메뉴 건너뛰기




Volumn 11, Issue 6, 2011, Pages 617-634

Cancer therapy trials employing level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1

Author keywords

clinical studies; clinical trials; individualized tailored cancer care; personalized cancer treatment; predictive impact; prognostic relevance; targeted therapy

Indexed keywords

ANTINEOPLASTIC AGENT; CAPECITABINE; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; EPIRUBICIN; ESTROGEN RECEPTOR; FLUOROURACIL; MESUPRON; METHOTREXATE; PLACEBO; PLASMINOGEN ACTIVATOR INHIBITOR; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROGESTERONE RECEPTOR; TAMOXIFEN; TAXANE DERIVATIVE; TRASTUZUMAB; TUMOR MARKER; UNCLASSIFIED DRUG; UROKINASE; WX 671;

EID: 79960209125     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/erm.11.47     Document Type: Review
Times cited : (86)

References (96)
  • 1
    • 0000256441 scopus 로고
    • Fibrinolytic activity of human tumors as measured by the fibrin-plate method
    • Cliffton EE, Grossi CE. Fibrinolytic activity of human tumors as measured by the fibrin-plate method. Cancer 8, 1146-1154 (1955)
    • (1955) Cancer , vol.8 , pp. 1146-1154
    • Cliffton, E.E.1    Grossi, C.E.2
  • 2
    • 56249137232 scopus 로고    scopus 로고
    • Assessment of urokinase-type plasminogen activator and its inhibitor PAI-1 in breast cancer tissue: Historical aspects and future prospects
    • S2
    • Schmitt M, Mengele K, Gkazepis A et al. Assessment of urokinase-type plasminogen activator and its inhibitor PAI-1 in breast cancer tissue: historical aspects and future prospects. Breast Care 3(S2), 3-10 (2008)
    • (2008) Breast Care , vol.3 , pp. 3-10
    • Schmitt, M.1    Mengele, K.2    Gkazepis, A.3
  • 3
    • 78649277216 scopus 로고    scopus 로고
    • Clinical utility of level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1
    • Schmitt M, Mengele K, Napieralski R et al. Clinical utility of level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1. Expert Rev. Mol. Diagn. 10(8), 1051-1067 (2010)
    • (2010) Expert Rev. Mol. Diagn , vol.10 , Issue.8 , pp. 1051-1067
    • Schmitt, M.1    Mengele, K.2    Napieralski, R.3
  • 4
    • 0036302814 scopus 로고    scopus 로고
    • Protease degradomics: A new challenge for proteomics
    • DOI 10.1038/nrm858
    • López-Otín C, Overall CM. Protease degradomics: a new challenge for proteomics. Nat. Rev. Mol. Cell. Biol. 3, 509-519 (2002) (Pubitemid 34733432)
    • (2002) Nature Reviews Molecular Cell Biology , vol.3 , Issue.7 , pp. 509-519
    • Lopez-Otin, C.1    Overall, C.M.2
  • 5
    • 78649269236 scopus 로고    scopus 로고
    • Characteristics of the level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1
    • Mengele K, Napieralski R, Magdolen V et al. Characteristics of the level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1. Expert Rev. Mol. Diagn. 10(7), 947-962 (2010)
    • (2010) Expert Rev. Mol. Diagn. , vol.10 , Issue.7 , pp. 947-962
    • Mengele, K.1    Napieralski, R.2    Magdolen, V.3
  • 7
    • 38649095227 scopus 로고    scopus 로고
    • UPA and PAI-1 in breast cancer: Review of their clinical utility and current validation in the prospective NNBC-3 trial
    • Annecke K, Schmitt M, Euler U et al. uPA and PAI-1 in breast cancer: review of their clinical utility and current validation in the prospective NNBC-3 trial. Adv. Clin. Chem. 45, 31-45 (2008)
    • (2008) Adv. Clin. Chem. , vol.45 , pp. 31-45
    • Annecke, K.1    Schmitt, M.2    Euler, U.3
  • 8
    • 0022353529 scopus 로고
    • Multiple forms of plasminogen activator in human breast tumors
    • O'Grady P, Lijnen HR, Duffy MJ. Multiple forms of plasminogen activator in human breast tumors. Cancer Res. 45(12 Pt 1), 6216-6218 (1985) (Pubitemid 16224783)
    • (1985) Cancer Research , vol.45 , Issue.12 , pp. 6216-6218
    • O'Grady, P.1    Lijnen, H.R.2    Duffy, M.J.3
