jensen AL, Blasi F, Dano K. Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol. J Biol Chem 1991;266(3):1926-1933.
    • (1991) J Biol Chem , vol.266 , Issue.3 , pp. 1926-1933
    • Ploug, M.1    Ronne, E.2    Behrendt, N.3    Jensen, A.L.4    Blasi, F.5    Dano, K.6
  • 11
    • 0032869914 scopus 로고    scopus 로고
    • Cleavage of urokinase receptor regulates its interaction with integrins in thyroid cells
    • Montuori N, Rossi G, Ragno P. Cleavage of urokinase receptor regulates its interaction with integrins in thyroid cells. FEBS Lett 1999;460(1):32-36.
    • (1999) FEBS Lett , vol.460 , Issue.1 , pp. 32-36
    • Montuori, N.1    Rossi, G.2    Ragno, P.3
  • 12
    • 0036332150 scopus 로고    scopus 로고
    • Metalloproteases cleave the urokinase-type plasminogen activator receptor in the D1-D2 linker region and expose epitopes not present in the intact soluble receptor
    • Andolfo A, English WR, Resnati M, Murphy G, Blasi F, Sidenius N. Metalloproteases cleave the urokinase-type plasminogen activator receptor in the D1-D2 linker region and expose epitopes not present in the intact soluble receptor. Thromb Haemost 2002;88(2):298-306.
    • (2002) Thromb Haemost , vol.88 , Issue.2 , pp. 298-306
    • Andolfo, A.1    English, W.R.2    Resnati, M.3    Murphy, G.4    Blasi, F.5    Sidenius, N.6
  • 13
    • 0347994948 scopus 로고    scopus 로고
    • Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G
    • Beaufort N, Leduc D, Rousselle JC, Magdolen V, Luther T, Namane A, Chignard M, Pidard D. Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G. J Immunol 2004;172(1):540-549.
    • (2004) J Immunol , vol.172 , Issue.1 , pp. 540-549
    • Beaufort, N.1    Leduc, D.2    Rousselle, J.C.3    Magdolen, V.4    Luther, T.5    Namane, A.6    Chignard, M.7    Pidard, D.8
  • 14
    • 4444317514 scopus 로고    scopus 로고
    • Plasmin cleaves the juxtamembrane domain and releases truncated species of the urokinase receptor (CD87) from human bronchial epithelial cells
    • Beaufort N, Leduc D, Rousselle JC, Namane A, Chignard M, Pidard D. Plasmin cleaves the juxtamembrane domain and releases truncated species of the urokinase receptor (CD87) from human bronchial epithelial cells. FEBS Lett 2004;574(1-3):89-94.
    • (2004) FEBS Lett , vol.574 , Issue.1-3 , pp. 89-94
    • Beaufort, N.1    Leduc, D.2    Rousselle, J.C.3    Namane, A.4    Chignard, M.5    Pidard, D.6
  • 15
    • 13844276866 scopus 로고    scopus 로고
    • Soluble and cleaved forms of the urokinase-receptor: Degradation products or active molecules?
    • Montuori N, Visconte V, Rossi G, Ragno P. Soluble and cleaved forms of the urokinase-receptor: Degradation products or active molecules? Thromb Haemost 2005;93(2):192-198.
    • (2005) Thromb Haemost , vol.93 , Issue.2 , pp. 192-198
    • Montuori, N.1    Visconte, V.2    Rossi, G.3    Ragno, P.4
  • 16
    • 0034282829 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator and its receptor synergize to promote pathogenic proteolysis
    • Zhou HM, Nichols A, Meda P, Vassalli JD. Urokinase-type plasminogen activator and its receptor synergize to promote pathogenic proteolysis. EMBO J 2000;19(17):4817-4826.
    • (2000) EMBO J , vol.19 , Issue.17 , pp. 4817-4826
    • Zhou, H.M.1    Nichols, A.2    Meda, P.3    Vassalli, J.D.4
  • 17
    • 0028953704 scopus 로고
    • The receptor for urokinase plasminogen activator is present in plasma from healthy donors and elevated in patients with paroxysmal nocturnal haemoglobinuria
    • Ronne E, Pappot H, Grondahl-Hansen J, Hoyer-Hansen G, Plesner T, Hansen NE, Dano K. The receptor for urokinase plasminogen activator is present in plasma from healthy donors and elevated in patients with paroxysmal nocturnal haemoglobinuria. Br J Haematol 1995;89(3):576-581.
    • (1995) Br J Haematol , vol.89 , Issue.3 , pp. 576-581
    • Ronne, E.1    Pappot, H.2    Grondahl-Hansen, J.3    Hoyer-Hansen, G.4    Plesner, T.5    Hansen, N.E.6    Dano, K.7
  • 18
    • 70249112937 scopus 로고    scopus 로고
    • Intact and cleaved forms of the urokinase receptor enhance discrimination of cancer from non-malignant conditions in patients presenting with symptoms related to colorectal cancer
    • Lomholt AF, Hoyer-Hansen G, Nielsen HJ, Christensen IJ. Intact and cleaved forms of the urokinase receptor enhance discrimination of cancer from non-malignant conditions in patients presenting with symptoms related to colorectal cancer. Br J Cancer 2009;101(6):992-997.
    • (2009) Br J Cancer , vol.101 , Issue.6 , pp. 992-997
    • Lomholt, A.F.1    Hoyer-Hansen, G.2    Nielsen, H.J.3    Christensen, I.J.4
  • 19
    • 0034823913 scopus 로고    scopus 로고
    • Soluble urokinase plasminogen activator receptor in preoperatively obtained plasma from patients with gynecological cancer or benign gynecological diseases
    • Riisbro R, Stephens RW, Brunner N, Christensen IJ, Nielsen HJ, Heilmann L, von Tempelhoff GF. Soluble urokinase plasminogen activator receptor in preoperatively obtained plasma from patients with gynecological cancer or benign gynecological diseases. Gynecol Oncol 2001;82(3):523-531.
    • (2001) Gynecol Oncol , vol.82 , Issue.3 , pp. 523-531
    • Riisbro, R.1    Stephens, R.W.2    Brunner, N.3    Christensen, I.J.4    Nielsen, H.J.5    Heilmann, L.6    von Tempelhoff, G.F.7
  • 20
    • 0029886219 scopus 로고    scopus 로고
    • Functional analysis of the cellular receptor for urokinase in plasminogen activation. Receptor binding has no influence on the zymogenic nature of pro-urokinase
    • Ellis V. Functional analysis of the cellular receptor for urokinase in plasminogen activation. Receptor binding has no influence on the zymogenic nature of pro-urokinase. J Biol Chem 1996;271(25):14779-14784.
    • (1996) J Biol Chem , vol.271 , Issue.25 , pp. 14779-14784
    • Ellis, V.1
  • 21
    • 0025883277 scopus 로고
    • Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor
    • Ellis V, Behrendt N, Dano K. Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor. J Biol Chem 1991;266(19):12752-12758.
    • (1991) J Biol Chem , vol.266 , Issue.19 , pp. 12752-12758
    • Ellis, V.1    Behrendt, N.2    Dano, K.3
  • 22
    • 0024508318 scopus 로고
    • Plasminogen activation initiated by single-chain urokinase-type plasminogen activator. Potentiation by U937 monocytes
    • Ellis V, Scully MF, Kakkar VV. Plasminogen activation initiated by single-chain urokinase-type plasminogen activator. Potentiation by U937 monocytes. J Biol Chem 1989;264(4):2185-2188.
    • (1989) J Biol Chem , vol.264 , Issue.4 , pp. 2185-2188
    • Ellis, V.1    Scully, M.F.2    Kakkar, V.V.3
  • 24
    • 18944401136 scopus 로고    scopus 로고
    • Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide
    • Llinas P, Le Du MH, Gardsvoll H, Dano K, Ploug M, Gilquin B, Stura EA, Menez A. Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide. EMBO J 2005;24(9):1655-1663.
    • (2005) EMBO J , vol.24 , Issue.9 , pp. 1655-1663
    • Llinas, P.1    Le Du, M.H.2    Gardsvoll, H.3    Dano, K.4    Ploug, M.5    Gilquin, B.6    Stura, E.A.7    Menez, A.8
  • 25
    • 0028925552 scopus 로고
    • Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytes
    • Bohuslav J, Horejsi V, Hansmann C, Stockl J, Weidle UH, Majdic O, Bartke I, Knapp W, Stockinger H. Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytes. J Exp Med 1995;181(4):1381-1390.
    • (1995) J Exp Med , vol.181 , Issue.4 , pp. 1381-1390
    • Bohuslav, J.1    Horejsi, V.2    Hansmann, C.3    Stockl, J.4    Weidle, U.H.5    Majdic, O.6    Bartke, I.7    Knapp, W.8    Stockinger, H.9
  • 27
    • 0030916129 scopus 로고    scopus 로고
    • 3rd Urokinase-type plasminogen activator receptors associate with beta1 and beta3 integrins of fibrosarcoma cells: Dependence on extracellular matrix components
    • Xue W, Mizukami I, Todd RF, 3rd, Petty HR. Urokinase-type plasminogen activator receptors associate with beta1 and beta3 integrins of fibrosarcoma cells: Dependence on extracellular matrix components. Cancer Res 1997;57(9):1682-1689.
    • (1997) Cancer Res , vol.57 , Issue.9 , pp. 1682-1689
    • Xue, W.1    Mizukami, I.2    Todd, R.F.3    Petty, H.R.4
  • 28
    • 77950412966 scopus 로고    scopus 로고
    • Interaction between urokinase receptor and heat shock protein MRJ enhances cell adhesion
    • De Bock CE, Lin Z, Mekkawy AH, Byrne JA, Wang Y. Interaction between urokinase receptor and heat shock protein MRJ enhances cell adhesion. Int J Oncol 2010;36(5):1155-1163.
    • (2010) Int J Oncol , vol.36 , Issue.5 , pp. 1155-1163
    • De Bock, C.E.1    Lin, Z.2    Mekkawy, A.H.3    Byrne, J.A.4    Wang, Y.5
  • 30
    • 84856419048 scopus 로고    scopus 로고
    • HAX1 augments cell proliferation, migration, adhesion, and invasion induced by urokinase-type plasminogen activator receptor
    • Mekkawy AH, Morris DL, Pourgholami MH. HAX1 augments cell proliferation, migration, adhesion, and invasion induced by urokinase-type plasminogen activator receptor. J Oncol 2012;2012:950749.
    • (2012) J Oncol , vol.2012 , pp. 950749
    • Mekkawy, A.H.1    Morris, D.L.2    Pourgholami, M.H.3
  • 31
    • 0028338844 scopus 로고
    • Binding of urokinase to its receptor promotes migration and invasion of human melanoma cells in vitro
    • Stahl A, Mueller BM. Binding of urokinase to its receptor promotes migration and invasion of human melanoma cells in vitro. Cancer Res 1994;54(11):3066-3071.
    • (1994) Cancer Res , vol.54 , Issue.11 , pp. 3066-3071
    • Stahl, A.1    Mueller, B.M.2
  • 32
    • 0029923744 scopus 로고    scopus 로고
    • Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect
    • Resnati M, Guttinger M, Valcamonica S, Sidenius N, Blasi F, Fazioli F. Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect. EMBO J 1996;15(7):1572-1582.
    • (1996) EMBO J , vol.15 , Issue.7 , pp. 1572-1582
    • Resnati, M.1    Guttinger, M.2    Valcamonica, S.3    Sidenius, N.4    Blasi, F.5    Fazioli, F.6
  • 33
    • 0030855023 scopus 로고    scopus 로고
    • Induction in human osteoblastic cells (SaOS2) of the early response genes fos, jun, and myc by the amino terminal fragment (ATF) of urokinase
    • Rabbani SA, Gladu J, Mazar AP, Henkin J, Goltzman D. Induction in human osteoblastic cells (SaOS2) of the early response genes fos, jun, and myc by the amino terminal fragment (ATF) of urokinase. J Cell Physiol 1997;172(2):137-145.
    • (1997) J Cell Physiol , vol.172 , Issue.2 , pp. 137-145
    • Rabbani, S.A.1    Gladu, J.2    Mazar, A.P.3    Henkin, J.4    Goltzman, D.5
  • 34
    • 84863125697 scopus 로고    scopus 로고
    • Crystal structure of the urokinase receptor in a ligand-free form
    • Xu X, Gardsvoll H, Yuan C, Lin L, Ploug M, Huang M. Crystal structure of the urokinase receptor in a ligand-free form. J Mol Biol 2012;416(5):629-641.
    • (2012) J Mol Biol , vol.416 , Issue.5 , pp. 629-641
    • Xu, X.1    Gardsvoll, H.2    Yuan, C.3    Lin, L.4    Ploug, M.5    Huang, M.6
  • 35
    • 0032539992 scopus 로고    scopus 로고
    • Photoaffinity labeling of the human receptor for urokinase-type plasminogen activator using a decapeptide antagonist. Evidence for a composite ligand-binding site and a short interdomain separation
    • Ploug M, Ostergaard S, Hansen LB, Holm A, Dano K. Photoaffinity labeling of the human receptor for urokinase-type plasminogen activator using a decapeptide antagonist. Evidence for a composite ligand-binding site and a short interdomain separation. Biochemistry 1998;37(11):3612-3622.
    • (1998) Biochemistry , vol.37 , Issue.11 , pp. 3612-3622
    • Ploug, M.1    Ostergaard, S.2    Hansen, L.B.3    Holm, A.4    Dano, K.5
  • 36
    • 0031583964 scopus 로고    scopus 로고
    • The intact urokinase receptor is required for efficient vitronectin binding: Receptor cleavage prevents ligand interaction
    • Hoyer-Hansen G, Behrendt N, Ploug M, Dano K, Preissner KT. The intact urokinase receptor is required for efficient vitronectin binding: Receptor cleavage prevents ligand interaction. FEBS Lett 1997;420(1):79-85.
    • (1997) FEBS Lett , vol.420 , Issue.1 , pp. 79-85
    • Hoyer-Hansen, G.1    Behrendt, N.2    Ploug, M.3    Dano, K.4    Preissner, K.T.5
  • 37
    • 0032555894 scopus 로고    scopus 로고
    • Urokinase receptor (CD87) regulates leukocyte recruitment via beta 2 integrins in vivo
    • May AE, Kanse SM, Lund LR, Gisler RH, Imhof BA, Preissner KT. Urokinase receptor (CD87) regulates leukocyte recruitment via beta 2 integrins in vivo. J Exp Med 1998;188(6):1029-1037.
    • (1998) J Exp Med , vol.188 , Issue.6 , pp. 1029-1037
    • May, A.E.1    Kanse, S.M.2    Lund, L.R.3    Gisler, R.H.4    Imhof, B.A.5    Preissner, K.T.6
  • 38
    • 83355169691 scopus 로고    scopus 로고
    • Mimicry of the regulatory role of urokinase in lamellipodia formation by introduction of a non-native interdomain disulfide bond in its receptor
    • Gardsvoll H, Kjaergaard M, Jacobsen B, Kriegbaum MC, Huang M, Ploug M. Mimicry of the regulatory role of urokinase in lamellipodia formation by introduction of a non-native interdomain disulfide bond in its receptor. J Biol Chem 2011;286(50):43515-43526.
    • (2011) J Biol Chem , vol.286 , Issue.50 , pp. 43515-43526
    • Gardsvoll, H.1    Kjaergaard, M.2    Jacobsen, B.3    Kriegbaum, M.C.4    Huang, M.5    Ploug, M.6
  • 40
    • 0026643004 scopus 로고
    • Plasma crosslinked fibrin polymers: Quantitation based on tissue plasminogen activator conversion to D-dimer and measurement in normal and patients with acute thrombotic disorders
    • Kornberg A, Francis CW, Marder VJ. Plasma crosslinked fibrin polymers: Quantitation based on tissue plasminogen activator conversion to D-dimer and measurement in normal and patients with acute thrombotic disorders. Blood 1992;80(3):709-717.
    • (1992) Blood , vol.80 , Issue.3 , pp. 709-717
    • Kornberg, A.1    Francis, C.W.2    Marder, V.J.3
  • 41
    • 74949099621 scopus 로고    scopus 로고
    • Urokinase plasminogen activator system as a potential target for cancer therapy
    • Mekkawy AH, Morris DL, Pourgholami MH. Urokinase plasminogen activator system as a potential target for cancer therapy. Future Oncol 2009;5(9):1487-1499.
    • (2009) Future Oncol , vol.5 , Issue.9 , pp. 1487-1499
    • Mekkawy, A.H.1    Morris, D.L.2    Pourgholami, M.H.3
  • 42
    • 0030943515 scopus 로고    scopus 로고
    • The role of the pericellular fibrinolytic system in angiogenesis
    • Fukao H, Ueshima S, Okada K, Matsuo O. The role of the pericellular fibrinolytic system in angiogenesis. Jpn J Physiol 1997;47(2):161-171.
    • (1997) Jpn J Physiol , vol.47 , Issue.2 , pp. 161-171
    • Fukao, H.1    Ueshima, S.2    Okada, K.3    Matsuo, O.4
  • 43
    • 0025021029 scopus 로고
    • The mechanism of the reaction between human plasminogen-activator inhibitor-1 and tissue plasminogen-activator
    • Lindahl TL, Ohlsson PI, Wiman B. The mechanism of the reaction between human plasminogen-activator inhibitor-1 and tissue plasminogen-activator. Biochem J 1990;265(1):109-113.
    • (1990) Biochem J , vol.265 , Issue.1 , pp. 109-113
    • Lindahl, T.L.1    Ohlsson, P.I.2    Wiman, B.3
  • 44
    • 0023711754 scopus 로고
    • Kinetics of inhibition of tissue-type and urokinase-type plasminogen activator by plasminogen-activator inhibitor type 1 and type 2
    • Thorsen S, Philips M, Selmer J, Lecander I, Astedt B. Kinetics of inhibition of tissue-type and urokinase-type plasminogen activator by plasminogen-activator inhibitor type 1 and type 2. Eur J Biochem 1988;175(1):33-39.
    • (1988) Eur J Biochem , vol.175 , Issue.1 , pp. 33-39
    • Thorsen, S.1    Philips, M.2    Selmer, J.3    Lecander, I.4    Astedt, B.5
  • 49
    • 0029745109 scopus 로고    scopus 로고
    • The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin
    • Stefansson S, Lawrence DA. The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin. Nature 1996;383(6599):441-443.
    • (1996) Nature , vol.383 , Issue.6599 , pp. 441-443
    • Stefansson, S.1    Lawrence, D.A.2
  • 50
    • 0027136633 scopus 로고
    • Plasminogen-activator inhibitor type 2 (PAI-2) is a spontaneously polymerising SERPIN. Biochemical characterisation of the recombinant intracellular and extracellular forms
    • Mikus P, Urano T, Liljestrom P, Ny T. Plasminogen-activator inhibitor type 2 (PAI-2) is a spontaneously polymerising SERPIN. Biochemical characterisation of the recombinant intracellular and extracellular forms. Eur J Biochem 1993;218(3):1071-1082.
