Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study

American Journal of Human Genetics

Volumn 90, Issue 4, 2012, Pages 648-660

  Lessard, Christopher J ^a,b,g   Adrianto, Indra ^a   Ice, John A ^a   Wiley, Graham B ^a   Kelly, Jennifer A ^a   Glenn, Stuart B ^a   Adler, Adam J ^a   Li, He ^a,b   Rasmussen, Astrid ^a   Williams, Adrienne H ^c   Ziegler, Julie ^c   Comeau, Mary E ^c   Marion, Miranda ^c   Wakeland, Benjamin E ^d   Liang, Chaoying ^d   Ramos, Paula S ^e   Grundahl, Kiely M ^a   Gallant, Caroline J ^f   Alarcón, Graciela S ^h   Anaya, Juan Manuel ⁱ   Bae, Sang Cheol ^j   Boackle, Susan A ^k   Brown, Elizabeth E ^h   Chang, Deh Ming ^l   Cho, Soo Kyung ^j   Criswell, Lindsey A ^m   Edberg, Jeffrey C ^h   Freedman, Barry I ⁿ   Gilkeson, Gary S ^e   Jacob, Chaim O ^o   James, Judith A ^a,b   Kamen, Diane L ^e   Kimberly, Robert P ^h   Kim, Jae Hoon ^j   Martin, Javier ^p   Merrill, Joan T ^a   Niewold, Timothy B ^q   Park, So Yeon ^j   Petri, Michelle A ^r   Pons Estel, Bernardo A ^s   Ramsey Goldman, Rosalind ^t   Reveille, John D ^u   Scofield, R Hal ^a,b,v   Song, Yeong Wook ^w   Stevens, Anne M ^x,y   Tsao, Betty P ^z   Vila, Luis M ^aa   Vyse, Timothy J ^ab   Yu, Chack Yung ^ac,ad   Guthridge, Joel M ^a   Kaufman, Kenneth M ^a,ae,af   Harley, John B ^ae,af   Wakeland, Edward K ^d   Langefeld, Carl D ^c   Gaffney, Patrick M ^a,b   Montgomery, Courtney G ^a   Moser, Kathy L ^a,b   more..

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^f UPPSALA UNIVERSITY   (Sweden)

^g JUNTA DE ANDALUCÍA   (Spain)

^h University of Alabama at Birmingham   (United States)

ⁱ UNIVERSIDAD DEL ROSARIO   (Colombia)

^j Hanyang University Hospital for Rheumatic Diseases   (South Korea)

^k UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^l NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^m UNIVERSITY OF CALIFORNIA   (United States)

ⁿ WAKE FOREST SCHOOL OF MEDICINE   (United States)

^o UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^p INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^q UNIVERSITY OF CHICAGO   (United States)

^r JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^s Sanatorio Parque   (Argentina)

^t NORTHWESTERN UNIVERSITY   (United States)

^u UNIVERSITY OF TEXAS   (United States)

^v VETERANS AFFAIRS MEDICAL CENTER   (United States)

^w Seoul National University   (South Korea)

^x UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^y SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

^z UNIVERSITY OF CALIFORNIA   (United States)

^aa UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

^ab KING'S COLLEGE LONDON   (United Kingdom)

^ac NATIONWIDE CHILDREN S HOSPITAL   (United States)

^ad OHIO STATE UNIVERSITY   (United States)

^ae CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^af VETERANS AFFAIRS MEDICAL CENTER   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; IKAROS TRANSCRIPTION FACTOR; INTERFERON; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; MEMBRANE PROTEIN; PROTEIN IKZF3; TRANSMEMBRANE PROTEIN 39A; UNCLASSIFIED DRUG; ZONA PELLUCIDA BINDING PROTEIN 2;

ADAMTSL1 GENE; AFRICAN AMERICAN; AMERICAN INDIAN; ARTICLE; ASIAN; C10ORF64 GENE; CADM2 GENE; CFHR1 GENE; CHROMOSOME 17Q; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; ETHNICITY; EUROPEAN AMERICAN; FAM19A2 GENE; GENE; GENE IDENTIFICATION; GENE LOCUS; GENE MAPPING; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOME ANALYSIS; GENOTYPE; HAPLOTYPE; HERITABILITY; HIGH RISK POPULATION; HISPANIC; HUMAN; IKZF3 GENE; IL12A GENE; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; IRF8 GENE; LOC63920 GENE; LPP GENE; MAJOR CLINICAL STUDY; OR8D4 GENE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SLU7 GENE; STXBP6 GENE; SYSTEMIC LUPUS ERYTHEMATOSUS; TMEM39A GENE; ZPBP2 GENE;