  • 9
    • 56249089339 scopus 로고    scopus 로고
    • Prospective biomarker trials Chemo-N0 and NNBC-3 Europe validate the clinical utility of invasion markers uPA and PAI-1 in node-negative breast cancer
    • S2
    • Harbeck N, Schmitt M, Vetter M et al. Prospective biomarker trials Chemo-N0 and NNBC-3 Europe validate the clinical utility of invasion markers uPA and PAI-1 in node-negative breast cancer. Breast Care 3(S2), 11-15 (2008)
    • (2008) Breast Care , vol.3 , pp. 11-15
    • Harbeck, N.1    Schmitt, M.2    Vetter, M.3
  • 10
    • 33847052927 scopus 로고    scopus 로고
    • Tumor-associated proteolytic factors uPA and PAI-1: Critical appraisal of their clinical relevance in breast cancer and their integration into decision-support algorithms
    • Harbeck N, Schmitt M, Paepke S, Allgayer H, Kates RE. Tumor-associated proteolytic factors uPA and PAI-1: critical appraisal of their clinical relevance in breast cancer and their integration into decision-support algorithms. Crit. Rev. Clin. Lab. Sci. 44, 179-201 (2007)
    • (2007) Crit. Rev. Clin. Lab. Sci. , vol.44 , pp. 179-201
    • Harbeck, N.1    Schmitt, M.2    Paepke, S.3    Allgayer, H.4    Kates, R.E.5
  • 12
    • 1642375334 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1: Novel tumor-derived factors with a high prognostic and predictive impact in breast cancer
    • Harbeck N, Kates RE, Gauger K et al. Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-I: novel tumor-derived factors with a high prognostic and predictive impact in breast cancer. Thromb. Haemost. 91, 450-456 (2004) (Pubitemid 38396866)
    • (2004) Thrombosis and Haemostasis , vol.91 , Issue.3 , pp. 450-456
    • Harbeck, N.1    Kates, R.E.2    Gauger, K.3    Willems, A.4    Kiechle, M.5    Magdolen, V.6    Schmitt, M.7
  • 13
    • 78349310879 scopus 로고    scopus 로고
    • Personalized treatment of early-stage breast cancer: Present concepts and future directions
    • Harbeck N, Salem M, Nitz U, Gluz O, Liedtke C. Personalized treatment of early-stage breast cancer: present concepts and future directions. Cancer Treat. Rev. 36, 584-594 (2010)
    • (2010) Cancer Treat. Rev. , vol.36 , pp. 584-594
    • Harbeck, N.1    Salem, M.2    Nitz, U.3    Gluz, O.4    Liedtke, C.5
  • 14
    • 15544384884 scopus 로고    scopus 로고
    • Gene expression profiling of breast cancer: A new tumor marker
    • DOI 10.1200/JCO.2005.12.005
    • van't Veer LJ, Paik S, Hayes DF. Gene expression profiling of breast cancer: a new tumor marker. J. Clin. Oncol. 23, 1631-1635 (2005) (Pubitemid 46211417)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.8 , pp. 1631-1635
    • Van't Veer, L.J.1    Paik, S.2    Hayes, D.F.3
  • 15
    • 71749091235 scopus 로고    scopus 로고
    • Prediction of adjuvant chemotherapy benefit in endocrine responsive, early breast cancer using multigene assays
    • Albain KS, Paik S, van't Veer L. Prediction of adjuvant chemotherapy benefit in endocrine responsive, early breast cancer using multigene assays. Breast 18(Suppl. 3), S141-S145 (2009)
    • (2009) Breast , vol.18 , Issue.SUPPL. 3
    • Albain, K.S.1    Paik, S.2    Van't Veer, L.3
  • 18
    • 14044250220 scopus 로고    scopus 로고
    • Adjuvant chemotherapy for primary breast cancer
    • Fornier M, Hudis C. Adjuvant chemotherapy for primary breast cancer. Curr. Oncol. Rep. 7, 18-22 (2005) (Pubitemid 40277586)
    • (2005) Current Oncology Reports , vol.7 , Issue.1 , pp. 18-22
    • Fornier, M.1    Hudis, C.2
  • 19
    • 9144268610 scopus 로고    scopus 로고
    • Facts and controversies in systemic treatment of metastatic breast cancer
    • DOI 10.1634/theoncologist.9-6-617
    • Bernard-Marty C, Cardoso F, Piccart MJ. Facts and controversies in systemic treatment of metastatic breast cancer. Oncologist 9, 617-632 (2004) (Pubitemid 39546403)
    • (2004) Oncologist , vol.9 , Issue.6 , pp. 617-632
