Urokinase receptor (CD87) regulates leukocyte recruitment via β2 integrins in vivo

Journal of Experimental Medicine

Volumn 188, Issue 6, 1998, Pages 1029-1037

  May, Andreas E ^a   Kanse, Sandip M ^a   Lund, Leif R ^b   Gisler, Roland H ^c   Imhof, Beat A ^d   Preissner, Klaus T ^a  

^a KERCKHOFF HEART CENTER   (Germany)

^b FINSEN LABORATORY   (Denmark)

^c BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^d UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

2 integrin; Endothelial cells; Inflammation; Leukocyte; Urokinase receptor

Indexed keywords

INTEGRIN; UROKINASE RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CELL INTERACTION; FEMALE; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE ADHERENCE; LEUKOCYTE MIGRATION; MOUSE; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; VASCULITIS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD18; CELL ADHESION; CELL MOVEMENT; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; LEUKOCYTES; MICE; MICE, KNOCKOUT; MUSCLE, SMOOTH; PLASMINOGEN ACTIVATORS; RECEPTORS, CELL SURFACE; TUMOR CELLS, CULTURED; UMBILICAL VEINS; URINARY PLASMINOGEN ACTIVATOR;

EID: 0032555894     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.6.1029     Document Type: Article

References (54)

1. Springer, T.A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 76:301-314.
2. Carlos, T.M., and J.M. Harlan. 1994. Leukocyte-endothelial adhesion molecules. Blood. 84:2068-2101.
3. Larson, R.S., and T.A. Springer. 1990. Structure and function of leukocyte integrins. Immunol. Rev. 114:181-217.
4. 2, binds preferentially to ICAM-3. Immunity. 3:683-690.
5. Smith, C.W., S.D. Marlin, R. Rothlein, C. Toman, and D.C. Anderson. 1989. Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro. J. Clin. Invest. 83:2008-2017.
6. Lu, H., C.W. Smith, J. Perrard, D. Bullard, L.P. Tang, S.B. Shappell, M.L. Entman, A.L. Beaudet, and C.M. Ballantyne. 1997. LFA-1 is sufficient in mediating neutrophil emigration in MAC-1-deficient mice. J. Clin. Invest. 99:1340-1350.
7. Miller, L.J., D.F. Bainton, N. Borregaard, and T.A. Springer. 1987. Stimulated mobilization of monocyte Mac-1 and p150,95 adhesion proteins from an intracellular vesicular compartment to the cell surface. J. Clin. Invest. 80:535-544.
8. Altieri, D.C. 1991. Occupancy of CD11b/CD18 (Mac-1) divalent ion binding site(s) induces leukocyte adhesion. J. Immunol. 147:1891-1898.
9. Couffinhal, T., C. Duplaa, C. Moreau, J.-M.D. Lamaziere, and J. Bonnet. 1994. Regulation of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 in human vascular smooth muscle cells. Circ. Res. 74:225-234.
10. Skubitz, K.M., K.D. Campbell, J. Iida, and A.P.N. Skubitz. 1996. CD63 associates with tyrosine kinase activity and CD11/CD18, and transmits an activation signal in neutrophils. J. Immunol. 157:3617-3626.
11. Zhou, M., R.F. Todd III, J.G. van de Winkel, and H.R. Petty. 1993. Cocapping of the leukoadhesin molecules complement receptor type 3 and lymphocyte function-associated antigen-1 with Fcγ receptor III on human neutrophils. Possible role of lectin-like interactions. J. Immunol. 150:3030-3038.
12. Bohuslav, J., V. Horejsí, C. Hansmann, J. Stöckl, U.H. Weidle, O. Majdic, I. Bartke, W. Knapp, and H. Stockinger. 1995. Urokinase plasminogen activator receptor, β2-integrins, and Src-kinases within a single receptor complex of human monocytes. J. Exp. Med. 181:1381-1390.
13. Xue, W., A.L. Kindzelskii, R.F. Todd III, and H.R. Petty. 1994. Physical association of complement receptor type 3 and urokinase-type plasminogen activator receptor in neutrophil membranes. J. Immunol. 152:4630-4640.
14. Ploug, M., E. Ronne, N. Behrendt, A.L. Jensen, F. Blasi, and K. Dano. 1991. Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol. J. Biol. Chem. 266: 1926-1933.