AFRICAN CONTINENTAL ANCESTRY GROUP; ASIAN CONTINENTAL ANCESTRY GROUP; CHROMOSOME MAPPING; EGG PROTEINS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HISPANIC AMERICANS; HUMANS; IKAROS TRANSCRIPTION FACTOR; INDIANS, NORTH AMERICAN; INTERFERON REGULATORY FACTORS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MEMBRANE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, DNA;

EID: 84859491100     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2012.02.023     Document Type: Article

References (66)

1. M. Petri Epidemiology of systemic lupus erythematosus Best Pract. Res. Clin. Rheumatol. 16 2002 847 858
2. K.L. Moser, J.A. Kelly, C.J. Lessard, and J.B. Harley Recent insights into the genetic basis of systemic lupus erythematosus Genes Immun. 10 2009 373 379
3. D. Alarcón-Segovia, M.E. Alarcón-Riquelme, M.H. Cardiel, F. Caeiro, L. Massardo, A.R. Villa, B.A. Pons-Estel Grupo Latinoamericano de Estudio del Lupus Eritematoso (GLADEL) Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases in 1,177 lupus patients from the GLADEL cohort Arthritis Rheum. 52 2005 1138 1147
4. J.M. Anaya, G.J. Tobon, P. Vega, and J. Castiblanco Autoimmune disease aggregation in families with primary Sjögren's syndrome J. Rheumatol. 33 2006 2227 2234
5. R.K. Arora-Singh, S. Assassi, D.J. del Junco, F.C. Arnett, M. Perry, U. Irfan, R. Sharif, T. Mattar, and M.D. Mayes Autoimmune diseases and autoantibodies in the first degree relatives of patients with systemic sclerosis J. Autoimmun. 35 2010 52 57
6. A.L. Sestak, T.S. Shaver, K.L. Moser, B.R. Neas, and J.B. Harley Familial aggregation of lupus and autoimmunity in an unusual multiplex pedigree J. Rheumatol. 26 1999 1495 1499
7. Y. Deng, and B.P. Tsao Genetic susceptibility to systemic lupus erythematosus in the genomic era Nat. Rev. Rheumatol. 6 2010 683 692
8. J.L. Reinertsen, J.H. Klippel, A.H. Johnson, A.D. Steinberg, J.L. Decker, and D.L. Mann B-lymphocyte alloantigens associated with systemic lupus erythematosus N. Engl. J. Med. 299 1978 515 518
9. K.M. Nies, J.C. Brown, E.L. Dubois, F.P. Quismorio, G.J. Friou, and P.I. Terasaki Histocompatibility (HL-A) antigens and lymphocytotoxic antibodies in systemic lupus erythematosus (SLE) Arthritis Rheum. 17 1974 397 402
10. R.R. Graham, W.A. Ortmann, C.D. Langefeld, D. Jawaheer, S.A. Selby, P.R. Rodine, E.C. Baechler, K.E. Rohlf, K.B. Shark, and K.J. Espe Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus Am. J. Hum. Genet. 71 2002 543 553
11. D.K. McCulloch, L.J. Klaff, S.E. Kahn, S.L. Schoenfeld, C.J. Greenbaum, R.S. Mauseth, E.A. Benson, G.T. Nepom, L. Shewey, and J.P. Palmer Nonprogression of subclinical beta-cell dysfunction among first-degree relatives of IDDM patients. 5-yr follow-up of the Seattle Family Study Diabetes 39 1990 549 556
12. E.C. Baechler, F.M. Batliwalla, G. Karypis, P.M. Gaffney, W.A. Ortmann, K.J. Espe, K.B. Shark, W.J. Grande, K.M. Hughes, and V. Kapur Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus Proc. Natl. Acad. Sci. USA 100 2003 2610 2615
13. L. Bennett, A.K. Palucka, E. Arce, V. Cantrell, J. Borvak, J. Banchereau, and V. Pascual Interferon and granulopoiesis signatures in systemic lupus erythematosus blood J. Exp. Med. 197 2003 711 723
14. K.A. Kirou, C. Lee, S. George, K. Louca, I.G. Papagiannis, M.G. Peterson, N. Ly, R.N. Woodward, K.E. Fry, and A.Y. Lau Coordinate overexpression of interferon-alpha-induced genes in systemic lupus erythematosus Arthritis Rheum. 50 2004 3958 3967