    • Bernard-Marty, C.1    Cardoso, F.2    Piccart, M.J.3
  • 20
    • 0037083657 scopus 로고    scopus 로고
    • Clinical relevance of invasion factors urokinase-type plasminogen activator and plasminogen activator inhibitor type 1 for individualized therapy decisions in primary breast cancer is greatest when used in combination
    • DOI 10.1200/JCO.20.4.1000
    • Harbeck N, Kates RE, Schmitt M. Clinical relevance of invasion factors urokinase-type plasminogen activator and plasminogen activator inhibitor type 1 for individualized therapy decisions in primary breast cancer is greatest when used in combination. J. Clin. Oncol. 20, 1000-1007 (2002) (Pubitemid 34141844)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.4 , pp. 1000-1007
    • Harbeck, N.1    Kates, R.E.2    Schmitt, M.3
  • 21
    • 0037102368 scopus 로고    scopus 로고
    • Enhanced benefit from adjuvant chemotherapy in breast cancer patients classified high-risk according to urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (n = 3424
    • Harbeck N, Kates RE, Look MP et al. Enhanced benefit from adjuvant chemotherapy in breast cancer patients classified high-risk according to urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (n = 3424). Cancer Res. 62, 4617-4622 (2002)
    • (2002) Cancer Res. , vol.62 , pp. 4617-4622
    • Harbeck, N.1    Kates, R.E.2    Look, M.P.3
  • 25
    • 0028358771 scopus 로고
    • Both the cytosols and detergent extracts of breast cancer tissues are suited to evaluate the prognostic impact of the urokinase-type plasminogen activator and its inhibitor, plasminogen activator inhibitor type 1
    • Jänicke F, Pache L, Schmitt M et al. Both the cytosols and detergent extracts of breast cancer tissues are suited to evaluate the prognostic impact of the urokinase-type plasminogen activator and its inhibitor, plasminogen activator inhibitor type 1. Cancer Res. 54, 2527-2530 (1994)
    • (1994) Cancer Res. , vol.54 , pp. 2527-2530
    • Jänicke, F.1    Pache, L.2    Schmitt, M.3
  • 26
    • 77950558276 scopus 로고    scopus 로고
    • Final 10-year analysis of prospective multicenter Chemo-N0 trial for validation of ASCO-recommended biomarkers uPA/PAI-1 for therapy decision making in node-negative breast cancer
    • (Abstract 511
    • Harbeck N, Schmitt M, Meisner C et al. Final 10-year analysis of prospective multicenter Chemo-N0 trial for validation of ASCO-recommended biomarkers uPA/PAI-1 for therapy decision making in node-negative breast cancer. J. Clin. Oncol. 27, 15S(Suppl.) (2009) (Abstract 511)
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL.
    • Harbeck, N.1    Schmitt, M.2    Meisner, C.3
  • 29
    • 67650834986 scopus 로고    scopus 로고
    • Feasibility of measuring the prognostic factors uPA and PAI-1 in core needle biopsy breast cancer specimens
    • Thomssen C, Harbeck N, Dittmer J et al. Feasibility of measuring the prognostic factors uPA and PAI-1 in core needle biopsy breast cancer specimens. J. Natl Cancer Inst. 101, 1028-1029 (2009)
    • (2009) J. Natl Cancer Inst. , vol.101 , pp. 1028-1029
    • Thomssen, C.1    Harbeck, N.2    Dittmer, J.3
  • 30
    • 78650657304 scopus 로고    scopus 로고
    • UPA and PAI-1 analysis from fixed tissues - New perspectives for a known set of predictive markers
    • Malinowsky K, Ballner C, Hipp S, Berg D, Schmitt M, Becker KF. uPA and PAI-1 analysis from fixed tissues - new perspectives for a known set of predictive markers. Curr. Med. Chem. 17, 4370-4377 (2010)
    • (2010) Curr. Med. Chem. , vol.17 , pp. 4370-4377
    • Malinowsky, K.1    Ballner, C.2    Hipp, S.3    Berg, D.4    Schmitt, M.5    Becker, K.F.6
  • 31
    • 24644505437 scopus 로고    scopus 로고
    • Measurement of plasminogen activator system components in plasma and tumor tissue extracts obtained from patients with breast cancer: An EORTC Receptor and Biomarker Group collaboration
