메뉴 건너뛰기




Volumn 28, Issue 4, 2010, Pages 639-648

Radiation resistance of cancer stem cells: The 4 R's of radiobiology revisited

Author keywords

Cancer stem cells; Cancer initiating cells; Radiation biology

Indexed keywords

NOTCH RECEPTOR; REACTIVE OXYGEN METABOLITE;

EID: 77950972011     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.318     Document Type: Review
Times cited : (305)

References (125)
  • 1
    • 0000537744 scopus 로고
    • Studies of the dissemination and quantitative transplantation of a lymphocytic leukaemia of CBA mice
    • Hewitt HB. Studies of the dissemination and quantitative transplantation of a lymphocytic leukaemia of CBA mice. Br J Cancer 1958;12(3):378-401.
    • (1958) Br J Cancer , vol.12 , Issue.3 , pp. 378-401
    • Hewitt, H.B.1
  • 2
    • 84981839279 scopus 로고
    • Quantitative studies of autotransplantation of human cancer. Preliminary report
    • Southam C, Brunschwig A. Quantitative studies of autotransplantation of human cancer. Preliminary report. Cancer 1961;14(5):971-978.
    • (1961) Cancer , vol.14 , Issue.5 , pp. 971-978
    • Southam, C.1    Brunschwig, A.2
  • 3
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • Reya T, Morrison SJ, Clarke MF et al. Stem cells, cancer, and cancer stem cells. Nature 2001;414(6859):105-111.
    • (2001) Nature , vol.414 , Issue.6859 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3
  • 5
    • 33750313208 scopus 로고    scopus 로고
    • Cancer Stem Cells - Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem Cells
    • Clarke MF, Dick JE, Dirks PB et al. Cancer Stem Cells - Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem Cells. Cancer Res 2006;66(19):9339-9344.
    • (2006) Cancer Res , vol.66 , Issue.19 , pp. 9339-9344
    • Clarke, M.F.1    Dick, J.E.2    Dirks, P.B.3
  • 8
    • 68549085529 scopus 로고    scopus 로고
    • Establishment of a normal hematopoietic and leukemia stem cell hierarchy
    • Chao MP, Seita J, Weissman IL. Establishment of a normal hematopoietic and leukemia stem cell hierarchy. Cold Spring Harb Symp Quant Biol 2008;73:439-449.
    • (2008) Cold Spring Harb Symp Quant Biol , vol.73 , pp. 439-449
    • Chao, M.P.1    Seita, J.2    Weissman, I.L.3
  • 9
    • 0028010792 scopus 로고
    • Tumour stem cells: The biological concept and its application in cancer treatment
    • Trott KR. Tumour stem cells: the biological concept and its application in cancer treatment. Radiother Oncol 1994;30(1):1-5.
    • (1994) Radiother Oncol , vol.30 , Issue.1 , pp. 1-5
    • Trott, K.R.1
  • 10
    • 33644559031 scopus 로고    scopus 로고
    • Identifying cancer stem cells in solid tumors: Case not proven
    • discussion 1890
    • Hill RP. Identifying cancer stem cells in solid tumors: case not proven. Cancer Res 2006;66(4):1891-1895, discussion 1890.
    • (2006) Cancer Res , vol.66 , Issue.4 , pp. 1891-1895
    • Hill, R.P.1
  • 11
    • 35148899178 scopus 로고    scopus 로고
    • "Destemming" cancer stem cells
    • Hill RP, Perris R. "Destemming" cancer stem cells. J Natl Cancer Inst 2007;99(19):1435-1440.
    • (2007) J Natl Cancer Inst , vol.99 , Issue.19 , pp. 1435-1440
    • Hill, R.P.1    Perris, R.2
  • 12
    • 63649119820 scopus 로고    scopus 로고
    • Cancer stem cell-directed therapies: Recent data from the laboratory and clinic
    • Park CY, Tseng D, Weissman IL. Cancer stem cell-directed therapies: recent data from the laboratory and clinic. Mol Ther 2009;17(2):219-230.
    • (2009) Mol Ther , vol.17 , Issue.2 , pp. 219-230
    • Park, C.Y.1    Tseng, D.2    Weissman, I.L.3
  • 13
    • 57349143739 scopus 로고    scopus 로고
    • Efficient tumour formation by single human melanoma cells
    • Quintana E, Shackleton M, Sabel MS et al. Efficient tumour formation by single human melanoma cells. Nature 2008;456(7222):593-598.
    • (2008) Nature , vol.456 , Issue.7222 , pp. 593-598
    • Quintana, E.1    Shackleton, M.2    Sabel, M.S.3
  • 14
    • 0035702972 scopus 로고    scopus 로고
    • Tumour stem cells - The evidence and the ambiguity
    • Kummermehr JC. Tumour stem cells - the evidence and the ambiguity. Acta Oncol 2001;40(8):981-988.
    • (2001) Acta Oncol , vol.40 , Issue.8 , pp. 981-988
    • Kummermehr, J.C.1
  • 16
    • 38349165576 scopus 로고    scopus 로고
    • Identification of cells initiating human melanomas
    • Schatton T, Murphy GF, Frank NY et al. Identification of cells initiating human melanomas. Nature 2008;451(7176):345-349.