    • (1993) Eur J Biochem , vol.218 , Issue.3 , pp. 1071-1082
    • Mikus, P.1    Urano, T.2    Liljestrom, P.3    Ny, T.4
  • 51
    • 0037195054 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 promotes formation of endothelial microparticles with procoagulant potential
    • Brodsky SV, Malinowski K, Golightly M, Jesty J, Goligorsky MS. Plasminogen activator inhibitor-1 promotes formation of endothelial microparticles with procoagulant potential. Circulation 2002;106(18):2372-2378.
    • (2002) Circulation , vol.106 , Issue.18 , pp. 2372-2378
    • Brodsky, S.V.1    Malinowski, K.2    Golightly, M.3    Jesty, J.4    Goligorsky, M.S.5
  • 52
    • 9244265563 scopus 로고    scopus 로고
    • Coagulation facilitates tumor cell spreading in the pulmonary vasculature during early metastatic colony formation
    • Im JH, Fu W, Wang H, Bhatia SK, Hammer DA, Kowalska MA, Muschel RJ. Coagulation facilitates tumor cell spreading in the pulmonary vasculature during early metastatic colony formation. Cancer Res 2004;64(23):8613-8619.
    • (2004) Cancer Res , vol.64 , Issue.23 , pp. 8613-8619
    • Im, J.H.1    Fu, W.2    Wang, H.3    Bhatia, S.K.4    Hammer, D.A.5    Kowalska, M.A.6    Muschel, R.J.7
  • 54
    • 0028569183 scopus 로고
    • Identification of the urokinase receptor as an adhesion receptor for vitronectin
    • Wei Y, Waltz DA, Rao N, Drummond RJ, Rosenberg S, Chapman HA. Identification of the urokinase receptor as an adhesion receptor for vitronectin. J Biol Chem 1994;269(51):32380-32388.
    • (1994) J Biol Chem , vol.269 , Issue.51 , pp. 32380-32388
    • Wei, Y.1    Waltz, D.A.2    Rao, N.3    Drummond, R.J.4    Rosenberg, S.5    Chapman, H.A.6
  • 55
    • 0029873910 scopus 로고    scopus 로고
    • The urokinase receptor is a major vitronectin-binding protein on endothelial cells
    • Kanse SM, Kost C, Wilhelm OG, Andreasen PA, Preissner KT. The urokinase receptor is a major vitronectin-binding protein on endothelial cells. Exp Cell Res 1996;224(2):344-353.
    • (1996) Exp Cell Res , vol.224 , Issue.2 , pp. 344-353
    • Kanse, S.M.1    Kost, C.2    Wilhelm, O.G.3    Andreasen, P.A.4    Preissner, K.T.5
  • 56
    • 0029816265 scopus 로고    scopus 로고
    • Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?
    • Deng G, Curriden SA, Wang S, Rosenberg S, Loskutoff DJ. Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release? J Cell Biol 1996;134(6):1563-1571.
    • (1996) J Cell Biol , vol.134 , Issue.6 , pp. 1563-1571
    • Deng, G.1    Curriden, S.A.2    Wang, S.3    Rosenberg, S.4    Loskutoff, D.J.5
  • 57
    • 0029931231 scopus 로고    scopus 로고
    • Structural and functional analysis of the plasminogen activator inhibitor-1 binding motif in the somatomedin B domain of vitronectin
    • Deng G, Royle G, Wang S, Crain K, Loskutoff DJ. Structural and functional analysis of the plasminogen activator inhibitor-1 binding motif in the somatomedin B domain of vitronectin. J Biol Chem 1996;271(22):12716-12723.
    • (1996) J Biol Chem , vol.271 , Issue.22 , pp. 12716-12723
    • Deng, G.1    Royle, G.2    Wang, S.3    Crain, K.4    Loskutoff, D.J.5
  • 58
    • 0000124642 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 represses integrin- and vitronectin-mediated cell migration independently of its function as an inhibitor of plasminogen activation
    • Kjoller L, Kanse SM, Kirkegaard T, Rodenburg KW, Ronne E, Goodman SL, Preissner KT, Ossowski L, Andreasen PA. Plasminogen activator inhibitor-1 represses integrin- and vitronectin-mediated cell migration independently of its function as an inhibitor of plasminogen activation. Exp Cell Res 1997;232(2):420-429.
    • (1997) Exp Cell Res , vol.232 , Issue.2 , pp. 420-429
    • Kjoller, L.1    Kanse, S.M.2    Kirkegaard, T.3    Rodenburg, K.W.4    Ronne, E.5    Goodman, S.L.6    Preissner, K.T.7    Ossowski, L.8    Andreasen, P.A.9
  • 59
    • 0035860418 scopus 로고    scopus 로고
    • PAI-1 inhibits urokinase-induced chemotaxis by internalizing the urokinase receptor
    • Degryse B, Sier CF, Resnati M, Conese M, Blasi F. PAI-1 inhibits urokinase-induced chemotaxis by internalizing the urokinase receptor. FEBS Lett 2001;505(2):249-254.
    • (2001) FEBS Lett , vol.505 , Issue.2 , pp. 249-254
    • Degryse, B.1    Sier, C.F.2    Resnati, M.3    Conese, M.4    Blasi, F.5
  • 61
    • 0024423657 scopus 로고
    • Expression and characterization of pro alpha 2-plasmin inhibitor
    • Sumi Y, Ichikawa Y, Nakamura Y, Miura O, Aoki N. Expression and characterization of pro alpha 2-plasmin inhibitor. J Biochem 1989;106(4):703-707.
    • (1989) J Biochem , vol.106 , Issue.4 , pp. 703-707
    • Sumi, Y.1    Ichikawa, Y.2    Nakamura, Y.3    Miura, O.4    Aoki, N.5
  • 62
    • 0026331304 scopus 로고
    • Basic and clinical aspects of fibrinolysis and thrombolysis
    • Collen D, Lijnen HR. Basic and clinical aspects of fibrinolysis and thrombolysis. Blood 1991;78(12):3114-3124.
    • (1991) Blood , vol.78 , Issue.12 , pp. 3114-3124
    • Collen, D.1    Lijnen, H.R.2
  • 63
    • 78049432691 scopus 로고    scopus 로고
    • Plasminogen activators in ischemic stroke: Introduction
    • del Zoppo GJ. Plasminogen activators in ischemic stroke: Introduction. Stroke 2010;41(Suppl 10):S39-S41.
    • (2010) Stroke , vol.41 , Issue.SUPPL 10
    • del Zoppo, G.J.1
  • 64
    • 0034969433 scopus 로고    scopus 로고
    • Elements of the fibrinolytic system
    • Lijnen HR. Elements of the fibrinolytic system. Ann N Y Acad Sci 2001;936:226-236.
    • (2001) Ann N Y Acad Sci , vol.936 , pp. 226-236
    • Lijnen, H.R.1
  • 65
    • 24644480749 scopus 로고    scopus 로고
    • Molecular requirements for epithelial-mesenchymal transition during tumor progression
    • Huber MA, Kraut N, Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 2005;17(5):548-558.
    • (2005) Curr Opin Cell Biol , vol.17 , Issue.5 , pp. 548-558
    • Huber, M.A.1    Kraut, N.2    Beug, H.3
  • 66
    • 84862770017 scopus 로고    scopus 로고
    • Regulation of EMT by TGFbeta in cancer
    • Heldin CH, Vanlandewijck M, Moustakas A. Regulation of EMT by TGFbeta in cancer. FEBS Lett 2012;586(14):1959-1970.
    • (2012) FEBS Lett , vol.586 , Issue.14 , pp. 1959-1970
    • Heldin, C.H.1    Vanlandewijck, M.2    Moustakas, A.3
  • 67
    • 0029944122 scopus 로고    scopus 로고
    • Angiostatin induces and sustains dormancy of human primary tumors in mice
    • O'Reilly MS, Holmgren L, Chen C, Folkman J. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med 1996;2(6):689-692.
    • (1996) Nat Med , vol.2 , Issue.6 , pp. 689-692
    • O'Reilly, M.S.1    Holmgren, L.2    Chen, C.3    Folkman, J.4
  • 68
    • 34547610957 scopus 로고    scopus 로고
    • uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells
    • Lester RD, Jo M, Montel V, Takimoto S, Gonias SL. uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells. J Cell Biol 2007;178(3):425-436.
    • (2007) J Cell Biol , vol.178 , Issue.3 , pp. 425-436
    • Lester, R.D.1    Jo, M.2    Montel, V.3    Takimoto, S.4    Gonias, S.L.5
  • 69
    • 69249111313 scopus 로고    scopus 로고
    • Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling
    • Jo M, Lester RD, Montel V, Eastman B, Takimoto S, Gonias SL. Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling. J Biol Chem 2009;284(34):22825-22833.
    • (2009) J Biol Chem , vol.284 , Issue.34 , pp. 22825-22833
    • Jo, M.1    Lester, R.D.2    Montel, V.3    Eastman, B.4    Takimoto, S.5    Gonias, S.L.6
  • 70
    • 0032478829 scopus 로고    scopus 로고
    • Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility
    • Nguyen DH, Hussaini IM, Gonias SL. Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility. J Biol Chem 1998;273(14):8502-8507.
    • (1998) J Biol Chem , vol.273 , Issue.14 , pp. 8502-8507
    • Nguyen, D.H.1    Hussaini, I.M.2    Gonias, S.L.3
  • 71
    • 0002460807 scopus 로고    scopus 로고
    • Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling
    • Aguirre Ghiso JA, Kovalski K, Ossowski L. Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling. J Cell Biol 1999;147(1):89-104.
    • (1999) J Cell Biol , vol.147 , Issue.1 , pp. 89-104
    • Aguirre Ghiso, J.A.1    Kovalski, K.2    Ossowski, L.3
  • 72
    • 33646920445 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator receptor regulates a novel pathway of fibronectin matrix assembly requiring Src-dependent transactivation of epidermal growth factor receptor
    • Monaghan-Benson E, McKeown-Longo PJ. Urokinase-type plasminogen activator receptor regulates a novel pathway of fibronectin matrix assembly requiring Src-dependent transactivation of epidermal growth factor receptor. J Biol Chem 2006;281(14):9450-9459.
    • (2006) J Biol Chem , vol.281 , Issue.14 , pp. 9450-9459
    • Monaghan-Benson, E.1    McKeown-Longo, P.J.2
  • 73
    • 0036596352 scopus 로고    scopus 로고
    • EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma
    • Liu D, Aguirre Ghiso J, Estrada Y, Ossowski L. EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma. Cancer Cell 2002;1(5):445-457.
    • (2002) Cancer Cell , vol.1 , Issue.5 , pp. 445-457
    • Liu, D.1    Aguirre Ghiso, J.2    Estrada, Y.3    Ossowski, L.4
  • 74
    • 34247340196 scopus 로고    scopus 로고
    • Urokinase receptor primes cells to proliferate in response to epidermal growth factor
    • Jo M, Thomas KS, Takimoto S, Gaultier A, Hsieh EH, Lester RD, Gonias SL. Urokinase receptor primes cells to proliferate in response to epidermal growth factor. Oncogene 2007;26(18):2585-2594.
    • (2007) Oncogene , vol.26 , Issue.18 , pp. 2585-2594
    • Jo, M.1    Thomas, K.S.2    Takimoto, S.3    Gaultier, A.4    Hsieh, E.H.5    Lester, R.D.6    Gonias, S.L.7
  • 75
    • 0028141447 scopus 로고
    • Increased levels and constitutive tyrosine phosphorylation of the epidermal growth factor receptor contribute to autonomous growth of human papillomavirus type 16 immortalized human keratinocytes
    • Zyzak LL, MacDonald LM, Batova A, Forand R, Creek KE, Pirisi L. Increased levels and constitutive tyrosine phosphorylation of the epidermal growth factor receptor contribute to autonomous growth of human papillomavirus type 16 immortalized human keratinocytes. Cell Growth Differ 1994;5(5):537-547.
    • (1994) Cell Growth Differ , vol.5 , Issue.5 , pp. 537-547
    • Zyzak, L.L.1    MacDonald, L.M.2    Batova, A.3    Forand, R.4    Creek, K.E.5    Pirisi, L.6
  • 76
    • 0032538798 scopus 로고    scopus 로고
    • Integrins induce activation of EGF receptor: Role in MAP kinase induction and adhesion-dependent cell survival
    • Moro L, Venturino M, Bozzo C, Silengo L, Altruda F, Beguinot L, Tarone G, Defilippi P. Integrins induce activation of EGF receptor: Role in MAP kinase induction and adhesion-dependent cell survival. EMBO J 1998;17(22):6622-6632.
    • (1998) EMBO J , vol.17 , Issue.22 , pp. 6622-6632
    • Moro, L.1    Venturino, M.2    Bozzo, C.3    Silengo, L.4    Altruda, F.5    Beguinot, L.6    Tarone, G.7    Defilippi, P.8
  • 77
    • 59349106066 scopus 로고    scopus 로고
    • Increased urokinase-type plasminogen activator receptor and epidermal growth factor receptor in serum of patients with prostate cancer
    • Milanese G, Dellabella M, Fazioli F, Pierpaoli E, Polito M, Siednius N, Montironi R, Blasi F, Muzzonigro G. Increased urokinase-type plasminogen activator receptor and epidermal growth factor receptor in serum of patients with prostate cancer. J Urol 2009;181(3):1393-1400.
    • (2009) J Urol , vol.181 , Issue.3 , pp. 1393-1400
    • Milanese, G.1    Dellabella, M.2    Fazioli, F.3    Pierpaoli, E.4    Polito, M.5    Siednius, N.6    Montironi, R.7    Blasi, F.8    Muzzonigro, G.9
  • 78
    • 0037449805 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptor
    • Jo M, Thomas KS, O'Donnell DM, Gonias SL. Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptor. J Biol Chem 2003;278(3):1642-1646.
    • (2003) J Biol Chem , vol.278 , Issue.3 , pp. 1642-1646
    • Jo, M.1    Thomas, K.S.2    O'Donnell, D.M.3    Gonias, S.L.4
  • 79
    • 20444478292 scopus 로고    scopus 로고
    • Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator
    • Jo M, Thomas KS, Marozkina N, Amin TJ, Silva CM, Parsons SJ, Gonias SL. Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator. J Biol Chem 2005;280(17):17449-17457.
    • (2005) J Biol Chem , vol.280 , Issue.17 , pp. 17449-17457
    • Jo, M.1    Thomas, K.S.2    Marozkina, N.3    Amin, T.J.4    Silva, C.M.5    Parsons, S.J.6    Gonias, S.L.7
  • 80
    • 59349083983 scopus 로고    scopus 로고
    • uPAR-deficient mouse keratinocytes fail to produce EGFR-dependent laminin-5, affecting migration in vivo and in vitro
    • D'Alessio S, Gerasi L, Blasi F. uPAR-deficient mouse keratinocytes fail to produce EGFR-dependent laminin-5, affecting migration in vivo and in vitro. J Cell Sci 2008;121(Pt 23):3922-3932.
    • (2008) J Cell Sci , vol.121 , Issue.PART 23 , pp. 3922-3932
    • D'Alessio, S.1    Gerasi, L.2    Blasi, F.3
  • 82
    • 0035854423 scopus 로고    scopus 로고
    • Deficient release of plasminogen activator inhibitor-1 from astrocytes triggers apoptosis in neuronal cells
    • Soeda S, Oda M, Ochiai T, Shimeno H. Deficient release of plasminogen activator inhibitor-1 from astrocytes triggers apoptosis in neuronal cells. Brain Res Mol Brain Res 2001;91(1-2):96-103.
    • (2001) Brain Res Mol Brain Res , vol.91 , Issue.1-2 , pp. 96-103
    • Soeda, S.1    Oda, M.2    Ochiai, T.3    Shimeno, H.4
  • 83
    • 16544370272 scopus 로고    scopus 로고
    • Inhibition of apoptosis and caspase-3 in vascular smooth muscle cells by plasminogen activator inhibitor type-1
    • Chen Y, Kelm RJ, Jr., Budd RC, Sobel BE, Schneider DJ. Inhibition of apoptosis and caspase-3 in vascular smooth muscle cells by plasminogen activator inhibitor type-1. J Cell Biochem 2004;92(1):178-188.
    • (2004) J Cell Biochem , vol.92 , Issue.1 , pp. 178-188
    • Chen, Y.1    Kelm Jr., R.J.2    Budd, R.C.3    Sobel, B.E.4    Schneider, D.J.5
  • 84
    • 34548569983 scopus 로고    scopus 로고
    • Down-regulation of uPAR and uPA activates caspase-mediated apoptosis and inhibits the PI3K/AKT pathway
    • Gondi CS, Kandhukuri N, Dinh DH, Gujrati M, Rao JS. Down-regulation of uPAR and uPA activates caspase-mediated apoptosis and inhibits the PI3K/AKT pathway. Int J Oncol 2007;31(1):19-27.
    • (2007) Int J Oncol , vol.31 , Issue.1 , pp. 19-27
    • Gondi, C.S.1    Kandhukuri, N.2    Dinh, D.H.3    Gujrati, M.4    Rao, J.S.5
  • 85
    • 60849136639 scopus 로고    scopus 로고
    • Urokinase mediates endothelial cell survival via induction of the X-linked inhibitor of apoptosis protein
    • Prager GW, Mihaly J, Brunner PM, Koshelnick Y, Hoyer-Hansen G, Binder BR. Urokinase mediates endothelial cell survival via induction of the X-linked inhibitor of apoptosis protein. Blood 2009;113(6):1383-1390.
    • (2009) Blood , vol.113 , Issue.6 , pp. 1383-1390
    • Prager, G.W.1    Mihaly, J.2    Brunner, P.M.3    Koshelnick, Y.4    Hoyer-Hansen, G.5    Binder, B.R.6
  • 87
    • 0026439778 scopus 로고
    • Ldl receptor-related protein internalizes and degrades Upa-Pai-1 complexes and is essential for embryo implantation
    • Herz J, Clouthier DE, Hammer RE. Ldl receptor-related protein internalizes and degrades Upa-Pai-1 complexes and is essential for embryo implantation. Cell 1992;71(3):411-421.
    • (1992) Cell , vol.71 , Issue.3 , pp. 411-421
    • Herz, J.1    Clouthier, D.E.2    Hammer, R.E.3
  • 88
    • 2542504291 scopus 로고    scopus 로고
    • The low density lipoprotein receptor-related protein is a motogenic receptor for plasminogen activator inhibitor-1
    • Degryse B, Neels JG, Czekay RP, Aertgeerts K, Kamikubo Y, Loskutoff DJ. The low density lipoprotein receptor-related protein is a motogenic receptor for plasminogen activator inhibitor-1. J Biol Chem 2004;279(21):22595-22604.