15. S. Sigurdsson, G. Nordmark, H.H. Göring, K. Lindroos, A.C. Wiman, G. Sturfelt, A. Jönsen, S. Rantapää-Dahlqvist, B. Möller, and J. Kere Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus Am. J. Hum. Genet. 76 2005 528 537
16. G. Hom, R.R. Graham, B. Modrek, K.E. Taylor, W. Ortmann, S. Garnier, A.T. Lee, S.A. Chung, R.C. Ferreira, and P.V. Pant Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX N. Engl. J. Med. 358 2008 900 909
17. J.B. Harley, M.E. Alarcón-Riquelme, L.A. Criswell, C.O. Jacob, R.P. Kimberly, K.L. Moser, B.P. Tsao, T.J. Vyse, C.D. Langefeld, S.K. Nath International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN) Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci Nat. Genet. 40 2008 204 210
18. W. Yang, N. Shen, D.Q. Ye, Q. Liu, Y. Zhang, X.X. Qian, N. Hirankarn, D. Ying, H.F. Pan, C.C. Mok Asian Lupus Genetics Consortium Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus PLoS Genet. 6 2010 e1000841
19. R.R. Graham, C. Cotsapas, L. Davies, R. Hackett, C.J. Lessard, J.M. Leon, N.P. Burtt, C. Guiducci, M. Parkin, and C. Gates Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus Nat. Genet. 40 2008 1059 1061
20. S.V. Kozyrev, A.K. Abelson, J. Wojcik, A. Zaghlool, M.V. Linga Reddy, E. Sanchez, I. Gunnarsson, E. Svenungsson, G. Sturfelt, and A. Jönsen Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus Nat. Genet. 40 2008 211 216
21. J.W. Han, H.F. Zheng, Y. Cui, L.D. Sun, D.Q. Ye, Z. Hu, J.H. Xu, Z.M. Cai, W. Huang, and G.P. Zhao Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus Nat. Genet. 41 2009 1234 1237
22. V. Gateva, J.K. Sandling, G. Hom, K.E. Taylor, S.A. Chung, X. Sun, W. Ortmann, R. Kosoy, R.C. Ferreira, and G. Nordmark A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus Nat. Genet. 41 2009 1228 1233
23. C.J. Lessard, I. Adrianto, J.A. Kelly, K.M. Kaufman, K.M. Grundahl, A. Adler, A.H. Williams, C.J. Gallant, J.M. Anaya, S.C. Bae Marta E. Alarcón-Riquelme on behalf of the BIOLUPUS and GENLES Networks Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study Am. J. Hum. Genet. 88 2011 83 91
24. B. Namjou, P.H. Kothari, J.A. Kelly, S.B. Glenn, J.O. Ojwang, A. Adler, M.E. Alarcón-Riquelme, C.J. Gallant, S.A. Boackle, and L.A. Criswell Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort Genes Immun. 12 2011 270 279
25. I. Adrianto, F. Wen, A. Templeton, G. Wiley, J.B. King, C.J. Lessard, J.S. Bates, Y. Hu, J.A. Kelly, K.M. Kaufman BIOLUPUS and GENLES Networks Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus Nat. Genet. 43 2011 253 258
26. W. Tan, K. Sunahori, J. Zhao, Y. Deng, K.M. Kaufman, J.A. Kelly, C.D. Langefeld, A.H. Williams, M.E. Comeau, J.T. Ziegler BIOLUPUS Network GENLES Network Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups Arthritis Rheum. 63 2011 2755 2763
27. J. Zhao, H. Wu, M. Khosravi, H. Cui, X. Qian, J.A. Kelly, K.M. Kaufman, C.D. Langefeld, A.H. Williams, M.E. Comeau BIOLUPUS Network GENLES Network Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility PLoS Genet. 7 2011 e1002079
28. E. Sanchez, A. Nadig, B.C. Richardson, B.I. Freedman, K.M. Kaufman, J.A. Kelly, T.B. Niewold, D.L. Kamen, G.S. Gilkeson, J.T. Ziegler BIOLUPUS and GENLES Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus Ann. Rheum. Dis. 70 2011 1752 1757
29. M.C. Hochberg Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus Arthritis Rheum. 40 1997 1725
30. J.C. Barrett, B. Fry, J. Maller, and M.J. Daly Haploview: Analysis and visualization of LD and haplotype maps Bioinformatics 21 2005 263 265
