EMMPRIN/CD147 up-regulates urokinase-type plasminogen activator: Implications in oral tumor progression

BMC Cancer

Volumn 12, Issue , 2012, Pages

  Lescaille, Géraldine ^a   Menashi, Suzanne ^b   Cavelier Balloy, Bénédicte ^c   Khayati, Farah ^a   Quemener, Cathy ^a   Podgorniak, Marie P ^d   Naïmi, Benyoussef ^e   Calvo, Fabien ^a,f   Lebbe, Céleste ^d,f   Mourah, Samia ^a,d,f  

^a INSERM   (France)

^b CNRS   (France)

^c Cabinet de Dermatopathologie   (France)

^d SAINT LOUIS HOSPITAL   (France)

^e UNIVERSITÉ PARIS EST CRÉTEIL   (France)

^f UNIVERSITÉ PARIS DIDEROT   (France)

Author keywords

EMMPRIN CD147; Invasion; Oral squamous cell carcinoma; Progression; uPA

Indexed keywords

AMILORIDE; CD147 ANTIGEN; GELATINASE A; GELATINASE B; MARIMASTAT; MESSENGER RNA; UROKINASE; TUMOR PROTEIN;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INVASION; CANCER STAGING; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME REGULATION; EXTRACELLULAR MATRIX METALLOPROTEINASE INDUCER GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MEMBRANE VESICLE; MOLECULAR PATHOLOGY; MOUTH SQUAMOUS CELL CARCINOMA; PARACRINE SIGNALING; PRECANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TUMOR GENE; UPREGULATION; UROKINASE TYPE PLASMINOGEN ACTIVATOR GENE; CELL MOTION; DISEASE COURSE; METABOLISM; MOUTH TUMOR; PATHOLOGY; PHYSIOLOGY; SQUAMOUS CELL CARCINOMA; TUMOR CELL LINE; WESTERN BLOTTING;

ANTIGENS, CD147; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL MOVEMENT; DISEASE PROGRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; MOUTH NEOPLASMS; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; PRECANCEROUS CONDITIONS; REAL-TIME POLYMERASE CHAIN REACTION; UP-REGULATION; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 84858717758     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-12-115     Document Type: Article

References (34)