    • (2008) Nature , vol.451 , Issue.7176 , pp. 345-349
    • Schatton, T.1    Murphy, G.F.2    Frank, N.Y.3
  • 18
    • 37149013962 scopus 로고    scopus 로고
    • Effects of recombinant erythropoietin on breast cancer-initiating cells
    • DOI 10.1593/neo.07694
    • Phillips TM, Kim K, Vlashi E et al. Effects of recombinant erythropoietin on breast cancer-initiating cells. Neoplasia 2007;9(12):1122-1129. (Pubitemid 350255350)
    • (2007) Neoplasia , vol.9 , Issue.12 , pp. 1122-1129
    • Phillips, T.M.1    Kim, K.2    Vlashi, E.3    McBride, W.H.4    Pajonk, F.5
  • 23
    • 28244472369 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic prostate cancer stem cells
    • DOI 10.1158/0008-5472.CAN-05-2018
    • Collins AT, Berry PA, Hyde C et al. Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res 2005;65(23):10946-10951. (Pubitemid 41713363)
    • (2005) Cancer Research , vol.65 , Issue.23 , pp. 10946-10951
    • Collins, A.T.1    Berry, P.A.2    Hyde, C.3    Stower, M.J.4    Maitland, N.J.5
  • 27
    • 68049114782 scopus 로고    scopus 로고
    • Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells
    • Shimono Y, Zabala M, Cho RW et al. Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell 2009;138(3):592-603.
    • (2009) Cell , vol.138 , Issue.3 , pp. 592-603
    • Shimono, Y.1    Zabala, M.2    Cho, R.W.3
  • 28
    • 59049087696 scopus 로고    scopus 로고
    • Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
    • Zhu L, Gibson P, Currle DS et al. Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature 2009;457(7229):603- 607.
    • (2009) Nature , vol.457 , Issue.7229 , pp. 603-607
    • Zhu, L.1    Gibson, P.2    Currle, D.S.3
  • 29
    • 59049106578 scopus 로고    scopus 로고
    • Crypt stem cells as the cells-of-origin of intestinal cancer
    • Barker N, Ridgway RA, van Es JH et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 2009;457(7229):608-611.
    • (2009) Nature , vol.457 , Issue.7229 , pp. 608-611
    • Barker, N.1    Ridgway, R.A.2    Van Es, J.H.3
  • 30
    • 58149333204 scopus 로고    scopus 로고
    • Cancer induction by restriction of oncogene expression to the stem cell compartment
    • Pérez-Caro M, Cobaleda C, Gonzalez-Herrero I et al. Cancer induction by restriction of oncogene expression to the stem cell compartment. Embo J 2009;28(1):8-20.
    • (2009) Embo J , vol.28 , Issue.1 , pp. 8-20
    • Pérez-Caro, M.1    Cobaleda, C.2    Gonzalez-Herrero, I.3
  • 31
    • 68549087353 scopus 로고    scopus 로고
    • Neural and cancer stem cells in tumor suppressor mouse models of malignant astrocytoma
    • Llaguno SA, Chen J, Kwon CH et al. Neural and cancer stem cells in tumor suppressor mouse models of malignant astrocytoma. Cold Spring Harb Symp Quant Biol 2008;73:421-426.
    • (2008) Cold Spring Harb Symp Quant Biol , vol.73 , pp. 421-426
    • Llaguno, S.A.1    Chen, J.2    Kwon, C.H.3
  • 34
    • 47749106106 scopus 로고    scopus 로고
    • Identification of CD133-positive radioresistant cells in atypical teratoid/rhabdoid tumor
    • Chiou SH, Kao CL, Chen YW et al. Identification of CD133-positive radioresistant cells in atypical teratoid/rhabdoid tumor. PLoS One 2008;3(5):e2090.
    • (2008) PLoS One , vol.3 , Issue.5
    • Chiou, S.H.1    Kao, C.L.2    Chen, Y.W.3
  • 35
    • 33845621982 scopus 로고    scopus 로고
    • Daoy medulloblastoma cells that express CD133 are radioresistant relative to CD133- Cells, and the CD133+ sector is enlarged by hypoxia
    • DOI 10.1016/j.ijrobp.2006.09.037, PII S036030160603207X
    • Blazek ER, Foutch JL, Maki G. Daoy medulloblastoma cells that express CD133 are radioresistant relative to CD133- cells, and the CD133+ sector is enlarged by hypoxia. Int J Radiat Oncol Biol Phys 2007;67(1):1-5. (Pubitemid 44959518)
    • (2007) International Journal of Radiation Oncology Biology Physics , vol.67 , Issue.1 , pp. 1-5
    • Blazek, E.R.1    Foutch, J.L.2    Maki, G.3
  • 36
    • 60349085855 scopus 로고    scopus 로고
    • Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression
    • Chang CJ, Hsu CC, Yung MC et al. Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression. Biochem Biophys Res Commun 2009;380(2):236-242.
    • (2009) Biochem Biophys Res Commun , vol.380 , Issue.2 , pp. 236-242
    • Chang, C.J.1    Hsu, C.C.2    Yung, M.C.3
  • 37
    • 20844463226 scopus 로고    scopus 로고
    • + progenitor are resistant to apoptosis induced by a wide range of proapoptotic stimuli
    • DOI 10.1038/sj.leu.2403724
    • Holtz MS, Forman SJ, Bhatia R. Nonproliferating CML CD34+ progenitors are resistant to apoptosis induced by a wide range of proapoptotic stimuli. Leukemia 2005;19(6):1034-1041. (Pubitemid 40862017)
    • (2005) Leukemia , vol.19 , Issue.6 , pp. 1034-1041
    • Holtz, M.S.1    Forman, S.J.2    Bhatia, R.3
  • 38
    • 64249138718 scopus 로고    scopus 로고
    • Evaluation of radiotherapy effect in resveratrol-treated medulloblastoma cancer stem-like cells
    • Lu KH, Chen YW, Tsai PH et al. Evaluation of radiotherapy effect in resveratrol-treated medulloblastoma cancer stem-like cells. Childs Nerv Syst 2009;25(5):543-550.