    • (2004) J Biol Chem , vol.279 , Issue.21 , pp. 22595-22604
    • Degryse, B.1    Neels, J.G.2    Czekay, R.P.3    Aertgeerts, K.4    Kamikubo, Y.5    Loskutoff, D.J.6
  • 89
    • 3042784666 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-2-induced initial endothelial cell migration depends on the presence of the urokinase receptor
    • Prager GW, Breuss JM, Steurer S, Olcaydu D, Mihaly J, Brunner PM, Stockinger H, Binder BR. Vascular endothelial growth factor receptor-2-induced initial endothelial cell migration depends on the presence of the urokinase receptor. Circ Res 2004;94(12):1562-1570.
    • (2004) Circ Res , vol.94 , Issue.12 , pp. 1562-1570
    • Prager, G.W.1    Breuss, J.M.2    Steurer, S.3    Olcaydu, D.4    Mihaly, J.5    Brunner, P.M.6    Stockinger, H.7    Binder, B.R.8
  • 90
    • 0030926412 scopus 로고    scopus 로고
    • Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes
    • Nykjaer A, Conese M, Christensen EI, Olson D, Cremona O, Gliemann J, Blasi F. Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes. EMBO J 1997;16(10):2610-2620.
    • (1997) EMBO J , vol.16 , Issue.10 , pp. 2610-2620
    • Nykjaer, A.1    Conese, M.2    Christensen, E.I.3    Olson, D.4    Cremona, O.5    Gliemann, J.6    Blasi, F.7
  • 91
    • 56649115742 scopus 로고    scopus 로고
    • Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR
    • Cortese K, Sahores M, Madsen CD, Tacchetti C, Blasi F. Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR. PLoS One 2008;3(11):e3730.
    • (2008) PLoS One , vol.3 , Issue.11
    • Cortese, K.1    Sahores, M.2    Madsen, C.D.3    Tacchetti, C.4    Blasi, F.5
  • 93
    • 0036791588 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis
    • 1429-1143
    • Hangai M, Kitaya N, Xu JS, Chan CK, Kim JJ, Werb Z, Ryan SJ, Brooks PC. Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis. Am J Pathol 2002;161(4):1429-1143.
    • (2002) Am J Pathol , vol.161 , Issue.4
    • Hangai, M.1    Kitaya, N.2    Xu, J.S.3    Chan, C.K.4    Kim, J.J.5    Werb, Z.6    Ryan, S.J.7    Brooks, P.C.8
  • 94
    • 0035802109 scopus 로고    scopus 로고
    • Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo
    • Xu J, Rodriguez D, Petitclerc E, Kim JJ, Hangai M, Moon YS, Davis GE, Brooks PC. Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo. J Cell Biol 2001;154(5):1069-1079.
    • (2001) J Cell Biol , vol.154 , Issue.5 , pp. 1069-1079
    • Xu, J.1    Rodriguez, D.2    Petitclerc, E.3    Kim, J.J.4    Hangai, M.5    Moon, Y.S.6    Davis, G.E.7    Brooks, P.C.8
  • 95
    • 0345829929 scopus 로고    scopus 로고
    • Collagen dissolution by keratinocytes requires cell surface plasminogen activation and matrix metalloproteinase activity
    • Netzel-Arnett S, Mitola DJ, Yamada SS, Chrysovergis K, Holmbeck K, Birkedal-Hansen H, Bugge TH. Collagen dissolution by keratinocytes requires cell surface plasminogen activation and matrix metalloproteinase activity. J Biol Chem 2002;277(47):45154-45161.
    • (2002) J Biol Chem , vol.277 , Issue.47 , pp. 45154-45161
    • Netzel-Arnett, S.1    Mitola, D.J.2    Yamada, S.S.3    Chrysovergis, K.4    Holmbeck, K.5    Birkedal-Hansen, H.6    Bugge, T.H.7
  • 96
    • 0030960367 scopus 로고    scopus 로고
    • The cell adhesion domain in plasma vitronectin is cryptic
    • Seiffert D, Smith JW. The cell adhesion domain in plasma vitronectin is cryptic. J Biol Chem 1997;272(21):13705-13710.
    • (1997) J Biol Chem , vol.272 , Issue.21 , pp. 13705-13710
    • Seiffert, D.1    Smith, J.W.2
  • 97
    • 0032055937 scopus 로고    scopus 로고
    • Vitronectin concentrates proteolytic activity on the cell surface and extracellular matrix by trapping soluble urokinase receptor-urokinase complexes
    • Chavakis T, Kanse SM, Yutzy B, Lijnen HR, Preissner KT. Vitronectin concentrates proteolytic activity on the cell surface and extracellular matrix by trapping soluble urokinase receptor-urokinase complexes. Blood 1998;91(7):2305-2312.
    • (1998) Blood , vol.91 , Issue.7 , pp. 2305-2312
    • Chavakis, T.1    Kanse, S.M.2    Yutzy, B.3    Lijnen, H.R.4    Preissner, K.T.5
  • 98
    • 0030935818 scopus 로고    scopus 로고
    • Melanoma cell migration on vitronectin: Regulation by components of the plasminogen activation system
    • Stahl A, Mueller BM. Melanoma cell migration on vitronectin: Regulation by components of the plasminogen activation system. Int J Cancer 1997;71(1):116-122.
    • (1997) Int J Cancer , vol.71 , Issue.1 , pp. 116-122
    • Stahl, A.1    Mueller, B.M.2
  • 99
    • 0030757506 scopus 로고    scopus 로고
    • Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin
    • Waltz DA, Natkin LR, Fujita RM, Wei Y, Chapman HA. Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin. J Clin Invest 1997;100(1):58-67.
    • (1997) J Clin Invest , vol.100 , Issue.1 , pp. 58-67
    • Waltz, D.A.1    Natkin, L.R.2    Fujita, R.M.3    Wei, Y.4    Chapman, H.A.5
  • 100
    • 0035911966 scopus 로고    scopus 로고
    • Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectin
    • Kjoller L, Hall A. Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectin. J Cell Biol 2001;152(6):1145-1157.
    • (2001) J Cell Biol , vol.152 , Issue.6 , pp. 1145-1157
    • Kjoller, L.1    Hall, A.2
  • 101
    • 0344507516 scopus 로고    scopus 로고
    • A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling
    • Wei Y, Yang X, Liu Q, Wilkins JA, Chapman HA. A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling. J Cell Biol 1999;144(6):1285-1294.
    • (1999) J Cell Biol , vol.144 , Issue.6 , pp. 1285-1294
    • Wei, Y.1    Yang, X.2    Liu, Q.3    Wilkins, J.A.4    Chapman, H.A.5
  • 102
    • 59549087883 scopus 로고    scopus 로고
    • Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins
    • Tang CH, Hill ML, Brumwell AN, Chapman HA, Wei Y. Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins. J Cell Sci 2008;121(Pt 22):3747-3756.
    • (2008) J Cell Sci , vol.121 , Issue.PART 22 , pp. 3747-3756
    • Tang, C.H.1    Hill, M.L.2    Brumwell, A.N.3    Chapman, H.A.4    Wei, Y.5
  • 104
    • 16844373820 scopus 로고    scopus 로고
    • Gangliosides inhibit urokinase-type plasminogen activator (uPA)-dependent squamous carcinoma cell migration by preventing uPA receptor/alphabeta integrin/epidermal growth factor receptor interactions
    • Wang XQ, Sun P, Paller AS. Gangliosides inhibit urokinase-type plasminogen activator (uPA)-dependent squamous carcinoma cell migration by preventing uPA receptor/alphabeta integrin/epidermal growth factor receptor interactions. J Invest Dermatol 2005;124(4):839-848.
    • (2005) J Invest Dermatol , vol.124 , Issue.4 , pp. 839-848
    • Wang, X.Q.1    Sun, P.2    Paller, A.S.3
  • 105
    • 0029847191 scopus 로고    scopus 로고
    • Requirement of receptor-bound urokinase-type plasminogen activator for integrin alphavbeta5-directed cell migration
    • Yebra M, Parry GC, Stromblad S, Mackman N, Rosenberg S, Mueller BM, Cheresh DA. Requirement of receptor-bound urokinase-type plasminogen activator for integrin alphavbeta5-directed cell migration. J Biol Chem 1996;271(46):29393-29399.
    • (1996) J Biol Chem , vol.271 , Issue.46 , pp. 29393-29399
    • Yebra, M.1    Parry, G.C.2    Stromblad, S.3    Mackman, N.4    Rosenberg, S.5    Mueller, B.M.6    Cheresh, D.A.7
  • 106
    • 0037175016 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 and -3 increase cell adhesion and motility of MDA-MB-435 breast cancer cells
    • Palmieri D, Lee JW, Juliano RL, Church FC. Plasminogen activator inhibitor-1 and -3 increase cell adhesion and motility of MDA-MB-435 breast cancer cells. J Biol Chem 2002;277(43):40950-40957.
    • (2002) J Biol Chem , vol.277 , Issue.43 , pp. 40950-40957
    • Palmieri, D.1    Lee, J.W.2    Juliano, R.L.3    Church, F.C.4
  • 107
    • 33750431883 scopus 로고    scopus 로고
    • Expression of urokinase-type plasminogen activator receptor is correlated with metastases of lingual squamous cell carcinoma
    • Wang J, Guo F, Wei H, Dong J, Wu J. Expression of urokinase-type plasminogen activator receptor is correlated with metastases of lingual squamous cell carcinoma. Br J Oral Maxillofac Surg 2006;44(6):515-519.
    • (2006) Br J Oral Maxillofac Surg , vol.44 , Issue.6 , pp. 515-519
    • Wang, J.1    Guo, F.2    Wei, H.3    Dong, J.4    Wu, J.5
  • 108
    • 0028339118 scopus 로고
    • Localization of vitronectin binding domain in plasminogen activator inhibitor-1
    • Lawrence DA, Berkenpas MB, Palaniappan S, Ginsburg D. Localization of vitronectin binding domain in plasminogen activator inhibitor-1. J Biol Chem 1994;269(21):15223-15228.
    • (1994) J Biol Chem , vol.269 , Issue.21 , pp. 15223-15228
    • Lawrence, D.A.1    Berkenpas, M.B.2    Palaniappan, S.3    Ginsburg, D.4
  • 109
    • 28244475975 scopus 로고    scopus 로고
    • Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine
    • Nilsson MB, Langley RR, Fidler IJ. Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine. Cancer Res 2005;65(23):10794-10800.
    • (2005) Cancer Res , vol.65 , Issue.23 , pp. 10794-10800
    • Nilsson, M.B.1    Langley, R.R.2    Fidler, I.J.3
  • 111
    • 0029943568 scopus 로고    scopus 로고
    • Plasminogen activators and matrix metalloproteinases in angiogenesis
    • Mignatti P, Rifkin DB. Plasminogen activators and matrix metalloproteinases in angiogenesis. Enzyme Protein 1996;49(1-3):117-137.
    • (1996) Enzyme Protein , vol.49 , Issue.1-3 , pp. 117-137
    • Mignatti, P.1    Rifkin, D.B.2
  • 112
    • 35349000515 scopus 로고    scopus 로고
    • Adhesive and proteolytic phenotype of migrating endothelial cells induced by thymosin beta-4
    • Cierniewski CS, Malinowski M, Bednarek R, Cierniewska-Cieslak A. Adhesive and proteolytic phenotype of migrating endothelial cells induced by thymosin beta-4. Ann N Y Acad Sci 2007;1112:123-139.
    • (2007) Ann N Y Acad Sci , vol.1112 , pp. 123-139
    • Cierniewski, C.S.1    Malinowski, M.2    Bednarek, R.3    Cierniewska-Cieslak, A.4
  • 116
    • 4644247804 scopus 로고    scopus 로고
    • Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth
    • Bajou K, Maillard C, Jost M, Lijnen RH, Gils A, Declerck P, Carmeliet P, Foidart JM, Noel A. Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth. Oncogene 2004;23(41):6986-6990.
    • (2004) Oncogene , vol.23 , Issue.41 , pp. 6986-6990
    • Bajou, K.1    Maillard, C.2    Jost, M.3    Lijnen, R.H.4    Gils, A.5    Declerck, P.6    Carmeliet, P.7    Foidart, J.M.8    Noel, A.9
  • 120
    • 0023885893 scopus 로고
    • Fibrinogen influx and accumulation of cross-linked fibrin in mouse carcinomas
    • Brown LF, Asch B, Harvey VS, Buchinski B, Dvorak HF. Fibrinogen influx and accumulation of cross-linked fibrin in mouse carcinomas. Cancer Res 1988;48(7):1920-1925.
    • (1988) Cancer Res , vol.48 , Issue.7 , pp. 1920-1925
    • Brown, L.F.1    Asch, B.2    Harvey, V.S.3    Buchinski, B.4    Dvorak, H.F.5
  • 124
    • 0023735157 scopus 로고
    • Urokinase-plasminogen activator, a marker for aggressive breast carcinomas. Preliminary report
    • Duffy MJ, O'Grady P, Devaney D, O'Siorain L, Fennelly JJ, Lijnen HJ. Urokinase-plasminogen activator, a marker for aggressive breast carcinomas. Preliminary report. Cancer 1988;62(3):531-533.
    • (1988) Cancer , vol.62 , Issue.3 , pp. 531-533
    • Duffy, M.J.1    O'Grady, P.2    Devaney, D.3    O'Siorain, L.4    Fennelly, J.J.5    Lijnen, H.J.6
  • 126
    • 13244251086 scopus 로고    scopus 로고
    • Real-time quantitative PCR determination of urokinase-type plasminogen activator receptor (uPAR) expression of isolated micrometastatic cells from bone marrow of breast cancer patients
    • Pierga JY, Bonneton C, Magdelenat H, Vincent-Salomon A, Nos C, Boudou E, Pouillart P, Thiery JP, de Cremoux P. Real-time quantitative PCR determination of urokinase-type plasminogen activator receptor (uPAR) expression of isolated micrometastatic cells from bone marrow of breast cancer patients. Int J Cancer 2005;114(2):291-298.
    • (2005) Int J Cancer , vol.114 , Issue.2 , pp. 291-298
    • Pierga, J.Y.1    Bonneton, C.2    Magdelenat, H.3    Vincent-Salomon, A.4    Nos, C.5    Boudou, E.6    Pouillart, P.7    Thiery, J.P.8    de Cremoux, P.9
  • 129
    • 80053626854 scopus 로고    scopus 로고
    • Prognostic significance of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor (PAI-1) in patients with primary invasive ductal breast carcinoma-A 7.5-year follow-up study
    • Jelisavac-Cosic S, Sirotkovic-Skerlev M, Kulic A, Jakic-Razumovic J, Kovac Z, Vrbanec D. Prognostic significance of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor (PAI-1) in patients with primary invasive ductal breast carcinoma-A 7.5-year follow-up study. Tumori 2011;97(4):532-539.
    • (2011) Tumori , vol.97 , Issue.4 , pp. 532-539
    • Jelisavac-Cosic, S.1    Sirotkovic-Skerlev, M.2    Kulic, A.3    Jakic-Razumovic, J.4    Kovac, Z.5    Vrbanec, D.6
  • 135
    • 53249103673 scopus 로고    scopus 로고
    • Cleaved forms of the urokinase plasminogen activator receptor in plasma have diagnostic potential and predict postoperative survival in patients with ovarian cancer
    • Henic E, Borgfeldt C, Christensen IJ, Casslen B, Hoyer-Hansen G. Cleaved forms of the urokinase plasminogen activator receptor in plasma have diagnostic potential and predict postoperative survival in patients with ovarian cancer. Clin Cancer Res 2008;14(18):5785-5793.
    • (2008) Clin Cancer Res , vol.14 , Issue.18 , pp. 5785-5793
    • Henic, E.1    Borgfeldt, C.2    Christensen, I.J.3    Casslen, B.4    Hoyer-Hansen, G.5
  • 138
    • 34447506468 scopus 로고    scopus 로고
    • Monitoring of chemotherapy successfulness of platina/taxol chemotherapy protocol by using determination of serum urokinase plasminogen activator (uPA) and soluble urokinase plasminogen activator receptor (suPAR) in patients with ovarian carcinoma FIGO II and III stage
    • Ljuca D, Fatusic Z, Iljazovic E, Ahmetovic B. Monitoring of chemotherapy successfulness of platina/taxol chemotherapy protocol by using determination of serum urokinase plasminogen activator (uPA) and soluble urokinase plasminogen activator receptor (suPAR) in patients with ovarian carcinoma FIGO II and III stage. Bosn J Basic Med Sci 2007;7(2):111-116.
    • (2007) Bosn J Basic Med Sci , vol.7 , Issue.2 , pp. 111-116
    • Ljuca, D.1    Fatusic, Z.2    Iljazovic, E.3    Ahmetovic, B.4
  • 139
    • 0028656476 scopus 로고
    • Urokinase (uPA) and PAI-1 predict survival in advanced ovarian cancer patients (FIGO III) after radical surgery and platinum-based chemotherapy
    • Kuhn W, Pache L, Schmalfeldt B, Dettmar P, Schmitt M, Janicke F, Graeff H. Urokinase (uPA) and PAI-1 predict survival in advanced ovarian cancer patients (FIGO III) after radical surgery and platinum-based chemotherapy. Gynecol Oncol 1994;55(3 Pt 1):401-409.
    • (1994) Gynecol Oncol , vol.55 , Issue.3 PART 1 , pp. 401-409
    • Kuhn, W.1    Pache, L.2    Schmalfeldt, B.3    Dettmar, P.4    Schmitt, M.5    Janicke, F.6    Graeff, H.7
  • 140
    • 0029086675 scopus 로고
    • Primary tumor and metastasis in ovarian cancer differ in their content of urokinase-type plasminogen activator, its receptor, and inhibitors types 1 and 2
    • Schmalfeldt B, Kuhn W, Reuning U, Pache L, Dettmar P, Schmitt M, Janicke F, Hofler H, Graeff H. Primary tumor and metastasis in ovarian cancer differ in their content of urokinase-type plasminogen activator, its receptor, and inhibitors types 1 and 2. Cancer Res 1995;55(18):3958-3963.
    • (1995) Cancer Res , vol.55 , Issue.18 , pp. 3958-3963
    • Schmalfeldt, B.1    Kuhn, W.2    Reuning, U.3    Pache, L.4    Dettmar, P.5    Schmitt, M.6    Janicke, F.7    Hofler, H.8    Graeff, H.9
  • 141
    • 0030464253 scopus 로고    scopus 로고
    • Expression of urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in benign, borderline, malignant primary and metastatic ovarian tumors
    • van der Burg ME, Henzen-Logmans SC, Berns EM, van Putten WL, Klijn JG, Foekens JA. Expression of urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in benign, borderline, malignant primary and metastatic ovarian tumors. Int J Cancer 1996;69(6):475-479.
