메뉴 건너뛰기




Volumn 90, Issue 8, 2014, Pages 687-699

CXCR4 as biomarker for radioresistant cancer stem cells

Author keywords

Biomarker; Cancer stem cells; Radioresistance; Radiotherapy

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; STROMAL CELL DERIVED FACTOR 1;

EID: 84905404344     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553002.2014.906766     Document Type: Article
Times cited : (77)

References (169)
  • 2
    • 84896843067 scopus 로고    scopus 로고
    • A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity
    • Ablett MP, OBrien CS, Sims AH, Farnie G, Clarke RB. 2013. A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity. Oncotarget 5: 599-612.
    • (2013) Oncotarget , vol.5 , pp. 599-612
    • Ablett, M.P.1    Obrien, C.S.2    Sims, A.H.3    Farnie, G.4    Clarke, R.B.5
  • 3
    • 33749499603 scopus 로고    scopus 로고
    • Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes
    • Aghi M, Cohen KS, Klein RJ, Scadden DT, Chiocca EA. 2006. Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Res 66: 9054-9064.
    • (2006) Cancer Res , vol.66 , pp. 9054-9064
    • Aghi, M.1    Cohen, K.S.2    Klein, R.J.3    Scadden, D.T.4    Chiocca, E.A.5
  • 4
    • 0031026475 scopus 로고    scopus 로고
    • The chemokine SDF-1 is a chemoattractant for human CD34 + hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34 + progenitors to peripheral blood
    • Aiuti A, Webb IJ, Bleul C, Springer T, Gutierrez-Ramos JC. 1997. The chemokine SDF-1 is a chemoattractant for human CD34 + hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34 + progenitors to peripheral blood. J Exp Med 185: 111-120.
    • (1997) J Exp Med , vol.185 , pp. 111-120
    • Aiuti, A.1    Webb, I.J.2    Bleul, C.3    Springer, T.4    Gutierrez-Ramos, J.C.5
  • 5
    • 84880555876 scopus 로고    scopus 로고
    • An undesired effect of chemotherapy: Gemcitabine promotes pancreatic cancer cell invasiveness through ROS-dependent, NF-κB-and HIF-1 α-mediated upregulation of CXCR4
    • Arora S, Bhardwaj A, Singh S, Srivastava SK, McClellan S, Nirodi CS, Piazza GA, Grizzle WE, Owen LB, Singh AP. 2013. An undesired effect of chemotherapy: Gemcitabine promotes pancreatic cancer cell invasiveness through ROS-dependent, NF-κB-and HIF-1 α-mediated upregulation of CXCR4. J Biol Chem 288: 21197-21207.
    • (2013) J Biol Chem , vol.288 , pp. 21197-21207
    • Arora, S.1    Bhardwaj, A.2    Singh, S.3    Srivastava, S.K.4    McClellan, S.5    Nirodi, C.S.6    Piazza, G.A.7    Grizzle, W.E.8    Owen, L.B.9    Singh, A.P.10
  • 6
    • 66149150580 scopus 로고    scopus 로고
    • CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy
    • Azab AK, Runnels JM, Pitsillides C, Moreau A-S, Azab F, Leleu X, Jia X, Wright R, Ospina B, Carlson AL, et al. 2009. CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy. Blood 113: 4341-4351.
    • (2009) Blood , vol.113 , pp. 4341-4351
    • Azab, A.K.1    Runnels, J.M.2    Pitsillides, C.3    Moreau, A.-S.4    Azab, F.5    Leleu, X.6    Jia, X.7    Wright, R.8    Ospina, B.9    Carlson, A.L.10
  • 7
    • 84862506605 scopus 로고    scopus 로고
    • Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features
    • Azab AK, Hu J, Quang P, Azab F, Pitsillides C, Awwad R, Thompson B, Maiso P, Sun JD, Hart CP, et al. 2012. Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features. Blood 119: 5782-5794.
    • (2012) Blood , vol.119 , pp. 5782-5794
    • Azab, A.K.1    Hu, J.2    Quang, P.3    Azab, F.4    Pitsillides, C.5    Awwad, R.6    Thompson, B.7    Maiso, P.8    Sun, J.D.9    Hart, C.P.10
  • 8
    • 84866447416 scopus 로고    scopus 로고
    • The evolving concept of cancer and metastasis stem cells
    • Baccelli I, Trumpp A. 2012. The evolving concept of cancer and metastasis stem cells. J Cell Biol 198: 281-293.
    • (2012) J Cell Biol , vol.198 , pp. 281-293
    • Baccelli, I.1    Trumpp, A.2
  • 10
    • 78049478203 scopus 로고    scopus 로고
    • CD44: A cancer stem cell-related biomarker with predictive potential for radiotherapy
    • Baumann M, Krause M. 2010. CD44: A cancer stem cell-related biomarker with predictive potential for radiotherapy. Clin Cancer Res 16: 5091-5093.
    • (2010) Clin Cancer Res , vol.16 , pp. 5091-5093
    • Baumann, M.1    Krause, M.2
  • 11
    • 45849089879 scopus 로고    scopus 로고
    • Exploring the role of cancer stem cells in radioresistance
    • Baumann M, Krause M, Hill R. 2008. Exploring the role of cancer stem cells in radioresistance. Nat Rev Cancer 8: 545-554.
    • (2008) Nat Rev Cancer , vol.8 , pp. 545-554
    • Baumann, M.1    Krause, M.2    Hill, R.3
  • 12
    • 84857186454 scopus 로고    scopus 로고
    • Intermittent hypoxia regulates stem-like characteristics and differentiation of neuroblastoma cells
    • Bhaskara VK, Mohanam I, Rao JS, Mohanam S. 2012. Intermittent hypoxia regulates stem-like characteristics and differentiation of neuroblastoma cells. PLoS One 7: e30905.
    • (2012) PLoS One , vol.7
    • Bhaskara, V.K.1    Mohanam, I.2    Rao, J.S.3    Mohanam, S.4
  • 13
    • 84883548338 scopus 로고    scopus 로고
    • Inhibiting vasculogenesis after radiation: A new paradigm to improve local control by radiotherapy
    • Brown JM. 2013. Inhibiting vasculogenesis after radiation: A new paradigm to improve local control by radiotherapy. Semin Radiat Oncol 23: 281-287.