    • (2009) Childs Nerv Syst , vol.25 , Issue.5 , pp. 543-550
    • Lu, K.H.1    Chen, Y.W.2    Tsai, P.H.3
  • 39
    • 67650095390 scopus 로고    scopus 로고
    • The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells
    • Lomonaco SL, Finniss S, Xiang C et al. The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells. Int J Cancer 2009;125(3):717-722.
    • (2009) Int J Cancer , vol.125 , Issue.3 , pp. 717-722
    • Lomonaco, S.L.1    Finniss, S.2    Xiang, C.3
  • 40
    • 48949119473 scopus 로고    scopus 로고
    • Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy
    • Fillmore CM, Kuperwasser C. Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res 2008;10(2):R25.
    • (2008) Breast Cancer Res , vol.10 , Issue.2
    • Fillmore, C.M.1    Kuperwasser, C.2
  • 41
    • 64749093574 scopus 로고    scopus 로고
    • Association of reactive oxygen species levels and radioresistance in cancer stem cells
    • Diehn M, Cho RW, Lobo NA et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 2009;458(7239):780-783.
    • (2009) Nature , vol.458 , Issue.7239 , pp. 780-783
    • Diehn, M.1    Cho, R.W.2    Lobo, N.A.3
  • 42
    • 62349116134 scopus 로고    scopus 로고
    • In-vivo imaging, tracking, and targeting of cancer stem cells
    • Vlashi E, Kim K, Dealla DL et al. In-vivo imaging, tracking, and targeting of cancer stem cells. J Natl Cancer Inst 2009;101(5):350-359.
    • (2009) J Natl Cancer Inst , vol.101 , Issue.5 , pp. 350-359
    • Vlashi, E.1    Kim, K.2    Dealla, D.L.3
  • 43
    • 45849089879 scopus 로고    scopus 로고
    • Exploring the role of cancer stem cells in radioresistance
    • DOI 10.1038/nrc2419, PII NRC2419
    • Baumann M, Krause M, Hill R. Exploring the role of cancer stem cells in radioresistance. Nat Rev Cancer 2008;8(7):545-554. (Pubitemid 351881850)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.7 , pp. 545-554
    • Baumann, M.1    Krause, M.2    Hill, R.3
  • 44
    • 0001086274 scopus 로고
    • The four R's of radiotherapy
    • Withers HR, ed. New York: Academic Press, Lett JT AH, ed.
    • Withers HR, ed. The four R's of radiotherapy. New York: Academic Press, 1975. Lett JT AH, ed. Advances in radiation biology; No.5.
    • (1975) Advances in Radiation Biology , Issue.5
  • 47
    • 0023270590 scopus 로고
    • The role of glutathione in radiation and drug induced cytotoxicity
    • Mitchell JB, Russo A. The role of glutathione in radiation and drug induced cytotoxicity. Br J Cancer 1987;8:96-104. (Pubitemid 17108366)
    • (1987) British Journal of Cancer , vol.55 , Issue.SUPPL. 8 , pp. 96-104
    • Mitchell, J.B.1    Russo, A.2
  • 48
    • 35548936968 scopus 로고    scopus 로고
    • A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the lowoxygenic niche
    • Jang YY, Sharkis SJ. A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the lowoxygenic niche. Blood 2007;110(8):3056-3063.
    • (2007) Blood , vol.110 , Issue.8 , pp. 3056-3063
    • Jang, Y.Y.1    Sharkis, S.J.2
  • 49
    • 16644392782 scopus 로고    scopus 로고
    • Detection of DNA Damage in Individual Cells by Analysis of Histone H2AX Phosphorylation
    • DOI 10.1016/S0091-679X(04)75014-1, PII S0091679X04750141, Cytometry, 4th Edition: New Developments
    • Olive PL. Detection of DNA damage in individual cells by analysis of histone H2AX phosphorylation. Methods Cell Biol 2004;75:355-373. (Pubitemid 39752532)
    • (2004) Methods in Cell Biology , vol.75 , pp. 355-373
    • Olive, P.L.1
  • 50
    • 33845874094 scopus 로고    scopus 로고
    • Cancer stem cells and radiotherapy: New insights into tumor radioresistance
    • DOI 10.1093/jnci/djj505
    • Diehn M, Clarke MF. Cancer stem cells and radiotherapy: new insights into tumor radioresistance. J Natl Cancer Inst 2006;98(24):1755-1757. (Pubitemid 46017927)
    • (2006) Journal of the National Cancer Institute , vol.98 , Issue.24 , pp. 1755-1757
    • Diehn, M.1    Clarke, M.F.2
  • 51
    • 62549142665 scopus 로고    scopus 로고
    • Comparative analysis of DNA repair in stem and nonstem glioma cell cultures
    • Ropolo M, Daga A, Griffero F et al. Comparative analysis of DNA repair in stem and nonstem glioma cell cultures. Mol Cancer Res 2009;7(3):383-392.