    • Grebenchtchikov N, Maguire TM, Riisbro R et al. Measurement of plasminogen activator system components in plasma and tumor tissue extracts obtained from patients with breast cancer: an EORTC Receptor and Biomarker Group collaboration. Oncol. Rep. 14, 235-239 (2005)
    • (2005) Oncol. Rep. , vol.14 , pp. 235-239
    • Grebenchtchikov, N.1    Maguire, T.M.2    Riisbro, R.3
  • 32
    • 0034873706 scopus 로고    scopus 로고
    • Adjuvant therapy of primary breast cancer: A review of key findings from the 7th International Conference, St. Gallen, February 2001
    • DOI 10.1634/theoncologist.6-4-376
    • Aapro MS. Adjuvant therapy of primary breast cancer: a review of key findings from the 7th international conference, St. Gallen, February 2001. Oncologist 6, 376-385 (2001) (Pubitemid 32816543)
    • (2001) Oncologist , vol.6 , Issue.4 , pp. 376-385
    • Aapro, M.S.1
  • 34
    • 78649732579 scopus 로고    scopus 로고
    • Adjuvant docetaxel for high-risk, node-negative breast cancer
    • Martín M, Seguí MA, Antón A et al. Adjuvant docetaxel for high-risk, node-negative breast cancer. N. Engl. J. Med. 363, 2200-2210 (2010)
    • (2010) N. Engl. J. Med. , vol.363 , pp. 2200-2210
    • Martín, M.1    Seguí, M.A.2    Antón, A.3
  • 35
    • 0035884636 scopus 로고    scopus 로고
    • Meeting highlights: International consensus panel on the treatment of primary breast cancer
    • Goldhirsch A, Glick JH, Gelber RD, Coates AS, Senn HJ. Meeting highlights: International Consensus Panel on the Treatment of Primary Breast Cancer Seventh International Conference on Adjuvant Therapy of Primary Breast Cancer. J. Clin. Oncol. 19, 3817-3827 (2001) (Pubitemid 32880060)
    • (2001) Journal of Clinical Oncology , vol.19 , Issue.18 , pp. 3817-3827
    • Goldhirsch, A.1    Glick, J.H.2    Gelber, R.D.3    Coates, A.S.4    Hans-Jorg, S.5
  • 36
    • 34548625292 scopus 로고    scopus 로고
    • Trastuzumab in the adjuvant treatment of breast cancer
    • Svetlovska D, Mardiak J, Kristova V. Trastuzumab in the adjuvant treatment of breast cancer. Bratisl. Lek. Listy 108, 100-103 (2007)
    • (2007) Bratisl. Lek. Listy , vol.108 , pp. 100-103
    • Svetlovska, D.1    Mardiak, J.2    Kristova, V.3
  • 37
    • 79960283783 scopus 로고    scopus 로고
    • Risk group selection in primary breast cancer according to ASCO recommended biomarkers Oncotype DX and uPA/PAI-1. First experience from prospective multicenter WSG Plan B trial
    • (Abstract P2-09-05
    • Degenhardt T, Gluz O, Thomssen C et al. Risk group selection in primary breast cancer according to ASCO recommended biomarkers Oncotype DX and uPA/PAI-1. First experience from prospective multicenter WSG Plan B trial. Cancer Res. 70, 209S (2010) (Abstract P2-09-05)
    • (2010) Cancer Res. , vol.70
    • Degenhardt, T.1    Gluz, O.2    Thomssen, C.3
  • 39
    • 55249116037 scopus 로고    scopus 로고
    • Trial assessing individualized options for treatment for breast cancer, the TAILORx trial
    • Zujewski JA, Kamin L. Trial assessing individualized options for treatment for breast cancer, the TAILORx trial. Future Oncol. 4, 603-610 (2008)
    • (2008) Future Oncol , vol.4 , pp. 603-610
    • Zujewski, J.A.1    Kamin, L.2
  • 40
    • 77951637777 scopus 로고    scopus 로고
    • Prediction of risk of distant recurrence using the 21-gene recurrence score in node-negative and node-positive postmenopausal patients with breast cancer treated with anastrozole or tamoxifen, a transATAC study
    • Dowsett M, Cuzick J, Wale C et al. Prediction of risk of distant recurrence using the 21-gene recurrence score in node-negative and node-positive postmenopausal patients with breast cancer treated with anastrozole or tamoxifen, a transATAC study. J. Clin. Oncol. 28, 1829-1834 (2010)
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1829-1834