1. Prince A, Aguirre-Ghizo J, Genden E, Posner M, Sikora A. Head and neck squamous cell carcinoma: new translational therapies. Mt Sinai J Med 2010, 77(6):684-699. 10.1002/msj.20216, 21105129.
2. Specenier P, Vermorken JB. Advances in the systemic treatment of head and neck cancers. Curr Opin Oncol 2010, 22(3):200-205. 10.1097/CCO.0b013e3283376e15, 20154619.
3. Braakhuis BJ, Snijders PJ, Keune WJ, Meijer CJ, Ruijter-Schippers HJ, Leemans CR, Brakenhoff RH. Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus. J Natl Cancer Inst 2004, 96(13):998-1006. 10.1093/jnci/djh183, 15240783.
4. Shi Z, Stack MS. Urinary-type plasminogen activator (uPA) and its receptor (uPAR) in squamous cell carcinoma of the oral cavity. Biochem J 2007, 407(2):153-159. 10.1042/BJ20071037, 17880283.
5. Siqueira AS, Gama-de-Souza LN, Arnaud MV, Pinheiro JJ, Jaeger RG. Laminin-derived peptide AG73 regulates migration, invasion, and protease activity of human oral squamous cell carcinoma cells through syndecan-1 and beta1 integrin. Tumour Biol 2010, 31(1):46-58. 10.1007/s13277-009-0008-x, 20237901.
6. Biswas C, Zhang Y, DeCastro R, Guo H, Nakamura T, Kataoka H, Nabeshima K. The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. Cancer Res 1995, 55(2):434-439.
7. Huet E, Gabison EE, Mourah S, Menashi S. Role of emmprin/CD147 in tissue remodeling. Connect Tissue Res 2008, 49(3):175-179. 10.1080/03008200802151722, 18661337.
8. Muramatsu T, Miyauchi T. Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion. Histol Histopathol 2003, 18(3):981-987.
9. Nabeshima K, Iwasaki H, Koga K, Hojo H, Suzumiya J, Kikuchi M. Emmprin (basigin/CD147): matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression. Pathol Int 2006, 56(7):359-367. 10.1111/j.1440-1827.2006.01972.x, 16792544.
10. Yan L, Zucker S, Toole BP. Roles of the multifunctional glycoprotein, emmprin (basigin; CD147), in tumour progression. Thromb Haemost 2005, 93(2):199-204.
11. Chen X, Lin J, Kanekura T, Su J, Lin W, Xie H, Wu Y, Li J, Chen M, Chang J. A small interfering CD147-targeting RNA inhibited the proliferation, invasiveness, and metastatic activity of malignant melanoma. Cancer Res 2006, 66(23):11323-11330. 10.1158/0008-5472.CAN-06-1536, 17145878.
12. Kanekura T, Chen X, Kanzaki T. Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts. Int J Cancer 2002, 99(4):520-528. 10.1002/ijc.10390, 11992541.
13. Toole BP, Slomiany MG. Hyaluronan, CD44 and Emmprin: partners in cancer cell chemoresistance. Drug Resist Updat 2008, 11(3):110-121. 10.1016/j.drup.2008.04.002, 2584579, 18490190.
14. Bougatef F, Quemener C, Kellouche S, Naimi B, Podgorniak MP, Millot G, Gabison EE, Calvo F, Dosquet C, Lebbe C, et al. EMMPRIN promotes angiogenesis through hypoxia-inducible factor-2alpha-mediated regulation of soluble VEGF isoforms and their receptor VEGFR-2. Blood 2009, 114(27):5547-5556. 10.1182/blood-2009-04-217380, 19837976.
15. Lacal PM, Ruffini F, Pagani E, D'Atri S. An autocrine loop directed by the vascular endothelial growth factor promotes invasiveness of human melanoma cells. Int J Oncol 2005, 27(6):1625-1632.
16. Tang Y, Nakada MT, Kesavan P, McCabe F, Millar H, Rafferty P, Bugelski P, Yan L. Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases. Cancer Res 2005, 65(8):3193-3199.
17. Bougatef F, Menashi S, Khayati F, Naimi B, Porcher R, Podgorniak MP, Millot G, Janin A, Calvo F, Lebbe C, et al. EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2. PLoS One 2010, 5(8):e12265. 10.1371/journal.pone.0012265, 2930842, 20824203.
18. Quemener C, Gabison EE, Naimi B, Lescaille G, Bougatef F, Podgorniak MP, Labarchede G, Lebbe C, Calvo F, Menashi S, et al. Extracellular matrix metalloproteinase inducer up-regulates the urokinase-type plasminogen activator system promoting tumor cell invasion. Cancer Res 2007, 67(1):9-15. 10.1158/0008-5472.CAN-06-2448, 17210677.