    • (2009) Mol Cancer Res , vol.7 , Issue.3 , pp. 383-392
    • Ropolo, M.1    Daga, A.2    Griffero, F.3
  • 52
    • 69349095324 scopus 로고    scopus 로고
    • CD133+ glioblastoma stem-like cells are radiosensitive with a defective DNA damage response compared with established cell lines
    • McCord AM, Jamal M, Williams ES et al. CD133+ glioblastoma stem-like cells are radiosensitive with a defective DNA damage response compared with established cell lines. Clin Cancer Res 2009;15(16):5145-5153.
    • (2009) Clin Cancer Res , vol.15 , Issue.16 , pp. 5145-5153
    • McCord, A.M.1    Jamal, M.2    Williams, E.S.3
  • 53
    • 70449721415 scopus 로고    scopus 로고
    • Radiation response of cancer stem-like cells from established human cell lines after sorting for surface markers
    • Al-Assar O, Muschel RJ, Mantoni TS et al. Radiation response of cancer stem-like cells from established human cell lines after sorting for surface markers. Int J Radiat Oncol Biol Phys 2009;75(4):1216-1225.
    • (2009) Int J Radiat Oncol Biol Phys , vol.75 , Issue.4 , pp. 1216-1225
    • Al-Assar, O.1    Muschel, R.J.2    Mantoni, T.S.3
  • 54
    • 70649094312 scopus 로고    scopus 로고
    • Separating stem cells by flow cytometry: Reducing variability for solid tissues
    • Alexander CM, Puchalski J, Klos KS et al. Separating stem cells by flow cytometry: reducing variability for solid tissues. Cell Stem Cell 2009;5(6):579-583.
    • (2009) Cell Stem Cell , vol.5 , Issue.6 , pp. 579-583
    • Alexander, C.M.1    Puchalski, J.2    Klos, K.S.3
  • 55
    • 56349113871 scopus 로고    scopus 로고
    • CD133 is a marker of bioenergetic stress in human glioma
    • Griguer CE, Oliva CR, Gobin E et al. CD133 is a marker of bioenergetic stress in human glioma. PLoS One 2008;3(11):e3655.
    • (2008) PLoS One , vol.3 , Issue.11
    • Griguer, C.E.1    Oliva, C.R.2    Gobin, E.3
  • 56
    • 66149152637 scopus 로고    scopus 로고
    • Limits of CD133 as a marker of glioma self-renewing cells
    • Clément V, Dutoit V, Marino D et al. Limits of CD133 as a marker of glioma self-renewing cells. Int J Cancer 2009;125(1):244-248.
    • (2009) Int J Cancer , vol.125 , Issue.1 , pp. 244-248
    • Clément, V.1    Dutoit, V.2    Marino, D.3
  • 57
    • 38349075007 scopus 로고    scopus 로고
    • CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells
    • Wang J, Sakariassen PO, Tsinkalovsky O et al. CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. Int J Cancer 2008;122(4):761-768.
    • (2008) Int J Cancer , vol.122 , Issue.4 , pp. 761-768
    • Wang, J.1    Sakariassen, P.O.2    Tsinkalovsky, O.3
  • 58
    • 65549120442 scopus 로고    scopus 로고
    • CD133 (Prominin) negative human neural stem cells are clonogenic and tripotent
    • Sun Y, Kong W, Falk A et al. CD133 (Prominin) negative human neural stem cells are clonogenic and tripotent. PLoS One 2009;4(5):e5498.
    • (2009) PLoS One , vol.4 , Issue.5
    • Sun, Y.1    Kong, W.2    Falk, A.3
  • 59
    • 38149030719 scopus 로고    scopus 로고
    • Phosphatases, DNA damage checkpoints and checkpoint deactivation
    • Heideker J, Lis ET, Romesberg FE. Phosphatases, DNA damage checkpoints and checkpoint deactivation. Cell Cycle 2007;6(24):3058-3064.
    • (2007) Cell Cycle , vol.6 , Issue.24 , pp. 3058-3064
    • Heideker, J.1    Lis, E.T.2    Romesberg, F.E.3
  • 60
    • 25444467978 scopus 로고    scopus 로고
    • CHK1 affecting cell radiosensitivity is independent of non-homologous end joining
    • Wang H, Hu B, Liu R et al. CHK1 affecting cell radiosensitivity is independent of non-homologous end joining. Cell Cycle 2005;4(2):300-303. (Pubitemid 41365338)
    • (2005) Cell Cycle , vol.4 , Issue.2 , pp. 300-303
    • Wang, H.1    Hu, B.2    Liu, R.3    Wang, Y.4
  • 61
    • 47249114406 scopus 로고    scopus 로고
    • Rad51 protein controls Rad52-mediated DNA annealing
    • Wu Y, Kantake N, Sugiyama T et al. Rad51 protein controls Rad52-mediated DNA annealing. J Biol Chem 2008;283(21):14883-14892.
    • (2008) J Biol Chem , vol.283 , Issue.21 , pp. 14883-14892
    • Wu, Y.1    Kantake, N.2    Sugiyama, T.3
  • 62
    • 60549111070 scopus 로고    scopus 로고
    • Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature
    • Charafe-Jauffret E, Ginestier C, Iovino F et al. Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res 2009;69(4):1302-1313.
