Mimicry of the regulatory role of urokinase in lamellipodia formation by introduction of a non-native interdomain disulfide bond in its receptor

Journal of Biological Chemistry

Volumn 286, Issue 50, 2011, Pages 43515-43526

  Gårdsvoll, Henrik ^a,b   Kjaergaard, Magnus ^b   Jacobsen, Benedikte ^a,b   Kriegbaum, Mette C ^a   Huang, Mingdong ^b,c   Ploug, Michael ^a,b  

^a FINSEN LABORATORY   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c FUJIAN INSTITUTE OF RESEARCH ON THE STRUCTURE OF MATTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING KINETICS; CELL SURFACES; COATED SURFACE; COMPLEX FORMATIONS; CONFORMATIONAL FLEXIBILITY; CONSTITUTIVELY ACTIVES; DISULFIDE BONDS; HEK293 CELLS; HYDRODYNAMIC VOLUMES; INTER-DOMAIN; LAMELLIPODIA; NON-NATIVE; SECONDARY STRUCTURES; SOLUBLE RECEPTOR; UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA); VITRONECTIN;

ADHESION; CELL MEMBRANES;

COVALENT BONDS;

CHYMOTRYPSIN; DISULFIDE; GLYCOLIPID; SOMATOMEDIN B; UROKINASE; UROKINASE RECEPTOR; VITRONECTIN;

ARTICLE; BINDING KINETICS; CELL SURFACE; COMPLEX FORMATION; CONTROLLED STUDY; DISULFIDE BOND; FIBRINOLYSIS; HUMAN; HUMAN CELL; HYDRODYNAMICS; LAMELLIPODIUM; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; PROTEIN TARGETING;

ANIMALS; CELL LINE; CHROMATOGRAPHY, GEL; CIRCULAR DICHROISM; DROSOPHILA; HUMANS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PSEUDOPODIA; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; SOMATOMEDINS; SURFACE PLASMON RESONANCE; UROKINASE-TYPE PLASMINOGEN ACTIVATOR; VITRONECTIN;

EID: 83355169691     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.300020     Document Type: Article

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