    • Dowsett, M.1    Cuzick, J.2    Wale, C.3
  • 41
    • 0035408087 scopus 로고    scopus 로고
    • Interference with the urokinase plasminogen activator system: A promising therapy concept for solid tumours
    • Muehlenweg B, Sperl S, Magdolen V, Schmitt M, Harbeck N. Interference with the urokinase plasminogen activator system: a promising therapy concept for solid tumours. Expert Opin. Biol. Ther. 1, 683-961 (2001)
    • (2001) Expert Opin. Biol. Ther. , vol.1 , pp. 683-961
    • Muehlenweg, B.1    Sperl, S.2    Magdolen, V.3    Schmitt, M.4    Harbeck, N.5
  • 43
    • 0034629461 scopus 로고    scopus 로고
    • Re-engineering of human urokinase provides a system for structure-based drug design at high resolution and reveals a novel structural subsite
    • DOI 10.1074/jbc.275.10.7239
    • Nienaber V, Wang J, Davidson D, Henkin J. Re-engineering of human urokinase provides a system for structure-based drug design at high resolution and reveals a novel structural subsite. J. Biol. Chem. 275, 7239-7248 (2000) (Pubitemid 30146275)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.10 , pp. 7239-7248
    • Nienaber, V.1    Wang, J.2    Davidson, D.3    Henkin, J.4
  • 45
    • 77749307359 scopus 로고    scopus 로고
    • Inhibition of urokinase activity reduces primary tumor growth and metastasis formation in a murine lung carcinoma model
    • Henneke I, Greschus S, Savai R et al. Inhibition of urokinase activity reduces primary tumor growth and metastasis formation in a murine lung carcinoma model. Am. J. Respir. Crit. Care Med. 181, 611-619 (2010)
    • (2010) Am. J. Respir. Crit. Care Med. , vol.181 , pp. 611-619
    • Henneke, I.1    Greschus, S.2    Savai, R.3
  • 46
    • 37449014883 scopus 로고    scopus 로고
    • Small, potent, and selective diaryl phosphonate inhibitors for urokinase-type plasminogen activator with in vivo antimetastatic properties
    • Joossens J, Ali OM, El-Sayed I et al. Small, potent, and selective diaryl phosphonate inhibitors for urokinase-type plasminogen activator with in vivo antimetastatic properties. J. Med. Chem. 50, 6638-6646 (2007)
    • (2007) J. Med. Chem. , vol.50 , pp. 6638-6646
    • Joossens, J.1    Ali, O.M.2    El-Sayed, I.3
  • 47
    • 56249141809 scopus 로고    scopus 로고
    • Experience in Phase i trials and an upcoming Phase II study with uPA inhibitors in metastatic breast cancer
    • S2
    • Goldstein LJ. Experience in Phase I trials and an upcoming Phase II study with uPA inhibitors in metastatic breast cancer. Breast Care 3(S2), 25-28 (2008)
    • (2008) Breast Care , vol.3 , pp. 25-28
    • Goldstein, L.J.1
  • 48
    • 78649245011 scopus 로고    scopus 로고
    • Randomized Phase II trial with an uPA inhibitor (WX-671) in patients with locally advanced nonmetastatic pancreatic cancer
    • (Abstract 4060
    • Heinemann V, Ebert MP, Pinter T, Bevan P, Neville NG, Mala C. Randomized Phase II trial with an uPA inhibitor (WX-671) in patients with locally advanced nonmetastatic pancreatic cancer. J. Clin. Oncol. 28, 15S(Suppl.) (2010) (Abstract 4060)
    • (2010) J. Clin. Oncol. , vol.28 , Issue.SUPPL.
    • Heinemann, V.1    Ebert, M.P.2    Pinter, T.3    Bevan, P.4    Neville, N.G.5    Mala, C.6
  • 49
    • 78649305580 scopus 로고    scopus 로고
    • Phase II, two-arm, double-blind, multicenter, randomized study of the combination of oral WX-671 plus capecitabine versus capecitabine in first-line HER2-negative metastatic breast cancer (MBC
    • (Abstract TPS131
    • Goldstein LJ, Stemmer SM, Schmalfeldt B et al. Phase II, two-arm, double-blind, multicenter, randomized study of the combination of oral WX-671 plus capecitabine versus capecitabine in first-line HER2-negative metastatic breast cancer (MBC). J. Clin. Oncol. 28, 15S(Suppl.) (2010) (Abstract TPS131)
    • (2010) J. Clin. Oncol. , vol.28 , Issue.SUPPL.