    • (2009) Cancer Res , vol.69 , Issue.4 , pp. 1302-1313
    • Charafe-Jauffret, E.1    Ginestier, C.2    Iovino, F.3
  • 63
    • 58149197153 scopus 로고    scopus 로고
    • Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines
    • Iwasa T, Okamoto I, Suzuki M et al. Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines. Clin Cancer Res 2008;14(20):6496-6504.
    • (2008) Clin Cancer Res , vol.14 , Issue.20 , pp. 6496-6504
    • Iwasa, T.1    Okamoto, I.2    Suzuki, M.3
  • 66
    • 41749094285 scopus 로고    scopus 로고
    • Survivin Antisense Oligonucleotides Effectively Radiosensitize Colorectal Cancer Cells in Both Tissue Culture and Murine Xenograft Models
    • DOI 10.1016/j.ijrobp.2008.02.011, PII S0360301608002861
    • Rödel F, Frey B, Leitmann W et al. Survivin antisense oligonucleotides effectively radiosensitize colorectal cancer cells in both tissue culture and murine xenograft models. Int J Radiat Oncol Biol Phys 2008;71(1):247-255. (Pubitemid 351491424)
    • (2008) International Journal of Radiation Oncology Biology Physics , vol.71 , Issue.1 , pp. 247-255
    • Rodel, F.1    Frey, B.2    Leitmann, W.3    Capalbo, G.4    Weiss, C.5    Rodel, C.6
  • 68
    • 0016430783 scopus 로고
    • Cell cycle redistribution as a factor in multifraction irradiation
    • Withers HR. Cell cycle redistribution as a factor in multifraction irradiation. Radiology 1975;114(1):199-202.
    • (1975) Radiology , vol.114 , Issue.1 , pp. 199-202
    • Withers, H.R.1
  • 69
    • 3242669145 scopus 로고    scopus 로고
    • Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche
    • DOI 10.1016/j.cell.2004.07.004, PII S0092867404006622
    • Arai F, Hirao A, Ohmura M et al. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 2004;118(2):149-161. (Pubitemid 38962572)
    • (2004) Cell , vol.118 , Issue.2 , pp. 149-161
    • Arai, F.1    Hirao, A.2    Ohmura, M.3    Sato, H.4    Matsuoka, S.5    Takubo, K.6    Ito, K.7    Koh, G.Y.8    Suda, T.9
  • 70
    • 56549128268 scopus 로고    scopus 로고
    • Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
    • Wilson A, Laurenti E, Oser G et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 2008;135(6):1118-1129.
    • (2008) Cell , vol.135 , Issue.6 , pp. 1118-1129
    • Wilson, A.1    Laurenti, E.2    Oser, G.3
  • 72
    • 63449116164 scopus 로고    scopus 로고
    • HER-2, notch, and breast cancer stem cells: Targeting an axis of evil
    • Korkaya H, Wicha MS. HER-2, notch, and breast cancer stem cells: targeting an axis of evil. Clin Cancer Res 2009;15(6):1845-1847.
    • (2009) Clin Cancer Res , vol.15 , Issue.6 , pp. 1845-1847
    • Korkaya, H.1    Wicha, M.S.2
  • 73
    • 67849124654 scopus 로고    scopus 로고
    • DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency
    • Hoey T, Yen WC, Axelrod F et al. DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency. Cell Stem Cell 2009;5(2):168-177.
    • (2009) Cell Stem Cell , vol.5 , Issue.2 , pp. 168-177
    • Hoey, T.1    Yen, W.C.2    Axelrod, F.3
  • 76
    • 26444472788 scopus 로고    scopus 로고
    • The effect of treatment interruptions in the postoperative irradiation of breast cancer
    • DOI 10.1159/000087909
    • Bese NS, Sut PA, Ober A. The effect of treatment interruptions in the postoperative irradiation of breast cancer. Oncology 2005;69(3):214-223. (Pubitemid 41433580)
    • (2005) Oncology , vol.69 , Issue.3 , pp. 214-223
    • Bese, N.S.1    Sut, P.A.2    Ober, A.3
  • 78
    • 0027298886 scopus 로고
    • Importance of tumor size and repopulation for radiocurability of skin cancer
    • Maciejewski BA, Skates S, Zajusz A et al. Importance of tumor size and repopulation for radiocurability of skin cancer. Neoplasma 1993;40(1):51-54. (Pubitemid 23138973)
    • (1993) Neoplasma , vol.40 , Issue.1 , pp. 51-54
    • Maciejewski, B.A.1    Skates, S.2    Zajusz, A.3    Lange, D.4
  • 79
    • 67649948804 scopus 로고    scopus 로고
    • WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics
    • Bisson I, Prowse DM. WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics. Cell Res 2009;19(6):683-697.
    • (2009) Cell Res , vol.19 , Issue.6 , pp. 683-697
    • Bisson, I.1    Prowse, D.M.2
  • 80
    • 58049193929 scopus 로고    scopus 로고
    • Hedgehog signalingregulates brain tumor-initiating cell proliferation and portends shorter survival for patients with PTEN-coexpressing glioblastomas
    • Xu Q, Yuan X, Liu G et al. Hedgehog signalingregulates brain tumor-initiating cell proliferation and portends shorter survival for patients with PTEN-coexpressing glioblastomas. Stem Cells 2008;26(12):3018-3026.