19. Zucker S, Hymowitz M, Rollo EE, Mann R, Conner CE, Cao J, Foda HD, Tompkins DC, Toole BP. Tumorigenic potential of extracellular matrix metalloproteinase inducer. Am J Pathol 2001, 158(6):1921-1928. 10.1016/S0002-9440(10)64660-3, 1891983, 11395366.
20. Nagata M, Fujita H, Ida H, Hoshina H, Inoue T, Seki Y, Ohnishi M, Ohyama T, Shingaki S, Kaji M, et al. Identification of potential biomarkers of lymph node metastasis in oral squamous cell carcinoma by cDNA microarray analysis. Int J Cancer 2003, 106(5):683-689. 10.1002/ijc.11283, 12866027.
21. Ziober AF, Falls EM, Ziober BL. The extracellular matrix in oral squamous cell carcinoma: friend or foe?. Head Neck 2006, 28(8):740-749. 10.1002/hed.20382, 16649214.
22. Lindberg P, Larsson A, Nielsen BS. Expression of plasminogen activator inhibitor-1, urokinase receptor and laminin gamma-2 chain is an early coordinated event in incipient oral squamous cell carcinoma. Int J Cancer 2006, 118(12):2948-2956. 10.1002/ijc.21568, 16395714.
23. Rosenthal EL, Shreenivas S, Peters GE, Grizzle WE, Desmond R, Gladson CL. Expression of extracellular matrix metalloprotease inducer in laryngeal squamous cell carcinoma. Laryngoscope 2003, 113(8):1406-1410. 10.1097/00005537-200308000-00027, 12897567.
24. Vigneswaran N, Beckers S, Waigel S, Mensah J, Wu J, Mo J, Fleisher KE, Bouquot J, Sacks PG, Zacharias W. Increased EMMPRIN (CD 147) expression during oral carcinogenesis. Exp Mol Pathol 2006, 80(2):147-159. 10.1016/j.yexmp.2005.09.011, 16310185.
25. Bordador LC, Li X, Toole B, Chen B, Regezi J, Zardi L, Hu Y, Ramos DM. Expression of emmprin by oral squamous cell carcinoma. Int J Cancer 2000, 85(3):347-352. 10.1002/(SICI)1097-0215(20000201)85:3<347::AID-IJC9>3.0.CO;2-#, 10652425.
26. Dang D, Atakilit A, Ramos DM. EMMPRIN modulates migration and deposition of TN-C in oral squamous carcinoma. Anticancer Res 2008, 28(4B):2049-2054.
27. Chang SE, Foster S, Betts D, Marnock WE. DOK, a cell line established from human dysplastic oral mucosa, shows a partially transformed non-malignant phenotype. Int J Cancer 1992, 52(6):896-902. 10.1002/ijc.2910520612, 1459732.
28. Toole BP. Emmprin (CD147), a cell surface regulator of matrix metalloproteinase production and function. Curr Top Dev Biol 2003, 54:371-389.
29. Gabison EE, Hoang-Xuan T, Mauviel A, Menashi S. EMMPRIN/CD147, an MMP modulator in cancer, development and tissue repair. Biochimie 2005, 87(3-4):361-368. 10.1016/j.biochi.2004.09.023, 15781323.
30. Liu Z, Hartman YE, Warram JM, Knowles JA, Sweeny L, Zhou T, Rosenthal EL. Fibroblast growth factor receptor mediates fibroblast-dependent growth in EMMPRIN-depleted head and neck cancer tumor cells. Mol Cancer Res 2011, 9(8):1008-1017. 10.1158/1541-7786.MCR-11-0043, 21665938.
31. Kanekura T, Chen X. CD147/basigin promotes progression of malignant melanoma and other cancers. J Dermatol Sci 2010, 57(3):149-154. 10.1016/j.jdermsci.2009.12.008, 20060267.
32. Newman JR, Bohannon IA, Zhang W, Skipper JB, Grizzle WE, Rosenthal EL. Modulation of tumor cell growth in vivo by extracellular matrix metalloprotease inducer. Arch Otolaryngol Head Neck Surg 2008, 134(11):1218-1224. 10.1001/archotol.134.11.1218, 2676729, 19015455.
33. Ghosh S, Koblinski J, Johnson J, Liu Y, Ericsson A, Davis JW, Shi Z, Ravosa MJ, Crawford S, Frazier S, et al. Urinary-type plasminogen activator receptor/alpha 3 beta 1 integrin signaling, altered gene expression, and oral tumor progression. Mol Cancer Res 2010, 8(2):145-158. 10.1158/1541-7786.MCR-09-0045, 2825738, 20145038.
34. Ghosh S, Munshi HG, Sen R, Linz-McGillem LA, Goldman RD, Lorch J, Green KJ, Jones JC, Stack MS. Loss of adhesion-regulated proteinase production is correlated with invasive activity in oral squamous cell carcinoma. Cancer 2002, 95(12):2524-2533. 10.1002/cncr.10997, 12467066.