31. A.L. Price, N.J. Patterson, R.M. Plenge, M.E. Weinblatt, N.A. Shadick, and D. Reich Principal components analysis corrects for stratification in genome-wide association studies Nat. Genet. 38 2006 904 909
32. P.M. McKeigue, J.R. Carpenter, E.J. Parra, and M.D. Shriver Estimation of admixture and detection of linkage in admixed populations by a Bayesian approach: Application to African-American populations Ann. Hum. Genet. 64 2000 171 186
33. C.J. Hoggart, E.J. Parra, M.D. Shriver, C. Bonilla, R.A. Kittles, D.G. Clayton, and P.M. McKeigue Control of confounding of genetic associations in stratified populations Am. J. Hum. Genet. 72 2003 1492 1504
34. C.J. Hoggart, M.D. Shriver, R.A. Kittles, D.G. Clayton, and P.M. McKeigue Design and analysis of admixture mapping studies Am. J. Hum. Genet. 74 2004 965 978
35. M.W. Smith, N. Patterson, J.A. Lautenberger, A.L. Truelove, G.J. McDonald, A. Waliszewska, B.D. Kessing, M.J. Malasky, C. Scafe, and E. Le A high-density admixture map for disease gene discovery in african americans Am. J. Hum. Genet. 74 2004 1001 1013
36. I. Halder, M. Shriver, M. Thomas, J.R. Fernandez, and T. Frudakis A panel of ancestry informative markers for estimating individual biogeographical ancestry and admixture from four continents: Utility and applications Hum. Mutat. 29 2008 648 658
37. S. Purcell, B. Neale, K. Todd-Brown, L. Thomas, M.A. Ferreira, D. Bender, J. Maller, P. Sklar, P.I. de Bakker, M.J. Daly, and P.C. Sham PLINK: A tool set for whole-genome association and population-based linkage analyses Am. J. Hum. Genet. 81 2007 559 575
38. C.J. Willer, Y. Li, and G.R. Abecasis METAL: Fast and efficient meta-analysis of genomewide association scans Bioinformatics 26 2010 2190 2191
39. W.G. Cochran The Combination of Estimates from Different Experiments Biometrics 10 1954 101 129
40. J.P. Higgins, S.G. Thompson, J.J. Deeks, and D.G. Altman Measuring inconsistency in meta-analyses BMJ 327 2003 557 560
41. H. Li, and R. Durbin Fast and accurate short read alignment with Burrows-Wheeler transform Bioinformatics 25 2009 1754 1760
42. A. McKenna, M. Hanna, E. Banks, A. Sivachenko, K. Cibulskis, A. Kernytsky, K. Garimella, D. Altshuler, S. Gabriel, M. Daly, and M.A. DePristo The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data Genome Res. 20 2010 1297 1303
43. S.R. Browning, and B.L. Browning Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering Am. J. Hum. Genet. 81 2007 1084 1097
44. J.T. Robinson, H. Thorvaldsdóttir, W. Winckler, M. Guttman, E.S. Lander, G. Getz, and J.P. Mesirov Integrative genomics viewer Nat. Biotechnol. 29 2011 24 26
45. K.A. Frazer, D.G. Ballinger, D.R. Cox, D.A. Hinds, L.L. Stuve, R.A. Gibbs, J.W. Belmont, A. Boudreau, P. Hardenbol, S.M. Leal International HapMap Consortium A second generation human haplotype map of over 3.1 million SNPs Nature 449 2007 851 861
46. B.N. Howie, P. Donnelly, and J. Marchini A flexible and accurate genotype imputation method for the next generation of genome-wide association studies PLoS Genet. 5 2009 e1000529
47. M. Via, C. Gignoux, and E.G. Burchard The 1000 Genomes Project: New opportunities for research and social challenges Genome Med. 2 2010 3
48. 1000 Genomes Project Consortium A map of human genome variation from population-scale sequencing Nature 467 2010 1061 1073
49. E. Birney, J.A. Stamatoyannopoulos, A. Dutta, R. Guigó, T.R. Gingeras, E.H. Margulies, Z. Weng, M. Snyder, E.T. Dermitzakis, R.E. Thurman ENCODE Project Consortium NISC Comparative Sequencing Program Baylor College of Medicine Human Genome Sequencing Center Washington University Genome Sequencing Center Broad Institute Children's Hospital Oakland Research Institute Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project Nature 447 2007 799 816