    • (2008) Stem Cells , vol.26 , Issue.12 , pp. 3018-3026
    • Xu, Q.1    Yuan, X.2    Liu, G.3
  • 81
    • 58149357077 scopus 로고    scopus 로고
    • Ionizing radiation shifts the PAI-1/ID-1 balance and activates notch signaling in endothelial cells
    • Scharpfenecker M, Kruse JJ, Sprong D et al. Ionizing radiation shifts the PAI-1/ID-1 balance and activates notch signaling in endothelial cells. Int J Radiat Oncol Biol Phys 2009;73(2):506-513.
    • (2009) Int J Radiat Oncol Biol Phys , vol.73 , Issue.2 , pp. 506-513
    • Scharpfenecker, M.1    Kruse, J.J.2    Sprong, D.3
  • 82
    • 33749404764 scopus 로고    scopus 로고
    • A garden of Notch-ly delights
    • Weinmaster G, Kopan R. A garden of Notch-ly delights. Development 2006;133(17):3277-3282.
    • (2006) Development , vol.133 , Issue.17 , pp. 3277-3282
    • Weinmaster, G.1    Kopan, R.2
  • 83
    • 53749089803 scopus 로고    scopus 로고
    • Notch activates cell cycle reentry and progression in quiescent cardiomyocytes
    • Campa VM, Gutierrez-Lanza R, Cerignoli F et al. Notch activates cell cycle reentry and progression in quiescent cardiomyocytes. J Cell Biol 2008;183(1):129-141.
    • (2008) J Cell Biol , vol.183 , Issue.1 , pp. 129-141
    • Campa, V.M.1    Gutierrez-Lanza, R.2    Cerignoli, F.3
  • 84
    • 0030770411 scopus 로고    scopus 로고
    • Latent transforming growth factor beta1 activation in situ: Quantitative and functional evidence after low-dose gamma-irradiation
    • Ehrhart EJ, Segarini P, Tsang ML et al. Latent transforming growth factor beta1 activation in situ: quantitative and functional evidence after low-dose gamma-irradiation. FASEB J 1997;11(12):991-1002. (Pubitemid 27425901)
    • (1997) FASEB Journal , vol.11 , Issue.12 , pp. 991-1002
    • Ehrhart, E.J.1    Segarini, P.2    Tsang, M.L.-S.3    Carroll, A.G.4    Barcellos-Hoff, M.H.5
  • 86
    • 0029736871 scopus 로고    scopus 로고
    • Redox-mediated activation of latent transforming growth factor-beta1
    • DOI 10.1210/me.10.9.1077
    • Barcellos-Hoff MH, Dix TA. Redox-mediated activation of latent transforming growth factor-beta 1. Mol Endocrinol 1996;10(9):1077-1083. (Pubitemid 26299216)
    • (1996) Molecular Endocrinology , vol.10 , Issue.9 , pp. 1077-1083
    • Barcellos-Hoff, M.H.1    Dix, T.A.2
  • 87
    • 66349135076 scopus 로고    scopus 로고
    • The TGF-beta paradox in human cancer: An update
    • Tian M, Schiemann WP. The TGF-beta paradox in human cancer: an update. Future Oncol 2009;5(2):259-271.
    • (2009) Future Oncol , vol.5 , Issue.2 , pp. 259-271
    • Tian, M.1    Schiemann, W.P.2
  • 90
    • 0028819716 scopus 로고
    • Local control of carcinoma of the tonsil by radiation therapy: An analysis of patterns of fractionation in nine institutions
    • Withers HR, Peters LJ, Taylor JM et al. Local control of carcinoma of the tonsil by radiation therapy: an analysis of patterns of fractionation in nine institutions. Int J Radiat Oncol Biol Phys 1995;33(3):549-562.
    • (1995) Int J Radiat Oncol Biol Phys , vol.33 , Issue.3 , pp. 549-562
    • Withers, H.R.1    Peters, L.J.2    Taylor, J.M.3
  • 91
    • 50849111710 scopus 로고    scopus 로고
    • Rational targeting of Notch signaling in cancer
    • Rizzo P, Osipo C, Foreman K et al. Rational targeting of Notch signaling in cancer. Oncogene 2008;27(38):5124-5131.
    • (2008) Oncogene , vol.27 , Issue.38 , pp. 5124-5131
    • Rizzo, P.1    Osipo, C.2    Foreman, K.3
  • 93
    • 36248953716 scopus 로고    scopus 로고
    • Mammary stem cells and breast cancer - Role of notch signalling
    • DOI 10.1007/s12015-007-0023-5, PII SCR32169
    • Farnie G, Clarke RB. Mammary stem cells and breast cancer-role of Notch signalling. Stem Cell Rev 2007;3(2):169-175. (Pubitemid 350129719)
    • (2007) Stem Cell Reviews , vol.3 , Issue.2 , pp. 169-175
    • Farnie, G.1    Clarke, R.B.2
  • 94
    • 0002623322 scopus 로고
    • Ueber Desensibilisierung gegen Roentgen und Radium Strahlen
    • Schwarz G. Ueber Desensibilisierung gegen Roentgen und Radium Strahlen. Muenchner Medizinische Wochenschrift 1909(24):1-2.
    • (1909) Muenchner Medizinische Wochenschrift , Issue.24 , pp. 1-2
    • Schwarz, G.1
  • 95
    • 0343022568 scopus 로고
    • Beiträge zur Biologie der Strahlenwirkung
    • Holthusen H. Beiträge zur Biologie der Strahlenwirkung. Pflüger's Arch Ges Physiol 1921;187:1-24.