    • (2013) Semin Radiat Oncol , vol.23 , pp. 281-287
    • Brown, J.M.1
  • 16
    • 33344464945 scopus 로고    scopus 로고
    • CXCR4: A key receptor in the crosstalk between tumor cells and their microenvironment
    • Burger JA, Kipps TJ. 2006. CXCR4: A key receptor in the crosstalk between tumor cells and their microenvironment. Blood 107: 1761-1767.
    • (2006) Blood , vol.107 , pp. 1761-1767
    • Burger, J.A.1    Kipps, T.J.2
  • 17
    • 23944488816 scopus 로고    scopus 로고
    • Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells
    • Burger M, Hartmann T, Krome M, Rawluk J, Tamamura H, Fujii N, Kipps TJ, Burger JA. 2005. Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood 106: 1824-1830.
    • (2005) Blood , vol.106 , pp. 1824-1830
    • Burger, M.1    Hartmann, T.2    Krome, M.3    Rawluk, J.4    Tamamura, H.5    Fujii, N.6    Kipps, T.J.7    Burger, J.A.8
  • 19
    • 84861913141 scopus 로고    scopus 로고
    • High-resolution in-vivo analysis of normal brain response to cranial irradiation
    • Burrell K, Hill RP, Zadeh G. 2012. High-resolution in-vivo analysis of normal brain response to cranial irradiation. PLoS One 7: e38366.
    • (2012) PLoS One , vol.7
    • Burrell, K.1    Hill, R.P.2    Zadeh, G.3
  • 20
    • 84887025650 scopus 로고    scopus 로고
    • Clinical perspectives of cancer stem cell research in radiation oncology
    • Bütof R, Dubrovska A, Baumann M. 2013. Clinical perspectives of cancer stem cell research in radiation oncology. Radiother Oncol 108: 388-396.
    • (2013) Radiother Oncol , vol.108 , pp. 388-396
    • Bütof, R.1    Dubrovska, A.2    Baumann, M.3
  • 21
    • 84871774384 scopus 로고    scopus 로고
    • Dual inhibition of plasminogen kringle 5 on angiogenesis and chemotaxis suppresses tumor metastasis by targeting HIF-1 α pathway
    • Cai W-B, Zhang Y, Cheng R, Wang Z, Fang S-H, Xu Z-M, Yang X, Yang Z-H, Ma J-X, Shao C-K, et al. 2012. Dual inhibition of plasminogen kringle 5 on angiogenesis and chemotaxis suppresses tumor metastasis by targeting HIF-1 α pathway. PLoS One 7: e53152.
    • (2012) PLoS One , vol.7
    • Cai, W.-B.1    Zhang, Y.2    Cheng, R.3    Wang, Z.4    Fang, S.-H.5    Xu, Z.-M.6    Yang, X.7    Yang, Z.-H.8    Ma, J.-X.9    Shao, C.-K.10
  • 22
    • 1542405875 scopus 로고    scopus 로고
    • Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma
    • Cairns RA, Hill RP. 2004. Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma. Cancer Res 64: 2054-2061.
    • (2004) Cancer Res , vol.64 , pp. 2054-2061
    • Cairns, R.A.1    Hill, R.P.2
  • 24
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • Chaffer CL, Weinberg RA. 2011. A perspective on cancer cell metastasis . Science 331: 1559-1564.
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 25
    • 65649136924 scopus 로고    scopus 로고
    • Increased expression of metastasisrelated genes in hypoxic cells sorted from cervical and lymph nodal xenograft tumors
    • Chaudary N, Hill RP. 2009. Increased expression of metastasisrelated genes in hypoxic cells sorted from cervical and lymph nodal xenograft tumors. Lab Invest 89: 587-596.
    • (2009) Lab Invest , vol.89 , pp. 587-596
    • Chaudary, N.1    Hill, R.P.2
  • 26
    • 84887019324 scopus 로고    scopus 로고
    • Hypoxia and metastasis in an orthotopic cervix cancer xenograft model
    • Chaudary N, Mujcic H, Wouters BG, Hill RP 2013. Hypoxia and metastasis in an orthotopic cervix cancer xenograft model. Radiother Oncol. http://dx.doi.org/10.1016/j.radonc.2013.06.019
    • (2013) Radiother Oncol
    • Chaudary, N.1    Mujcic, H.2    Wouters, B.G.3    Hill, R.P.4
  • 27
    • 84879240401 scopus 로고    scopus 로고
    • Combination of vessel-targeting agents and fractionated radiation therapy: The role of the SDF-1/CXCR4 Pathway
    • Chen F-H, Fu S-Y, Yang Y-C, Wang C-C, Chiang C-S, Hong J-H. 2013a. Combination of vessel-targeting agents and fractionated radiation therapy: The role of the SDF-1/CXCR4 Pathway. Int J Radiat Oncol 86: 777-784.
    • (2013) Int J Radiat Oncol , vol.86 , pp. 777-784
    • Chen, F.-H.1    Fu, S.-Y.2    Yang, Y.-C.3    Wang, C.-C.4    Chiang, C.-S.5    Hong, J.-H.6
  • 28
    • 84878529330 scopus 로고    scopus 로고
    • CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia
    • Chen Y, Jacamo R, Konopleva M, Garzon R, Croce C, Andreeff M. 2013b. CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia. J Clin Invest 123: 2395-2407.
    • (2013) J Clin Invest , vol.123 , pp. 2395-2407
    • Chen, Y.1    Jacamo, R.2    Konopleva, M.3    Garzon, R.4    Croce, C.5    Andreeff, M.6
  • 30
    • 29344451650 scopus 로고    scopus 로고
    • CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: The role of bone microenvironment-associated CXCL12
    • Chinni SR, Sivalogan S, Dong Z, Filho JCT, Deng X, Bonfil RD, Cher ML. 2006. CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: The role of bone microenvironment-associated CXCL12. The Prostate 66: 32-48.
    • (2006) The Prostate , vol.66 , pp. 32-48
    • Chinni, S.R.1    Sivalogan, S.2    Dong, Z.3    Filho, J.C.T.4    Deng, X.5    Bonfil, R.D.6    Cher, M.L.7
  • 31
    • 84893093656 scopus 로고    scopus 로고
    • CXCR4, but not CXCR7, discriminates metastatic behavior in nonsmall cell lung cancer cells
    • Choi YH, Burdick MD, Strieter BA, Mehrad B, Strieter RM. 2013. CXCR4, but not CXCR7, discriminates metastatic behavior in nonsmall cell lung cancer cells. Mol Cancer Res 12: 38-47.
