Two missense variants in UHRF1BP1 are independently associated with systemic lupus erythematosus in Hong Kong Chinese

Genes and Immunity

Volumn 12, Issue 3, 2011, Pages 231-234

  Zhang, Y ^a   Yang, W ^a   Mok, C C ^b   Chan, T M ^a   Wong, R W S ^a   Mok, M Y ^a   Lee, K W ^c   Wong, S N ^b   Leung, A M H ^d   Lee, T L ^a   Ho, M H K ^a   Lee, P P W ^a   Wong, W H S ^a   Yang, J ^a   Zhang, J ^a   Wong, C M ^e   Ng, I O L ^e   Garcia Barcelo M M ^e   Cherny, S S ^e   Tam, P K H ^e   Sham, P C ^e   Lau, C S ^a   Lau, Y L ^a   more..

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b TUEN MUN HOSPITAL   (Hong Kong)

^c PAMELA YOUDE NETHERSOLE EASTERN HOSPITAL   (Hong Kong)

^d QUEEN ELIZABETH HOSPITAL   (Hong Kong)

^e UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Asian; association; SLE; UHRF1BP1

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; PROTEIN UHRF1BP1; UNCLASSIFIED DRUG;

ARTICLE; CHINESE; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENE LOCUS; GENE REPLICATION; HONG KONG; HUMAN; MAJOR CLINICAL STUDY; MISSENSE MUTATION; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

ALLELES; AMINO ACID SEQUENCE; ASIAN CONTINENTAL ANCESTRY GROUP; CCAAT-ENHANCER-BINDING PROTEINS; GENE FREQUENCY; GENE ORDER; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HONG KONG; HUMANS; LINKAGE DISEQUILIBRIUM; LUPUS ERYTHEMATOSUS, SYSTEMIC; MUTATION, MISSENSE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 79955464760     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2010.66     Document Type: Article

References (18)

1. Arnett FC, Shulman LE. Studies in familial systemic lupus erythematosus. Medicine (Baltimore) 1976; 55: 313-322.
2. Ramos-Niembro F, Alarcon-Segovia D. Familial aspects of mixed connective tissue disease (MCTD). I. Occurrence of systemic lupus erythematosus in another member in two families and aggregation of MCTD in another family. J Rheumatol 1978; 5: 433-440.
3. Sestak AL, Shaver TS, Moser KL, Neas BR, Harley JB. Familial aggregation of lupus and autoimmunity in an unusual multiplex pedigree. J Rheumatol 1999; 26: 1495-1499. (Pubitemid 29317871)
4. Mok CC, Lau CS. Lupus in Hong Kong Chinese. Lupus 2003; 12: 717-722. (Pubitemid 37173672)
5. Wong SN, Tse KC, Lee TL, Lee KW, Chim S, Lee KP et al. Lupus nephritis in Chinese children-a territory-wide cohort study in Hong Kong. Pediatr Nephrol 2006; 21: 1104-1112. (Pubitemid 44083882)
6. Hom G, Graham RR, Modrek B, Taylor KE, Ortmann W, Garnier S et al. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med 2008; 358: 900-909. (Pubitemid 351397089)
7. Gateva V, Sandling JK, Hom G, Taylor KE, Chung SA, Sun X et al. A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet 2009; 41: 1228-1233.
8. Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ, Hu Z et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet 2009; 41: 1234-1237.
9. Harley JB, Alarcon-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Moser KL et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 2008; 40: 204-210. (Pubitemid 351171405)
10. Yang W, Shen N, Ye DQ, Liu Q, Zhang Y, Qian XX et al. Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus. PLoS Genet 2010; 6: e1000841.
11. Siu HO, YangW, Lau CS, Chan TM,Wong RW,Wong WH et al. Association of a haplotype of IRF5 gene with systemic lupus erythematosus in Chinese. J Rheumatol 2008; 35: 360-362.
12. Yang W, Ng P, Zhao M, Hirankarn N, Lau CS, Mok CC et al. Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese. Genes Immun 2009; 10: 219-226.
13. Yang W, Zhao M, Hirankarn N, Lau CS, Mok CC, Chan TM et al. ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai. Hum Mol Genet 2009; 18: 2063-2070.
14. Chang YK, Yang W, Zhao M, Mok CC, Chan TM, Wong RW et al. Association of BANK1 and TNFSF4 with systemic lupus erythematosus in Hong Kong Chinese. Genes Immun 2009; 10: 414-420.
15. Kim I, Kim YJ, Kim K, Kang C, Choi CB, Sung YK et al. Genetic studies of systemic lupus erythematosus in Asia: where are we now? Genes Immun 2009; 10: 421-432.
16. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559-575. (Pubitemid 47330214)
17. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. NatGenet 2006; 38: 904-909. (Pubitemid 44141658)
18. Unoki M, Nishidate T, Nakamura Y. ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. Oncogene 2004; 23: 7601-7610. (Pubitemid 39424918)