    • (1921) Pflüger's Arch Ges Physiol , vol.187 , pp. 1-24
    • Holthusen, H.1
  • 96
    • 84966192535 scopus 로고
    • The histological structure of some human lung cancers and the possible implications for radiotherapy
    • Thomlinson RH, Gray LH. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 1955;9:539-549.
    • (1955) Br J Cancer , vol.9 , pp. 539-549
    • Thomlinson, R.H.1    Gray, L.H.2
  • 97
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Hockel M, Schlenger K, Aral B et al. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 1996;56(19):4509-4515. (Pubitemid 26330463)
    • (1996) Cancer Research , vol.56 , Issue.19 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 98
    • 0030022252 scopus 로고    scopus 로고
    • Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma
    • Brizel DM, Scully SP, Harrelson JM et al. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 1996;56(5):941-943.
    • (1996) Cancer Res , vol.56 , Issue.5 , pp. 941-943
    • Brizel, D.M.1    Scully, S.P.2    Harrelson, J.M.3
  • 101
    • 26444466467 scopus 로고    scopus 로고
    • Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study
    • Nordsmark M, Bentzen SM, Rudat V et al. Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol 2005;77(1):18-24.
    • (2005) Radiother Oncol , vol.77 , Issue.1 , pp. 18-24
    • Nordsmark, M.1    Bentzen, S.M.2    Rudat, V.3
  • 102
    • 57149142495 scopus 로고    scopus 로고
    • The impact of O2 availability on human cancer
    • Bertout JA, Patel SA, Simon MC. The impact of O2 availability on human cancer. Nat Rev Cancer 2008;8(12):967-975.
    • (2008) Nat Rev Cancer , vol.8 , Issue.12 , pp. 967-975
    • Bertout, J.A.1    Patel, S.A.2    Simon, M.C.3
  • 103
    • 39749114978 scopus 로고    scopus 로고
    • Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
    • Bristow RG, Hill RP. Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer 2008;8(3):180-192.
    • (2008) Nat Rev Cancer , vol.8 , Issue.3 , pp. 180-192
    • Bristow, R.G.1    Hill, R.P.2
  • 104
    • 0036833897 scopus 로고    scopus 로고
    • Increased radiosensitivity with chronic hypoxia in four human tumor cell lines
    • Zölzer F, Streffer C. Increased radiosensitivity with chronic hypoxia in four human tumor cell lines. Int J Radiat Oncol Biol Phys 2002;54(3):910-920.
    • (2002) Int J Radiat Oncol Biol Phys , vol.54 , Issue.3 , pp. 910-920
    • Zölzer, F.1    Streffer, C.2
  • 106
    • 0031688165 scopus 로고    scopus 로고
    • Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix
    • Sundfor K, Lyng H, Rofstad EK. Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix. Br J Cancer 1998;78(6):822-827. (Pubitemid 28418321)
    • (1998) British Journal of Cancer , vol.78 , Issue.6 , pp. 822-827
    • Sundfor, K.1    Lyng, H.2    Rofstad, E.K.3
  • 108
    • 44649197646 scopus 로고    scopus 로고
    • Targeting Angiogenesis in Head and Neck Cancer
    • DOI 10.1053/j.seminoncol.2008.03.005, PII S0093775408000699
    • Seiwert TY, Cohen EE. Targeting angiogenesis in head and neck cancer. Semin Oncol 2008;35(3):274-285. (Pubitemid 351787696)
    • (2008) Seminars in Oncology , vol.35 , Issue.3 , pp. 274-285
    • Seiwert, T.Y.1    Cohen, E.E.W.2
  • 109
    • 34447258681 scopus 로고    scopus 로고
    • Tumor microenvironment abnormalities: Causes, consequences, and strategies to normalize
    • DOI 10.1002/jcb.21187
    • Fukumura D, Jain RK. Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize. J Cell Biochem 2007;101(4):937-949. (Pubitemid 47040874)
    • (2007) Journal of Cellular Biochemistry , vol.101 , Issue.4 , pp. 937-949
    • Fukumura, D.1    Jain, R.K.2
  • 110
    • 62749193771 scopus 로고    scopus 로고
    • Study of tumor blood perfusion and its variation due to vascular normalization by anti-angiogenic therapy based on 3D angiogenic microvasculature
    • Wu J, Long Q, Xu S et al. Study of tumor blood perfusion and its variation due to vascular normalization by anti-angiogenic therapy based on 3D angiogenic microvasculature. J Biomech 2009;42(6):712-721.
    • (2009) J Biomech , vol.42 , Issue.6 , pp. 712-721
    • Wu, J.1    Long, Q.2    Xu, S.3
  • 112
    • 63449083667 scopus 로고    scopus 로고
    • Radiotherapy decreases vascular density and causes hypoxia with macrophage aggregation in TRAMPC1 prostate tumors
    • Chen FH, Chiang CS, Wang CC et al. Radiotherapy decreases vascular density and causes hypoxia with macrophage aggregation in TRAMPC1 prostate tumors. Clin Cancer Res 2009;15(5):1721-1729.