    • (1996) Int J Cancer , vol.69 , Issue.6 , pp. 475-479
    • van der Burg, M.E.1    Henzen-Logmans, S.C.2    Berns, E.M.3    van Putten, W.L.4    Klijn, J.G.5    Foekens, J.A.6
  • 142
    • 68149138779 scopus 로고    scopus 로고
    • Coexpression of invasive markers (uPA, CD44) and multiple drug-resistance proteins (MDR1, MRP2) is correlated with epithelial ovarian cancer progression
    • Chen H, Hao J, Wang L, Li Y. Coexpression of invasive markers (uPA, CD44) and multiple drug-resistance proteins (MDR1, MRP2) is correlated with epithelial ovarian cancer progression. Br J Cancer 2009;101(3):432-440.
    • (2009) Br J Cancer , vol.101 , Issue.3 , pp. 432-440
    • Chen, H.1    Hao, J.2    Wang, L.3    Li, Y.4
  • 143
    • 67549104876 scopus 로고    scopus 로고
    • Expression of urokinase plasminogen activator and its receptor in advanced epithelial ovarian cancer patients
    • Wang L, Madigan MC, Chen H, Liu F, Patterson KI, Beretov J, O'Brien PM, Li Y. Expression of urokinase plasminogen activator and its receptor in advanced epithelial ovarian cancer patients. Gynecol Oncol 2009;114(2):265-272.
    • (2009) Gynecol Oncol , vol.114 , Issue.2 , pp. 265-272
    • Wang, L.1    Madigan, M.C.2    Chen, H.3    Liu, F.4    Patterson, K.I.5    Beretov, J.6    O'Brien, P.M.7    Li, Y.8
  • 144
    • 79953309892 scopus 로고    scopus 로고
    • Impact of expression differences of kallikrein-related peptidases and of uPA and PAI-1 between primary tumor and omentum metastasis in advanced ovarian cancer
    • Dorn J, Harbeck N, Kates R, Gkazepis A, Scorilas A, Soosaipillai A, Diamandis E, Kiechle M, Schmalfeldt B, Schmitt M. Impact of expression differences of kallikrein-related peptidases and of uPA and PAI-1 between primary tumor and omentum metastasis in advanced ovarian cancer. Ann Oncol 2011;22(4):877-883.
    • (2011) Ann Oncol , vol.22 , Issue.4 , pp. 877-883
    • Dorn, J.1    Harbeck, N.2    Kates, R.3    Gkazepis, A.4    Scorilas, A.5    Soosaipillai, A.6    Diamandis, E.7    Kiechle, M.8    Schmalfeldt, B.9    Schmitt, M.10
  • 146
    • 0033017371 scopus 로고    scopus 로고
    • Urokinase and plasminogen activator-inhibitor (PAI-1) status in primary ovarian carcinomas and ovarian metastases compared to benign ovarian tumors as a function of histopathological parameters
    • Hoffmann G, Pollow K, Weikel W, Strittmatter HJ, Bach J, Schaffrath M, Knapstein P, Melchert F, Pollow B. Urokinase and plasminogen activator-inhibitor (PAI-1) status in primary ovarian carcinomas and ovarian metastases compared to benign ovarian tumors as a function of histopathological parameters. Clin Chem Lab Med 1999;37(1):47-54.
    • (1999) Clin Chem Lab Med , vol.37 , Issue.1 , pp. 47-54
    • Hoffmann, G.1    Pollow, K.2    Weikel, W.3    Strittmatter, H.J.4    Bach, J.5    Schaffrath, M.6    Knapstein, P.7    Melchert, F.8    Pollow, B.9
  • 147
    • 0033756855 scopus 로고    scopus 로고
    • Differential mRNA expression of urokinase-type plasminogen activator, plasminogen activator receptor and plasminogen activator inhibitor type-2 in normal human endometria and endometrial carcinomas
    • Foca C, Moses EK, Quinn MA, Rice GE. Differential mRNA expression of urokinase-type plasminogen activator, plasminogen activator receptor and plasminogen activator inhibitor type-2 in normal human endometria and endometrial carcinomas. Gynecol Oncol 2000;79(2):244-250.
    • (2000) Gynecol Oncol , vol.79 , Issue.2 , pp. 244-250
    • Foca, C.1    Moses, E.K.2    Quinn, M.A.3    Rice, G.E.4
  • 148
    • 0023689428 scopus 로고
    • Increased plasma levels of urokinase-type plasminogen activator with endometrial and cervical cancer
    • Koelbl H, Kirchheimer JC, Tatra G, Christ G, Binder BR. Increased plasma levels of urokinase-type plasminogen activator with endometrial and cervical cancer. Obstet Gynecol 1988;72(2):252-256.
    • (1988) Obstet Gynecol , vol.72 , Issue.2 , pp. 252-256
    • Koelbl, H.1    Kirchheimer, J.C.2    Tatra, G.3    Christ, G.4    Binder, B.R.5
  • 151
    • 0037137848 scopus 로고    scopus 로고
    • High tumor tissue concentration of plasminogen activator inhibitor 2 (PAI-2) is an independent marker for shorter progression-free survival in patients with early stage endometrial cancer
    • Nordengren J, Fredstorp Lidebring M, Bendahl PO, Brunner N, Ferno M, Hogberg T, Stephens RW, Willen R, Casslen B. High tumor tissue concentration of plasminogen activator inhibitor 2 (PAI-2) is an independent marker for shorter progression-free survival in patients with early stage endometrial cancer. Int J Cancer 2002;97(3):379-385.
    • (2002) Int J Cancer , vol.97 , Issue.3 , pp. 379-385
    • Nordengren, J.1    Fredstorp Lidebring, M.2    Bendahl, P.O.3    Brunner, N.4    Ferno, M.5    Hogberg, T.6    Stephens, R.W.7    Willen, R.8    Casslen, B.9
  • 152
    • 0025255847 scopus 로고
    • The concentration of tissue plasminogen activator and urokinase in plasma and tissues of patients with ovarian and uterine tumors
    • Saito K, Nagashima M, Iwata M, Hamada H, Sumiyoshi K, Takada Y, Takada A. The concentration of tissue plasminogen activator and urokinase in plasma and tissues of patients with ovarian and uterine tumors. Thromb Res 1990;58(4):355-366.
    • (1990) Thromb Res , vol.58 , Issue.4 , pp. 355-366
    • Saito, K.1    Nagashima, M.2    Iwata, M.3    Hamada, H.4    Sumiyoshi, K.5    Takada, Y.6    Takada, A.7
  • 154
    • 0032861405 scopus 로고    scopus 로고
    • Urokinase gene expression indicates early invasive growth in squamous cell lesions of the uterine cervix
    • Riethdorf L, Riethdorf S, Petersen S, Bauer M, Herbst H, Janicke F, Loning T. Urokinase gene expression indicates early invasive growth in squamous cell lesions of the uterine cervix. J Pathol 1999;189(2):245-250.
    • (1999) J Pathol , vol.189 , Issue.2 , pp. 245-250
    • Riethdorf, L.1    Riethdorf, S.2    Petersen, S.3    Bauer, M.4    Herbst, H.5    Janicke, F.6    Loning, T.7
  • 155
    • 0023631532 scopus 로고
    • Tissue plasminogen activator and urokinase in normal, dysplastic and cancerous squamous epithelium of the uterine cervix
    • Larsson G, Larsson A, Astedt B. Tissue plasminogen activator and urokinase in normal, dysplastic and cancerous squamous epithelium of the uterine cervix. Thromb Haemost 1987;58(3):822-826.
    • (1987) Thromb Haemost , vol.58 , Issue.3 , pp. 822-826
    • Larsson, G.1    Larsson, A.2    Astedt, B.3
  • 156
    • 0028639208 scopus 로고
    • Impact of urokinase-type plasminogen activator and its inhibitor type 1 on prognosis in cervical cancer of the uterus
    • Kobayashi H, Fujishiro S, Terao T. Impact of urokinase-type plasminogen activator and its inhibitor type 1 on prognosis in cervical cancer of the uterus. Cancer Res 1994;54(24):6539-6548.
    • (1994) Cancer Res , vol.54 , Issue.24 , pp. 6539-6548
    • Kobayashi, H.1    Fujishiro, S.2    Terao, T.3
  • 160
    • 0028194881 scopus 로고
    • Biochemical markers as a predictor for lymph-node involvement in patients with cervical-cancer of the uterus
    • Kobayashi H, Fujishiro S, Terao T. Biochemical markers as a predictor for lymph-node involvement in patients with cervical-cancer of the uterus. Int J Oncol 1994;4(5):1053-1059.
    • (1994) Int J Oncol , vol.4 , Issue.5 , pp. 1053-1059
    • Kobayashi, H.1    Fujishiro, S.2    Terao, T.3
  • 161
    • 0028326708 scopus 로고
    • Urokinase-type plasminogen activator as a predictor for lymph nodes metastasis of uterine cervical cancer
    • Fujishiro S, Kobayashi H, Terao T. Urokinase-type plasminogen activator as a predictor for lymph nodes metastasis of uterine cervical cancer. Nihon Sanka Fujinka Gakkai zasshi 1994;46(2):129-136.
    • (1994) Nihon Sanka Fujinka Gakkai zasshi , vol.46 , Issue.2 , pp. 129-136
    • Fujishiro, S.1    Kobayashi, H.2    Terao, T.3
  • 162
    • 0026722185 scopus 로고
    • Clinical significance of urokinase-type plasminogen activator (uPA) in invasive cervical cancer of the uterus
    • Sugimura M, Kobayashi H, Kanayama N, Terao T. Clinical significance of urokinase-type plasminogen activator (uPA) in invasive cervical cancer of the uterus. Gynecol Oncol 1992;46(3):330-336.
    • (1992) Gynecol Oncol , vol.46 , Issue.3 , pp. 330-336
    • Sugimura, M.1    Kobayashi, H.2    Kanayama, N.3    Terao, T.4
  • 163
  • 164
    • 33847617415 scopus 로고    scopus 로고
    • Free PSA isoforms and intact and cleaved forms of urokinase plasminogen activator receptor in serum improve selection of patients for prostate cancer biopsy
    • Steuber T, Vickers A, Haese A, Kattan MW, Eastham JA, Scardino PT, Huland H, Lilja H. Free PSA isoforms and intact and cleaved forms of urokinase plasminogen activator receptor in serum improve selection of patients for prostate cancer biopsy. Int J Cancer 2007;120(7):1499-1504.
    • (2007) Int J Cancer , vol.120 , Issue.7 , pp. 1499-1504
    • Steuber, T.1    Vickers, A.2    Haese, A.3    Kattan, M.W.4    Eastham, J.A.5    Scardino, P.T.6    Huland, H.7    Lilja, H.8
  • 165
    • 33646336629 scopus 로고    scopus 로고
    • Enhanced discrimination of benign from malignant prostatic disease by selective measurements of cleaved forms of urokinase receptor in serum
    • Piironen T, Haese A, Huland H, Steuber T, Christensen IJ, Brunner N, Dano K, Hoyer-Hansen G, Lilja H. Enhanced discrimination of benign from malignant prostatic disease by selective measurements of cleaved forms of urokinase receptor in serum. Clin Chem 2006;52(5):838-844.
    • (2006) Clin Chem , vol.52 , Issue.5 , pp. 838-844
    • Piironen, T.1    Haese, A.2    Huland, H.3    Steuber, T.4    Christensen, I.J.5    Brunner, N.6    Dano, K.7    Hoyer-Hansen, G.8    Lilja, H.9
  • 166
    • 79951709761 scopus 로고    scopus 로고
    • Soluble urokinase plasminogen activator receptor as a prognostic marker in men participating in prostate cancer screening
    • Kjellman A, Akre O, Gustafsson O, Hoyer-Hansen G, Lilja H, Norming U, Piironen T, Tornblom M. Soluble urokinase plasminogen activator receptor as a prognostic marker in men participating in prostate cancer screening. J Intern Med 2011;269(3):299-305.
    • (2011) J Intern Med , vol.269 , Issue.3 , pp. 299-305
    • Kjellman, A.1    Akre, O.2    Gustafsson, O.3    Hoyer-Hansen, G.4    Lilja, H.5    Norming, U.6    Piironen, T.7    Tornblom, M.8
  • 167
    • 79953687971 scopus 로고    scopus 로고
    • Prognostic and predictive value of intact and cleaved forms of the urokinase plasminogen activator receptor in metastatic prostate cancer
    • Almasi CE, Brasso K, Iversen P, Pappot H, Hoyer-Hansen G, Dano K, Christensen IJ. Prognostic and predictive value of intact and cleaved forms of the urokinase plasminogen activator receptor in metastatic prostate cancer. Prostate 2011;71(8):899-907.
    • (2011) Prostate , vol.71 , Issue.8 , pp. 899-907
    • Almasi, C.E.1    Brasso, K.2    Iversen, P.3    Pappot, H.4    Hoyer-Hansen, G.5    Dano, K.6    Christensen, I.J.7
  • 168
    • 67650457467 scopus 로고    scopus 로고
    • Urokinase-plasminogen-activator receptor expression in disseminated tumour cells in the bone marrow and peripheral blood of patients with clinically localized prostate cancer
    • Thomas C, Wiesner C, Melchior SW, Schmidt F, Gillitzer R, Thuroff JW, Pfitzenmaier J. Urokinase-plasminogen-activator receptor expression in disseminated tumour cells in the bone marrow and peripheral blood of patients with clinically localized prostate cancer. BJU Int 2009;104(1):29-34.
    • (2009) BJU Int , vol.104 , Issue.1 , pp. 29-34
    • Thomas, C.1    Wiesner, C.2    Melchior, S.W.3    Schmidt, F.4    Gillitzer, R.5    Thuroff, J.W.6    Pfitzenmaier, J.7
  • 171
    • 61649122594 scopus 로고    scopus 로고
    • Expression of urokinase-type plasminogen activator system in prostate cancer: Correlation with clinicopathological outcomes in patients undergoing radical prostatectomy
    • Kumano M, Miyake H, Muramaki M, Furukawa J, Takenaka A, Fujisawa M. Expression of urokinase-type plasminogen activator system in prostate cancer: Correlation with clinicopathological outcomes in patients undergoing radical prostatectomy. Urol Oncol 2009;27(2):180-186.
    • (2009) Urol Oncol , vol.27 , Issue.2 , pp. 180-186
    • Kumano, M.1    Miyake, H.2    Muramaki, M.3    Furukawa, J.4    Takenaka, A.5    Fujisawa, M.6
  • 172
    • 33846978442 scopus 로고    scopus 로고
    • Association of the circulating levels of the urokinase system of plasminogen activation with the presence of prostate cancer and invasion, progression, and metastasis
    • Shariat SF, Roehrborn CG, McConnell JD, Park S, Alam N, Wheeler TM, Slawin KM. Association of the circulating levels of the urokinase system of plasminogen activation with the presence of prostate cancer and invasion, progression, and metastasis. J Clin Oncol 2007;25(4):349-355.
    • (2007) J Clin Oncol , vol.25 , Issue.4 , pp. 349-355
    • Shariat, S.F.1    Roehrborn, C.G.2    McConnell, J.D.3    Park, S.4    Alam, N.5    Wheeler, T.M.6    Slawin, K.M.7
  • 173
    • 62649132399 scopus 로고    scopus 로고
    • Predictive value of the differential expression of the urokinase plasminogen activation axis in radical prostatectomy patients
    • Gupta A, Lotan Y, Ashfaq R, Roehrborn CG, Raj GV, Aragaki CC, Montorsi F, Shariat SF. Predictive value of the differential expression of the urokinase plasminogen activation axis in radical prostatectomy patients. Eur Urol 2009;55(5):1124-1133.
    • (2009) Eur Urol , vol.55 , Issue.5 , pp. 1124-1133
    • Gupta, A.1    Lotan, Y.2    Ashfaq, R.3    Roehrborn, C.G.4    Raj, G.V.5    Aragaki, C.C.6    Montorsi, F.7    Shariat, S.F.8
  • 174
    • 84874795895 scopus 로고    scopus 로고
    • Discovery of specific ligands for oral squamous carcinoma to develop anti-cancer drug loaded precise targeting nanotherapeutics
    • Yang F, Liu R, Kramer R, Xiao W, Jordan R, Lam KS. Discovery of specific ligands for oral squamous carcinoma to develop anti-cancer drug loaded precise targeting nanotherapeutics. J Calif Dental Assoc 2012;40(12):939-943.
    • (2012) J Calif Dental Assoc , vol.40 , Issue.12 , pp. 939-943
    • Yang, F.1    Liu, R.2    Kramer, R.3    Xiao, W.4    Jordan, R.5    Lam, K.S.6
  • 175
    • 33646396782 scopus 로고    scopus 로고
    • Expression of plasminogen activator inhibitor-1, urokinase receptor and laminin gamma-2 chain is an early coordinated event in incipient oral squamous cell carcinoma
    • Lindberg P, Larsson A, Nielsen BS. Expression of plasminogen activator inhibitor-1, urokinase receptor and laminin gamma-2 chain is an early coordinated event in incipient oral squamous cell carcinoma. Int J Cancer 2006;118(12):2948-2956.
    • (2006) Int J Cancer , vol.118 , Issue.12 , pp. 2948-2956
    • Lindberg, P.1    Larsson, A.2    Nielsen, B.S.3
  • 176
    • 77956189457 scopus 로고    scopus 로고
    • Urokinase and tissue plasminogen activators and their PAI-1 inhibitor in tumors of patients with oral mucosal cancer: Relationship with the main clinical morphological factors
    • Gershtein ES, Batsev AF, Matyakin EG, Kushlinskii NE. Urokinase and tissue plasminogen activators and their PAI-1 inhibitor in tumors of patients with oral mucosal cancer: Relationship with the main clinical morphological factors. Bull Exp Biol Med 2010;149(3):347-350.
    • (2010) Bull Exp Biol Med , vol.149 , Issue.3 , pp. 347-350
    • Gershtein, E.S.1    Batsev, A.F.2    Matyakin, E.G.3    Kushlinskii, N.E.4
  • 177
    • 0030931986 scopus 로고    scopus 로고
    • Localization of plasminogen activators and their inhibitor in squamous cell carcinomas of the head and neck
    • Yasuda T, Sakata Y, Kitamura K, Morita M, Ishida T. Localization of plasminogen activators and their inhibitor in squamous cell carcinomas of the head and neck. Head Neck 1997;19(7):611-616.
    • (1997) Head Neck , vol.19 , Issue.7 , pp. 611-616
    • Yasuda, T.1    Sakata, Y.2    Kitamura, K.3    Morita, M.4    Ishida, T.5
  • 178
    • 0030744040 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator and its inhibitor plasminogen activator inhibitor-1
    • Wollenberg B, Jan N, Jund R, Chaubal S, Untch M. Urokinase-type plasminogen activator and its inhibitor plasminogen activator inhibitor-1. Oncol Rep 1997;4(4):853-855.