    • Goldstein, L.J.1    Stemmer, S.M.2    Schmalfeldt, B.3
  • 51
  • 53
    • 0037102259 scopus 로고    scopus 로고
    • An antiangiogenic urokinase-derived peptide combined with tamoxifen decreases tumor growth and metastasis in a syngeneic model of breast cancer
    • Guo Y, Mazar AP, Lebrun JJ, Rabbani SA. An antiangiogenic urokinase-derived peptide combined with tamoxifen decreases tumor growth and metastasis in a syngeneic model of breast cancer. Cancer Res. 62, 4678-4684 (2002)
    • (2002) Cancer Res. , vol.62 , pp. 4678-4684
    • Guo, Y.1    Mazar, A.P.2    Lebrun, J.J.3    Rabbani, S.A.4
  • 54
    • 0037289755 scopus 로고    scopus 로고
    • A urokinase-derived peptide (A6) increases survival of mice bearing orthotopically grown prostate cancer and reduces lymph node metastasis
    • Boyd DD, Kim SJ, Wang H, Jones TR, Gallick GE. A urokinase-derived peptide (A6) increases survival of mice bearing orthotopically grown prostate cancer and reduces lymph node metastasis. Am. J. Pathol. 162, 619-626 (2003) (Pubitemid 36267868)
    • (2003) American Journal of Pathology , vol.162 , Issue.2 , pp. 619-626
    • Boyd, D.D.1    Kim, S.-J.2    Wang, H.3    Jones, T.R.4    Gallick, G.E.5
  • 56
    • 79960244249 scopus 로고    scopus 로고
    • A6 peptide exhibits potent anti chemotactic activity against human breast and ovarian cancer cell lines
    • San Diego, CA, USA 12-16 April Abstract 1170
    • Damaj BB, Wen Y, Schneider L, Howell S, Finlayson F. A6 peptide exhibits potent anti chemotactic activity against human breast and ovarian cancer cell lines. Presented at: American Association for Cancer Research Annual Meeting. San Diego, CA, USA, 12-16 April 2008 (Abstract 1170)
    • (2008) American Association for Cancer Research Annual Meeting
    • Damaj, B.B.1    Wen, Y.2    Schneider, L.3    Howell, S.4    Finlayson, F.5
  • 61
    • 52049127235 scopus 로고    scopus 로고
    • A Phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous A6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer
    • Ghamande SA, Silverman MH, Huh W et al. A Phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous A6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer. Gynecol. Oncol. 111, 89-94 (2008)
    • (2008) Gynecol. Oncol. , vol.111 , pp. 89-94
    • Ghamande, S.A.1    Silverman, M.H.2    Huh, W.3
  • 62
    • 51349095135 scopus 로고    scopus 로고
    • A peptide inhibitor of the urokinase/urokinase receptor system inhibits alteration of the blood-retinal barrier in diabetes
    • Navaratna D, Menicucci G, Maestas J, Srinivasan R, McGuire P, Das A. A peptide inhibitor of the urokinase/urokinase receptor system inhibits alteration of the blood-retinal barrier in diabetes. FASEB J. 22, 3310-3317 (2008)
    • (2008) FASEB J. , vol.22 , pp. 3310-3317
    • Navaratna, D.1    Menicucci, G.2    Maestas, J.3    Srinivasan, R.4    McGuire, P.5    Das, A.6
  • 64
    • 33645741867 scopus 로고    scopus 로고
    • Effect of a novel octapeptide urokinase fragment, A°6, on experimental choroidal neovascularization in the monkey
    • DOI 10.1097/00006982-200602000-00014, PII 0000698220060200000014
    • Koh HJ, Freeman WR, Azen SP et al. Effect of a novel octapeptide urokinase fragment, A6, on experimental choroidal neovascularization in the monkey. Retina 26, 202-209 (2006) (Pubitemid 44400718)
    • (2006) Retina , vol.26 , Issue.2 , pp. 202-209
    • Koh, H.J.1    Freeman, W.R.2    Azen, S.P.3    Flaxel, C.J.4    Labree, L.D.5    Cheng, L.6    Wills, M.7    Jones, T.R.8
  • 65
    • 0023735157 scopus 로고