    • (2013) Mol Cancer Res , vol.12 , pp. 38-47
    • Choi, Y.H.1    Burdick, M.D.2    Strieter, B.A.3    Mehrad, B.4    Strieter, R.M.5
  • 32
    • 0038681342 scopus 로고    scopus 로고
    • The bicyclam AMD3100 story
    • De Clercq E. 2003. The bicyclam AMD3100 story. Nat Rev Drug Discov 2: 581-587.
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 581-587
    • De Clercq, E.1
  • 34
    • 84880854554 scopus 로고    scopus 로고
    • PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling
    • Conley-LaComb MK, Saliganan A, Kandagatla P, Chen YQ, Cher ML, Chinni SR. 2013. PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling . Mol Cancer 12: 85.
    • (2013) Mol Cancer , vol.12 , pp. 85
    • Conley-Lacomb, M.K.1    Saliganan, A.2    Kandagatla, P.3    Chen, Y.Q.4    Cher, M.L.5    Chinni, S.R.6
  • 35
    • 0023574890 scopus 로고
    • Electron transfer from protein to DNA in irradiated chromatin
    • Cullis PM, Jones GD, Symons MC, Lea JS. 1987. Electron transfer from protein to DNA in irradiated chromatin. Nature 330: 773-774.
    • (1987) Nature , vol.330 , pp. 773-774
    • Cullis, P.M.1    Jones, G.D.2    Symons, M.C.3    Lea, J.S.4
  • 36
  • 37
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean M, Fojo T, Bates S. 2005. Tumour stem cells and drug resistance. Nat Rev Cancer 5: 275-284.
    • (2005) Nat Rev Cancer , vol.5 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 38
    • 80052768977 scopus 로고    scopus 로고
    • CXCR7/CXCR4 heterodimer constitutively recruits ã -arrestin to enhance cell migration
    • Décaillot FM, Kazmi MA, Lin Y, Ray-Saha S, Sakmar TP, Sachdev P. 2011. CXCR7/CXCR4 heterodimer constitutively recruits ã -arrestin to enhance cell migration. J Biol Chem 286: 32188-32197.
    • (2011) J Biol Chem , vol.286 , pp. 32188-32197
    • Décaillot, F.M.1    Kazmi, M.A.2    Lin, Y.3    Ray-Saha, S.4    Sakmar, T.P.5    Sachdev, P.6
  • 39
    • 84860335684 scopus 로고    scopus 로고
    • Radioresistance of prostate cancer cells with low proteasome activity
    • Della Donna L, Lagadec C, Pajonk F. 2012. Radioresistance of prostate cancer cells with low proteasome activity. Prostate 72: 868-874.
    • (2012) Prostate , vol.72 , pp. 868-874
    • Della Donna, L.1    Lagadec, C.2    Pajonk, F.3
  • 45
  • 47
    • 84863005214 scopus 로고    scopus 로고
    • CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signalling
    • Dubrovska A, Hartung A, Bouchez LC, Walker JR, Reddy VA, Cho CY, Schultz PG. 2012b. CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signalling. Br J Cancer 107: 43-52.
    • (2012) Br J Cancer , vol.107 , pp. 43-52
    • Dubrovska, A.1    Hartung, A.2    Bouchez, L.C.3    Walker, J.R.4    Reddy, V.A.5    Cho, C.Y.6    Schultz, P.G.7
  • 48
    • 79954606458 scopus 로고    scopus 로고
    • CXCL12 (SDF1?)-CXCR4/CXCR7 pathway inhibition: An emerging sensitizer for anti-cancer therapies?
    • Duda DG, Kozin SV, Kirkpatrick ND, Xu L, Fukumura D, Jain RK. 2011. CXCL12 (SDF1?)-CXCR4/CXCR7 pathway inhibition: An emerging sensitizer for anti-cancer therapies? Clin Cancer Res 17: 2074-2080.
    • (2011) Clin Cancer Res , vol.17 , pp. 2074-2080
    • Duda, D.G.1    Kozin, S.V.2    Kirkpatrick, N.D.3    Xu, L.4    Fukumura, D.5    Jain, R.K.6
  • 49
    • 79960363201 scopus 로고    scopus 로고
    • Radiobiology goes 3D: How ECM and cell morphology impact on cell survival after irradiation
    • Eke I, Cordes N. 2011. Radiobiology goes 3D: How ECM and cell morphology impact on cell survival after irradiation. Radiother Oncol 99: 271-278.
    • (2011) Radiother Oncol , vol.99 , pp. 271-278
    • Eke, I.1    Cordes, N.2
  • 52
    • 84876252582 scopus 로고    scopus 로고
    • SDF-1-CXCR4 axis: Cell trafficking in the cancer stem cell niche of head and neck squamous cell carcinoma
    • Faber A. 2013. SDF-1-CXCR4 axis: Cell trafficking in the cancer stem cell niche of head and neck squamous cell carcinoma. Oncol Rep 29: 2325-2331.
    • (2013) Oncol Rep , vol.29 , pp. 2325-2331
    • Faber, A.1
  • 56
    • 84862785015 scopus 로고    scopus 로고
    • Expression of chemokine receptors on circulating tumor cells in patients with solid tumors
    • Fusi A, Liu Z, Kümmerlen V, Nonnemacher A, Jeske J, Keilholz U. 2012. Expression of chemokine receptors on circulating tumor cells in patients with solid tumors. J Transl Med 10: 52.
    • (2012) J Transl Med , vol.10 , pp. 52
    • Fusi, A.1    Liu, Z.2    Kümmerlen, V.3    Nonnemacher, A.4    Jeske, J.5    Keilholz, U.6
  • 57
    • 0036467638 scopus 로고    scopus 로고
    • Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer
    • Fyles A, Milosevic M, Hedley D, Pintilie M, Levin W, Manchul L, Hill RP. 2002. Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer. J Clin Oncol 20: 680-687.
    • (2002) J Clin Oncol , vol.20 , pp. 680-687
    • Fyles, A.1    Milosevic, M.2    Hedley, D.3    Pintilie, M.4    Levin, W.5    Manchul, L.6    Hill, R.P.7
  • 58
    • 33748150486 scopus 로고    scopus 로고
    • Long-term performance of interstial fluid pressure and hypoxia as prognostic factors in cervix cancer
    • Fyles A, Milosevic M, Pintilie M, Syed A, Levin W, Manchul L, Hill RP. 2006. Long-term performance of interstial fluid pressure and hypoxia as prognostic factors in cervix cancer. Radiother Oncol 80: 132-137.