    • (1997) Oncol Rep , vol.4 , Issue.4 , pp. 853-855
    • Wollenberg, B.1    Jan, N.2    Jund, R.3    Chaubal, S.4    Untch, M.5
  • 179
    • 4644346134 scopus 로고    scopus 로고
    • Comparison of urokinase type plasminogen activators (uPA) and plasminogen activator inhibitors (PAI-1) in primary resection of oral squamous cell carcinoma
    • Hundsdorfer B, Zeilhofer HF, Bock KP, Dettmar P, Schmitt M, Horch HH. Comparison of urokinase type plasminogen activators (uPA) and plasminogen activator inhibitors (PAI-1) in primary resection of oral squamous cell carcinoma. Mund Kiefer Gesichtschir 2004;8(3):180-190.
    • (2004) Mund Kiefer Gesichtschir , vol.8 , Issue.3 , pp. 180-190
    • Hundsdorfer, B.1    Zeilhofer, H.F.2    Bock, K.P.3    Dettmar, P.4    Schmitt, M.5    Horch, H.H.6
  • 180
    • 4644364079 scopus 로고    scopus 로고
    • The prognostic importance of urinase type plasminogen activators (uPA) and plasminogen activator inhibitors (PAI-1) in the primary resection of oral squamous cell carcinoma
    • Hundsdorfer B, Zeilhofer HF, Bock KP, Dettmar P, Schmitt M, Horch HH. The prognostic importance of urinase type plasminogen activators (uPA) and plasminogen activator inhibitors (PAI-1) in the primary resection of oral squamous cell carcinoma. Mund Kiefer Gesichtschir 2004;8(3):173-179.
    • (2004) Mund Kiefer Gesichtschir , vol.8 , Issue.3 , pp. 173-179
    • Hundsdorfer, B.1    Zeilhofer, H.F.2    Bock, K.P.3    Dettmar, P.4    Schmitt, M.5    Horch, H.H.6
  • 181
    • 18144427905 scopus 로고    scopus 로고
    • Tumour-associated urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in normal and neoplastic tissues of patients with squamous cell cancer of the oral cavity-Clinical relevance and prognostic value
    • Hundsdorfer B, Zeilhofer HF, Bock KP, Dettmar P, Schmitt M, Kolk A, Pautke C, Horch HH. Tumour-associated urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in normal and neoplastic tissues of patients with squamous cell cancer of the oral cavity-Clinical relevance and prognostic value. J Craniomaxillofac Surg 2005;33(3):191-196.
    • (2005) J Craniomaxillofac Surg , vol.33 , Issue.3 , pp. 191-196
    • Hundsdorfer, B.1    Zeilhofer, H.F.2    Bock, K.P.3    Dettmar, P.4    Schmitt, M.5    Kolk, A.6    Pautke, C.7    Horch, H.H.8
  • 186
    • 80053525848 scopus 로고    scopus 로고
    • Expression of urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor and maspin in oral squamous cell carcinoma: Association with mode of invasion and clinicopathological factors
    • Yoshizawa K, Nozaki S, Kitahara H, Kato K, Noguchi N, Kawashiri S, Yamamoto E. Expression of urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor and maspin in oral squamous cell carcinoma: Association with mode of invasion and clinicopathological factors. Oncol Rep 2011;26(6):1555-1560.
    • (2011) Oncol Rep , vol.26 , Issue.6 , pp. 1555-1560
    • Yoshizawa, K.1    Nozaki, S.2    Kitahara, H.3    Kato, K.4    Noguchi, N.5    Kawashiri, S.6    Yamamoto, E.7
  • 187
    • 78650242881 scopus 로고    scopus 로고
    • Expressions and clinical significance of urokinase-type plasminogen activator (uPA) and uPA receptor (uPAR) in tongue squamous cell carcinoma
    • Wang QX, Wang TX, Sun CF, Zhang J. Expressions and clinical significance of urokinase-type plasminogen activator (uPA) and uPA receptor (uPAR) in tongue squamous cell carcinoma. Shanghai Kou Qiang Yi Xue 2006;15(1):85-87.
    • (2006) Shanghai Kou Qiang Yi Xue , vol.15 , Issue.1 , pp. 85-87
    • Wang, Q.X.1    Wang, T.X.2    Sun, C.F.3    Zhang, J.4
  • 188
    • 79251539562 scopus 로고    scopus 로고
    • Survey of risk factors contributed to lymphatic metastasis in patients with oral tongue cancer by immunohistochemistry
    • Zhang Z, Pan J, Li L, Wang Z, Xiao W, Li N. Survey of risk factors contributed to lymphatic metastasis in patients with oral tongue cancer by immunohistochemistry. J Oral Pathol Med 2011;40(2):127-134.
    • (2011) J Oral Pathol Med , vol.40 , Issue.2 , pp. 127-134
    • Zhang, Z.1    Pan, J.2    Li, L.3    Wang, Z.4    Xiao, W.5    Li, N.6
  • 189
    • 84865089370 scopus 로고    scopus 로고
    • Factors affecting survival of patients with oesophageal cancer: A study using inverse Gaussian frailty models
    • Ghadimi MR, Mahmoodi M, Mohammad K, Rasouli M, Zeraati H, Fotouhi A. Factors affecting survival of patients with oesophageal cancer: A study using inverse Gaussian frailty models. Singapore Med J 2012;53(5):336-343.
    • (2012) Singapore Med J , vol.53 , Issue.5 , pp. 336-343
    • Ghadimi, M.R.1    Mahmoodi, M.2    Mohammad, K.3    Rasouli, M.4    Zeraati, H.5    Fotouhi, A.6
  • 190
    • 0031426780 scopus 로고    scopus 로고
    • Prognostic significance of urokinase-type plasminogen activator expression in squamous cell carcinomas of the esophagus
    • Torzewski M, Sarbia M, Verreet P, Dutkowski P, Heep H, Willers R, Gabbert HE. Prognostic significance of urokinase-type plasminogen activator expression in squamous cell carcinomas of the esophagus. Clin Cancer Res 1997;3(12 Pt 1):2263-2268.
    • (1997) Clin Cancer Res , vol.3 , Issue.12 PART 1 , pp. 2263-2268
    • Torzewski, M.1    Sarbia, M.2    Verreet, P.3    Dutkowski, P.4    Heep, H.5    Willers, R.6    Gabbert, H.E.7
  • 191
    • 0031776764 scopus 로고    scopus 로고
    • Strong prognostic impact of tumor-associated urokinase-type plasminogen activator in completely resected adenocarcinoma of the esophagus
    • Nekarda H, Schlegel P, Schmitt M, Stark M, Mueller JD, Fink U, Siewert JR. Strong prognostic impact of tumor-associated urokinase-type plasminogen activator in completely resected adenocarcinoma of the esophagus. Clin Cancer Res 1998;4(7):1755-1763.
    • (1998) Clin Cancer Res , vol.4 , Issue.7 , pp. 1755-1763
    • Nekarda, H.1    Schlegel, P.2    Schmitt, M.3    Stark, M.4    Mueller, J.D.5    Fink, U.6    Siewert, J.R.7
  • 192
    • 0036265895 scopus 로고    scopus 로고
    • Clinical significance of plasma tissue factor pathway and urokinase-type plasminogen activator system in cancer patients
    • Zhao W, Wang X, Qu B, Huang X, Wang H. Clinical significance of plasma tissue factor pathway and urokinase-type plasminogen activator system in cancer patients. Chin Med J 2002;115(5):702-704.
    • (2002) Chin Med J , vol.115 , Issue.5 , pp. 702-704
    • Zhao, W.1    Wang, X.2    Qu, B.3    Huang, X.4    Wang, H.5
  • 193
    • 0029742666 scopus 로고    scopus 로고
    • Plasminogen activators in oesophageal carcinoma
    • Hewin DF, Savage PB, Alderson D, Vipond MN. Plasminogen activators in oesophageal carcinoma. Br J Surg 1996;83(8):1152-1155.
    • (1996) Br J Surg , vol.83 , Issue.8 , pp. 1152-1155
    • Hewin, D.F.1    Savage, P.B.2    Alderson, D.3    Vipond, M.N.4
  • 194
    • 0027507132 scopus 로고
    • Plasminogen activators in normal tissue and carcinomas of the human oesophagus and stomach
    • Sier CF, Verspaget HW, Griffioen G, Ganesh S, Vloedgraven HJ, Lamers CB. Plasminogen activators in normal tissue and carcinomas of the human oesophagus and stomach. Gut 1993;34(1):80-85.
    • (1993) Gut , vol.34 , Issue.1 , pp. 80-85
    • Sier, C.F.1    Verspaget, H.W.2    Griffioen, G.3    Ganesh, S.4    Vloedgraven, H.J.5    Lamers, C.B.6
  • 195
    • 51349093303 scopus 로고    scopus 로고
    • Seprase, dipeptidyl peptidase IV and urokinase-type plasminogen activator expression in dysplasia and invasive squamous cell carcinoma of the esophagus. A study of 229 cases from Anyang Tumor Hospital, Henan Province, China
    • Goscinski MA, Suo ZH, Nesland JM, Chen WT, Zakrzewska M, Wang J, Zhang S, Florenes VA, Giercksky KE. Seprase, dipeptidyl peptidase IV and urokinase-type plasminogen activator expression in dysplasia and invasive squamous cell carcinoma of the esophagus. A study of 229 cases from Anyang Tumor Hospital, Henan Province, China. Oncology 2008;75(1-2):49-59.
    • (2008) Oncology , vol.75 , Issue.1-2 , pp. 49-59
    • Goscinski, M.A.1    Suo, Z.H.2    Nesland, J.M.3    Chen, W.T.4    Zakrzewska, M.5    Wang, J.6    Zhang, S.7    Florenes, V.A.8    Giercksky, K.E.9
  • 196
    • 79954487333 scopus 로고    scopus 로고
    • Markers of angiogenesis and epidermal growth factor receptor signalling in patients with pancreatic and gastroesophageal junction cancer
    • Rohrberg KS, Skov BG, Lassen U, Christensen IJ, Hoyer-Hansen G, Buysschaert I, Pappot H. Markers of angiogenesis and epidermal growth factor receptor signalling in patients with pancreatic and gastroesophageal junction cancer. Cancer Biomark 2010;7(3):141-151.
    • (2010) Cancer Biomark , vol.7 , Issue.3 , pp. 141-151
    • Rohrberg, K.S.1    Skov, B.G.2    Lassen, U.3    Christensen, I.J.4    Hoyer-Hansen, G.5    Buysschaert, I.6    Pappot, H.7
  • 199
    • 0033870240 scopus 로고    scopus 로고
    • Cellular distribution and clinical value of urokinase-type plasminogen activator, its receptor, and plasminogen activator inhibitor-2 in esophageal squamous cell carcinoma
    • Shiomi H, Eguchi Y, Tani T, Kodama M, Hattori T. Cellular distribution and clinical value of urokinase-type plasminogen activator, its receptor, and plasminogen activator inhibitor-2 in esophageal squamous cell carcinoma. Am J Pathol 2000;156(2):567-575.
    • (2000) Am J Pathol , vol.156 , Issue.2 , pp. 567-575
    • Shiomi, H.1    Eguchi, Y.2    Tani, T.3    Kodama, M.4    Hattori, T.5
  • 200
    • 33747529782 scopus 로고    scopus 로고
    • Clinical study of hemostatic molecular markers expression in patients with cancer
    • Wu F, Qu B, Wang XF, Yang CM, Wang HL. Clinical study of hemostatic molecular markers expression in patients with cancer. Zhonghua Nei Ke Za Zhi 2004;43(11):837-840.
    • (2004) Zhonghua Nei Ke Za Zhi , vol.43 , Issue.11 , pp. 837-840
    • Wu, F.1    Qu, B.2    Wang, X.F.3    Yang, C.M.4    Wang, H.L.5
  • 201
    • 56149098136 scopus 로고    scopus 로고
    • Serum cathepsin B and plasma urokinase-type plasminogen activator levels in gastrointestinal tract cancers
    • Herszenyi L, Istvan G, Cardin R, De Paoli M, Plebani M, Tulassay Z, Farinati F. Serum cathepsin B and plasma urokinase-type plasminogen activator levels in gastrointestinal tract cancers. Eur J Cancer Prev 2008;17(5):438-445.
    • (2008) Eur J Cancer Prev , vol.17 , Issue.5 , pp. 438-445
    • Herszenyi, L.1    Istvan, G.2    Cardin, R.3    De Paoli, M.4    Plebani, M.5    Tulassay, Z.6    Farinati, F.7
  • 202
    • 72249094330 scopus 로고    scopus 로고
    • High preoperative serum vascular endothelial growth factor levels predict poor clinical outcome after curative resection of gastric cancer
    • Vidal O, Metges JP, Elizalde I, Valentini M, Volant A, Molina R, Castells A, Pera M. High preoperative serum vascular endothelial growth factor levels predict poor clinical outcome after curative resection of gastric cancer. Br J Surg 2009;96(12):1443-1451.
    • (2009) Br J Surg , vol.96 , Issue.12 , pp. 1443-1451
    • Vidal, O.1    Metges, J.P.2    Elizalde, I.3    Valentini, M.4    Volant, A.5    Molina, R.6    Castells, A.7    Pera, M.8
  • 203
    • 33644513101 scopus 로고    scopus 로고
    • Tissue-type plasminogen activator activity in morphologically normal tissues adjacent to gastrointestinal carcinomas is associated with the degree of tumor progression
    • Scicolone G, Sanchez V, Vauthay L, Fuentes F, Scicolone A, Scicolone L, Rapacioli M, Flores V. Tissue-type plasminogen activator activity in morphologically normal tissues adjacent to gastrointestinal carcinomas is associated with the degree of tumor progression. J Cancer Res Clin Oncol 2006;132(5):309-319.
    • (2006) J Cancer Res Clin Oncol , vol.132 , Issue.5 , pp. 309-319
    • Scicolone, G.1    Sanchez, V.2    Vauthay, L.3    Fuentes, F.4    Scicolone, A.5    Scicolone, L.6    Rapacioli, M.7    Flores, V.8
  • 204
    • 22144497157 scopus 로고    scopus 로고
    • Relationship between matrix metalloproteinase-2 mRNA expression and clinicopathological and urokinase-type plasminogen activator system parameters and prognosis in human gastric cancer
    • Ji F, Chen YL, Jin EY, Wang WL, Yang ZL, Li YM. Relationship between matrix metalloproteinase-2 mRNA expression and clinicopathological and urokinase-type plasminogen activator system parameters and prognosis in human gastric cancer. World J Gastroenterol 2005;11(21):3222-3226.
    • (2005) World J Gastroenterol , vol.11 , Issue.21 , pp. 3222-3226
    • Ji, F.1    Chen, Y.L.2    Jin, E.Y.3    Wang, W.L.4    Yang, Z.L.5    Li, Y.M.6
  • 205
    • 0037838422 scopus 로고    scopus 로고
    • Tumor-specific transcription factor binding to an activator protein-2/Sp1 element of the urokinase-type plasminogen activator receptor promoter in a first large series of resected gastrointestinal cancers
    • Schewe DM, Leupold JH, Boyd DD, Lengyel ER, Wang H, Gruetzner KU, Schildberg FW, Jauch KW, Allgayer H. Tumor-specific transcription factor binding to an activator protein-2/Sp1 element of the urokinase-type plasminogen activator receptor promoter in a first large series of resected gastrointestinal cancers. Clin Cancer Res 2003;9(6):2267-2276.
    • (2003) Clin Cancer Res , vol.9 , Issue.6 , pp. 2267-2276
    • Schewe, D.M.1    Leupold, J.H.2    Boyd, D.D.3    Lengyel, E.R.4    Wang, H.5    Gruetzner, K.U.6    Schildberg, F.W.7    Jauch, K.W.8    Allgayer, H.9
  • 207
    • 33644522032 scopus 로고    scopus 로고
    • Urokinase system expression in gastric carcinoma: Prognostic impact in an independent patient series and first evidence of predictive value in preoperative biopsy and intestinal metaplasia specimens
    • Beyer BC, Heiss MM, Simon EH, Gruetzner KU, Babic R, Jauch KW, Schildberg FW, Allgayer H. Urokinase system expression in gastric carcinoma: Prognostic impact in an independent patient series and first evidence of predictive value in preoperative biopsy and intestinal metaplasia specimens. Cancer 2006;106(5):1026-1035.
    • (2006) Cancer , vol.106 , Issue.5 , pp. 1026-1035
    • Beyer, B.C.1    Heiss, M.M.2    Simon, E.H.3    Gruetzner, K.U.4    Babic, R.5    Jauch, K.W.6    Schildberg, F.W.7    Allgayer, H.8
  • 208
    • 0038663072 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator expression correlates with tumor angiogenesis and poor outcome in gastric cancer
    • Kaneko T, Konno H, Baba M, Tanaka T, Nakamura S. Urokinase-type plasminogen activator expression correlates with tumor angiogenesis and poor outcome in gastric cancer. Cancer Sci 2003;94(1):43-49.
    • (2003) Cancer Sci , vol.94 , Issue.1 , pp. 43-49
    • Kaneko, T.1    Konno, H.2    Baba, M.3    Tanaka, T.4    Nakamura, S.5
  • 209
    • 0037530308 scopus 로고    scopus 로고
    • Urokinase and tissue type plasminogen activators and their type-1 inhibitor (PAI-1) in gastric cancer
    • Gerstein ES, Shcherbakov AM, Kaz'min AI, Ognerubov NA, Kushlinskii NE. Urokinase and tissue type plasminogen activators and their type-1 inhibitor (PAI-1) in gastric cancer. Vopr Onkol 2003;49(2):165-169.
    • (2003) Vopr Onkol , vol.49 , Issue.2 , pp. 165-169
    • Gerstein, E.S.1    Shcherbakov, A.M.2    Kaz'min, A.I.3    Ognerubov, N.A.4    Kushlinskii, N.E.5
  • 210
    • 33746238306 scopus 로고    scopus 로고
    • Correlative studies on uPA mRNA and uPAR mRNA expression with vascular endothelial growth factor, microvessel density, progression and survival time of patients with gastric cancer
    • Zhang L, Zhao ZS, Ru GQ, Ma J. Correlative studies on uPA mRNA and uPAR mRNA expression with vascular endothelial growth factor, microvessel density, progression and survival time of patients with gastric cancer. World J Gastroenterol 2006;12(25):3970-3976.
    • (2006) World J Gastroenterol , vol.12 , Issue.25 , pp. 3970-3976
    • Zhang, L.1    Zhao, Z.S.2    Ru, G.Q.3    Ma, J.4
  • 211
    • 3042570089 scopus 로고    scopus 로고
    • Relationship between urokinase-type plasminogen receptor, interleukin-8 gene expression and clinicopathological features in gastric cancer
    • Lee KH, Bae SH, Lee JL, Hyun MS, Kim SH, Song SK, Kim HS. Relationship between urokinase-type plasminogen receptor, interleukin-8 gene expression and clinicopathological features in gastric cancer. Oncology 2004;66(3):210-217.