    • Urokinase-plasminogen activator, a marker for aggressive breast carcinomas. Preliminary report
    • Duffy MJ, O'Grady P, Devaney D, O'Siorain L, Fennelly JJ, Lijnen HJ. Urokinase-plasminogen activator, a marker for aggressive breast carcinomas. Preliminary report. Cancer 62, 531-533 (1988)
    • (1988) Cancer , vol.62 , pp. 531-533
    • Duffy, M.J.1    O'Grady, P.2    Devaney, D.3    O'Siorain, L.4    Fennelly, J.J.5    Lijnen, H.J.6
  • 66
    • 0024428950 scopus 로고
    • Urokinase-type plasminogen activator antigen and early relapse in breast cancer
    • Jänicke F, Schmitt M, Ulm K, Gossner W, Graeff H. Urokinase-type plasminogen activator antigen and early relapse in breast cancer. Lancet 2(8670), 1049 (1989) (Pubitemid 19257967)
    • (1989) Lancet , vol.2 , Issue.8670 , pp. 1049
    • Janicke, F.1    Schmitt, M.2    Ulm, K.3    Gossner, W.4    Graeff, H.5
  • 67
    • 0025995880 scopus 로고
    • Clinical relevance of the urokinase-type and tissue-type plasminogen activators and of their type 1 inhibitor in breast cancer
    • Jänicke F, Schmitt M, Graeff H. Clinical relevance of the urokinase-type and tissue-type plasminogen activators and of their type 1 inhibitor in breast cancer. Semin. Thromb. Hemost. 17, 303-312 (1991)
    • (1991) Semin. Thromb. Hemost. , vol.17 , pp. 303-312
    • Jänicke, F.1    Schmitt, M.2    Graeff, H.3
  • 69
    • 77954442176 scopus 로고    scopus 로고
    • Optimizing chemotherapy regimens for patients with early-stage breast
    • Dotan E, Goldstein LJ. Optimizing chemotherapy regimens for patients with early-stage breast Cancer Clin. Breast Cancer 10(Suppl. 1), E8-E15 (2010)
    • (2010) Cancer Clin. Breast Cancer , vol.10 , Issue.SUPPL. 1
    • Dotan, E.1    Goldstein, L.J.2
  • 72
    • 77952348327 scopus 로고    scopus 로고
    • RNA aptamers as conformational probes and regulatory agents for plasminogen activator inhibitor-1
    • Madsen JB, Dupont DM, Andersen TB et al. RNA aptamers as conformational probes and regulatory agents for plasminogen activator inhibitor-1. Biochemistry 49, 4103-4115 (2010)
    • (2010) Biochemistry , vol.49 , pp. 4103-4115
    • Madsen, J.B.1    Dupont, D.M.2    Andersen, T.B.3
  • 73
    • 35348834104 scopus 로고    scopus 로고
    • PAI-1 - A potential therapeutic target in cancer
    • DOI 10.2174/138945007781662346
    • Andreasen PA. PAI-1 - a potential therapeutic target in cancer. Curr. Drug Targets 8, 1030-1041 (2007) (Pubitemid 47578151)
    • (2007) Current Drug Targets , vol.8 , Issue.9 , pp. 1030-1041
    • Andreasen, P.A.1
  • 74
    • 33745641883 scopus 로고    scopus 로고
    • Uses and abuses of tumor markers in the diagnosis, monitoring, and treatment of primary and metastatic breast cancer
    • DOI 10.1634/theoncologist.11-6-541
    • Henri NL, Hayes DF. Uses and abuses of tumor markers in the diagnosis, monitoring, and treatment of primary and metastatic breast Cancer Oncol. 11, 541-552 (2006). (Pubitemid 43967610)
    • (2006) Oncologist , vol.11 , Issue.6 , pp. 541-552
    • Henry, N.L.1    Hayes, D.F.2
  • 76
    • 60849097255 scopus 로고    scopus 로고
    • Gene-expression signatures in breast cancer
    • Sotiriou C, Pusztai L. Gene-expression signatures in breast cancer. N. Engl. J. Med. 360, 790-800 (2009)
    • (2009) N. Engl. J. Med. , vol.360 , pp. 790-800
    • Sotiriou, C.1    Pusztai, L.2
  • 77
    • 78149342432 scopus 로고    scopus 로고
    • ASCO Clinical Practice Guideline on uses of serum tumor markers in adult males with germ cell tumors
    • Gilligan TD, Hayes DF, Seidenfeld J, Temin S. ASCO Clinical Practice Guideline on uses of serum tumor markers in adult males with germ cell tumors. J. Oncol. Pract. 6, 199-202 (2010)