    • (2006) Radiother Oncol , vol.80 , pp. 132-137
    • Fyles, A.1    Milosevic, M.2    Pintilie, M.3    Syed, A.4    Levin, W.5    Manchul, L.6    Hill, R.P.7
  • 59
    • 65649149328 scopus 로고    scopus 로고
    • Activation of signal transducers and activators of transcription 3 and focal adhesion kinase by stromal cell-derived factor 1 is required for migration of human mesenchymal stem cells in response to tumor cell-conditioned medium
    • Gao H, Priebe W, Glod J, Banerjee D. 2009. Activation of signal transducers and activators of transcription 3 and focal adhesion kinase by stromal cell-derived factor 1 is required for migration of human mesenchymal stem cells in response to tumor cell-conditioned medium. Stem Cells 27: 857-865.
    • (2009) Stem Cells , vol.27 , pp. 857-865
    • Gao, H.1    Priebe, W.2    Glod, J.3    Banerjee, D.4
  • 61
    • 85006555769 scopus 로고    scopus 로고
    • Connexin-43 regulates p38-mediated cell migration and invasion induced selectively in tumour cells by low doses of ã -radiation in an ERK-1/2-independent manner
    • Ghosh S, Kumar A, Tripathi RP, Chandna S. 2013. Connexin-43 regulates p38-mediated cell migration and invasion induced selectively in tumour cells by low doses of ã -radiation in an ERK-1/2-independent manner. Carcinogenesis bg t 303.
    • (2013) Carcinogenesis Bgt , vol.303
    • Ghosh, S.1    Kumar, A.2    Tripathi, R.P.3    Chandna, S.4
  • 62
    • 46749121459 scopus 로고    scopus 로고
    • Causes and consequences of increased glucose metabolism of cancers
    • Gillies RJ, Robey I, Gatenby RA. 2008. Causes and consequences of increased glucose metabolism of cancers. J Nucl Med 49: 24S-42S.
    • (2008) J Nucl Med , vol.49
    • Gillies, R.J.1    Robey, I.2    Gatenby, R.A.3
  • 66
    • 84864287761 scopus 로고    scopus 로고
    • Can irradiation of potential cancer stem-cell niche in the subventricular zone influence survival in patients with newly diagnosed glioblastoma?
    • Gupta T, Nair V, Paul SN, Kannan S, Moiyadi A, Epari S, Jalali R. 2012. Can irradiation of potential cancer stem-cell niche in the subventricular zone influence survival in patients with newly diagnosed glioblastoma? J Neurooncol 109: 195-203.
    • (2012) J Neurooncol , vol.109 , pp. 195-203
    • Gupta, T.1    Nair, V.2    Paul, S.N.3    Kannan, S.4    Moiyadi, A.5    Epari, S.6    Jalali, R.7
  • 69
    • 84875785031 scopus 로고    scopus 로고
    • CXCR4 expression and treatment with SDF-1? or plerixafor modulate proliferation and chemosensitivity of colon cancer cells
    • Heckmann D, Maier P, Laufs S, Wenz F, Zeller WJ, Fruehauf S, Allgayer H. 2013. CXCR4 expression and treatment with SDF-1? or plerixafor modulate proliferation and chemosensitivity of colon cancer cells. Transl Oncol 6: 124-132.
    • (2013) Transl Oncol , vol.6 , pp. 124-132
    • Heckmann, D.1    Maier, P.2    Laufs, S.3    Wenz, F.4    Zeller, W.J.5    Fruehauf, S.6    Allgayer, H.7
  • 73
    • 0024535580 scopus 로고
    • The proportion of stem cells in murine tumors
    • Hill RP, Milas L. 1989. The proportion of stem cells in murine tumors. Int J Radiat Oncol 16: 513-518.
    • (1989) Int J Radiat Oncol , vol.16 , pp. 513-518
    • Hill, R.P.1    Milas, L.2
  • 75
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, molecular aspects
    • Höckel M, Vaupel P. 2001. Tumor hypoxia: Definitions and current clinical, biologic, molecular aspects. J Natl Cancer Inst 93: 266-276.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 266-276
    • Höckel, M.1    Vaupel, P.2
  • 77
    • 77956213104 scopus 로고    scopus 로고
    • Radiotherapy suppresses angiogenesis in mice through TGF-Ã RI/ ALK5-dependent inhibition of endothelial cell sprouting
    • Imaizumi N, Monnier Y, Hegi M, Mirimanoff R-O, Rüegg C. 2010. Radiotherapy suppresses angiogenesis in mice through TGF-ã RI/ ALK5-dependent inhibition of endothelial cell sprouting. PLoS One 5: e11084.
    • (2010) PLoS One , vol.5
    • Imaizumi, N.1    Monnier, Y.2    Hegi, M.3    Mirimanoff, R.-O.4    Rüegg, C.5
  • 81
    • 77957157551 scopus 로고    scopus 로고
    • The multiple faces of CXCL12 (SDF-1 á ) in the regulation of immunity during health and disease
    • Karin N. 2010. The multiple faces of CXCL12 (SDF-1 á ) in the regulation of immunity during health and disease. J Leukoc Biol 88: 463-473.
    • (2010) J Leukoc Biol , vol.88 , pp. 463-473
    • Karin, N.1
  • 82
    • 67349192258 scopus 로고    scopus 로고
    • Biochip arrays for the discovery of a biomarker surrogate in a phase I/II study assessing a novel antimetastasis agent
    • Kavsak PA, Henderson M, Moretto P, Hirte H, Evans K, Wong D, Korz W, Hotte SJ. 2009. Biochip arrays for the discovery of a biomarker surrogate in a phase I/II study assessing a novel antimetastasis agent. Clin Biochem 42: 1162-1165.
    • (2009) Clin Biochem , vol.42 , pp. 1162-1165
    • Kavsak, P.A.1    Henderson, M.2    Moretto, P.3    Hirte, H.4    Evans, K.5    Wong, D.6    Korz, W.7    Hotte, S.J.8
  • 83
    • 77949697909 scopus 로고    scopus 로고
    • Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice
    • Kioi M, Vogel H, Schultz G, Hoffman RM, Harsh GR, Brown JM. 2010. Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J Clin Invest 120: 694-705.
