CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation

Nature Genetics

Volumn 44, Issue 11, 2012, Pages 1227-1230

  Manjarrez Orduño, Nataly ^a   Marasco, Emiliano ^a   Chung, Sharon A ^b   Katz, Matthew S ^a   Kiridly, Jenna F ^a   Simpfendorfer, Kim R ^a   Freudenberg, Jan ^a   Ballard, David H ^a   Nashi, Emil ^a,h   Hopkins, Thomas J ^a   Cunninghame Graham, Deborah S ^c   Lee, Annette T ^a   Coenen, Marieke J H ^d   Franke, Barbara ^d   Swinkels, Dorine W ^d   Graham, Robert R ^e   Kimberly, Robert P ^f   Gaffney, Patrick M ^g   Vyse, Timothy J ^c   Behrens, Timothy W ^e   Criswell, Lindsey A ^b   Diamond, Betty ^a   Gregersen, Peter K ^a   more..

^a FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^e GENENTECH INC   (United States)

^f University of Alabama at Birmingham   (United States)

^g OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^h MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN M; PROTEIN KINASE CSK; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CALCIUM MOBILIZATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; CROSS LINKING; GENE INTERACTION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN BLOOD LEVEL; INTRACELLULAR SIGNALING; MEMORY CELL; MONOCYTE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS; UMBILICAL CORD BLOOD;

ALLELES; B-LYMPHOCYTES; GENETIC ASSOCIATION STUDIES; HUMANS; INTRONS; LUPUS ERYTHEMATOSUS, SYSTEMIC; PHOSPHORYLATION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 22; REGULATORY SEQUENCES, NUCLEIC ACID; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 84868208900     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.2439     Document Type: Article

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