    • (2010) J. Oncol. Pract. , vol.6 , pp. 199-202
    • Gilligan, T.D.1    Hayes, D.F.2    Seidenfeld, J.3    Temin, S.4
  • 79
    • 77952982992 scopus 로고    scopus 로고
    • National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for use of tumor markers in liver, bladder, cervical, and gastric cancers
    • Sturgeon CM, Duffy MJ, Hofmann BR et al. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for use of tumor markers in liver, bladder, cervical, and gastric cancers. Clin. Chem. 56(6), E1-E48 (2010)
    • (2010) Clin. Chem , vol.56 , Issue.6
    • Sturgeon, C.M.1    Duffy, M.J.2    Hofmann, B.R.3
  • 81
    • 79957582351 scopus 로고    scopus 로고
    • A new look at node-negative breast cancer
    • Harbeck N, Thomssen C. A new look at node-negative breast cancer. Oncologist 16(Suppl. 1), 51-60 (2011)
    • (2011) Oncologist , vol.16 , Issue.SUPPL. 1 , pp. 51-60
    • Harbeck, N.1    Thomssen, C.2
  • 82
    • 35748943826 scopus 로고    scopus 로고
    • Anti-cancer therapies targeting the tumor stroma
    • DOI 10.1007/s00262-007-0365-5
    • Hofmeister V, Schrama D, Becker JC. Anti-cancer therapies targeting the tumor stroma. Cancer Immunol. Immunother. 57, 1-17 (2008) (Pubitemid 350043655)
    • (2008) Cancer Immunology, Immunotherapy , vol.57 , Issue.1 , pp. 1-17
    • Hofmeister, V.1    Schrama, D.2    Becker, J.C.3
  • 83
    • 79951579884 scopus 로고    scopus 로고
    • The plasmin-antiplasmin system: Structural and functional aspects
    • Schaller J, Gerber SS. The plasmin-antiplasmin system: structural and functional aspects. Cell. Mol. Life Sci. 68, 785-801 (2011)
    • (2011) Cell. Mol. Life Sci. , vol.68 , pp. 785-801
    • Schaller, J.1    Gerber, S.S.2
  • 84
    • 57749189817 scopus 로고    scopus 로고
    • New insights into the molecular mechanisms of the fibrinolytic system
    • Rijken DC, Lijnen HR. New insights into the molecular mechanisms of the fibrinolytic system. J. Thromb. Haemost. 7, 4-13 (2009)
    • (2009) J. Thromb. Haemost. , vol.7 , pp. 4-13
    • Rijken, D.C.1    Lijnen, H.R.2
  • 85
    • 79955660079 scopus 로고    scopus 로고
    • Prospective evaluation of prognostic factors uPA/PAI-1 in node-negative breast cancer: Phase III NNBC3-Europe trial (AGO, GBG, EORTC-PBG) comparing 6 A FEC versus 3 A FEC/3 A docetaxel
    • Kantelhardt EJ, Vetter M, Schmidt M et al. Prospective evaluation of prognostic factors uPA/PAI-1 in node-negative breast cancer: Phase III NNBC3-Europe trial (AGO, GBG, EORTC-PBG) comparing 6 A FEC versus 3 A FEC/3 A docetaxel. BMC Cancer 11, 140 (2011)
    • (2011) BMC Cancer , vol.11 , pp. 140
    • Kantelhardt, E.J.1    Vetter, M.2    Schmidt, M.3
  • 88
    • 79960241079 scopus 로고    scopus 로고
    • German Breast Group
    • German Breast Group www.germanbreastgroup.de
  • 89
    • 79960286838 scopus 로고    scopus 로고
    • WILEX AG
    • WILEX AG www.wilex.com
  • 91
    • 79960226137 scopus 로고    scopus 로고
    • National Cancer Institute cancer staging
    • National Cancer Institute: cancer staging www.cancer.gov/cancertopics/ factsheet/ detection/staging
  • 93
    • 79960277768 scopus 로고    scopus 로고
    • Bio-Quant www.bio-quant.com
    • Bio-Quant
  • 94
    • 79960232536 scopus 로고    scopus 로고
    • EORTC. MINDACT
    • EORTC. MINDACT www.eortc.be/services/unit/mindact/ documents/MINDACT- trial-outline.pdf
  • 96
    • 79960260400 scopus 로고    scopus 로고
    • West German Study Group
    • West German Study Group www.wsg-online.com/wsg/default. aspx~ID=142&CID=2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.