    • (2010) J Clin Invest , vol.120 , pp. 694-705
    • Kioi, M.1    Vogel, H.2    Schultz, G.3    Hoffman, R.M.4    Harsh, G.R.5    Brown, J.M.6
  • 84
    • 77955019652 scopus 로고    scopus 로고
    • Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation
    • Kozin SV, Kamoun WS, Huang Y, Dawson MR, Jain RK, Duda DG. 2010. Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation. Cancer Res 70: 5679-5685.
    • (2010) Cancer Res , vol.70 , pp. 5679-5685
    • Kozin, S.V.1    Kamoun, W.S.2    Huang, Y.3    Dawson, M.R.4    Jain, R.K.5    Duda, D.G.6
  • 85
    • 82555205497 scopus 로고    scopus 로고
    • Cancer stem cells: Targets and potential biomarkers for radiotherapy
    • Krause M, Yaromina A, Eicheler W, Koch U, Baumann M. 2011. Cancer stem cells: Targets and potential biomarkers for radiotherapy. Clin Cancer Res 17: 7224-7229.
    • (2011) Clin Cancer Res , vol.17 , pp. 7224-7229
    • Krause, M.1    Yaromina, A.2    Eicheler, W.3    Koch, U.4    Baumann, M.5
  • 87
    • 84866895030 scopus 로고    scopus 로고
    • Molecular pathways: Emerging pathways mediating growth, invasion, metastasis of tumors progressing in an irradiated microenvironment
    • Kuonen F, Secondini C, Rüegg C. 2012. Molecular pathways: Emerging pathways mediating growth, invasion, metastasis of tumors progressing in an irradiated microenvironment. Clin Cancer Res 18: 5196-5202.
    • (2012) Clin Cancer Res , vol.18 , pp. 5196-5202
    • Kuonen, F.1    Secondini, C.2    Rüegg, C.3
  • 88
    • 77956034139 scopus 로고    scopus 로고
    • Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment
    • Lagadec C, Vlashi E, Donna LD, Meng Y, Dekmezian C, Kim K, Pajonk F. 2010. Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment. Breast Cancer Res 12: R13.
    • (2010) Breast Cancer Res , vol.12
    • Lagadec, C.1    Vlashi, E.2    Donna, L.D.3    Meng, Y.4    Dekmezian, C.5    Kim, K.6    Pajonk, F.7
  • 91
    • 67650349084 scopus 로고    scopus 로고
    • CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling
    • Levoye A, Balabanian K, Baleux F, Bachelerie F, Lagane B. 2009. CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling. Blood 113: 6085-6093.
    • (2009) Blood , vol.113 , pp. 6085-6093
    • Levoye, A.1    Balabanian, K.2    Baleux, F.3    Bachelerie, F.4    Lagane, B.5
  • 92
    • 78349257041 scopus 로고    scopus 로고
    • Hypoxia and hypoxia inducible factors in cancer stem cell maintenance
    • Simon, MC, editor. New York Springer Berlin Heidelberg
    • Li Z, Rich JN. 2010. Hypoxia and hypoxia inducible factors in cancer stem cell maintenance. In: Simon, MC, editor. Diverse effects of hypoxia on tumor progression. New York: Springer Berlin Heidelberg; pp. 21-30.
    • (2010) Diverse Effects of Hypoxia on Tumor Progression , pp. 21-30
    • Li, Z.1    Rich, J.N.2
  • 93
    • 84861692240 scopus 로고    scopus 로고
    • SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial-mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway
    • Li X, Ma Q, Xu Q, Liu H, Lei J, Duan W, Bhat K, Wang F, Wu E, Wang Z. 2012. SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial-mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway. Cancer Lett 322: 169-176.
    • (2012) Cancer Lett , vol.322 , pp. 169-176
    • Li, X.1    Ma, Q.2    Xu, Q.3    Liu, H.4    Lei, J.5    Duan, W.6    Bhat, K.7    Wang, F.8    Wu, E.9    Wang, Z.10
  • 96
    • 0036786348 scopus 로고    scopus 로고
    • CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, adhesion
    • Presented at the Annual Meeting of the American Society of Hematology Orlando, FL, December 7-11, 2001
    • Libura J, Drukala J, Majka M, Tomescu O, Navenot JM, Kucia M, Marquez L, Peiper SC, Barr FG, Janowska-Wieczorek A, et al. 2002. CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, adhesion Presented at the Annual Meeting of the American Society of Hematology, Orlando, FL, December 7-11, 2001. Blood 100: 2597-2606.
    • (2002) Blood , vol.100 , pp. 2597-2606
    • Libura, J.1    Drukala, J.2    Majka, M.3    Tomescu, O.4    Navenot, J.M.5    Kucia, M.6    Marquez, L.7    Peiper, S.C.8    Barr, F.G.9    Janowska-Wieczorek, A.10
  • 97
    • 67650675165 scopus 로고    scopus 로고
    • Stromal cell-derived factor-1 promotes survival of pancreatic beta cells by the stabilisation of beta-catenin and activation of transcription factor 7-like 2 (TCF7L2)
    • Liu Z, Habener JF. 2009. Stromal cell-derived factor-1 promotes survival of pancreatic beta cells by the stabilisation of beta-catenin and activation of transcription factor 7-like 2 (TCF7L2). Diabetologia 52: 1589-1598.
    • (2009) Diabetologia , vol.52 , pp. 1589-1598
    • Liu, Z.1    Habener, J.F.2
  • 98
    • 84872771277 scopus 로고    scopus 로고
    • SDF-1 promotes endochondral bone repair during fracture healing at the traumatic brain injury condition
    • Liu X, Zhou C, Li Y, Ji Y, Xu G, Wang X, Yan J. 2013. SDF-1 promotes endochondral bone repair during fracture healing at the traumatic brain injury condition. PLoS One 8: e54077.