15. Hoyer-Hansen, G., E. Ronne, H. Solberg, N. Behrendt, M. Ploug, L.R. Lund, V. Ellis, and K. Dano. 1992. Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain. J. Biol. Chem. 267:18224-18229.
16. Kanse, S.M., C. Kost, O.G. Wilhelm, P.A. Andreasen, and K.T. Preissner. 1996. The urokinase receptor is a major vitronectin binding protein on endothelial cells. Exp. Cell Res. 224:344-353.
17. Chapman, H.A. 1997. Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration. Curr. Opin. Cell Biol. 9:714-724.
18. Cao, D., I.F. Mizukami, B.A. Garni-Wagner, A.L. Kindzelskii, R.F. Todd III, L.A. Boxer, and H.R. Petty. 1995. Human urokinase-type plasminogen activator primes neutrophils for superoxide anion release. Possible roles of complement receptor type 3 and calcium. J. Immunol. 154:1817-1829.
19. Dumler, I., T. Petri, and W.-D. Schleuning. 1993. Interaction of urokinase-type plasminogenactivator (u-PA) with its cellular receptor (u-PAR) induces phosphorylation on tyrosine of a 38 kDA protein. FEBS Lett. 322:37-40.
20. Busso, N., S.K. Masur, D. Lazega, S. Waxman, and L. Ossowski. 1994. Induction of cell migration by pro-urokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cells. J. Cell Biol. 126:259-270.
21. Resnati, M., M. Guttinger, S. Valcamonica, N. Sidenius, F. Blasi, and F. Fazioli. 1996. Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect. EMBO (Eur. Mol. Biol. Organ.) J. 15:1572-1582.
22. Rao, N.K., G.-P. Shi, and H.A. Chapman. 1995. Urokinase receptor is a multifunctional protein: influence of receptor occupancy on macrophage gene expression. J. Clin. Invest. 96:465-474.
23. Petty, H.R., and R.F. Todd III. 1996. Integrins as promiscuous signal transduction devices. Immunol. Today. 17:209-212.
24. Pöllänen, J., R.W. Stephens, and A. Vaheri. 1991. Directed plasminogen activation at the surface of normal and malignant cells. Adv. Cancer Res. 57:273-328.
25. Gyetko, M.R., R.F. Todd III, C.C. Wilkinson, and R.G. Sitrin. 1994. The urokinase receptor is required for human monocyte chemotaxis in vitro. J. Clin. Invest. 93:1380-1387.
26. Wei, Y., M. Lukashev, D.I. Simon, S.C. Bodary, S. Rosenberg, M.V. Doyle, and H.A. Chapman. 1996. Regulation of integrin function by the urokinase receptor. Science. 273: 1551-1555.
27. Sitrin, R.G., R.F. Todd III, H.R. Petty, T.G. Brock, S.B. Shollenberger, E. Albrecht, and M.R. Gyetko. 1996. The urokinase receptor (CD87) facilitates CD11B/CD18-mediated adhesion of human monocytes. J. Clin. Invest. 97:1942-1951.
28. Simon, D.I., N.K. Rao, H. Xu, Y. Wei, O. Majdic, O. Ronne, L. Kobzik, and H.A. Chapman. 1996. Mac-1 (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on nionocytic cells. Blood. 88:3185-3194.
29. 2-terminal amino acid sequence and glycosylation variants. J. Biol. Chem. 265:6453-6460.
30. Behrendt, N., M. Ploug, L. Patthy, G. Houen, F. Blasi, and K. Dano. 1991. The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator. J. Biol. Chem. 266:7842-7847.
31. Waltz, D.A., L.Z. Sailor, and H.A. Chapman. 1993. Cytokines induce urokinase-dependent adhesion of human myeloid cells. A regulatory role for plasminogen activator inhibitors. J. Clin. Invest. 91:1541-1552.
32. Mizukami, I.F., S.D. Vinjamuri, R.D. Trochelman, and R.F. Todd III. 1990. A structural characterization of the uPA-R activation antigen expressed on the plasma membrane of human mononuclear phagocytes. J. Immunol. 146:1841-1848.
33. 2-terminal domain of the urokinase receptor. FEBS Lett. 288:1-2.
34. Wallis, W.J., D.D. Hickstein, B.R. Schwartz, C.H. June, H.D. Ochs, P.G. Beatty, S.J. Klebanoff, and J.M. Harlan. 1986. Monoclonal antibody-defined functional epitopes on the adhesion-promoting glycoprotein complex (CDw18) of human neutrophils. Blood. 67:1007-1013.
35. Sanchez-Madrid, F., P. Simon, S. Thompson, and T.A. Springer. 1983. Mapping of antigenic and functional epitopes on the α and β subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1. J. Exp. Med. 158:586-602.