    • (2009) Clin Cancer Res , vol.15 , Issue.5 , pp. 1721-1729
    • Chen, F.H.1    Chiang, C.S.2    Wang, C.C.3
  • 113
    • 34250182435 scopus 로고    scopus 로고
    • Lack of prognostic and predictive value of CA IX in radiotherapy of squamous cell carcinoma of the head and neck with known modifiable hypoxia: An evaluation of the DAHANCA 5 study
    • DOI 10.1016/j.radonc.2007.05.009, PII S0167814007002150, Highlights from the 10th International ESTRO-Wolfsberg Meeting on Molecular Radiation Biology/Oncology 2007
    • Eriksen JG, Overgaard J. Lack of prognostic and predictive value of CA IX in radiotherapy of squamous cell carcinoma of the head and neck with known modifiable hypoxia: an evaluation of the DAHANCA 5 study. Radiother Oncol 2007;83(3):383-388. (Pubitemid 46907987)
    • (2007) Radiotherapy and Oncology , vol.83 , Issue.3 , pp. 383-388
    • Eriksen, J.G.1    Overgaard, J.2
  • 114
    • 33750588816 scopus 로고    scopus 로고
    • Do erythropoietin receptors on cancer cells explain unexpected clinical findings?
    • Henke M, Mattern D, Pepe M et al. Do erythropoietin receptors on cancer cells explain unexpected clinical findings? J Clin Oncol 2006;24(29):4708-4713.
    • (2006) J Clin Oncol , vol.24 , Issue.29 , pp. 4708-4713
    • Henke, M.1    Mattern, D.2    Pepe, M.3
  • 116
    • 34047221511 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial of erythropoietin in non-small-cell lung cancer with disease-related anemia
    • Wright JR, Ung YC, Julian JA et al. Randomized, double-blind, placebo-controlled trial of erythropoietin in non-small-cell lung cancer with disease-related anemia. J Clin Oncol 2007;25(9):1027-1032.
    • (2007) J Clin Oncol , vol.25 , Issue.9 , pp. 1027-1032
    • Wright, J.R.1    Ung, Y.C.2    Julian, J.A.3
  • 118
    • 10644295624 scopus 로고    scopus 로고
    • The erythropoietin-receptor pathway modulates survival of cancer cells
    • DOI 10.1038/sj.onc.1208140
    • Pajonk F, Weil A, Sommer A et al. The erythropoietin-receptor pathway modulates survival of cancer cells. Oncogene 2004;23(55):8987-8991. (Pubitemid 39657789)
    • (2004) Oncogene , vol.23 , Issue.55 , pp. 8987-8991
    • Pajonk, F.1    Weil, A.2    Sommer, A.3    Suwinski, R.4    Henke, M.5
  • 120
    • 0031658227 scopus 로고    scopus 로고
    • Enhanced radiosensitivity in experimental tumours following erythropoietin treatment of chemotherapy-induced anaemia
    • Thews O, Koenig R, Kelleher DK et al. Enhanced radiosensitivity in experimental tumours following erythropoietin treatment of chemotherapy-induced anaemia. Br J Cancer 1998;78(6):752-756. (Pubitemid 28418307)
    • (1998) British Journal of Cancer , vol.78 , Issue.6 , pp. 752-756
    • Thews, O.1    Koenig, R.2    Kelleher, D.K.3    Kutzner, J.4    Vaupel, P.5
  • 121
    • 0027969025 scopus 로고
    • Erythropoietin increases the radioresistance of a clonal hematopoietic progenitor cell line expressing a transgene for the erythropoietin receptor
    • Santucci MA, Pierce JH, Zannini S et al. Erythropoietin increases the radioresistance of a clonal hematopoietic progenitor cell line expressing a transgene for the erythropoietin receptor. Stem Cells 1994;12(5):506-513. (Pubitemid 24278229)
    • (1994) Stem Cells , vol.12 , Issue.5 , pp. 506-513
    • Santucci, M.A.1    Pierce, J.H.2    Zannini, S.3    Fortuna, A.4    Frezza, G.5    Babini, L.6    Rosenstein, M.M.7    Greenberger, J.S.8
  • 122
    • 0027520210 scopus 로고
    • The effect of recombinant human erythropoietin treatment on tumour radiosensitivity and cancer-associated anaemia in the mouse
    • Joiner B, Hirst VK, McKeown SR et al. The effect of recombinant human erythropoietin treatment on tumour radiosensitivity and cancer-associated anaemia in the mouse. Br J Cancer 1993;68(4):720-726. (Pubitemid 23301276)
    • (1993) British Journal of Cancer , vol.68 , Issue.4 , pp. 720-726
    • Joiner, B.1    Hirst, V.K.2    Mckeown, S.R.3    McAleer, J.J.A.4    Hirst, D.G.5
  • 123
    • 0000459772 scopus 로고
    • Ueber den Stoffwechsel der Tumoren
    • Warburg O, Posener K, Negelein E. Ueber den Stoffwechsel der Tumoren. Biochem Z 1924;152:319-344.
    • (1924) Biochem Z , vol.152 , pp. 319-344
    • Warburg, O.1    Posener, K.2    Negelein, E.3
  • 124
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis RJ, Lum JJ, Hatzivassiliou G et al. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008;7(1):11-20.
    • (2008) Cell Metab , vol.7 , Issue.1 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3
  • 125
    • 38349168416 scopus 로고    scopus 로고
    • Stem cell and kinase activity-independent pathway in resistance of leukaemia to BCR-ABL kinase inhibitors
    • Li S, Li D. Stem cell and kinase activity-independent pathway in resistance of leukaemia to BCR-ABL kinase inhibitors. J Cell Mol Med 2007;11(6):1251-1262.
    • (2007) J Cell Mol Med , vol.11 , Issue.6 , pp. 1251-1262
    • Li, S.1    Li, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.