    • (2013) PLoS One , vol.8
    • Liu, X.1    Zhou, C.2    Li, Y.3    Ji, Y.4    Xu, G.5    Wang, X.6    Yan, J.7
  • 99
    • 0037076290 scopus 로고    scopus 로고
    • Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor
    • Lu M, Grove EA, Miller RJ. 2002. Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor. Proc Natl Acad Sci USA 99: 7090-7095.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 7090-7095
    • Lu, M.1    Grove, E.A.2    Miller, R.J.3
  • 100
    • 84912525332 scopus 로고    scopus 로고
    • The impact of radiation therapy on the antitumor immunity: Local effects and systemic consequences
    • Lumniczky K, Sáfrány G 2013. The impact of radiation therapy on the antitumor immunity: Local effects and systemic consequences. Cancer Lett. http://dx.doi.org/10.1016/j.canlet.2013.08.024
    • (2013) Cancer Lett
    • Lumniczky, K.1    Sáfrány, G.2
  • 101
    • 84901489826 scopus 로고    scopus 로고
    • Infiltrating bone marrow mesenchymal stem cells increase prostate cancer stem cell population and metastatic ability via secreting cytokines to suppress androgen receptor signaling
    • doi: 10.1038/onc.2013.233
    • Luo J, Ok Lee S, Liang L, Huang C-K, Li L, Wen S, Chang C. 2013. Infiltrating bone marrow mesenchymal stem cells increase prostate cancer stem cell population and metastatic ability via secreting cytokines to suppress androgen receptor signaling. Oncogene. doi: 10.1038/onc.2013.233
    • (2013) Oncogene
    • Luo, J.1    Ok Lee, S.2    Liang, L.3    Huang, C.-K.4    Li, L.5    Wen, S.6    Chang, C.7
  • 102
    • 33646353217 scopus 로고    scopus 로고
    • SDF1alpha/CXCR4 signaling stimulates beta-catenin transcriptional activity in rat neural progenitors
    • Luo Y, Cai J, Xue H, Mattson MP, Rao MS. 2006. SDF1alpha/CXCR4 signaling stimulates beta-catenin transcriptional activity in rat neural progenitors. Neurosci Lett 398: 291-295.
    • (2006) Neurosci Lett , vol.398 , pp. 291-295
    • Luo, Y.1    Cai, J.2    Xue, H.3    Mattson, M.P.4    Rao, M.S.5
  • 106
    • 77954626403 scopus 로고    scopus 로고
    • Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4
    • Malik R, Marchese A. 2010. Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4. Mol Biol Cell 21: 2529-2541.
    • (2010) Mol Biol Cell , vol.21 , pp. 2529-2541
    • Malik, R.1    Marchese, A.2
  • 107
    • 0035824563 scopus 로고    scopus 로고
    • Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sorting
    • Marchese A, Benovic JL. 2001. Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sorting. J Biol Chem 276: 45509-45512.
    • (2001) J Biol Chem , vol.276 , pp. 45509-45512
    • Marchese, A.1    Benovic, J.L.2
  • 108
    • 0242362743 scopus 로고    scopus 로고
    • The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4
    • Marchese A, Raiborg C, Santini F, Keen JH, Stenmark H, Benovic JL. 2003. The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. Dev Cell 5: 709-722.
    • (2003) Dev Cell , vol.5 , pp. 709-722
    • Marchese, A.1    Raiborg, C.2    Santini, F.3    Keen, J.H.4    Stenmark, H.5    Benovic, J.L.6
  • 109
    • 84867514301 scopus 로고    scopus 로고
    • Targeting hypoxia, HIF-1, tumor glucose metabolism to improve radiotherapy efficacy
    • Meijer TWH, Kaanders JHAM, Span PN, Bussink J. 2012. Targeting hypoxia, HIF-1, tumor glucose metabolism to improve radiotherapy efficacy. Clin Cancer Res 18: 5585-5594.
    • (2012) Clin Cancer Res , vol.18 , pp. 5585-5594
    • Meijer, T.W.H.1    Kaanders, J.H.A.M.2    Span, P.N.3    Bussink, J.4
  • 111
    • 60649100252 scopus 로고    scopus 로고
    • Cancer stem cells and tumor response to therapy: Current problems and future prospects
    • Milas L, Hittelman WN. 2009. Cancer stem cells and tumor response to therapy: Current problems and future prospects. Semin Radiat Oncol 19: 96-105.
    • (2009) Semin Radiat Oncol , vol.19 , pp. 96-105
    • Milas, L.1    Hittelman, W.N.2
  • 114
    • 84865175881 scopus 로고    scopus 로고
    • Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4
    • Ok S, Kim S-M, Kim C, Nam D, Shim BS, Kim S-H, Ahn KS, Choi S-H, Ahn KS. 2012. Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4. Immunopharmacol Immunotoxicol 34: 768-778.
    • (2012) Immunopharmacol Immunotoxicol , vol.34 , pp. 768-778
    • Ok, S.1    Kim, S.-M.2    Kim, C.3    Nam, D.4    Shim, B.S.5    Kim, S.-H.6    Ahn, K.S.7    Choi, S.-H.8    Ahn, K.S.9
  • 116
    • 0033215242 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
    • Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR. 1999. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res 59: 5002-5011.
    • (1999) Cancer Res , vol.59 , pp. 5002-5011
    • Olumi, A.F.1    Grossfeld, G.D.2    Hayward, S.W.3    Carroll, P.R.4    Tlsty, T.D.5    Cunha, G.R.6
  • 117
  • 118
    • 50549121134 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • Paget S. 1889. The distribution of secondary growths in cancer of the breast. Lancet 133: 571-573.
    • (1889) Lancet , vol.133 , pp. 571-573
    • Paget, S.1
  • 119
    • 84883492517 scopus 로고    scopus 로고
    • Characterization of the stem cell niche and its importance in radiobiological response
    • Pajonk F, Vlashi E. 2013. Characterization of the stem cell niche and its importance in radiobiological response. Semin Radiat Oncol 23: 237-241.
    • (2013) Semin Radiat Oncol , vol.23 , pp. 237-241
    • Pajonk, F.1    Vlashi, E.2
  • 120
    • 77950972011 scopus 로고    scopus 로고
    • Radiation resistance of cancer stem cells: The 4 R s of radiobiology revisited
    • Pajonk F, Vlashi E, McBride WH. 2010. Radiation resistance of cancer stem cells: The 4 R s of radiobiology revisited. Stem Cells 28: 639-648.
