Association of a functional IRF7 variant with systemic lupus erythematosus

Arthritis and Rheumatism

Volumn 63, Issue 3, 2011, Pages 749-754

  Fu, Qiong ^a,b   Zhao, Jian ^a,b   Qian, Xiaoxia ^b   Wong, Jonathan L H ^a,b   Kaufman, Kenneth M ^c   Yu, C Yung ^d   Howe, Hwee Siew ^e   Mok, Mo Yin ^f   Harley, John B ^g   Guthridge, Joel M ^h   Song, Yeong Wook ⁱ   Cho, Soo Kyung ^j   Bae, Sang Cheol ^j   Grossman, Jennifer M ^a,b   Hahn, Bevra H ^a,b   Arnett, Frank C ^k   Shen, Nan ^b   Tsao, Betty P ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^d OHIO STATE UNIVERSITY   (United States)

^e TAN TOCK SENG HOSPITAL   (Singapore)

^f UNIVERSITY OF HONG KONG   (Hong Kong)

^g CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^h OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

ⁱ Seoul National University   (South Korea)

^j Hanyang University Hospital for Rheumatic Diseases   (South Korea)

^k UNIVERSITY OF TEXAS   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; INTERFERON REGULATORY FACTOR 7; LUCIFERASE;

AFRICAN AMERICAN; ARTICLE; ASIAN; CHINESE; CONTROLLED STUDY; ETHNICITY; EUROPEAN AMERICAN; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOME ANALYSIS; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POPULATION GENETICS; PRIORITY JOURNAL; RACE DIFFERENCE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; AFRICAN AMERICANS; AMINO ACID SEQUENCE; ASIAN CONTINENTAL ANCESTRY GROUP; ETHNIC GROUPS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; INTERFERON REGULATORY FACTOR-7; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MOLECULAR SEQUENCE DATA; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 79953707345     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.30193     Document Type: Article

References (10)

1. Harley IT, Kaufman KM, Langefeld CD, Harley JB, Kelly JA. Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies. Nat Rev Genet 2009;10:285-90.
2. Moser KL, Kelly JA, Lessard CJ, Harley JB. Recent insights into the genetic basis of systemic lupus erythematosus. Genes Immun 2009;10:373-9.
3. Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mitzutani T, et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 2005;434:772-7. (Pubitemid 44739521)
4. Harley JB, Alarcon-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Moser KL, et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 2008;40:204-10. (Pubitemid 351171405)
5. Crow MK. Collaboration, genetic associations, and lupus erythematosus. N Engl J Med 2008;358:956-61. (Pubitemid 351397097)
6. Salloum R, Franek BS, Kariuki SN, Rhee L, Mikolaitis RA, Jolly M, et al. Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-α activity in lupus patients. Arthritis Rheum 2010;62:553-61.
7. Hochberg MC, for the Diagnostic and Therapeutic Criteria Committee of the American College of Rheumatology. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. [letter]. Arthritis Rheum 1997;40:1725.
8. Zhang L, Pagano JS. Structure and function of IRF-7. J Interferon Cytokine Res 2002;22:95-101. (Pubitemid 34161287)
9. Taniguchi T, Ogasawara K, Takaoka A, Tanaka N. IRF family of transcription factor as regulators of host defense. Annu Rev Immunol 2001;19:623-55. (Pubitemid 32368048)
10. Feng X, Wu H, Grossman JM, Hanvivadhanakul P, FitzGerald JD, Park GS, et al. Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus. Arthritis Rheum 2006;54:2951-62. (Pubitemid 44497776)