50. T. Tamura, H. Yanai, D. Savitsky, and T. Taniguchi The IRF family transcription factors in immunity and oncogenesis Annu. Rev. Immunol. 26 2008 535 584
51. E.C. Baechler, P.K. Gregersen, and T.W. Behrens The emerging role of interferon in human systemic lupus erythematosus Curr. Opin. Immunol. 16 2004 801 807
52. E.C. Baechler, F.M. Batliwalla, A.M. Reed, E.J. Peterson, P.M. Gaffney, K.L. Moser, P.K. Gregersen, and T.W. Behrens Gene expression profiling in human autoimmunity Immunol. Rev. 210 2006 120 137
53. P.L. De Jager, X. Jia, J. Wang, P.I. de Bakker, L. Ottoboni, N.T. Aggarwal, L. Piccio, S. Raychaudhuri, D. Tran, C. Aubin International MS Genetics Consortium Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci Nat. Genet. 41 2009 776 782
54. International Multiple Sclerosis Genetics Consortium (IMSGC) Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci Hum. Mol. Genet. 19 2010 953 962
55. A. Franke, D.P. McGovern, J.C. Barrett, K. Wang, G.L. Radford-Smith, T. Ahmad, C.W. Lees, T. Balschun, J. Lee, and R. Roberts Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci Nat. Genet. 42 2010 1118 1125
56. X. Liu, P. Invernizzi, Y. Lu, R. Kosoy, Y. Lu, I. Bianchi, M. Podda, C. Xu, G. Xie, and F. Macciardi Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis Nat. Genet. 42 2010 658 660
57. G.M. Hirschfield, X. Liu, Y. Han, I.P. Gorlov, Y. Lu, C. Xu, Y. Lu, W. Chen, B.D. Juran, and C. Coltescu Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis Nat. Genet. 42 2010 655 657
58. E.A. Stahl, S. Raychaudhuri, E.F. Remmers, G. Xie, S. Eyre, B.P. Thomson, Y. Li, F.A. Kurreeman, A. Zhernakova, A. Hinks BIRAC Consortium YEAR Consortium Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci Nat. Genet. 42 2010 508 514
59. C.A. Anderson, G. Boucher, C.W. Lees, A. Franke, M. D'Amato, K.D. Taylor, J.C. Lee, P. Goyette, M. Imielinski, and A. Latiano Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 Nat. Genet. 43 2011 246 252
60. G.M. Hirschfield, X. Liu, C. Xu, Y. Lu, G. Xie, Y. Lu, X. Gu, E.J. Walker, K. Jing, and B.D. Juran Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants N. Engl. J. Med. 360 2009 2544 2555
61. J. Sun, G. Matthias, M.J. Mihatsch, K. Georgopoulos, and P. Matthias Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice J. Immunol. 170 2003 1699 1706
62. International Multiple Sclerosis Genetics Conssortium (IMSGC) IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci Genes Immun. 11 2010 397 405
63. I. Peluso, F. Pallone, and G. Monteleone Interleukin-12 and Th1 immune response in Crohn's disease: Pathogenetic relevance and therapeutic implication World J. Gastroenterol. 12 2006 5606 5610
64. E.F. Remmers, R.M. Plenge, A.T. Lee, R.R. Graham, G. Hom, T.W. Behrens, P.I. de Bakker, J.M. Le, H.S. Lee, and F. Batliwalla STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus N. Engl. J. Med. 357 2007 977 986
65. Y. Jin, S.A. Birlea, P.R. Fain, K. Gowan, S.L. Riccardi, P.J. Holland, C.M. Mailloux, A.J. Sufit, S.M. Hutton, and A. Amadi-Myers Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo N. Engl. J. Med. 362 2010 1686 1697
66. K.A. Hunt, A. Zhernakova, G. Turner, G.A. Heap, L. Franke, M. Bruinenberg, J. Romanos, L.C. Dinesen, A.W. Ryan, and D. Panesar Newly identified genetic risk variants for celiac disease related to the immune response Nat. Genet. 40 2008 395 402