    • (2010) Stem Cells , vol.28 , pp. 639-648
    • Pajonk, F.1    Vlashi, E.2    McBride, W.H.3
  • 123
    • 33845904383 scopus 로고    scopus 로고
    • The response of CD24(-/ low)/CD44 + breast cancer-initiating cells to radiation
    • Phillips TM, McBride WH, Pajonk F. 2006. The response of CD24(-/ low)/CD44 + breast cancer-initiating cells to radiation. J Natl Cancer Inst 98: 1777-1785.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1777-1785
    • Phillips, T.M.1    McBride, W.H.2    Pajonk, F.3
  • 125
    • 33750294009 scopus 로고    scopus 로고
    • The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis, regeneration and tumorigenesis
    • Ratajczak MZ, Zuba-Surma E, Kucia M, Reca R, Wojakowski W, Ratajczak J. 2006. The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis, regeneration and tumorigenesis. Leukemia 20: 1915-1924.
    • (2006) Leukemia , vol.20 , pp. 1915-1924
    • Ratajczak, M.Z.1    Zuba-Surma, E.2    Kucia, M.3    Reca, R.4    Wojakowski, W.5    Ratajczak, J.6
  • 126
    • 84856712678 scopus 로고    scopus 로고
    • Mobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4
    • Rettig MP, Ansstas G, DiPersio JF. 2012. Mobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4. Leukemia 26: 34-53.
    • (2012) Leukemia , vol.26 , pp. 34-53
    • Rettig, M.P.1    Ansstas, G.2    Dipersio, J.F.3
  • 130
    • 84881254331 scopus 로고    scopus 로고
    • Cortical lesion stimulates adult subventricular zone neural progenitor cell proliferation and migration to the site of injury
    • Saha B, Peron S, Murray K, Jaber M, Gaillard A. 2013. Cortical lesion stimulates adult subventricular zone neural progenitor cell proliferation and migration to the site of injury. Stem Cell Res 11: 965-977.
    • (2013) Stem Cell Res , vol.11 , pp. 965-977
    • Saha, B.1    Peron, S.2    Murray, K.3    Jaber, M.4    Gaillard, A.5
  • 132
    • 0018102359 scopus 로고
    • The relationship between the spleen colony-forming cell and the haemopoietic stem cell
    • Schofield R. 1978. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells 4: 7-25.
    • (1978) Blood Cells , vol.4 , pp. 7-25
    • Schofield, R.1
  • 135
    • 84874714149 scopus 로고    scopus 로고
    • MLLrearranged acute lymphoblastic leukaemia stem cell interactions with bone marrow stroma promote survival and therapeutic resistance that can be overcome with CXCR4 antagonism
    • Sison EAR, Rau RE, McIntyre E, Li L, Small D, Brown P. 2013. MLLrearranged acute lymphoblastic leukaemia stem cell interactions with bone marrow stroma promote survival and therapeutic resistance that can be overcome with CXCR4 antagonism. Br J Haematol 160: 785-797.
    • (2013) Br J Haematol , vol.160 , pp. 785-797
    • Sison, E.A.R.1    Rau, R.E.2    McIntyre, E.3    Li, L.4    Small, D.5    Brown, P.6
  • 139
    • 84865794221 scopus 로고    scopus 로고
    • Involvement of Wnt signaling in the injury of murine mesenchymal stem cells exposed to X-radiation
    • Su W, Chen Y, Zeng W, Liu W, Sun H. 2012. Involvement of Wnt signaling in the injury of murine mesenchymal stem cells exposed to X-radiation. Int J Radiat Biol 88: 635-641.
    • (2012) Int J Radiat Biol , vol.88 , pp. 635-641
    • Su, W.1    Chen, Y.2    Zeng, W.3    Liu, W.4    Sun, H.5
  • 140
    • 33749262441 scopus 로고    scopus 로고
    • Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF-Ã -dependent HIF-1 á -mediated induction of CXCL12
    • Tabatabai G, Frank B, Möhle R, Weller M, Wick W. 2006. Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF-ã -dependent HIF-1 á -mediated induction of CXCL12. Brain 129: 2426-2435.
    • (2006) Brain , vol.129 , pp. 2426-2435
    • Tabatabai, G.1    Frank, B.2    Möhle, R.3    Weller, M.4    Wick, W.5
  • 145
    • 84857789336 scopus 로고    scopus 로고
    • Understanding cancer stem cell heterogeneity and plasticity
    • Tang DG. 2012. Understanding cancer stem cell heterogeneity and plasticity. Cell Res 22: 457-472.
    • (2012) Cell Res , vol.22 , pp. 457-472
    • Tang, D.G.1
  • 146
    • 77953090345 scopus 로고    scopus 로고
    • CXCL12 (SDF-1)/CXCR4 pathway in cancer
    • Teicher BA, Fricker SP. 2010. CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res 16: 2927-2931.
    • (2010) Clin Cancer Res , vol.16 , pp. 2927-2931
    • Teicher, B.A.1    Fricker, S.P.2
  • 148
    • 79958107497 scopus 로고    scopus 로고
    • Targeting SDF-1/ CXCR4 to inhibit tumour vasculature for treatment of glioblastomas
    • Tseng D, Vasquez-Medrano DA, Brown JM. 2011. Targeting SDF-1/ CXCR4 to inhibit tumour vasculature for treatment of glioblastomas. Br J Cancer 104: 1805-1809.
    • (2011) Br J Cancer , vol.104 , pp. 1805-1809
    • Tseng, D.1    Vasquez-Medrano, D.A.2    Brown, J.M.3
  • 149
    • 33846430034 scopus 로고    scopus 로고
    • Structure-activity relationships of cyclic peptide-based chemokine receptor cxcr4 antagonists: Disclosing the importance of side-chain and backbone functionalities
    • Ueda S, Oishi S, Wang Z, Araki T, Tamamura H, Cluzeau J, Ohno H, Kusano S, Nakashima H, Trent JO, et al. 2007. Structure-activity relationships of cyclic peptide-based chemokine receptor cxcr4 antagonists: Disclosing the importance of side-chain and backbone functionalities. J Med Chem 50: 192-198.
    • (2007) J Med Chem , vol.50 , pp. 192-198
    • Ueda, S.1    Oishi, S.2    Wang, Z.3    Araki, T.4    Tamamura, H.5    Cluzeau, J.6    Ohno, H.7    Kusano, S.8    Nakashima, H.9    Trent, J.O.10
  • 150
    • 56249128987 scopus 로고    scopus 로고
    • Plerixafor, a CXCR4 antagonist for the mobilization of hematopoietic stem cells
    • Uy GL, Rettig MP, Cashen AF. 2008. Plerixafor, a CXCR4 antagonist for the mobilization of hematopoietic stem cells. Expert Opin Biol Ther 8: 1797-1804.