36. Prieto, J., F. Takei, R. Gendelman, B. Christenson, P. Biberfeld, and M. Patarroyo. 1989. MALA-2, mouse homologue of human adhesion molecule ICAM-1 (CD54). Eur. J. Immunol. 19:1551-1557.
37. Jaffe, E.A., R.L. Nachman, C.G. Becker, and C.R. Minick. 1973. Culture of human endothelial cells derived from umbilical veins. J. Clin. Invest. 52:2745-2756.
38. Kanse, S.M., E. Wijelath, C. Kanthou, P. Newman, and V.V. Kakkar. 1995. The proliferative responsiveness of human vascular smooth muscle cells to endothelin correlates with endothelin receptor density. Lab. Invest. 72:376-382.
39. Bugge, T.H., T.T. Suh, M.J. Flick, C.C. Daugherty, J. Romer, H. Solberg, V. Ellis, K. Dano, and J.L. Degen. 1995. The receptor for urokinase-type plasminogen activator is not essential for mouse development or fertility. J. Biol. Chem. 270:16886-16894.
40. Sligh, J.E., C.M. Ballantyne, S.S. Rich, H.K. Hawkins, C.W. Smith, A. Bradley, and A.L. Beaudet. 1993. Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc. Natl. Acad. Sci. USA. 90:8529-8533.
41. Oppenheimer-Marks, N., and P.E. Lipsky. 1993. The adhesion and trans-endothelial migration of human T lymphocyte subsets. Behring Inst. Mitt. 92:44-50.
42. Hogg, N., and C. Berlin. 1995. Structure and function of adhesion receptors in leukocyte trafficking. Immunol. Today. 16: 327-330.
43. Anderson, D.C., and T.A. Springer. 1987. Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1 and p150/95 glycoprotein. Annu. Rev. Med. 38:175-194.
44. Kuijpers, T.W., and J.M. Harlan. 1993. Monocyte-endothelial interactions: insights and questions. J. Lab. Clin. Med. 122:641-651.
45. Mizgerd, J.P., H. Kubo, G.J. Kutkoski, S.D. Bhagwan, K. Scharffetter-Kochanek, A.L. Beaudet, and C.M. Doerschuk. 1997. Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice. J. Exp. Med. 186:1357-1364.
46. Schmits, R., T.M. Kündig, D.M. Baker, G. Shumaker, J.J.L. Simard, G. Duncan, A. Wakeham, A. Shahinian, A. van der Heiden, M.F. Bachmann, et al. 1996. LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. J. Exp. Med. 183:1415-1426.
47. Dewerchin, M., A. Van Nufelen, G. Wallays, A. Bouche, L. Moons, P. Carmeliet, R.C. Mulligan, and D. Collen. 1996. Generation and characterization of urokinase receptor-deficient mice. J. Clin. Invest. 97:870-878.
48. Kirchheimer, J.C., and H.G. Remold. 1989. Endogenous receptor-bound urokinase mediates tissue invasion of human monocytes. J. Immunol. 143:2634-2639.
49. Gyetko, M.R., G.-H. Chen, R.A. McDonald, R. Goodman, G.B. Huffnagle, C.C. Wilkinson, J.A. Fuller, and G.B. Toews. 1996. Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans. J. Clin. Invest. 97:1818-1826.
50. Stefansson, S., and D.A. Lawrence. 1996. The serpin PAI-1 inhibits cell migration by blocking integrin αvβ3 binding to vitronectin. Nature. 383:441-443.
51. Deng, G., S.A. Curriden, S. Wang, S. Rosenberg, and D.J. Loskutoff. 1996. Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release? J. Cell Biol. 134:1563-1571.
52. Kjoller, L., S.M. Kanse, T. Kierkegaard, K.W. Rodenburg, E. Ronne, S.L. Goodman, K.T. Preissner, L. Ossowski, and P.A. Andreasen. 1997. Plasminogen activator inhibitor-1 represses integrin-and vitronectin-mediated cell migration independently of its function as an inhibitor of plasminogen activation. Exp. Cell Res. 232:420-429.
53. Pedersen, T.L., K. Yong, J.O. Pedersen, N.E. Hansen, K. Dano, and T. Plesner. 1996. Impaired migration in vitro of neutrophils from patients with paroxysmal nocturnal haemoglobinuria. Brit. J. Haematol. 95:45-51.
54. Poston, R.N., D.O. Haskard, J.R. Coucher, N.P. Gall, and R.R. Johnson-Tidey. 1992. Expression of intercellular adhesion molecule-1 in atherosclerotic plaques. Am. J. Pathol. 140:665-673.