    • (2004) Oncology , vol.66 , Issue.3 , pp. 210-217
    • Lee, K.H.1    Bae, S.H.2    Lee, J.L.3    Hyun, M.S.4    Kim, S.H.5    Song, S.K.6    Kim, H.S.7
  • 212
    • 75049084716 scopus 로고    scopus 로고
    • Prognostic value of tumor-related molecular expression in gastric carcinoma
    • Zhao ZS, Wang YY, Ye ZY, Tao HQ. Prognostic value of tumor-related molecular expression in gastric carcinoma. Pathol Oncol Res 2009;15(4):589-596.
    • (2009) Pathol Oncol Res , vol.15 , Issue.4 , pp. 589-596
    • Zhao, Z.S.1    Wang, Y.Y.2    Ye, Z.Y.3    Tao, H.Q.4
  • 213
    • 0037089596 scopus 로고    scopus 로고
    • Minimal residual disease in gastric cancer: Evidence of an independent prognostic relevance of urokinase receptor expression by disseminated tumor cells in the bone marrow
    • Heiss MM, Simon EH, Beyer BC, Gruetzner KU, Tarabichi A, Babic R, Schildberg FW, Allgayer H. Minimal residual disease in gastric cancer: Evidence of an independent prognostic relevance of urokinase receptor expression by disseminated tumor cells in the bone marrow. J Clin Oncol 2002;20(8):2005-2016.
    • (2002) J Clin Oncol , vol.20 , Issue.8 , pp. 2005-2016
    • Heiss, M.M.1    Simon, E.H.2    Beyer, B.C.3    Gruetzner, K.U.4    Tarabichi, A.5    Babic, R.6    Schildberg, F.W.7    Allgayer, H.8
  • 218
    • 67349145945 scopus 로고    scopus 로고
    • Analysis of NM23 protein and components of plasminogen activation system in tumors of patients with stomach cancer with consideration for disease clinical picture and morphology
    • Kushlinskii NE, Delektorskaya VV, Mochal'nikova VV, Sini L, Yurchenko AA, Ryabov AB, Stilidi IS. Analysis of NM23 protein and components of plasminogen activation system in tumors of patients with stomach cancer with consideration for disease clinical picture and morphology. Bull Exp Biol Med 2008;146(6):786-790.
    • (2008) Bull Exp Biol Med , vol.146 , Issue.6 , pp. 786-790
    • Kushlinskii, N.E.1    Delektorskaya, V.V.2    Mochal'nikova, V.V.3    Sini, L.4    Yurchenko, A.A.5    Ryabov, A.B.6    Stilidi, I.S.7
  • 219
    • 33644535360 scopus 로고    scopus 로고
    • Expression of HLA-DR and urokinase-type plasminogen activator in stage IV gastric cancer
    • Murata S, Eguchi Y, Terata N, Tani T, Kodama M. Expression of HLA-DR and urokinase-type plasminogen activator in stage IV gastric cancer. Gastric Cancer 1998;1(1):71-77.
    • (1998) Gastric Cancer , vol.1 , Issue.1 , pp. 71-77
    • Murata, S.1    Eguchi, Y.2    Terata, N.3    Tani, T.4    Kodama, M.5
  • 220
    • 43249090599 scopus 로고    scopus 로고
    • Positive VEGF immunostaining independently predicts poor prognosis in curatively resected gastric cancer patients: Results of a study assessing a panel of angiogenic markers
    • Vidal O, Soriano-Izquierdo A, Pera M, Elizalde JI, Palacin A, Castells A, Pique JM, Volant A, Metges JP. Positive VEGF immunostaining independently predicts poor prognosis in curatively resected gastric cancer patients: Results of a study assessing a panel of angiogenic markers. J Gastroint Surg 2008;12(6):1005-1014.
    • (2008) J Gastroint Surg , vol.12 , Issue.6 , pp. 1005-1014
    • Vidal, O.1    Soriano-Izquierdo, A.2    Pera, M.3    Elizalde, J.I.4    Palacin, A.5    Castells, A.6    Pique, J.M.7    Volant, A.8    Metges, J.P.9
  • 222
    • 48249109135 scopus 로고    scopus 로고
    • Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer
    • Herszenyi L, Farinati F, Cardin R, Istvan G, Molnar LD, Hritz I, De Paoli M, Plebani M, Tulassay Z. Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer. BMC Cancer 2008;8:194.
    • (2008) BMC Cancer , vol.8 , pp. 194
    • Herszenyi, L.1    Farinati, F.2    Cardin, R.3    Istvan, G.4    Molnar, L.D.5    Hritz, I.6    De Paoli, M.7    Plebani, M.8    Tulassay, Z.9
  • 223
    • 0036559388 scopus 로고    scopus 로고
    • Significance of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 (PAI-1) expression in human colorectal carcinomas
    • Papadopoulou S, Scorilas A, Yotis J, Arnogianaki N, Plataniotis G, Agnanti N, Talieri M. Significance of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 (PAI-1) expression in human colorectal carcinomas. Tumour Biol 2002;23(3):170-178.
    • (2002) Tumour Biol , vol.23 , Issue.3 , pp. 170-178
    • Papadopoulou, S.1    Scorilas, A.2    Yotis, J.3    Arnogianaki, N.4    Plataniotis, G.5    Agnanti, N.6    Talieri, M.7
  • 224
    • 33847145778 scopus 로고    scopus 로고
    • Activity and expression of urokinase-type plasminogen activator and matrix metalloproteinases in human colorectal cancer
    • Kim TD, Song KS, Li G, Choi H, Park HD, Lim K, Hwang BD, Yoon WH. Activity and expression of urokinase-type plasminogen activator and matrix metalloproteinases in human colorectal cancer. BMC Cancer 2006;6:211.
    • (2006) BMC Cancer , vol.6 , pp. 211
    • Kim, T.D.1    Song, K.S.2    Li, G.3    Choi, H.4    Park, H.D.5    Lim, K.6    Hwang, B.D.7    Yoon, W.H.8
  • 230
    • 0033668753 scopus 로고    scopus 로고
    • Plasminogen activator system, vascular endothelial growth factor, and colorectal cancer progression
    • Baker EA, Bergin FG, Leaper DJ. Plasminogen activator system, vascular endothelial growth factor, and colorectal cancer progression. Mol Pathol 2000;53(6):307-312.
    • (2000) Mol Pathol , vol.53 , Issue.6 , pp. 307-312
    • Baker, E.A.1    Bergin, F.G.2    Leaper, D.J.3
  • 231
    • 71049141779 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator is a marker of aggressive phenotype and an independent prognostic factor in mismatch repair-proficient colorectal cancer
    • Minoo P, Baker K, Baumhoer D, Terracciano L, Lugli A, Zlobec I. Urokinase-type plasminogen activator is a marker of aggressive phenotype and an independent prognostic factor in mismatch repair-proficient colorectal cancer. Hum Pathol 2010;41(1):70-78.
    • (2010) Hum Pathol , vol.41 , Issue.1 , pp. 70-78
    • Minoo, P.1    Baker, K.2    Baumhoer, D.3    Terracciano, L.4    Lugli, A.5    Zlobec, I.6
  • 232
    • 0033801887 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator and its receptor in colorectal cancer: Independent prognostic factors of metastasis and cancer-specific survival and potential therapeutic targets
    • Yang JL, Seetoo D, Wang Y, Ranson M, Berney CR, Ham JM, Russell PJ, Crowe PJ. Urokinase-type plasminogen activator and its receptor in colorectal cancer: Independent prognostic factors of metastasis and cancer-specific survival and potential therapeutic targets. Int J Cancer 2000;89(5):431-439.
    • (2000) Int J Cancer , vol.89 , Issue.5 , pp. 431-439
    • Yang, J.L.1    Seetoo, D.2    Wang, Y.3    Ranson, M.4    Berney, C.R.5    Ham, J.M.6    Russell, P.J.7    Crowe, P.J.8
  • 233
    • 0037374532 scopus 로고    scopus 로고
    • Quantitative expression of protein markers of plasminogen activation system in prognosis of colorectal cancer
    • Seetoo DQ, Crowe PJ, Russell PJ, Yang JL. Quantitative expression of protein markers of plasminogen activation system in prognosis of colorectal cancer. J Surg Oncol 2003;82(3):184-193.
    • (2003) J Surg Oncol , vol.82 , Issue.3 , pp. 184-193
    • Seetoo, D.Q.1    Crowe, P.J.2    Russell, P.J.3    Yang, J.L.4
  • 236
    • 22944435823 scopus 로고    scopus 로고
    • Preoperative plasma soluble urokinase plasminogen activator receptor as a prognostic marker in rectal cancer patients. An EORTC-Receptor and Biomarker Group collaboration
    • Riisbro R, Christensen IJ, Nielsen HJ, Brunner N, Nilbert M, Fernebro E. Preoperative plasma soluble urokinase plasminogen activator receptor as a prognostic marker in rectal cancer patients. An EORTC-Receptor and Biomarker Group collaboration. Int J Biol Markers 2005;20(2):93-102.
    • (2005) Int J Biol Markers , vol.20 , Issue.2 , pp. 93-102
    • Riisbro, R.1    Christensen, I.J.2    Nielsen, H.J.3    Brunner, N.4    Nilbert, M.5    Fernebro, E.6
  • 238
    • 0033960934 scopus 로고    scopus 로고
    • Expression and cellular localization of the urokinase-type plasminogen activator and its receptor in human hepatocellular carcinoma
    • Dubuisson L, Monvoisin A, Nielsen BS, Le Bail B, Bioulac-Sage P, Rosenbaum J. Expression and cellular localization of the urokinase-type plasminogen activator and its receptor in human hepatocellular carcinoma. J Pathol 2000;190(2):190-195.
    • (2000) J Pathol , vol.190 , Issue.2 , pp. 190-195
    • Dubuisson, L.1    Monvoisin, A.2    Nielsen, B.S.3    Le Bail, B.4    Bioulac-Sage, P.5    Rosenbaum, J.6
  • 239
    • 1842864600 scopus 로고    scopus 로고
    • Inhibitor of plasminogen activator 1 (PAI-1) in hepatocellular carcinoma
    • Zheng Q, Tang Z, Wu Z, Shi D, Song H. Inhibitor of plasminogen activator 1 (PAI-1) in hepatocellular carcinoma. Zhonghua Wai Ke Za Zhi 1998;36(8):474-476.
    • (1998) Zhonghua Wai Ke Za Zhi , vol.36 , Issue.8 , pp. 474-476
    • Zheng, Q.1    Tang, Z.2    Wu, Z.3    Shi, D.4    Song, H.5
  • 240
    • 38049069889 scopus 로고    scopus 로고
    • Expression and clinical significance of coagulate and fibrolysis factors in tissue and plasma from hepatocellular carcinoma patients
    • Zhou Q, Liang LJ, Peng BG, Zhen YY. Expression and clinical significance of coagulate and fibrolysis factors in tissue and plasma from hepatocellular carcinoma patients. Ai Zheng 2006;25(11):1433-1438.
    • (2006) Ai Zheng , vol.25 , Issue.11 , pp. 1433-1438
    • Zhou, Q.1    Liang, L.J.2    Peng, B.G.3    Zhen, Y.Y.4
  • 241
    • 0037255048 scopus 로고    scopus 로고
    • HGF, MET, and matrix-related proteases in hepatocellular carcinoma, fibrolamellar variant, cirrhotic and normal liver
    • Schoedel KE, Tyner VZ, Kim TH, Michalopoulos GK, Mars WM. HGF, MET, and matrix-related proteases in hepatocellular carcinoma, fibrolamellar variant, cirrhotic and normal liver. Modern Pathol 2003;16(1):14-21.
    • (2003) Modern Pathol , vol.16 , Issue.1 , pp. 14-21
    • Schoedel, K.E.1    Tyner, V.Z.2    Kim, T.H.3    Michalopoulos, G.K.4    Mars, W.M.5
  • 242
    • 0031862546 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator (uPA), uPA receptor (uPA-R) and inhibitors (PA I -1) expression in hepatocellular carcinoma in relation to cancer invasion/metastasis and prognosis
    • Zheng Q, Tang Z, Wu Z. Urokinase-type plasminogen activator (uPA), uPA receptor (uPA-R) and inhibitors (PA I -1) expression in hepatocellular carcinoma in relation to cancer invasion/metastasis and prognosis. Zhonghua Zhong Liu Za Zhi 1998;20(1):57-59.
    • (1998) Zhonghua Zhong Liu Za Zhi , vol.20 , Issue.1 , pp. 57-59
    • Zheng, Q.1    Tang, Z.2    Wu, Z.3
  • 243
    • 34249742466 scopus 로고    scopus 로고
    • Fibrinolytic characteristics and their significance in malignant, tuberculous and cirrhotic pleural and ascitic fluids
    • Lu XG, Mao JS, Tong JF, Zhu L, Liu J, Gong XB, Huang J. Fibrinolytic characteristics and their significance in malignant, tuberculous and cirrhotic pleural and ascitic fluids. Int J Lab Hematol 2007;29(2):132-138.
    • (2007) Int J Lab Hematol , vol.29 , Issue.2 , pp. 132-138
    • Lu, X.G.1    Mao, J.S.2    Tong, J.F.3    Zhu, L.4    Liu, J.5    Gong, X.B.6    Huang, J.7
  • 245
    • 0033935188 scopus 로고    scopus 로고
    • Expression of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor, and plasminogen activator inhibitor-1 and -2 in hepatocellular carcinoma
    • Zhou L, Hayashi Y, Itoh T, Wang W, Rui J, Itoh H. Expression of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor, and plasminogen activator inhibitor-1 and -2 in hepatocellular carcinoma. Pathol Int 2000;50(5):392-397.
    • (2000) Pathol Int , vol.50 , Issue.5 , pp. 392-397
    • Zhou, L.1    Hayashi, Y.2    Itoh, T.3    Wang, W.4    Rui, J.5    Itoh, H.6
  • 246
    • 0033784038 scopus 로고    scopus 로고
    • Invasion and metastasis of hepatocellular carcinoma in relation to urokinase-type plasminogen activator, its receptor and inhibitor
    • Zheng Q, Tang ZY, Xue Q, Shi DR, Song HY, Tang HB. Invasion and metastasis of hepatocellular carcinoma in relation to urokinase-type plasminogen activator, its receptor and inhibitor. J Cancer Res Clin Oncol 2000;126(11):641-646.
    • (2000) J Cancer Res Clin Oncol , vol.126 , Issue.11 , pp. 641-646
    • Zheng, Q.1    Tang, Z.Y.2    Xue, Q.3    Shi, D.R.4    Song, H.Y.5    Tang, H.B.6
  • 247
    • 0031738954 scopus 로고    scopus 로고
    • Stromal expression of urokinase-type plasminogen activator receptor (uPAR) is associated with invasive growth in primary liver cancer
    • Akahane T, Ishii M, Ohtani H, Nagura H, Toyota T. Stromal expression of urokinase-type plasminogen activator receptor (uPAR) is associated with invasive growth in primary liver cancer. Liver 1998;18(6):414-419.
    • (1998) Liver , vol.18 , Issue.6 , pp. 414-419
    • Akahane, T.1    Ishii, M.2    Ohtani, H.3    Nagura, H.4    Toyota, T.5
  • 248
    • 1842419052 scopus 로고    scopus 로고
    • Association of VEGF, uPA, ICAM-1 and PCNA expression with metastasis and recurrence in hepato cellular carcinoma
    • Meng C, Chen X. Association of VEGF, uPA, ICAM-1 and PCNA expression with metastasis and recurrence in hepato cellular carcinoma. Zhonghua Wai Ke Za Zhi 2002;40(9):673-675.
    • (2002) Zhonghua Wai Ke Za Zhi , vol.40 , Issue.9 , pp. 673-675
    • Meng, C.1    Chen, X.2
  • 250
    • 0033867263 scopus 로고    scopus 로고
    • u-PA and c-MET mRNA expression is co-ordinately enhanced while hepatocyte growth factor mRNA is down-regulated in human hepatocellular carcinoma
    • Tavian D, De Petro G, Benetti A, Portolani N, Giulini SM, Barlati S. u-PA and c-MET mRNA expression is co-ordinately enhanced while hepatocyte growth factor mRNA is down-regulated in human hepatocellular carcinoma. Int J Cancer 2000;87(5):644-649.
    • (2000) Int J Cancer , vol.87 , Issue.5 , pp. 644-649
    • Tavian, D.1    De Petro, G.2    Benetti, A.3    Portolani, N.4    Giulini, S.M.5    Barlati, S.6
  • 251
    • 14844304638 scopus 로고    scopus 로고
    • Significant overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma using real-time quantitative reverse transcription polymerase chain reaction
    • Nielsen A, Scarlett CJ, Samra JS, Gill A, Li Y, Allen BJ, Smith RC. Significant overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma using real-time quantitative reverse transcription polymerase chain reaction. J Gastroenterol Hepatol 2005;20(2):256-263.
    • (2005) J Gastroenterol Hepatol , vol.20 , Issue.2 , pp. 256-263
    • Nielsen, A.1    Scarlett, C.J.2    Samra, J.S.3    Gill, A.4    Li, Y.5    Allen, B.J.6    Smith, R.C.7
  • 252
    • 45549094584 scopus 로고    scopus 로고
    • Prognostic significance of growth factors and the urokinase-type plasminogen activator system in pancreatic ductal adenocarcinoma
    • Xue A, Scarlett CJ, Jackson CJ, Allen BJ, Smith RC. Prognostic significance of growth factors and the urokinase-type plasminogen activator system in pancreatic ductal adenocarcinoma. Pancreas 2008;36(2):160-167.
    • (2008) Pancreas , vol.36 , Issue.2 , pp. 160-167
    • Xue, A.1    Scarlett, C.J.2    Jackson, C.J.3    Allen, B.J.4    Smith, R.C.5
  • 253
    • 67049164972 scopus 로고    scopus 로고
    • Amplification of the urokinase-type plasminogen activator receptor (uPAR) gene in ductal pancreatic carcinomas identifies a clinically high-risk group
    • Hildenbrand R, Niedergethmann M, Marx A, Belharazem D, Allgayer H, Schleger C, Strobel P. Amplification of the urokinase-type plasminogen activator receptor (uPAR) gene in ductal pancreatic carcinomas identifies a clinically high-risk group. Am J Pathol 2009;174(6):2246-2253.
    • (2009) Am J Pathol , vol.174 , Issue.6 , pp. 2246-2253
    • Hildenbrand, R.1    Niedergethmann, M.2    Marx, A.3    Belharazem, D.4    Allgayer, H.5    Schleger, C.6    Strobel, P.7
  • 254
  • 255
    • 80053996648 scopus 로고    scopus 로고
    • Elevated urinary levels of urokinase-type plasminogen activator receptor (uPAR) in pancreatic ductal adenocarcinoma identify a clinically high-risk group
    • Sorio C, Mafficini A, Furlan F, Barbi S, Bonora A, Brocco G, Blasi F, Talamini G, Bassi C, Scarpa A. Elevated urinary levels of urokinase-type plasminogen activator receptor (uPAR) in pancreatic ductal adenocarcinoma identify a clinically high-risk group. BMC Cancer 2011;11:448.