    • (2008) Expert Opin Biol Ther , vol.8 , pp. 1797-1804
    • Uy, G.L.1    Rettig, M.P.2    Cashen, A.F.3
  • 152
    • 41149111580 scopus 로고    scopus 로고
    • Chemokines and their receptors: Drug targets in immunity and inflammation
    • Viola A, Luster AD. 2008. Chemokines and their receptors: Drug targets in immunity and inflammation. Ann Rev Pharmacol Toxicol 48: 171-197.
    • (2008) Ann Rev Pharmacol Toxicol , vol.48 , pp. 171-197
    • Viola, A.1    Luster, A.D.2
  • 153
    • 84862517728 scopus 로고    scopus 로고
    • Cancer stem cells: Current status and evolving complexities
    • Visvader JE, Lindeman GJ. 2012. Cancer stem cells: Current status and evolving complexities. Cell Stem Cell 10: 717-728.
    • (2012) Cell Stem Cell , vol.10 , pp. 717-728
    • Visvader, J.E.1    Lindeman, G.J.2
  • 158
    • 0016430783 scopus 로고
    • Cell cycle redistribution as a factor in multifraction irradiation
    • Withers HR. 1975. Cell cycle redistribution as a factor in multifraction irradiation. Radiology 114: 199-202.
    • (1975) Radiology , vol.114 , pp. 199-202
    • Withers, H.R.1
  • 159
    • 80455129861 scopus 로고    scopus 로고
    • CXCR4-based imaging agents
    • Woodard LE, Nimmagadda S. 2011. CXCR4-based imaging agents. J Nucl Med 52: 1665-1669.
    • (2011) J Nucl Med , vol.52 , pp. 1665-1669
    • Woodard, L.E.1    Nimmagadda, S.2
  • 161
    • 70350225520 scopus 로고    scopus 로고
    • Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1 α , CXCR4, CXCL6, Neuropilin 1 in tumors from patients with rectal cancer
    • Xu L, Duda DG, Tomaso E, Ancukiewicz M, Chung DC, Lauwers GY, Samuel R, Shellito P, Czito BG, Lin P-C, et al. 2009. Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1 α , CXCR4, CXCL6, Neuropilin 1 in tumors from patients with rectal cancer. Cancer Res 69: 7905-7910.
    • (2009) Cancer Res , vol.69 , pp. 7905-7910
    • Xu, L.1    Duda, D.G.2    Tomaso, E.3    Ancukiewicz, M.4    Chung, D.C.5    Lauwers, G.Y.6    Samuel, R.7    Shellito, P.8    Czito, B.G.9    Lin, P.-C.10
  • 162
    • 84876005256 scopus 로고    scopus 로고
    • Low-dose radiation-induced epithelial-mesenchymal transition through NF-# B in cervical cancer cells
    • Yan S, Wang Y, Yang Q, Li X, Kong X, Zhang N, Yuan C, Yang N, Kong B.. 2013. Low-dose radiation-induced epithelial-mesenchymal transition through NF-# B in cervical cancer cells. Int J Oncol 42: 1801-1806.
    • (2013) Int J Oncol , vol.42 , pp. 1801-1806
    • Yan, S.1    Wang, Y.2    Yang, Q.3    Li, X.4    Kong, X.5    Zhang, N.6    Yuan, C.7    Yang, N.8    Kong, B.9
  • 164
    • 33751256842 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: Implications for angiogenesis and glioma cell invasion
    • Zagzag D, Lukyanov Y, Lan L, Ali MA, Esencay M, Mendez O, Yee H, Voura EB, Newcomb EW. 2006. Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: Implications for angiogenesis and glioma cell invasion. Lab Invest 86: 1221-1232.
    • (2006) Lab Invest , vol.86 , pp. 1221-1232
    • Zagzag, D.1    Lukyanov, Y.2    Lan, L.3    Ali, M.A.4    Esencay, M.5    Mendez, O.6    Yee, H.7    Voura, E.B.8    Newcomb, E.W.9
  • 165
    • 84874729595 scopus 로고    scopus 로고
    • Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor-1 á in hepatocellular carcinoma
    • Zhang L, Huang G, Li X, Zhang Y, Jiang Y, Shen J, Liu J, Wang Q, Zhu J, Feng X, et al. 2013. Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor-1 á in hepatocellular carcinoma. BMC Cancer 13: 108.
    • (2013) BMC Cancer , vol.13 , pp. 108
    • Zhang, L.1    Huang, G.2    Li, X.3    Zhang, Y.4    Jiang, Y.5    Shen, J.6    Liu, J.7    Wang, Q.8    Zhu, J.9    Feng, X.10
  • 166
    • 84864780648 scopus 로고    scopus 로고
    • CD133+ CXCR4+ colon cancer cells exhibit metastatic potential and predict poor prognosis of patients
    • Zhang S, Han Z, Jing Y, Tao S, Li T, Wang H, Wang Y, Li R, Yang Y, Zhao X, et al. 2012. CD133+ CXCR4+ colon cancer cells exhibit metastatic potential and predict poor prognosis of patients. BMC Med 10: 85.
    • (2012) BMC Med , vol.10 , pp. 85
    • Zhang, S.1    Han, Z.2    Jing, Y.3    Tao, S.4    Li, T.5    Wang, H.6    Wang, Y.7    Li, R.8    Yang, Y.9    Zhao, X.10
  • 167
    • 81755184035 scopus 로고    scopus 로고
    • Assessment of hypoxia inducible factor levels in cancer cell lines upon hypoxic induction using a novel reporter construct
    • Zhou W, Dosey TL, Biechele T, Moon RT, Horwitz MS, Ruohola-Baker H. 2011. Assessment of hypoxia inducible factor levels in cancer cell lines upon hypoxic induction using a novel reporter construct. PLoS One 6: e27460.
    • (2011) PLoS One , vol.6
    • Zhou, W.1    Dosey, T.L.2    Biechele, T.3    Moon, R.T.4    Horwitz, M.S.5    Ruohola-Baker, H.6
  • 169
    • 0032507962 scopus 로고    scopus 로고
    • Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    • Zou Y-R, Kottmann AH, Kuroda M, Taniuchi I, Littman DR. 1998. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393: 595-599.
    • (1998) Nature , vol.393 , pp. 595-599
    • Zou, Y.-R.1    Kottmann, A.H.2    Kuroda, M.3    Taniuchi, I.4    Littman, D.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.