    • (2011) BMC Cancer , vol.11 , pp. 448
    • Sorio, C.1    Mafficini, A.2    Furlan, F.3    Barbi, S.4    Bonora, A.5    Brocco, G.6    Blasi, F.7    Talamini, G.8    Bassi, C.9    Scarpa, A.10
  • 258
    • 33847686021 scopus 로고    scopus 로고
    • High expression of plasminogen activator inhibitor-2 (PAI-2) is a predictor of improved survival in patients with pancreatic adenocarcinoma
    • discussion 503.
    • Smith R, Xue A, Gill A, Scarlett C, Saxby A, Clarkson A, Hugh T. High expression of plasminogen activator inhibitor-2 (PAI-2) is a predictor of improved survival in patients with pancreatic adenocarcinoma. World J Surg 2007;31(3):493-502; discussion 503.
    • (2007) World J Surg , vol.31 , Issue.3 , pp. 493-502
    • Smith, R.1    Xue, A.2    Gill, A.3    Scarlett, C.4    Saxby, A.5    Clarkson, A.6    Hugh, T.7
  • 260
    • 0035718420 scopus 로고    scopus 로고
    • Differential expression levels of urokinase-type plasminogen activator and cathepsin D in locally advanced laryngeal squamous cell carcinoma: Clinical implications
    • Leto G, Tumminello FM, Gebbia N, Bazan V, Tomasino RM, Dardanoni G, Russo A. Differential expression levels of urokinase-type plasminogen activator and cathepsin D in locally advanced laryngeal squamous cell carcinoma: Clinical implications. Int J Biol Markers 2001;16(4):245-249.
    • (2001) Int J Biol Markers , vol.16 , Issue.4 , pp. 245-249
    • Leto, G.1    Tumminello, F.M.2    Gebbia, N.3    Bazan, V.4    Tomasino, R.M.5    Dardanoni, G.6    Russo, A.7
  • 261
    • 33747199640 scopus 로고    scopus 로고
    • Expressions and clinical significance of urokinase-type activator (uPA) and uPA receptor (uPAR) in laryngeal squamous cell carcinoma
    • Wang D, Wang T. Expressions and clinical significance of urokinase-type activator (uPA) and uPA receptor (uPAR) in laryngeal squamous cell carcinoma. Lin Chuang Er Bi Yan Hou Ke Za Zhi 2005;19(12):529-531.
    • (2005) Lin Chuang Er Bi Yan Hou Ke Za Zhi , vol.19 , Issue.12 , pp. 529-531
    • Wang, D.1    Wang, T.2
  • 262
    • 0032127859 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) in tissue and serum of head and neck squamous cell carcinoma patients
    • Strojan P, Budihna M, Smid L, Vrhovec I, Skrk J. Urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) in tissue and serum of head and neck squamous cell carcinoma patients. Eur J Cancer 1998;34(8):1193-1197.
    • (1998) Eur J Cancer , vol.34 , Issue.8 , pp. 1193-1197
    • Strojan, P.1    Budihna, M.2    Smid, L.3    Vrhovec, I.4    Skrk, J.5
  • 263
    • 33746828304 scopus 로고    scopus 로고
    • Prognostic value of the urokinase-type plasminogen activator and its inhibitors in squamous cell carcinoma of human larynx
    • Zhao E, Han D, Yu Z, Fan E, Li Y, Zhou Z. Prognostic value of the urokinase-type plasminogen activator and its inhibitors in squamous cell carcinoma of human larynx. Lin Chuang Er Bi Yan Hou Ke Za Zhi 2002;16(11):599-602.
    • (2002) Lin Chuang Er Bi Yan Hou Ke Za Zhi , vol.16 , Issue.11 , pp. 599-602
    • Zhao, E.1    Han, D.2    Yu, Z.3    Fan, E.4    Li, Y.5    Zhou, Z.6
  • 264
    • 79954432662 scopus 로고    scopus 로고
    • Methylation status of uPA promoter in laryngeal squamous cell carcinoma
    • Wang D, Wang T, Ren Z. Methylation status of uPA promoter in laryngeal squamous cell carcinoma. Lin Chuang Er Bi Yan Hou Ke Za Zhi 2006;20(9):409-411.
    • (2006) Lin Chuang Er Bi Yan Hou Ke Za Zhi , vol.20 , Issue.9 , pp. 409-411
    • Wang, D.1    Wang, T.2    Ren, Z.3
  • 265
    • 14644400398 scopus 로고    scopus 로고
    • Increased plasma levels of urokinase plasminogen activator and matrix metalloproteinase-9 in nonsmall cell lung cancer patients
    • Yang SF, Hsieh YS, Lin CL, Hsu NY, Chiou HL, Chou FP, Chu SC. Increased plasma levels of urokinase plasminogen activator and matrix metalloproteinase-9 in nonsmall cell lung cancer patients. Clin Chim Acta 2005;354(1-2):91-99.
    • (2005) Clin Chim Acta , vol.354 , Issue.1-2 , pp. 91-99
    • Yang, S.F.1    Hsieh, Y.S.2    Lin, C.L.3    Hsu, N.Y.4    Chiou, H.L.5    Chou, F.P.6    Chu, S.C.7
  • 266
    • 79958036150 scopus 로고    scopus 로고
    • Detection of cathepsin B, cathepsin L, cystatin C, urokinase plasminogen activator and urokinase plasminogen activator receptor in the sera of lung cancer patients
    • Chen Q, Fei J, Wu L, Jiang Z, Wu Y, Zheng Y, Lu G. Detection of cathepsin B, cathepsin L, cystatin C, urokinase plasminogen activator and urokinase plasminogen activator receptor in the sera of lung cancer patients. Oncol Lett 2011;2(4):693-699.
    • (2011) Oncol Lett , vol.2 , Issue.4 , pp. 693-699
    • Chen, Q.1    Fei, J.2    Wu, L.3    Jiang, Z.4    Wu, Y.5    Zheng, Y.6    Lu, G.7
  • 268
    • 0033003596 scopus 로고    scopus 로고
    • The urokinase plasminogen activator receptor in blood from healthy individuals and patients with cancer
    • Brunner N, Nielsen HJ, Hamers M, Christensen IJ, Thorlacius-Ussing O, Stephens RW. The urokinase plasminogen activator receptor in blood from healthy individuals and patients with cancer. APMIS 1999;107(1):160-167.
    • (1999) APMIS , vol.107 , Issue.1 , pp. 160-167
    • Brunner, N.1    Nielsen, H.J.2    Hamers, M.3    Christensen, I.J.4    Thorlacius-Ussing, O.5    Stephens, R.W.6
  • 269
    • 0041328254 scopus 로고    scopus 로고
    • Pretreatment determination of the serum urokinase plasminogen activator and its soluble receptor in advanced small-cell lung cancer or non-small-cell lung cancer
    • Cobos E, Jumper C, Lox C. Pretreatment determination of the serum urokinase plasminogen activator and its soluble receptor in advanced small-cell lung cancer or non-small-cell lung cancer. Clin Appl Thromb Hemost 2003;9(3):241-246.
    • (2003) Clin Appl Thromb Hemost , vol.9 , Issue.3 , pp. 241-246
    • Cobos, E.1    Jumper, C.2    Lox, C.3
  • 270
    • 70349324792 scopus 로고    scopus 로고
    • Prognostic significance of urokinase plasminogen activator receptor and its cleaved forms in blood from patients with non-small cell lung cancer
    • Almasi CE, Hoyer-Hansen G, Christensen IJ, Pappot H. Prognostic significance of urokinase plasminogen activator receptor and its cleaved forms in blood from patients with non-small cell lung cancer. APMIS 2009;117(10):755-761.
    • (2009) APMIS , vol.117 , Issue.10 , pp. 755-761
    • Almasi, C.E.1    Hoyer-Hansen, G.2    Christensen, I.J.3    Pappot, H.4
  • 272
    • 0036335984 scopus 로고    scopus 로고
    • The circulating urokinase plasminogen activator (uPA) and its soluble receptor (suPAR) are not up-regulated by the circulating P105 fraction of the HER-2/neu proto-oncogene: In vivo evidence from patients with advanced non-small cell lung cancer (NSCLC)
    • Jumper C, Cobos E, Lox C. The circulating urokinase plasminogen activator (uPA) and its soluble receptor (suPAR) are not up-regulated by the circulating P105 fraction of the HER-2/neu proto-oncogene: In vivo evidence from patients with advanced non-small cell lung cancer (NSCLC). Anticancer Res 2002;22(4):2073-2076.
    • (2002) Anticancer Res , vol.22 , Issue.4 , pp. 2073-2076
    • Jumper, C.1    Cobos, E.2    Lox, C.3
  • 274
    • 0038558477 scopus 로고    scopus 로고
    • Urokinase-mediated posttranscriptional regulation of urokinase-receptor expression in non small cell lung carcinoma
    • Montuori N, Mattiello A, Mancini A, Taglialatela P, Caputi M, Rossi G, Ragno P. Urokinase-mediated posttranscriptional regulation of urokinase-receptor expression in non small cell lung carcinoma. Int J Cancer 2003;105(3):353-360.
    • (2003) Int J Cancer , vol.105 , Issue.3 , pp. 353-360
    • Montuori, N.1    Mattiello, A.2    Mancini, A.3    Taglialatela, P.4    Caputi, M.5    Rossi, G.6    Ragno, P.7
  • 276
    • 0033995384 scopus 로고    scopus 로고
    • The urokinase-type plasminogen activator system in resected non-small-cell lung cancer. Rotterdam Oncology Thoracic Study Group
    • Salden M, Splinter TA, Peters HA, Look MP, Timmermans M, van Meerbeeck JP, Foekens JA. The urokinase-type plasminogen activator system in resected non-small-cell lung cancer. Rotterdam Oncology Thoracic Study Group. Ann Oncol 2000;11(3):327-332.
    • (2000) Ann Oncol , vol.11 , Issue.3 , pp. 327-332
    • Salden, M.1    Splinter, T.A.2    Peters, H.A.3    Look, M.P.4    Timmermans, M.5    van Meerbeeck, J.P.6    Foekens, J.A.7
  • 277
    • 0034874279 scopus 로고    scopus 로고
    • Urokinase and tissue plasminogen activators and their inhibitor PAI-1 in human tumors
    • Gershtein ES, Kushlinskii NE. Urokinase and tissue plasminogen activators and their inhibitor PAI-1 in human tumors. Bull Exp Biol Med 2001;131(1):67-72.
    • (2001) Bull Exp Biol Med , vol.131 , Issue.1 , pp. 67-72
    • Gershtein, E.S.1    Kushlinskii, N.E.2
  • 279
    • 18844459391 scopus 로고    scopus 로고
    • Prognostic impact of liberated domain I of the urokinase plasminogen activator receptor in squamous cell lung cancer tissue
    • Almasi CE, Hoyer-Hansen G, Christensen IJ, Dano K, Pappot H. Prognostic impact of liberated domain I of the urokinase plasminogen activator receptor in squamous cell lung cancer tissue. Lung Cancer 2005;48(3):349-355.
    • (2005) Lung Cancer , vol.48 , Issue.3 , pp. 349-355
    • Almasi, C.E.1    Hoyer-Hansen, G.2    Christensen, I.J.3    Dano, K.4    Pappot, H.5
  • 280
    • 31344473450 scopus 로고    scopus 로고
    • The complex between urokinase (uPA) and its type-1 inhibitor (PAI-1) in pulmonary adenocarcinoma: Relation to prognosis
    • Pappot H, Pedersen AN, Brunner N, Christensen IJ. The complex between urokinase (uPA) and its type-1 inhibitor (PAI-1) in pulmonary adenocarcinoma: Relation to prognosis. Lung Cancer 2006;51(2):193-200.
    • (2006) Lung Cancer , vol.51 , Issue.2 , pp. 193-200
    • Pappot, H.1    Pedersen, A.N.2    Brunner, N.3    Christensen, I.J.4
  • 281
    • 0031679213 scopus 로고    scopus 로고
    • Significance of plasminogen activator inhibitor 2 as a prognostic marker in primary lung cancer: Association of decreased plasminogen activator inhibitor 2 with lymph node metastasis
    • Yoshino H, Endo Y, Watanabe Y, Sasaki T. Significance of plasminogen activator inhibitor 2 as a prognostic marker in primary lung cancer: Association of decreased plasminogen activator inhibitor 2 with lymph node metastasis. Br J Cancer 1998;78(6):833-839.
    • (1998) Br J Cancer , vol.78 , Issue.6 , pp. 833-839
    • Yoshino, H.1    Endo, Y.2    Watanabe, Y.3    Sasaki, T.4
  • 282
    • 40449101393 scopus 로고    scopus 로고
    • Influence of overexpressed coagulant and fibrolytic components in tumor tissues on the prognosis of non-small cell lung cancer
    • Chen WH, Wang C, Zhang YH, Yang YH, Zhan HY, Zhang LM. Influence of overexpressed coagulant and fibrolytic components in tumor tissues on the prognosis of non-small cell lung cancer. Zhonghua Yi Xue Za Zhi 2007;87(45):3228-3232.
    • (2007) Zhonghua Yi Xue Za Zhi , vol.87 , Issue.45 , pp. 3228-3232
    • Chen, W.H.1    Wang, C.2    Zhang, Y.H.3    Yang, Y.H.4    Zhan, H.Y.5    Zhang, L.M.6
  • 285
    • 0033126809 scopus 로고    scopus 로고
    • Relationship of urokinase and urokinase receptor in non-small cell lung cancer to proliferation, angiogenesis, metastasis and patient survival
    • Volm M, Mattern J, Koomagi R. Relationship of urokinase and urokinase receptor in non-small cell lung cancer to proliferation, angiogenesis, metastasis and patient survival. Oncol Rep 1999;6(3):611-615.
    • (1999) Oncol Rep , vol.6 , Issue.3 , pp. 611-615
    • Volm, M.1    Mattern, J.2    Koomagi, R.3
  • 286
    • 84905488668 scopus 로고    scopus 로고
    • The liberated domain I of urokinase plasminogen activator receptor - a new tumour marker in small cell lung cancer
    • Almasi CE, Drivsholm L, Pappot H, Hoyer-Hansen G, Christensen IJ. The liberated domain I of urokinase plasminogen activator receptor - a new tumour marker in small cell lung cancer. APMIS 2012.
    • (2012) APMIS
    • Almasi, C.E.1    Drivsholm, L.2    Pappot, H.3    Hoyer-Hansen, G.4    Christensen, I.J.5
  • 287
    • 33847671384 scopus 로고    scopus 로고
    • Urokinase plasminogen activator and plasminogen activator inhibitor type-1 in nonsmall-cell lung cancer: Relation to prognosis and angiogenesis
    • Offersen BV, Pfeiffer P, Andreasen P, Overgaard J. Urokinase plasminogen activator and plasminogen activator inhibitor type-1 in nonsmall-cell lung cancer: Relation to prognosis and angiogenesis. Lung Cancer 2007;56(1):43-50.
    • (2007) Lung Cancer , vol.56 , Issue.1 , pp. 43-50
    • Offersen, B.V.1    Pfeiffer, P.2    Andreasen, P.3    Overgaard, J.4
  • 298
    • 84867006576 scopus 로고    scopus 로고
    • From development to cancer: Lessons from the kidney to uncover new therapeutic targets
    • Dormoy V, Jacqmin D, Lang H, Massfelder T. From development to cancer: Lessons from the kidney to uncover new therapeutic targets. Anticancer Res 2012;32(9):3609-3617.
    • (2012) Anticancer Res , vol.32 , Issue.9 , pp. 3609-3617
    • Dormoy, V.1    Jacqmin, D.2    Lang, H.3    Massfelder, T.4
  • 300
    • 0024847605 scopus 로고
    • The study of plasminogen activator in renal cell carcinoma with special remarks on urokinase type plasminogen activator
    • Hata M. The study of plasminogen activator in renal cell carcinoma with special remarks on urokinase type plasminogen activator. Nihon Hinyokika Gakkai zasshi The japanese journal of urology 1989;80(11):1558-1565.
    • (1989) Nihon Hinyokika Gakkai zasshi The japanese journal of urology , vol.80 , Issue.11 , pp. 1558-1565
    • Hata, M.1
  • 301
    • 0031942989 scopus 로고    scopus 로고
    • Expression of the plasminogen activation system in kidney cancer correlates with its aggressive phenotype
    • Swiercz R, Wolfe JD, Zaher A, Jankun J. Expression of the plasminogen activation system in kidney cancer correlates with its aggressive phenotype. Clin Cancer Res 1998;4(4):869-877.
    • (1998) Clin Cancer Res , vol.4 , Issue.4 , pp. 869-877
    • Swiercz, R.1    Wolfe, J.D.2    Zaher, A.3    Jankun, J.4
  • 306
    • 22144436254 scopus 로고    scopus 로고
    • Expression of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and plasminogen activator inhibitors in patients with renal cell carcinoma: Correlation with tumor associated macrophage and prognosis
    • Ohba K, Miyata Y, Kanda S, Koga S, Hayashi T, Kanetake H. Expression of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and plasminogen activator inhibitors in patients with renal cell carcinoma: Correlation with tumor associated macrophage and prognosis. J Urol 2005;174(2):461-465.
    • (2005) J Urol , vol.174 , Issue.2 , pp. 461-465
    • Ohba, K.1    Miyata, Y.2    Kanda, S.3    Koga, S.4    Hayashi, T.5    Kanetake, H.6
  • 307
    • 0029898212 scopus 로고    scopus 로고
    • Clinical relevance of urokinase plasminogen activator, its receptor, and its inhibitor in patients with renal cell carcinoma
    • Hofmann R, Lehmer A, Buresch M, Hartung R, Ulm K. Clinical relevance of urokinase plasminogen activator, its receptor, and its inhibitor in patients with renal cell carcinoma. Cancer 1996;78(3):487-492.
    • (1996) Cancer , vol.78 , Issue.3 , pp. 487-492
    • Hofmann, R.1    Lehmer, A.2    Buresch, M.3    Hartung, R.4    Ulm, K.5
  • 308
    • 0030061899 scopus 로고    scopus 로고
    • Prognostic value of urokinase plasminogen activator and plasminogen activator inhibitor-1 in renal cell cancer
    • Hofmann R, Lehmer A, Hartung R, Robrecht C, Buresch M, Grothe F. Prognostic value of urokinase plasminogen activator and plasminogen activator inhibitor-1 in renal cell cancer. J Urol 1996;155(3):858-862.
    • (1996) J Urol , vol.155 , Issue.3 , pp. 858-862
    • Hofmann, R.1    Lehmer, A.2    Hartung, R.3    Robrecht, C.4    Buresch, M.5    Grothe, F.6
  • 309
    • 16344368632 scopus 로고    scopus 로고
    • Four tumour markers for urinary bladder cancer-tissue polypeptide antigen (TPA), HER-2/neu (ERB B2), urokinase-type plasminogen activator receptor (uPAR) and TP53 mutation
    • Ecke TH, Schlechte HH, Schulze G, Lenk SV, Loening SA. Four tumour markers for urinary bladder cancer-tissue polypeptide antigen (TPA), HER-2/neu (ERB B2), urokinase-type plasminogen activator receptor (uPAR) and TP53 mutation. Anticancer Res 2005;25(1B):635-641.
    • (2005) Anticancer Res , vol.25 B , Issue.1 , pp. 635-641
    • Ecke, T.H.1    Schlechte, H.H.2    Schulze, G.3    Lenk, S.V.4    Loening, S.A.5
  • 310
    • 0037114665 scopus 로고    scopus 로고
    • Urinary levels of urokinase-type plasminogen activator and its receptor in the detection of bladder carcinoma
    • Casella R, Shariat SF, Monoski MA, Lerner SP. Urinary levels of urokinase-type plasminogen activator and its receptor in the detection of bladder carcinoma. Cancer 2002;95(12):2494-2499.
    • (2002) Cancer , vol.95 , Issue.12 , pp. 2494-2499
    • Casella, R.1    Shariat, S.F.2    Monoski, M.A.3    Lerner, S.P.4
  • 311
    • 0037963311 scopus 로고    scopus 로고
    • Association of plasma urokinase-type plasminogen activator and its receptor with clinical outcome in patients undergoing radical cystectomy for transitional cell carcinoma of the bladder
    • Shariat SF, Monoski MA, Andrews B, Wheeler TM, Lerner SP, Slawin KM. Association of plasma urokinase-type plasminogen activator and its receptor with clinical outcome in patients undergoing radical cystectomy for transitional cell carcinoma of the bladder. Urology 2003;61(5):1053-1058.
    • (2003) Urology , vol.61 , Issue.5 , pp. 1053-1058
    • Shariat, S.F.1    Monoski, M.A.2    Andrews, B.3    Wheeler, T.M.4    Lerner, S.P.5    Slawin, K.M.6
  • 312
    • 0242440249 scopus 로고    scopus 로고
    • The addition of urinary urokinase-type plasminogen activator to urinary nuclear matrix protein 22 and cytology improves the detection of bladder cancer
    • Shariat SF, Casella R, Monoski MA, Sulser T, Gasser TC, Lerner SP. The addition of urinary urokinase-type plasminogen activator to urinary nuclear matrix protein 22 and cytology improves the detection of bladder cancer. J Urol 2003;170(6 Pt 1):2244-2247.
    • (2003) J Urol , vol.170 , Issue.6 PART 1 , pp. 2244-2247
    • Shariat, S.F.1    Casella, R.2    Monoski, M.A.3    Sulser, T.4    Gasser, T.C.5    Lerner, S.P.6
  • 313
    • 16644402997 scopus 로고    scopus 로고
    • In situ gene expression of urokinase-type plasminogen activator and its receptor in transitional cell carcinoma of the human bladder
    • Bhuvarahamurthy V, Schroeder J, Denkert C, Kristiansen G, Schnorr D, Loening SA, Jung K, Staack A. In situ gene expression of urokinase-type plasminogen activator and its receptor in transitional cell carcinoma of the human bladder. Oncol Rep 2004;12(4):909-913.
    • (2004) Oncol Rep , vol.12 , Issue.4 , pp. 909-913
    • Bhuvarahamurthy, V.1    Schroeder, J.2    Denkert, C.3    Kristiansen, G.4    Schnorr, D.5    Loening, S.A.6    Jung, K.7    Staack, A.8
  • 314
    • 1642446682 scopus 로고    scopus 로고
    • The expression of urokinase-type plasminogen activator and its receptor in urinary transitional cell carcinoma
    • Li YJ, Zheng BZ, Zhou ZL. The expression of urokinase-type plasminogen activator and its receptor in urinary transitional cell carcinoma. Sichuan Da Xue Xue Bao Yi Xue Ban 2004;35(1):57-59.
    • (2004) Sichuan Da Xue Xue Bao Yi Xue Ban , vol.35 , Issue.1 , pp. 57-59
    • Li, Y.J.1    Zheng, B.Z.2    Zhou, Z.L.3
  • 315
    • 0028057940 scopus 로고
    • The content of urokinase-type plasminogen activator and tumor recurrence in superficial bladder cancer
    • discussion 19-20.
    • Hasui Y, Marutsuka K, Nishi S, Kitada S, Osada Y, Sumiyoshi A. The content of urokinase-type plasminogen activator and tumor recurrence in superficial bladder cancer. J Urol 1994;151(1):16-19; discussion 19-20.
    • (1994) J Urol , vol.151 , Issue.1 , pp. 16-19
    • Hasui, Y.1    Marutsuka, K.2    Nishi, S.3    Kitada, S.4    Osada, Y.5    Sumiyoshi, A.6
  • 316
    • 0030044316 scopus 로고    scopus 로고
    • Prognostic value of urokinase-type plasminogen activator in patients with superficial bladder cancer
    • Hasui Y, Marutsuka K, Asada Y, Osada Y. Prognostic value of urokinase-type plasminogen activator in patients with superficial bladder cancer. Urology 1996;47(1):34-37.
    • (1996) Urology , vol.47 , Issue.1 , pp. 34-37
    • Hasui, Y.1    Marutsuka, K.2    Asada, Y.3    Osada, Y.4
  • 319
    • 16544371740 scopus 로고    scopus 로고
    • Association of uPA and uPAR expression with invasive behaviors of urinary transitional cell carcinoma
    • Li YJ, Zheng BZ, Zhou ZL. Association of uPA and uPAR expression with invasive behaviors of urinary transitional cell carcinoma. Ai Zheng 2004;23(6):704-706.
    • (2004) Ai Zheng , vol.23 , Issue.6 , pp. 704-706
    • Li, Y.J.1    Zheng, B.Z.2    Zhou, Z.L.3
  • 320
    • 0026603255 scopus 로고
    • The content of urokinase-type plasminogen activator antigen as a prognostic factor in urinary bladder cancer
    • Hasui Y, Marutsuka K, Suzumiya J, Kitada S, Osada Y, Sumiyoshi A. The content of urokinase-type plasminogen activator antigen as a prognostic factor in urinary bladder cancer. Int J Cancer 1992;50(6):871-873.
    • (1992) Int J Cancer , vol.50 , Issue.6 , pp. 871-873
    • Hasui, Y.1    Marutsuka, K.2    Suzumiya, J.3    Kitada, S.4    Osada, Y.5    Sumiyoshi, A.6
  • 323
    • 0032520105 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator, its inhibitor, and its receptor in patients with upper urinary tract carcinoma
    • Nakanishi K, Kawai T, Torikata C, Aurues T, Ikeda T. Urokinase-type plasminogen activator, its inhibitor, and its receptor in patients with upper urinary tract carcinoma. Cancer 1998;82(4):724-732.
    • (1998) Cancer , vol.82 , Issue.4 , pp. 724-732
    • Nakanishi, K.1    Kawai, T.2    Torikata, C.3    Aurues, T.4    Ikeda, T.5
  • 324
    • 12244295434 scopus 로고    scopus 로고
    • Plasminogen- and colony-stimulating factor-1-associated markers in bladder carcinoma: Diagnostic value of urokinase plasminogen activator receptor and plasminogen activator inhibitor type-2 using immunocytochemical analysis
    • Champelovier P, Boucard N, Levacher G, Simon A, Seigneurin D, Praloran V. Plasminogen- and colony-stimulating factor-1-associated markers in bladder carcinoma: Diagnostic value of urokinase plasminogen activator receptor and plasminogen activator inhibitor type-2 using immunocytochemical analysis. Urol Res 2002;30(5):301-309.
    • (2002) Urol Res , vol.30 , Issue.5 , pp. 301-309
    • Champelovier, P.1    Boucard, N.2    Levacher, G.3    Simon, A.4    Seigneurin, D.5    Praloran, V.6
  • 325
    • 12444284820 scopus 로고    scopus 로고
    • Immunohistochemical expressions of uPA and its receptor uPAR and their prognostic significant in urinary bladder carcinoma
    • El-Kott AF, Khalil AM, El-Kenawy Ael M. Immunohistochemical expressions of uPA and its receptor uPAR and their prognostic significant in urinary bladder carcinoma. Int Urol Nephrol 2004;36(3):417-423.
    • (2004) Int Urol Nephrol , vol.36 , Issue.3 , pp. 417-423
    • El-Kott, A.F.1    Khalil, A.M.2    El-Kenawy Ael, M.3
  • 326
    • 79960007941 scopus 로고    scopus 로고
    • Cytokine networks in glioma
    • discussion 263-254.
    • Iwami K, Natsume A, Wakabayashi T. Cytokine networks in glioma. Neurosurg Rev 2011;34(3):253-263; discussion 263-254.
    • (2011) Neurosurg Rev , vol.34 , Issue.3 , pp. 253-263
    • Iwami, K.1    Natsume, A.2    Wakabayashi, T.3
  • 327
    • 79251599407 scopus 로고    scopus 로고
    • Grading of gliomas: The road from eminence to evidence
    • Kros JM. Grading of gliomas: The road from eminence to evidence. J Neuropathol Exp Neurol 2011;70(2):101-109.
    • (2011) J Neuropathol Exp Neurol , vol.70 , Issue.2 , pp. 101-109
    • Kros, J.M.1
  • 329
  • 330
    • 0028859647 scopus 로고
    • Plasminogen activator inhibitor-1 in brain tumors: Relation to malignancy and necrosis
    • discussion 380-371.
    • Sawaya R, Yamamoto M, Ramo OJ, Shi ML, Rayford A, Rao JS. Plasminogen activator inhibitor-1 in brain tumors: Relation to malignancy and necrosis. Neurosurgery 1995;36(2):375-380; discussion 380-371.
    • (1995) Neurosurgery , vol.36 , Issue.2 , pp. 375-380
    • Sawaya, R.1    Yamamoto, M.2    Ramo, O.J.3    Shi, M.L.4    Rayford, A.5    Rao, J.S.6
  • 331
    • 0031803957 scopus 로고    scopus 로고
    • Production of urokinase-type plasminogen activator (u-PA) and plasminogen activator inhibitor-1 (PAI-1) in human brain tumours
    • discussion 385-376.
    • Arai Y, Kubota T, Nakagawa T, Kabuto M, Sato K, Kobayashi H. Production of urokinase-type plasminogen activator (u-PA) and plasminogen activator inhibitor-1 (PAI-1) in human brain tumours. Acta Neurochir 1998;140(4):377-385; discussion 385-376.
    • (1998) Acta Neurochir , vol.140 , Issue.4 , pp. 377-385
    • Arai, Y.1    Kubota, T.2    Nakagawa, T.3    Kabuto, M.4    Sato, K.5    Kobayashi, H.6
  • 332
    • 79959799979 scopus 로고    scopus 로고
    • uPA/PAI-1 expression and uPA promoter methylation in meningiomas
    • Kandenwein JA, Park-Simon TW, Schramm J, Simon M. uPA/PAI-1 expression and uPA promoter methylation in meningiomas. J Neurooncol 2011;103(3):533-539.
    • (2011) J Neurooncol , vol.103 , Issue.3 , pp. 533-539
    • Kandenwein, J.A.1    Park-Simon, T.W.2    Schramm, J.3    Simon, M.4
  • 333
    • 0042662973 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinases, their inhibitors, and urokinase plasminogen activator in human meningiomas
    • Siddique K, Yanamandra N, Gujrati M, Dinh D, Rao JS, Olivero W. Expression of matrix metalloproteinases, their inhibitors, and urokinase plasminogen activator in human meningiomas. Int J Oncol 2003;22(2):289-294.
    • (2003) Int J Oncol , vol.22 , Issue.2 , pp. 289-294
    • Siddique, K.1    Yanamandra, N.2    Gujrati, M.3    Dinh, D.4    Rao, J.S.5    Olivero, W.6
  • 334
    • 18044398758 scopus 로고    scopus 로고
    • High expression of urokinase plasminogen activator receptor (UPA-R) in acute myeloid leukemia (AML) is associated with worse prognosis
    • Graf M, Reif S, Hecht K, Pelka-Fleischer R, Pfister K, Schmetzer H. High expression of urokinase plasminogen activator receptor (UPA-R) in acute myeloid leukemia (AML) is associated with worse prognosis. Am J Hematol 2005;79(1):26-35.
    • (2005) Am J Hematol , vol.79 , Issue.1 , pp. 26-35
    • Graf, M.1    Reif, S.2    Hecht, K.3    Pelka-Fleischer, R.4    Pfister, K.5    Schmetzer, H.6
  • 335
  • 339
    • 0032910575 scopus 로고    scopus 로고
    • Blast cell-surface and plasma soluble urokinase receptor in acute leukemia patients: Relationship to classification and response to therapy
    • Mustjoki S, Alitalo R, Stephens RW, Vaheri A. Blast cell-surface and plasma soluble urokinase receptor in acute leukemia patients: Relationship to classification and response to therapy. Thromb Haemost 1999;81(5):705-710.
    • (1999) Thromb Haemost , vol.81 , Issue.5 , pp. 705-710
    • Mustjoki, S.1    Alitalo, R.2    Stephens, R.W.3    Vaheri, A.4
  • 341
    • 0035686340 scopus 로고    scopus 로고
    • Tissue- and urokinase-type plasminogen activators and type 1 plasminogen activator inhibitor in melanomas and benign skin pigment neoplasms
    • Gershtein ES, Medvedeva SV, Babkina IV, Kushlinskii NE, Trapeznikov NN. Tissue- and urokinase-type plasminogen activators and type 1 plasminogen activator inhibitor in melanomas and benign skin pigment neoplasms. Bull Exp Biol Med 2001;132(1):670-674.
    • (2001) Bull Exp Biol Med , vol.132 , Issue.1 , pp. 670-674
    • Gershtein, E.S.1    Medvedeva, S.V.2    Babkina, I.V.3    Kushlinskii, N.E.4    Trapeznikov, N.N.5
  • 343
    • 0642375754 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator and plasminogen activator inhibitor type 1 and type 2 in stage I malignant melanoma
    • Stabuc B, Markovic J, Bartenjev I, Vrhovec I, Medved U, Kocijancic B. Urokinase-type plasminogen activator and plasminogen activator inhibitor type 1 and type 2 in stage I malignant melanoma. Oncol Rep 2003;10(3):635-639.
    • (2003) Oncol Rep , vol.10 , Issue.3 , pp. 635-639
    • Stabuc, B.1    Markovic, J.2    Bartenjev, I.3    Vrhovec, I.4    Medved, U.5    Kocijancic, B.6
  • 344
    • 0038364216 scopus 로고    scopus 로고
    • The urokinase plasminogen activator system in cancer: Recent advances and implication for prognosis and therapy
    • Sidenius N, Blasi F. The urokinase plasminogen activator system in cancer: Recent advances and implication for prognosis and therapy. Cancer Metastasis Rev 2003;22(2-3):205-222.
    • (2003) Cancer Metastasis Rev , vol.22 , Issue.2-3 , pp. 205-222
    • Sidenius, N.1    Blasi, F.2
  • 345
    • 52049127235 scopus 로고    scopus 로고
    • A phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous A6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer
    • Ghamande SA, Silverman MH, Huh W, Behbakht K, Ball G, Cuasay L, Wurtz SO, Brunner N, Gold MA. A phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous A6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer. Gynecol Oncol 2008;111(1):89-94.
    • (2008) Gynecol Oncol , vol.111 , Issue.1 , pp. 89-94
    • Ghamande, S.A.1    Silverman, M.H.2    Huh, W.3    Behbakht, K.4    Ball, G.5    Cuasay, L.6    Wurtz, S.O.7    Brunner, N.8    Gold, M.A.9
  • 347
    • 84861189808 scopus 로고    scopus 로고
    • A phase II study of a urokinase-derived peptide (A6) in the treatment of persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma: A Gynecologic Oncology Group study
    • Gold MA, Brady WE, Lankes HA, Rose PG, Kelley JL, De Geest K, Crispens MA, Resnick KE, Howell SB. A phase II study of a urokinase-derived peptide (A6) in the treatment of persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma: A Gynecologic Oncology Group study. Gynecol Oncol 2012;125(3):635-639.
    • (2012) Gynecol Oncol , vol.125 , Issue.3 , pp. 635-639
    • Gold, M.A.1    Brady, W.E.2    Lankes, H.A.3    Rose, P.G.4    Kelley, J.L.5    De Geest, K.6    Crispens, M.A.7    Resnick, K.E.8    Howell, S.B.9
  • 348
    • 84905488659 scopus 로고    scopus 로고
    • 2005_EraofHope_WX_UK1_Poster.pdf.
    • 2005_EraofHope_WX_UK1_Poster.pdf. http://www.wilex.de/pdf/Poster/Poster_MESUPRON/2005_EraofHope_WX_UK1_Poster.pdf.
  • 349
    • 84905488660 scopus 로고    scopus 로고
    • 2008_EraofHope_WX_MESUPRON_Poster.pdf.
    • 2008_EraofHope_WX_MESUPRON_Poster.pdf. http://www.wilex.de/pdf/Poster/Poster_MESUPRON/2008_EraofHope_WX_MESUPRON_Poster.pdf.
  • 350
    • 84905488661 scopus 로고    scopus 로고
    • Phase I with WX-UK1.
    • Phase I with WX-UK1. http://www.wilex.de/portfolio-english/mesupron/phase-i-with-wx-uk1/.
  • 351
    • 84905488662 scopus 로고    scopus 로고
    • Phase I & II with MESUPRON®.
    • Phase I & II with MESUPRON®. http://www.wilex.de/portfolio-english/mesupron/phase-i-ii-with-mesu/.
  • 352
    • 84905488663 scopus 로고    scopus 로고
    • 2010_ASCO_Breast_PhII.pdf.
    • 2010_ASCO_Breast_PhII.pdf. http://www.wilex.de/pdf/Poster/Poster_MESUPRON/2010_ASCO_Breast_PhII.pdf.
  • 353
    • 84875215526 scopus 로고    scopus 로고
    • Phase II randomised proof-of-concept study of the urokinase inhibitor upamostat (WX-671) in combination with gemcitabine compared with gemcitabine alone in patients with non-resectable, locally advanced pancreatic cancer
    • Heinemann V, Ebert MP, Laubender RP, Bevan P, Mala C, Boeck S. Phase II randomised proof-of-concept study of the urokinase inhibitor upamostat (WX-671) in combination with gemcitabine compared with gemcitabine alone in patients with non-resectable, locally advanced pancreatic cancer. Br J Cancer 2013;108(4):766-770.
    • (2013) Br J Cancer , vol.108 , Issue.4 , pp. 766-770
    • Heinemann, V.1    Ebert, M.P.2    Laubender, R.P.3    Bevan, P.4    Mala, C.5    Boeck, S.6


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